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Pesticide residues in bayberry(Myrica rubra)and probabilistic risk assessment for consumers in Zhejiang,China

Journal of Integrative Agriculture 2017年第9期16卷 2101-2109页

作者： YANG Gui-ling WANG Wen liang sen-miao YU Yi-jun ZHAO Hui-yu WANG Qiang QIAN Yong-zhong Key Laboratory of Agro-Product Quality and Safety Ministry of Agriculture~Institute of Quality Standards and Testing Technology for Agro-ProductsChinese Academy of Agricultural SciencesBeijing 100081P.R.China Laboratory of Quality&Safety Risk Assessment for Agro-Products(Hangzhou)/Key Laboratory for Pesticide Residue Detection Ministry of Agriculture/Institute of Quality and Standards for Agricultural ProductsZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China Zhejiang Bureau for Agriculture Hangzhou 310021P.R.China

As pesticide residues in bayberry has raised serious concern from the public in China, a monitoring survey was carried out during 2013–2014 and 157 samples were analyzed in total. Twenty-three pesticides were detected among the 44 pesticides analyzed and at least one pesticide was detected in 63% of 99 samples. Whereas 45.6% of samples were found with two or more pesticide residues, and 23.6% of samples with four or more pesticide residues. Probabilistic risk assessments indicated that estimated daily intake（EDI） of cyhalothrin at the P97.5th percentile level is 1.11 times larger than the acceptable daily intake（ADI） for children, the estimated short-term intake（ESTI） at the P97.5th percentile level is 1.9 and 1.78 times larger than the acute reference dose（ARf D） for adult and children, respectively, indicating the potential risk concern from pyrethroids. EDI of the pesticides with anti-androgenic effects ranged from 0.15–2.46 of ADI, the probability of exposure exceeding the ADI was 7.1 and 31.1% for adults and children, respectively, the probability of exposure of pyrethroids exceeding the ADI was 3.8% for children. Exposures for other pesticides and groups were below 1.0. Because the co-occurrence of frequency of cyhalothrin and cypermethrin was 9.55%, the combinations of pesticides detected with anti-androgenic effects has not been found in the present monitoring, the results indicate that the pesticide residues in bayberry will not constitute serious public health risk, however, they are significant for the management of pesticide use on bayberry and dietary health risk in China.

关键词： bayberry pesticide residues probabilistic risk assessment

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Water and other volatiles on Mars

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National Science Review 2024年第06期11卷 12-14页

作者： sen Hu Yubing Gao Zhan Zhou liang Gao Yangting Lin Key Laboratory of the Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

Mars, the intriguing red planet, is one of the planets most similar to the Earth in our solar system. It is widely accepted that Mars could have had a warm and wet climate in its early history supported by numerous lines of evidence, e.g. topography, canyons, outflow channels, presence of phyllosilicates and evaporative salts,sedimentary formation, and many others (e.g.[1]), and thus Mars is believed to once have a potentially habitable environment which could be able to supply fundamental conditions for the evolution of potential lives.

关键词： ISOTOPIC COMPOSITION MARTIAN ATMOSPHERE SUBSURFACE WATER ABUNDANCE TISSINT H2O CO2

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Complex granular flows of sticky-wet material on flip-flow screens:Calibration of discrete element simulations

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Particuology 2024年第1期84卷 290-308页

作者： Ningning Xu sen Tang Dongdong Lin Runhui Geng Xinwen Wang Xihui liang School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing100083China Department of Mechanical Engineering University of ManitobaWinnipegManitobaR3T 5V6Canada

Discrete element method(DEM)is an effective approach for studying the screening process of flip-flow ***,there have been few studies focusing on the thick layer of sticky-wet particles on flip-flow *** achieve accurate simulations of the thick layer of sticky-wet particles on a flip-flow screen,firstly,the movement law of particle flow was studied,and a multi-regime combination cali-bration method based on characteristics of particle flow regimes was *** on the Plackett-Burman experiment,the curse of dimensionality caused by multi-state and multi-contact parameters was ***,the lifting cylinder,rotating drum,and trampoline tests were carried out to obtain macroscopic reference values under various granular flow *** calibration results were then determined using the response surface method and climbing ***,the calibration results were tested at both macroscopic and mesoscopic scales and compared with a commonly used calibration *** results demonstrate that the calibration method,which considers the multi-state characteristics,improves simulation accuracy by 2%-10%and reduces the simulation error to less than 10%,thus meeting the requirements for engineering optimization of flip-flow screens.

关键词： DEM Complex granular flow Parameter calibration Flip-flow screen Sticky-wet particles Thick layer

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The pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black hole

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 55-75页

作者： Li-Ming Cao Jia-Ning Chen liang-Bi Wu Libo Xie Yu-sen Zhou School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Peng Huanwu Center for Fundamental Theory Hefei 230026China Interdisciplinary Center for Theoretical Study and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

In this study,we investigate the pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black ***,we use the hyperboloidal framework to cast the quasinormal mode(QNM)problem into an eigenvalue problem associated with a non-selfadjoint operator,and then the spectrum and pseudospectrum are ***,the invariant subspace method is exploited to improve the computational efficiency for *** investigation into the spectrum(in)stability entails two main *** the one hand,we calculate the spectra of the quantum corrected black hole,then by the means of the migration ratio,the impact of the quantum correction effect on the Schwarzschild black hole has been *** results indicate that the so-called“migration ratio instability”will occur for small black holes with small angular momentum number *** the eikonal limit,the migration ratios remain the same for each *** the other hand,we study the spectrum(in)stability of the quantum corrected black hole by directly adding some particular perturbations into the effective potential,where perturbations are located at the event horizon and null infinity,*** are two interesting observations under the same perturbation energy ***,perturbations at infinity are more capable of generating spectrum instability than those at the event ***,we find that the peak distribution can lead to the instability of QNM spectrum more efficiently than the average distribution.

关键词： quasinormal modes pseudospectrum hyperboloidal coordinate

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Large animal models for Huntington's disease research

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Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien liang Xiao-Jiang Li Shihua Li sen Yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

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Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： Jian-Hu Gong Zheng-Ming Zhang Cheng-liang Zhang Peng-Qiang Hu Chao Zhou Dun-Hui Wang sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

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Cuproptosis mediates copper-induced testicular spermatogenic cell death

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Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-Jun Yu Jun-Jun Li Yao Xiao Guang-sen Li Fang Yang liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Landscape ecological risk assessment and its driving factors in the Weihe River basin,China

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Journal of Arid Land 2024年第5期16卷 603-614页

作者： CHANG sen WEI Yaqi DAI Zhenzhong XU Wen WANG Xing DUAN Jiajia ZOU liang ZHAO Guorong REN Xiaoying FENG Yongzhong College of Agronomy Northwest A&F UniversityYangling 712100China

Weihe River basin is of great significance to analyze the changes of land use pattern and landscape ecological risk and to improve the ecological basis of regional *** on land use data of the Weihe River basin in 2000,2010,and 2020,with the support of Aeronautical Reconnaissance Coverage Geographic Information System(ArcGIS),GeoDa,and other technologies,this study analyzed the spatial-temporal characteristics and driving factors of land use pattern and landscape ecological *** showed that land use structure of the Weihe River basin has changed significantly,with the decrease of cropland and the increase of forest land and construction *** the past 20 a,cropland has decreased by 7347.70 km2,and cropland was mainly converted into forest land,grassland,and construction *** fragmentation and dispersion of ecological landscape pattern in the Weihe River basin were improved,and land use pattern became more ***,landscape ecological risk of the Weihe River basin has been *** landscape ecological risk area decreased by 19,177.87 km2,high landscape ecological risk area decreased by 3904.35 km2,and moderate and low landscape ecological risk areas continued to *** is worth noting that landscape ecological risks in the upper reaches of the Weihe River basin are still relatively serious,especially in the contiguous areas of high ecological risk,such as Tianshui,Pingliang,Dingxi areas and some areas of Ningxia Hui Autonomous *** ecological risk showed obvious spatial dependence,and high ecological risk area was *** the driving factors,population density,precipitation,normalized difference vegetation index(NDVI),and their interactions are the most important factors affecting the landscape ecological risk of the Weihe River *** findings significantly contribute to our understanding of the ecological dynamics in the Weihe River basin,providing crucial insights for sustainable mana

关键词： land use ecological risk spatiotemporal distribution geographic detector driving factors

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The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui Jiang Dong-Xu liang Zhi-sen Jiang Huai-Na Yu Hua Wang Cheng-Wen Mao Jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

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Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression

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Genes & Diseases 2024年第5期11卷 456-469页

作者： Lixin liang Tian Cai Xiaojia Li Jianhong An sen Yu Yang Zhang Fengjie Guo Fang Wei Jie He Keping Xie Tingting Jiang Center for Pancreatic Cancer Research South China University of Technology School of MedicineGuangzhouGuangdong 510006China Department of Laboratory Medicine The Sixth Affiliated Hospital and Nanhai People’s HospitalSouth China University of Technology School of MedicineFoshanGuangdong 528200China The Second Affiliated Hospital and Guangzhou First People’s Hospital South China University of Technology School of MedicineGuangzhouGuangdong 510006China

Transcriptional factor Forkhead box M1(FOXM1)plays an important role in pancreatic ductal adenocarcinoma(PDAC)development and *** molecular mechanisms underlying its dysregulation remain *** identified and functionally validated the microRNAs(miRNAs)that critically regulate FOXM1 expression in *** expression levels of miRNA-23a(miR-23a-3p and-5p)were altered in PDAC cell lines and their effects on FOXM1 signaling and cell proliferation and migration and tumorigenesis were examined in vitro and in vivo using mouse PDAC *** with non-tumor pancreatic tissues,PDAC tissues and cell lines exhibited significantly reduced levels of miR-23a *** miR-23a expression and concomitant increase in FOXM1 expression were also observed in acinar-toductal metaplasia and pancreatic intraepithelial neoplasia,the major premalignant lesions of *** expression of miR-23a reduced the expression of FOXM1 and suppressed cell proliferation and migration in PDAC cells,whereas the inhibitors of miR-23a did the *** or reduced levels of miR-23a increased the levels of FOXM1 expression,while increased expression of FOXM1 down-regulated miR-23a expression,suggesting that miR-23a and FOXM1 were mutual negative regulators of their expression in PDAC ***,the miR-23a/FOXM1 signaling axis is important in PDAC initiation and progression and could serve as an interventional or therapeutic target for patients with early or late stages of PDAC.

关键词： FOXM1 Gene expression Gene regulation MicroRNA Pancreatic cancer Targeted therapy

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