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Influencing factors and solution strategies of chimeric antigen receptor T-cell therapy(CAR–T)cell immunotherapy

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Oncology Research 2024年第9期32卷 1479-1516页

作者： ZHENGYI WANG liang zhou XIAOYING WU Department of Institute of Laboratory Animal Sciences Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Ministry of Education and Training Chengdu Second People’s HospitalChengduChina

Chimeric antigen receptor T-cesll therapy(CAR–T)has achieved groundbreaking advancements in clinical application,ushering in a new era for innovative cancer ***,the challenges associated with implementing this novel targeted cell therapy are increasingly *** in the clinical management of solid tumors,obstacles such as the immunosuppressive effects of the tumor microenvironment,limited local tumor infiltration capability of CAR–T cells,heterogeneity of tumor targeting antigens,uncertainties surrounding CAR–T quality,control,and clinical adverse reactions have contributed to increased drug resistance and decreased compliance in tumor *** factors have significantly impeded the widespread adoption and utilization of this therapeutic *** this paper,we comprehensively analyze recent preclinical and clinical reports on CAR–T therapy while summarizing crucial factors influencing its ***,we aim to identify existing solution strategies and explore their current research *** this review article,our objective is to broaden perspectives for further exploration into CAR–T therapy strategies and their clinical applications.

关键词： Chimeric antigen receptor T-cell therapy(CAR-T) Tumor targeting therapy Influencing factor Solution strategies

Model-free adaptive robust control method for high-speed trains

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Transportation Safety and Environment 2024年第1期6卷 93-102页

作者： Zhongqi Li liang zhou Hui Yang Yue Yan School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang 330013JiangxiChina State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong UniversityNanchang 330013JiangxiChina

Aiming at the robustness issue in high-speed trains(HSTs)operation control,this article proposes a model-free adaptive control(MFAC)scheme to suppress ***,the dynamic linearization data model of train system under the action of measurement disturbance is given,and the Kalman filter(KF)based on this model is derived under the minimum variance estimation ***,according to the KF,an anti-interference MFAC scheme is *** scheme only needs the input and output data of the controlled system to realize the MFAC of the train under strong ***,the simulation experiment of CRH380A HSTs is carried out and compared with the traditional MFAC and the MFAC with attenuation *** proposed control algorithm can effectively suppress the measurement disturbance,and obtain smaller tracking error and larger signal to noise ratio with better applicability.

关键词： automatic train operation(ATO) model-free adaptive control(MFAC) disturbance suppression minimum variance estimation Kalman filtering(KF) partial format data model

Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： Lin Chen Yu-Xin Xu Yuan-Shuo Wang Jian-liang zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic *** in lipid metabolism affect the proliferation and metastatic capabilities of PCa *** cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy ***,changes occur in amino acid metabolism in *** cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival *** changes are closely associated with disease progression and treatment response in PCa ***,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

Multifunctional 2-(2-hydroxyphenyl)benzoxazoles: Ready synthesis,mechanochromism, fluorescence imaging, and OLEDs

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Chinese Chemical Letters 2024年第10期35卷 223-227页

作者： Kangmin Wang Liqiu Wan Jingyu Wang Chunlin zhou Ke Yang liang zhou Bijin Li Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China jiangsu Key Laboratory of Advanced Catalytic Materials&Technology School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Triphenylamine(TPA)-containing 2-(2-hydroxyphenyl)benzoxazoles(2a-2c)have been synthesized via a highly efficient rhodium-catalyzed C–H/C–H cross-coupling *** 2a is a novel mechanofluorochromic material with blue-shifted mechanochromic *** 2b and 2c presented opposite mechanochromic *** 2b,the enol-form emission enhanced,and the ketoform emission blue-shift after *** contrast,2c exhibited the weak enol-form emission disappeared and the keto-form emission slightly red-shift after grinding *** estrone-containing2b-based water-dispersed nanoparticles(NPs)exhibit apparent dual-emission and were applied for fluorescence *** addition,bis(TPA)-containing 2c-based devices exhibit dual-emission with good performance and a singlet exciton yield of 92%,which breaks through the theoretical upper limit of 25%in conventional fluorescent *** is one of the highest exciton utilization values recorded for the ESIPT molecules with a dual emission system.

关键词： Rhodium-catalyzed 2-(2'-Hydroxyphenyl)benzoxazoles Mechanochromism Fluorescence images OLEDS

Continuous Fe^(3+)releasing enabled complete reconstruction of Ni-based MOF for promoted water oxidation in industrial alkali

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Science China Chemistry 2024年第9期67卷 2949-2957页

作者： Zhaojian Wang Wei Zhang Wenzhong Huang Ruohan Yu Changliang Chen Liqiang Mai liang zhou State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya 572000China Hubei Longzhong Laboratory Wuhan University of Technology(Xiangyang Demonstration Zone)Xiangyang 441000China

Most oxygen evolution reaction(OER)electrocatalysts show poor stability under industrial alkaline conditions(20–30 wt.%KOH).Therefore,it is essential to develop stable,efficient,and low-cost OER catalysts for industrial water ***,we present a straightforward approach for the complete electrochemical reconstruction of Ni-BDC,a Ni-based metal-organic framework,for *** method involves the continuous release of Fe^(3+)from Fe foam counter electrode in a high-concentration(6.0 M,25 wt.%)KOH *** continuously Fe^(3+)releasing not only realizes in situ Fe^(3+)doping,but also introduces abundant defects in the obtained catalyst during cyclic voltammetry activation,thereby accelerating the electrochemical *** reconstructed OER catalyst(Fe-doped nickel hydroxide/oxyhydroxide nanosheets supported on Ni foam,Fe-NiO_(x)(OH)y/NF)manifests a low overpotential of 217 mV at 10 mA cm^(-2)and 263 m V at 100 m A cm^(-2)in 1.0 M ***,the Fe-NiO_(x)(OH)_(y)/NF also demonstrates high stability in 30 wt.%*** strategy of regulating the electrochemical reconstruction process sheds light on the construction of stable and efficient OER catalysts for industrial water electrolysis.

关键词： oxygen evolution reaction industrial alkaline conditions metal-organic framework complete reconstruction

Chaotic Motions of the van der Pol-Duffing Oscillator Subjected to Periodic External and Parametric Excitations with Delayed Feedbacks

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 1111-1126页

作者： liang-qiang zhou Fang-qi CHEN School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Chaotic dynamics of the van der Pol-Duffing oscillator subjected to periodic external and parametric excitations with delayed feedbacks are investigated both analytically and numerically in this *** the Melnikov method,the critical value of chaos arising from homoclinic or heteroclinic intersections is derived *** feature of the critical curves separating chaotic and non-chaotic regions on the excitation frequency and the time delay is investigated analytically in *** monotonicity of the critical value to the excitation frequency and time delay is obtained *** is presented that there may exist a special frequency for this *** this frequency,chaos in the sense of Melnikov may not occur for any excitation *** also exists a uncontrollable time delay with which chaos always occurs for this *** simulations are carried out to verify the chaos threshold obtained by the analytical method.

关键词： Van der Pol-Duffing oscillator time delay chaos parametric excitation Melnikov method

Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia

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Genes & Diseases 2024年第5期11卷 105-108页

作者： liang zhou Youyou Li Jiaren Li Hanyu Yao Jin Huang Cheng Li Long Wang Department of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign prostatic hyperplasia(BPH)is a chronic pathological process that primarily causes lower urinary tract *** to histopathology,BPH is caused by an imbalance between cell death and proliferation.1 However,the exact pathophysiology remains *** is a newly discovered form of programmed cell *** cell morphology is characterized primarily by the reduction or disappearance of mitochondrial cristae and mitochondrial shrinkage.2,3 Competing endogenous RNAs(ceRNAs)are important regulators of many biological processes and have been involved in various diseases.

关键词： prostatic endogenous BPH

Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia

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Fundamental Research 2024年第4期4卷 829-840页

作者： liang zhou Qipeng Ran Rulan Yi Huanyao Tang Yu Zhang Tian Yu Key Laboratory of Brain Science Zunyi Medical UniversityZunyi 563003China Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003China Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical UniversityZunyi 563003China

Since their clinical application in the 1840s,the greatest mystery surrounding general anesthesia(GA)is how different kinds of general anesthetics cause reversible unconsciousness,and the precise neural mechanisms underlying the *** past years,although many studies revealed the roles of cortex,thalamus,brainstem,especially the sleep-wake circuits in GA-induced loss of consciousness(LOC),the full picture of the neural circuit mechanism of GA is still largely *** studies have focused on the importance of other brain ***,we report that the activity of glutamatergic(Glu)neurons in the piriform cortex(PC),a critical brain region for odor encoding,began to increase during the LOC of GA and gradually recovered after recovery of *** lesions of the anterior PC(APC)neurons accelerated the induction time of isoflurane *** and optogenetic activation of APcGlu neurons prolonged isoflurane and sevoflurane anesthesia induction,whereas APcclu neuron inhibition displayed the opposite ***,the modification of APcclu neurons did not affect the induction or emergence time of propofol *** addition,odor processing may be partially involved in the induction of isoflurane and sevofurane GA regulated by APCclu *** conclusion,our findings reveal a critical role of APCGlu neurons in inhalational GA induction.

关键词： Piriform cortex Inhalationalgeneral anesthesia Glutamatergic Induction time odor

Flexible ureteroscopic treatment of kidney stones: How do the new laser systems change our concepts?

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Asian Journal of Urology 2024年第2期11卷 156-168页

作者： Simin Yu Linhu Liu Ya Li liang zhou Jixiang Chen Hong Li Kunjie Wang Department of Urology Institute of Urology(Laboratory of Reconstructive Urology)West China HospitalSichuan UniversityChengduSichuanChina

Objective: Flexible ureteroscopy (fURS) has become a widely accepted and effective technique for treating kidney stones. With the development of new laser systems, the fURS approach has evolved significantly. This literature review aims to examine the current state of knowledge on fURS treatment of kidney stones, with a particular focus on the impact of the latest laser technologies on clinical outcomes and patient ***: We conducted a search of the PubMed/PMC, Web of Science Core Collection, Scopus, Embase (Ovid), and Cochrane Databases for all randomized controlled trial articles on laser lithotripsy in September 2023 without time ***: We found a total of 22 relevant pieces of literature. Holmium laser has been used for intracavitary laser lithotripsy for nearly 30 years and has become the golden standard for the treatment of urinary stones. However, the existing holmium laser cannot completely powder the stone, and the retropulsion of the stone after the laser emission and the thermal damage to the tissue have caused many problems for clinicians. The introduction of thulium fiber laser and Moses technology brings highly efficient dusting lithotripsy effect through laser innovation, limiting pulse energy and broadening pulse ***: While the holmium:yttrium-aluminum-garnet laser remains the primary choice for endoscopic laser lithotripsy, recent technological advancements hint at a potential new gold standard. Parameter range, retropulsion effect, laser fiber adaptability, and overall system performance demand comprehensive attention. The ablation efficacy of high-pulse-frequency devices relies on precise targeting, which may pose practical challenges.

关键词： Laser lithotripsy Urolithiasis Thulium laser Holmium:yttrium-aluminum-garnet Moses effect