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Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3432-3456页

作者： Xueqiang Peng Jianjun Fang Chuyuan Lou liang Yang Shaobo Shan Zixian Wang Yutong Chen Hangyu Li Xuexin Li Department of General Surgery The Fourth Affiliated HospitalChina Medical UniversityShenyang 110032China Department of Ophthalmology Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 10050China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhou 510060China Department of Pathology Medical CollegeJinan UniversityGuangzhou 510632China Department of Physiology and Pharmacology Karolinska InstitutetStockholm SE-17177Sweden

The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune ***,the challenge of practical and precise targeting of malignant cells *** address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface *** comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic ***,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic ***,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.

关键词： Engineered nanoparticles Cancer immunotherapy Drug delivery Bloodebrain barrier Tumor-barrier Nanomedicine Nanomaterial Cancer

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Global trends of tropopause folds in recent decades

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 14-19页

作者： Yufeng Lin Wenshou Tian Haiyang Xue Jiali Luo Jiankai Zhang Hongying Tian Wenjun liang College of Atmospheric Sciences Lanzhou UniversityLanzhouChina School of Atmospheric Sciences Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityZhuhaiChina

对流层顶折卷是平流层-对流层物质交换的主要机制.本研究采用三维标记方法,利用1979-2020年间的ERA5再分析数据,分析了对流层顶折卷的时空变化特征及机理.研究结果表明,全球对流层顶折卷的多年变化趋势存在明显的季节性和区域性差异.总... 详细信息

对流层顶折卷是平流层-对流层物质交换的主要机制.本研究采用三维标记方法,利用1979-2020年间的ERA5再分析数据,分析了对流层顶折卷的时空变化特征及机理.研究结果表明,全球对流层顶折卷的多年变化趋势存在明显的季节性和区域性差异.总体上,对流层顶折卷呈增加趋势,其中北半球的春季,夏季和冬季,对流层顶折卷主要沿副热带急流区呈现明显增加的趋势.进一步分析表明,对流层顶折卷发生频率的增加与大气斜压性增大导致的锋生增强有关,而经向位温梯度的增大使得次级环流增强,也可能促进了对流层顶折卷活动的增多.

关键词：对流层顶折卷趋势锋生大气斜压性

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Viral hepatitis E:Clinical manifestations,treatment,and prevention

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肝脏研究（英文） 2024年第1期8卷 11-21页

作者： Qiumin Luo Jia Chen Yeqiong Zhang Wenxiong Xu Ying Liu Chan Xie liang Peng Department of Infectious Disease The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Hepatitis E is a globally distributed infection that varies in seroprevalence between developed and developing *** the less developed regions of Asia and Africa,a high seropositivity rate has been reported for hepatitis E virus(HEV)*** acute hepatitis E is often self-limited and has a favorable prognosis,some populations experience severe manifestations,which may progress to liver ***,some immunocompromised patients are at risk of developing chronic HEV infection and *** screening,reducing misdiagnosis,improving patient management,timely anti-viral therapy for severe and chronic cases,and vaccination of high-risk groups are important measures to reduce the morbidity of hepatitis *** review focused on the clinical presentation,management,and prevention of hepatitis E.

关键词： Hepatitis E Chronic hepatitis Screening Antiviral therapy Vaccination

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奎宁酸的抗氧化活性和神经保护作用研究

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食品与发酵工业 2024年第5期50卷 42-47页

作者：王硕梁婷罗磊刘永清方勇李森管骁上海理工大学健康科学与工程学院上海200093 国家粮食产业(城市粮油保障)技术创新中心上海200093 南京财经大学食品科学与工程学院江苏南京210023

奎宁酸是一种小米来源的类黄酮类物质,为探究奎宁酸的神经保护作用,该研究建立了H_(2)O_(2)诱导的SH-SY5Y细胞氧化应激模型,通过MTT法测定奎宁酸对SH-SY5Y细胞活性影响,同时测定了抗氧化酶超氧化物歧化酶(superoxide dismutase,SOD)的... 详细信息

奎宁酸是一种小米来源的类黄酮类物质,为探究奎宁酸的神经保护作用,该研究建立了H_(2)O_(2)诱导的SH-SY5Y细胞氧化应激模型,通过MTT法测定奎宁酸对SH-SY5Y细胞活性影响,同时测定了抗氧化酶超氧化物歧化酶(superoxide dismutase,SOD)的活性和氧化应激标志分子谷胱甘肽(glutathione,GSH)、丙二醛(malondialdehyde,MDA)的含量,利用实时荧光定量PCR检测了抗氧化酶和炎症因子表达情况,并用Western blot测定了炎症因子的蛋白表达量。研究结果表明,100μg/mL的奎宁酸处理显著抑制H_(2)O_(2)引起的SH-SY5Y细胞存活率下降;对细胞抗氧化指标的检测显示,奎宁酸处理可以增强细胞SOD的活性,增加GSH的水平并降低细胞的MDA水平,提高SOD、过氧化氢酶(catalase,CAT)、谷胱甘肽过氧化物酶(glutathione peroxidase,GPx)等抗氧化酶基因的表达水平,降低氧化损伤;另外,奎宁酸还可以降低H_(2)O_(2)诱导的SH-SY5Y细胞中炎症因子白介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的表达水平,减轻SH-SY5Y细胞的损伤。综上,奎宁酸可以通过抑制细胞氧化应激水平、发挥抗炎作用保护神经细胞不被损伤,为进一步探究小米多酚在氧化应激相关疾病中的作用奠定了基础。

关键词： SH-SY5Y细胞奎宁酸氧化应激抗炎作用抗氧化作用

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Electrolyte Effect on Photoetching of Gallium Nitride

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Nanomanufacturing and Metrology 2024年第1期7卷 61-74页

作者： Huiqiang liang Zhenghao Wei Jiongchong Fang Yanming Li Changli Li Zhirun Xie Yun Hau Ng Guosong Zeng Shenzhen Key Laboratory of Intelligent Robotics and Flexible Manufacturing Systems Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China School of Materials Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China School of Energy and Environment City University of Hong KongKowloon 999077Hong Kong SARPeople’s Republic of China City University of Hong Kong Shenzhen Research Institute Shenzhen Hi-Tech Industrial ParkNanshan DistrictShenzhen 518000People’s Republic of China SUSTech Energy Institute for Carbon Neutrality Southern University of Science and TechnologyShenzhen 518055People’s Republic of China

The limited material removal rate of conventional chemical mechanical polishing(CMP)significantly hinders the fabrica-tion efficiency and surface quality,thereby preventing the development of gallium nitride(GaN)-based ***,the incorporation of photoelectrochemistry in CMP has garnered increasing attention because of its potential to enhance the quality and efficiency of the GaN ***,a considerable gap still exists in the comprehensive understanding of the specific photoelectrochemical(PEC)behavior of ***,we report the influence of the electrolyte on the PEC etching of *** acids and bases were tested,with their pH being carefully *** concentrations of the cations and anions were also *** results showed that photocorrosion/photoetching was more pronounced in sulfuric acid,phosphoric acid,and nitric acid environments than in alkaline environments,but it was less pronounced in hydrochloric ***,the effects of pH and anion concentration on photoetching were investigated,and the results revealed that pho-toetching in acidic environments weakened with increasing pH levels and diminished with increasing sulfate *** underlying reasons contributing to this observation were *** findings provide ideas for improving the pho-toetching efficiency of GaN,thereby enriching the photoelectrochemical mechanical polishing(PECMP)technology of GaN.

关键词： GaN Photoelectrochemistry Photoetching pH

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Ascending phase of solar cycle 25 tilts the current El Ni?o-Southern oscillation transition

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Atmospheric and Oceanic Science Letters 2024年第1期 36-40页

作者： Wenjuan Huo Ziniu Xiao liang Zhao Fei Liu GEOMAR Helmholtz Centre for Ocean Research State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences School of Atmospheric Sciences Sun Yat-Sen UniversityKey Laboratory of Tropical Atmosphere-Ocean SystemMinistry of Educationand Southern Marine Science and Engineering Guangdong Laboratory

自2020年初夏,赤道太平洋地区出现拉尼娜现象并持续两年半多(以下简称2020拉尼娜),对其未来演变的预测引起了很多关注,考虑到11年太阳周期活动对热带太平洋SST异常可能存在锁相影响,本研究分析了当前太阳活动周(即第25太阳周(SC25))对... 详细信息

自2020年初夏,赤道太平洋地区出现拉尼娜现象并持续两年半多(以下简称2020拉尼娜),对其未来演变的预测引起了很多关注,考虑到11年太阳周期活动对热带太平洋SST异常可能存在锁相影响,本研究分析了当前太阳活动周(即第25太阳周(SC25))对目前热带太平洋ENSO现象未来演变的调节作用,基于历史太阳周的统计特征,作者对第25太阳周达到其最大值的时间提出三种可能的情景,并讨论了不同情景下的太阳活动对未来两年ENSO演变的可能影响,第25太阳周的持续上升阶段在一定程度上抑制了当前2023厄尔尼诺现象发展为超级事件.

关键词：厄尔尼诺-南方涛动太阳活动热带太平洋位相转变预测三重拉尼娜现象

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非对称针尖结构对远红外超材料谐振性能的影响研究

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红外与毫米波学报 2024年第3期43卷 322-328页

作者：陆小森吴旭魏小柯王俊杰王奇亮金钻明彭滟上海理工大学光电信息与计算机工程学院上海200093

为提高远红外超材料的品质因子Q和检测灵敏度,本文研究了一种用于金属远红外超材料的非对称针尖设计。以传统双开口方形谐振环为模型,通过理论模拟,研究了开口狭缝针尖角度变化对其电场分布、谐振频谱以及品质因子Q的影响。结果表明,非... 详细信息

为提高远红外超材料的品质因子Q和检测灵敏度,本文研究了一种用于金属远红外超材料的非对称针尖设计。以传统双开口方形谐振环为模型,通过理论模拟,研究了开口狭缝针尖角度变化对其电场分布、谐振频谱以及品质因子Q的影响。结果表明,非对称针尖增强了谐振环的表面电场局域性,减小了谐振峰的半峰全宽,并使品质因子Q提高到传统谐振环(非针尖设计)的三倍以上。该研究结果为开发高灵敏远红外超材料传感器提供了新的思路,并为传统开口谐振环提出了一种简单实用的Q因子优化方法。

关键词：太赫兹传感器超材料远红外品质因子Q

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中国樱桃品种‘诸暨短柄樱桃’

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园艺学报 2007年第4期34卷 1065-1065页

作者：李建华戚行江梁森苗孟瑜清郑锡良求盈盈浙江省诸暨市农业局浙江诸暨311800 浙江省农业科学院园艺研究所杭州310021

‘诸暨短柄樱桃’是从地方野樱桃中提纯并筛选出的优质大果中国樱桃品种,果实大,外形美观,品质优,平均单果质量2.8g,最大4g,可溶性固形物含量13.8%,可食率89%。

关键词：中国樱桃品种

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Scalable electronic and optoelectronic devices based on 2D TMDs

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Materials Futures 2024年第4期3卷 142-170页

作者： Guigang Zhou Jinsheng Ji Ziling Chen Jing Shuai Qijie liang Qian Zhang School of Materials Shenzhen Campus of Sun Yat-sen UniversityNo.66Gongchang RoadGuangming DistrictShenzhen 518107People’s Republic of China Songshan Lake Materials Laboratory Songshan Lake Mat LabDongguan 523808People’s Republic of China

Materials are the building blocks of various functional *** Moore’s Law approaching Si’s physical limits,traditional semiconductor-based monolithic three-dimensional(M3D)integrated circuits always suffer from the issues,including electrical performance(carrier scattering),chip-overheating(low heat conductivity),electromagnetic ***,two-dimensional transition metal dichalcogenides(2D TMDs)inherit the atomically-thin thickness of 2D materials and exhibit outstanding natures,such as smooth flatness(excellent compatibility),electronic property(thickness below 1 nm),absence of dangling bonds(decreasing carrier scattering),making them highly promising for next-generation functional devices in comparison with traditional bulk *** to now,2D TMD-based transistors have already exhibited the feasibility of replacing conventional one in terms of ***,the technology of large-area 2D TMDs films has been greatly successful,which lays the foundation for the fabrication of scalable 2D TMD-based ***,the scalable devices based on 2D TMDs also show the prospects of realizing ultra-high-density M3D integrated circuits owing to the presence of outstanding ***,we focus some thriving research areas and provide a systematic review of recent advances in the field of scalable electronic and optoelectronic devices based on 2D TMDs,including large-area synthesis,property modulation,large-scale device applications,and multifunctional device *** research in 2D TMDs has clearly exhibited the tremendous promise for scalable diversified *** addition,scalable 2D TMD-based devices in terms of mass production,controllability,reproducibility,and low-cost have also been highlighted,showing the importance and benefits in modern ***,we summarize the remaining challenges and discuss the future directions of scalable 2D TMDs devices.

关键词： two-dimensional materials wafer-Scale scalable electronics

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A multi-terminal ion-controlled transistor with multifunctionality and wide temporal dynamics for reservoir computing

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Nano Research 2024年第5期17卷 4444-4453页

作者： Kekang Liu Jie Li Fangzhou Li Yiyuan Lin Hongrui Liu Linzi liang Zhiyuan Luo Wei Liu Mengye Wang Feichi Zhou Yanghui Liu School of Materials Sun Yat-Sen UniversityShenzhen 518107China School of Microelectronics Southern University of Science and TechnologyShenzhen 518055China School of Software East China Jiaotong UniversityNanchang 330013China

Reservoir computing(RC)is an energy-efficient computational framework with low training cost and high efficiency in processing spatiotemporal *** state-of-the-art fully memristor-based hardware RC system suffers from bottlenecks in the computation efficiencies and accuracy due to the limited temporal tunability in the volatile memristor for the reservoir layer and the nonlinearity in the nonvolatile memristor for the readout ***,integrating different types of memristors brings fabrication and integration *** overcome the challenges,a multifunctional multi-terminal electrolyte-gated transistor(MTEGT)that combines both electrostatic and electrochemical doping mechanisms is proposed in this work,integrating both widely tunable volatile dynamics with high temporal tunable range of 10^(2) and nonvolatile memory properties with high long-term potentiation/long-term depression(LTP/LTD)linearity into a single *** ion-controlled physical RC system fully implemented with only one type of MTEGT is constructed for image recognition using the volatile dynamics for the reservoir and nonvolatility for the readout ***,an ultralow normalized mean square error of 0.002 is achieved in a time series prediction *** is believed that the MTEGT would underlie next-generation neuromorphic computing systems with low hardware costs and high computational performance.

关键词： reservoir computing multi-terminal electrolyte-gated transistor ionic controlling rich dynamics nonlinear dynamical prediction

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