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Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai Yan-Yan Xue Weigang Ge liang yue Xiao-Yan Li Rong-Rong Lin Guo-Ping Peng Wenhao Jiang Sainan Li Kun-Mu Zheng Bin Jiang Jian-Ping Jia Tiannan Guo Zhi-Ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic biomarkers.More ADspecific early diagnostic and disease staging biomarkers are needed.In this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 participants.Candidate biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 participants.We quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,respectively.In the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,respectively.Separate 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,respectively.The 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative diseases.Moreover,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD stages.Our findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

Resource allocation for D2D-assisted haptic communications

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Digital Communications and Networks 2024年第1期10卷 63-74页

作者： Yan Wu Chao yue Yang Yang liang Ao College of Telecommunication Engineering Army Engineering University of PLANanjing210000China

Haptic communications is recognized as a promising enabler of extensive services by enabling real-time haptic control and feedback in remote environments,e.g.,teleoperation and autonomous driving.Considering the strict transmission requirements on reliability and latency,Device-to-Device(D2D)communications is introduced to assist haptic communications.In particular,the teleoperators with poor channel quality are assisted by auxiliaries,and each auxiliary and its corresponding teleoperator constitute a D2D pair.However,the haptic interaction and the scarcity of radio resources pose severe challenges to the resource allocation,especially facing the sporadic packet arrivals.First,the contentionbased access scheme is applied to achieve low-latency transmission,where the resource scheduling latency is omitted and users can directly access available resources.In this context,we derive the reliability index of D2D pairs under the contention-based access scheme,i.e.,closed-loop packet error probability.Then,the reliability performance is guaranteed by bidirectional power control,which aims to minimize the sum packet error probability of all D2D pairs.Potential game theory is introduced to solve the problem with low complexity.Accordingly,a distributed power control algorithm based on synchronous log-linear learning is proposed to converge to the optimal Nash Equilibrium.Experimental results demonstrate the superiority of the proposed learning algorithm.

关键词： Haptic communications D2D Power control Contention-based access Potential game

Mechanical Performance of Bio-inspired Bidirectional Corrugated Sandwich Pressure Shell Under External Hydrostatic Pressure

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China Ocean Engineering 2024年第2期38卷 297-312页

作者： ZHANG Yi CHEN yue YUN Lai liang Xu Ocean College Zhejiang UniversityZhoushan 316000China Hainan Institute Zhejiang UniversitySanya 572000China

This paper aims to enhance the compression capacity of underwater cylindrical shells by adopting the corrugated sandwich structure of cuttlebone.The cuttlebone suffers uniaxial external compression,while underwater cylindrical shells are in a biaxial compressive stress state.To suit the biaxial compressive stress state,a novel bidirectional corrugated sandwich structure is proposed to improve the bearing capacity of cylindrical shells.The static and buckling analysis for the sandwich shell and the unstiffened cylindrical shell with the same volume-weight ratio are studied by numerical simulation.It is indicated that the proposed sandwich shell can effectively reduce the ratio between circumferential and axial stress from 2 to 1.25 and improve the critical buckling load by about 1.63 times.Numerical simulation shows that optimizing and adjusting the structural parameters could significantly improve the advantage of the sandwich shell.Then,the hydrostatic pressure tests for shell models fabricated by 3D printing are carried out.According to the experimental results,the overall failure position of the sandwich shell is at the center part of the sandwich shell.It has been found the average critical load of the proposed sandwich shell models exceeds two times that of the unstiffened shell models.Hence,the proposed bio-inspired bidirectional corrugated sandwich structure can significantly enhance the pressure resistance capability of cylindrical shells.

关键词： bio-inspiration bidirectional corrugation sandwich shell external pressure buckling

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An Investigation into the Compressive Strength,Permeability and Microstructure of Quartzite-Rock-Sand Mortar

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Fluid Dynamics & Materials Processing 2024年第4期20卷 859-872页

作者： Wei Chen Wuwen Liu yue liang School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China

River sand is an essential component used as a fine aggregate in mortar and concrete.Due to unrestrained exploitation,river sand resources are gradually being exhausted.This requires alternative solutions.This study deals with the properties of cement mortar containing different levels of manufactured sand(MS)based on quartzite,used to replace river sand.The river sand was replaced at 20%,40%,60%and 80%with MS(by weight or volume).The mechanical properties,transfer properties,and microstructure were examined and compared to a control group to study the impact of the replacement level.The results indicate that the compressive strength can be improved by increasing such a level.The strength was improved by 35.1%and 45.5%over that of the control mortar at replacement levels of 60%and 80%,respectively.Although there was a weak link between porosity and gas permeability in the mortars with manufactured sand,the gas permeability decreased with growing the replacement level.The microstructure of the MS mortar was denser,and the cement paste had fewer microcracks with increasing the replacement level.

关键词： Manufactured sand quartzite compressive strength gas permeability microstructure

Synthesis of Anti-Pancreatic Cancer Natural Product Majusculamide D and Analogues Reveals a Preliminary Structure-Activity Relationships

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Chinese Journal of Chemistry 2024年第6期42卷 605-610页

作者： Xiuhe Zhao Mengxue Lv Xiaonan Xi Yaxin Lu liang Wang yue Chen The State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin300350 China College of Chemistry Nankai UniversityTianjin300071 China

The total synthesis of majusculamide D(1)was achieved from commercially available materials.In addition,we synthesized eight analogues including three stereoisomers of majusculamide D that differ in the fatty acid chain.Six analogues including a simplified analogue 29 exhibited significant nanomolar-level IC50 values against Panc-1 cells in MTT assays.A preliminary SAR analysis indicated that the hydroxyl group at C10 and C2−C3 unsaturated double bond of majusculamide D were essential in maintaining the high activity against Panc-1 cells and the orientation of C40-Me and C42-Me groups was tolerable.

关键词： Majusculamide D Natural products SAR Anti-pancreatic cancer Lipopentapeptide

Influence of Ultra Fine Glass Powder on the Properties and Microstructure of Mortars

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Fluid Dynamics & Materials Processing 2024年第5期20卷 915-938页

作者： Wei Chen Dingdan Liu yue liang School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China

This study focuses on the effect of ultrafine waste glass powder on cement strength,gas permeability and pore structure.Varying contents were considered,with particle sizes ranging from 2 to 20μm.Moreover,alkali activation was considered to ameliorate the reactivity and cementitious properties,which were assessed by using scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDS),and specific surface area pore size distribution analysis.According to the results,without the addition of alkali activators,the performance of glass powder mortar decreases as the amount of glass powder increases,affecting various aspects such as strength and resistance to gas permeability.Only 5%glass powder mortar demonstrated a compressive strength at 60 days higher than that of the control group.However,adding alkali activator(CaO)during hydration ameliorated the hydration environment,increased the alkalinity of the composite system,activated the reactivity of glass powder,and enhanced the interaction of glass powder and pozzolanic reaction.In general,compared to ordinary cement mortar,alkali-activated glass powder mortar produces more hydration products,showcases elevated density,and exhibits improved gas resistance.Furthermore,alkali-activated glass powder mortar demonstrates an improvement in performance across various aspects as the content increases.At a substitution rate of 15%,the glass powder mortar reaches its optimal levels of strength and resistance to gas permeability,with a compressive strength increase ranging from 28.4%to 34%,and a gas permeation rate reduction between 51.8%and 66.7%.

关键词： Mortar waste glass powder alkali activation compressive strength gas permeability pore structure

Model-free adaptive robust control method for high-speed trains

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Transportation Safety and Environment 2024年第1期6卷 93-102页

作者： Zhongqi Li liang Zhou Hui Yang yue Yan School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang 330013JiangxiChina State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong UniversityNanchang 330013JiangxiChina

Aiming at the robustness issue in high-speed trains(HSTs)operation control,this article proposes a model-free adaptive control(MFAC)scheme to suppress disturbance.Firstly,the dynamic linearization data model of train system under the action of measurement disturbance is given,and the Kalman filter(KF)based on this model is derived under the minimum variance estimation criterion.Then,according to the KF,an anti-interference MFAC scheme is designed.This scheme only needs the input and output data of the controlled system to realize the MFAC of the train under strong disturbance.Finally,the simulation experiment of CRH380A HSTs is carried out and compared with the traditional MFAC and the MFAC with attenuation factor.The proposed control algorithm can effectively suppress the measurement disturbance,and obtain smaller tracking error and larger signal to noise ratio with better applicability.

关键词： automatic train operation(ATO) model-free adaptive control(MFAC) disturbance suppression minimum variance estimation Kalman filtering(KF) partial format data model

Multiobjective Differential Evolution for Higher-Dimensional Multimodal Multiobjective Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1458-1475页

作者： Jing liang Hongyu Lin Caitong yue Ponnuthurai Nagaratnam Suganthan Yaonan Wang School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001 School of Electrical Engineering and Automation Henan Institute of TechnologyXinxiang 453003China School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China KINDI Center for Computing Research Qatar UniversityDohaQatarand also with the Nanyang Technology UniversitySingapore College of Electrical and Information Engineering and also with the National Engineering Research Center for Robot Visual Perception and Control TechnologyHunan UniversityChangsha 410082China IEEE

In multimodal multiobjective optimization problems(MMOPs),there are several Pareto optimal solutions corre-sponding to the identical objective vector.This paper proposes a new differential evolution algorithm to solve MMOPs with higher-dimensional decision variables.Due to the increase in the dimensions of decision variables in real-world MMOPs,it is diffi-cult for current multimodal multiobjective optimization evolu-tionary algorithms(MMOEAs)to find multiple Pareto optimal solutions.The proposed algorithm adopts a dual-population framework and an improved environmental selection method.It utilizes a convergence archive to help the first population improve the quality of solutions.The improved environmental selection method enables the other population to search the remaining decision space and reserve more Pareto optimal solutions through the information of the first population.The combination of these two strategies helps to effectively balance and enhance conver-gence and diversity performance.In addition,to study the per-formance of the proposed algorithm,a novel set of multimodal multiobjective optimization test functions with extensible decision variables is designed.The proposed MMOEA is certified to be effective through comparison with six state-of-the-art MMOEAs on the test functions.

关键词： Benchmark functions diversity measure evolution-ary algorithms multimodal multiobjective optimization.

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The engineering of circular causality for specialization and design of complex systems:cad2CAS and casCAD2

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 323-332页

作者： Xiaolong liang Rui QIN Juanjuan LI Fei-yue WANG Faculty of Innovation Engineering Macao University of Science and TechnologyMacao999078China State Key Laboratory of Multimodal Artificial Intelligence Systems Chinese Academy of SciencesBeijing100190China The State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing100190China

The emergence of decentralized autonomous organizations and operations(DAOs),equipped with innovative mechanisms,enables new possibilities for transforming traditional social collaborative relationships.Mechanisms are the underlying driver for DAOs.However,as a complex system encompassing both social complexity and engineering complexity.

关键词： complexity. circular equipped

维普期刊数据库