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Nagilactone E increases PD-L1 expression through activation of c-jun in lung cancer cells

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Chinese Journal of Natural Medicines 2020年第7期18卷 517-525页

作者： CHEN yu-Chi HUANG mu-Yang ZHANG Le-Le feng Zhe-ling JIANG xiao-Ming yuAN Luo-Wei HUANG Run-yue liu Bo yu Hua WANG yi-tao CHEN Xiu-Ping lin Li-Gen LU Jin-Jian State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China School of Medicine Chengdu UniversityChengdu 610106China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) Guangzhou 510120China

Nagilactone E(NLE),a natural product with anticancer activities,is isolated from Podocarpus *** this study,we reported that NLE increased programmed death ligand 1(PD-L1)expressions at both protein and mRNA levels in human lung cancer cells,and enhanced its localization on the cell ***,NLE increased the phosphorylation and expression of cjun,and promoted the localization of c-jun in the nucleus,while silencing of c-jun by small interfering RNA(siRNA)reduced NLEinduced *** study showed that NLE activated the c-jun N-terminal kinases(JNK),the upstream of c-jun,and its inhibitor SP600125 reversed the NLE-increased ***,NLE-induced PD-L1 increased the binding intensity of PD-1 on the cell *** summary,NLE upregulates the expression of PD-L1 in lung cancer cells through the activation of JNK-c-jun axis,which has the potential to combine with the PD-1/PD-L1 antibody therapies in lung cancer.

关键词： Programmed death ligand 1 Nagilactone E Lung cancer c-jun JNK

Recent progress in nuclear astrophysics research and its astrophysical implications at the China Institute of Atomic Energy

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Nuclear Science and Techniques 2024年第12期35卷 376-408页

作者： Wei-Ping liu Bing Guo Zhu An Bao-Qun Cui xiao Fang Chang-Bo Fu Bin-Shui Gao Jian-jun He yu-Chen Jiang Chong Lv Er-tao Li Ge-Xing Li yun-Ju Li Zhi-Hong Li Gang Lian Wei-Ping lin yi-Hui liu Wei Nan Wei-Ke Nan Yang-Ping Shen Na Song jun Su liang-Ting Sun xiao-Dong Tang Luo-Huan Wang Shuo Wang You-Bao Wang Di Wu xiao-feng Xi Sheng-Quan Yan Li-Yong Zhang China Institute of Atomic Energy Beijing 102413China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Jinping Deep Underground Frontier Science and Dark Matter Key Laboratory of Sichuan Province Liangshan 615000China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Key Laboratory of Nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Joint Department for Nuclear Physics Institute of Modern PhysicsChinese Academy of Sciences and Lanzhou UniversityLanzhou 730000China CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 73000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenChina Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Mathematics and Physics Handan UniversityHandan 056005China Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China State Key Laboratory of Nuclear Physics and Technology School of PhysicsCAPTPeking UniversityBeijing 100871China

Nuclear astrophysics is a rapidly developing interdisciplinary feld of research that has received extensive attention from the scientifc community since the midtwentieth ***,it uses the laws of extremely small atomic nuclei to explain the evolution of the *** to the complexity of nucleosynthesis processes and our limited understanding of nuclear physics in astrophysical environments,several critical astrophysical problems remain *** achieve a better understanding of astrophysics,it is necessary to measure the cross sections of key nuclear reactions with the precision required by astrophysical *** measurement of nuclear reaction cross sections is an important method of investigating how nuclear reactions infuence stellar *** the challenges involved in measuring the extremely low crosssections of nuclear reactions in the Gamow peak and preparing radioactive targets,indirect methods,such as the transfer reaction,coulomb dissociation,and surrogate ratio methods,have been developed over the past several *** are powerful tools in the investigation of,for example,neutron-capture(n,r)reactions with short-lived radioactive ***,direct measurement is still preferable,such as in the case of reactions involving light and stable *** an essential part of stellar evolution,these low-energy stable nuclear reactions have been of particular interest in recent *** overcome the diffculties in measurements near or deeply within the Gamow window,the combination of an underground laboratory and high-exposure accelerator/detector complex is currently the optimal ***,underground experiments have emerged as a new and promising direction of *** addition,to better simulate the stellar environment in the laboratory,research on nuclear physics under laser-driven plasma conditions has gradually become a frontier *** recent years,the CIAE team conducted a series of distinctive nuclea

关键词： Nuclear astrophysics Indirect method Underground laboratory Direct measurement Lowenergy nuclear reaction

A von-Neumann-like photonic processor and its application in studying quantum signature of chaos

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Light(Science & Applications) 2024年第4期13卷 672-681页

作者： Shang yu Wei liu Si-Jing tao Zhi-Peng Li yi-tao Wang Zhi-Peng Zhong Raj BPatel yu Meng yuan-Ze Yang Zhao-An Wang Nai-Jie Guo xiao-Dong Zeng Zhe Chen liang Xu Ning Zhang xiao liu mu Yang Wen-Hao Zhang Zong-Quan Zhou Jin-Shi Xu Jian-Shun Tang Yong-Jian Han Chuan-feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China. CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China. Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China. Research Center for Quantum Sensing Zhejiang LabHangzhou 310000China. Quantum Optics and Laser Science Blackett LaboratoryImperial College LondonPrince Consort RdLondon SW72AZUK. Clarendon Laboratory Department of PhysicsOxford UniversityParks Road OX13PUOxfordUK

Photonic quantum computation plays an important role and offers unique *** decades after the milestone work of Knill-Laflamme-Milburn,various architectures of photonic processors have been proposed,and quantum advantage over classical computers has also been *** is now the opportune time to apply this technology to real-world ***,at current technology level,this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors,for which the resource cost is also a *** we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table,which is capable of multimode-universal programmability,resource-efficiency,phasestability and *** order to illustrate these merits,we execute two different programs with varying resource requirements on the same processor,to investigate quantum signature of chaos from two aspects:the signature behaviors exhibited in phase space(13 modes),and the Fermi golden rule which has not been experimentally studied in quantitative way before(26 modes).The maximal program contains an optical interferometer network with 1694 freely-adjustable *** current state-of-the-art,our architecture stands as the most promising candidate for real-world applications.

关键词： quantum signature chaos

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-tao Zhang Xue-Qian Wang feng-Qi Zhang xiao-Ya Cui Bing-Bing Fan Jia-Ming Guo Zhi-Min Guo Rui Huang Wen Huang Xu-Bo Li Meng-Ru Li Yan Ma Zhi-Hua Shen Yong-Gang Sun De-Zhuang Wang Fei-Yang Wang Li-Qiang Wang Nan Wang Tian-Li Wang Wei Wang xiao-Yang Wang yi-Han Wang Fu-Jie yu yu-Zhen yin ling-Kun Zhang yi Zhang Jian-Yang Zhang Qi Zhao yu-Ping Zhao Xin-Dong Zhu Yasir Sohail Ya-Nan Chen tao feng Qi-Long Gao Hai-Yan He Yong-Jiang Huang Zeng-Bao Jiao Hua Ji Yao Jiang Qiang Li xiao-Ming Li Wei-Bing Liao Huai-jun lin Hui liu Qi liu Qing-feng liu Wei-Di liu Xiong-jun liu Yang Lu yi-Ping Lu Wen Ma Xue-Fei Miao Jie Pan Qing Wang Hong-Hui Wu yuan Wu tao Yang Wei-Ming Yang Qian yu Jin-yu Zhang Zhi-Gang Chen liang Mao Yang Ren Bao-Long Shen Xun-Li Wang Zhe Jia He Zhu Zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： Xian-tao Zeng ying-Hui Jin Tong-Zu liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-jun Li Chao-Zhao liang Xiu-Heng liu Zhi-yu liu Chun-xiao liu Jiu-Min liu Guang-Heng Luo yi Luo Wei-jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian feng Wang feng Wang yin-Huai Wang yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-Hui xiao Wan-Hai Xu Fa-Xian yi Chao-Yang Zhu Qian-yuan Zhuang Li-Qun Zhou xiao-feng Zou Nian-Zeng Xing Da-lin He Xing-Huan Wang 无 Department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China Department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China Department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Urology Qinghai University Affiliated HospitalXi’ning810012China Department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China Department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China Department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China Department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： Xing-Yan liu yi-Wei Yang Rong liu Jie Wen Zhong-Wei Wen Zi-Jie Han Zhi-Zhou Ren Qi An Huai-Yong Bai Jie Bao Ping Cao Qi-Ping Chen Yong-Hao Chen Pin-Jing Cheng Zeng-Qi Cui Rui-Rui Fan Chang-Qing feng Min-Hao Gu feng-Qin Guo Chang-Cai Han Guo-Zhu He Yong-Cheng He yue-feng He Han-Xiong Huang Wei-ling Huang Xi-Ru Huang xiao-Lu Ji Xu-Yang Ji Hao-yu Jiang Wei Jiang Han-tao Jing ling Kang Ming-tao Kang Bo Li Lun Li Qiang Li xiao Li Yang Li Yang Li Shu-Bin liu Guang-yuan Luan ying-lin Ma Chang-jun Ning Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Hong Sun xiao-Yang Sun Zhi-Jia Sun Zhi-Xin Tan Hong-Qing Tang Jing-yu Tang Peng-Cheng Wang Qi Wang tao-feng Wang Yan-feng Wang Zhao-Hui Wang Zheng Wang Qing-Biao Wu xiao-Guang Wu Xuan Wu Li-Kun Xie Han yi Li yu tao yu Yong-Ji yu Guo-Hui Zhang Jing Zhang lin-Hao Zhang Li-ying Zhang Qing-Min Zhang Qi-Wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang ying-Tan Zhao liang Zhou Zu-ying Zhou Dan-Yang Zhu Ke-jun Zhu Peng Zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State Key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University Key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center University of South China Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang University Xi’an Jiaotong University

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon multilayer fast fission chamber

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren yi-Wei Yang Yong-Hao Chen Rong liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-Ping Chen Zhong-Wei Wen Wei-Li Sun Han yi Xing-Yan liu tao Ye Jiang-Bo Bai Qi An Jie Bao yu Bao Ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing feng Ke-Qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-Cheng He Yang Hong yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-yu Jiang Wei Jiang Zhi-Jie Jiang Han-tao Jing ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li xiao Li Yang Li Jie liu Shu-Bin liu Ze Long Guang-yuan Luan Chang-jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-yu Tang Xin-yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-yun Yang Li yu tao yu Yong-Ji yu Guo-Hui Zhang lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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Nuclear Science and Techniques 2024年第10期35卷 149-160页

作者： Jin-Cheng Wang Jie Ren Wei Jiang Xi-Chao Ruan ying-yi liu Hao-Lan Yang Kuo-Zhi Xu Xin-yi Pan Qi Sun Jie Bao Han-Xiong Huang Hao-Fan Bai Jiang-Bo Bai Ping Cao Qi-Ping Chen Yong-Hao Chen Wen-Hao Duan An-Chuan Fan Rui-Rui Fan Chang-Qing feng Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong yi-Wei Hu Zhi-Jie Jiang ling Kang Chang-lin Lan Bo Li feng Li Qiang Li xiao Li Yang Li Jie liu Rong liu Shu-Bin liu yi-Na liu Guang-yuan Luan Chang-jun Ning yi-Jia Qiu Wen-Kai Ren Zhi-Zhou Ren Zhao-Hui Song Kang Sun Zhi-Xin Tan Jing-yu Tang Sheng-Da Tang Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen xiao-Guang Wu Xuan Wu Ze-Peng Wu Cong Xia Li-Kun Xie Han yi tao yu Yong-Ji yu Guo-Hui Zhang Hang-Chang Zhang Qi-Wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang Mao-yuan Zhao Zhi-Hao Zhou Ke-jun Zhu Chong Zou Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230027China

The back-streaming white-neutron beamline(Back-n)of the China Spallation Neutron Source is an essential neutronresearch platform built for the study of nuclear data,neutron physics,and neutron *** types of cross-sectional neutron-reaction measurements have been performed at Back-n since early *** measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron *** gamma rays,commonly referred to as in-beam gamma rays,can induce a non-negligible experimental background in neutron-reaction *** the characteristics of in-beam gamma rays is important for understanding the experimental ***,measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons;thus,discriminating between neutron-induced signals and those from in-beam gamma rays is *** this study,we propose the use of the black resonance filter method and a CeBr_(3) scintillation detector to measure the characteristics of the in-beam gamma rays of *** types of black resonance filters,^(181)Ta,^(59)Co,^(nat)Ag,and^(nat)Cd,were used in this *** time-of-flight(TOF)technique was used to select the detector signals remaining in the absorption region of the TOF spectra,which were mainly induced by in-beam gamma *** energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr_(3) scintillation detector and using Monte Carlo *** on the results of this study,the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated,which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n CeBr_(3)scintillator Black filter resonance technique

Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： Jing-yu Tang Qi An Jiang-Bo Bai Jie Bao yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing feng Ke-Qing Gao xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-yu Jiang Wei Jiang Zhi-Jie Jiang Han-tao Jing ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li xiao Li Yang Li Jie liu Rong liu Shu-Bin liu Xing-Yan liu Ze Long Guang-yuan Luan Chang-jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen xiao-Guang Wu Xuan Wu Li-Kun Xie xiao-yun Yang yi-Wei Yang Han yi Li yu tao yu Yong-Ji yu Guo-Hui Zhang lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang yu-liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications