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Regulation of hepatic lipid metabolism by intestine epithelium-derived exosomes

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Life Metabolism 2023年第6期2卷 42-57页

作者： Tiange Feng Yuan liang Lijun Sun Lu Feng jiajie Min Michael W.Mulholland Yue Yin Weizhen Zhang Department of Physiology and Pathophysiology School of Basic Medical Sciencesand Key Laboratory of Molecular Cardiovascular ScienceMinistry of EducationPeking UniversityBeijing 100191China Department of Surgery University of Michigan Medical CenterAnn ArborMI 48109United States Department of Pharmacology School of Basic Medical Sciencesand Key Laboratory of Molecular Cardiovascular ScienceMinistry of EducationPeking UniversityBeijing 100191China

The“gut-liver axis”is critical for the control of hepatic lipid homeostasis,where the intestine affects the liver through multiple pathways,such as nutrient uptake,gastrointestinal hormone release,and gut microbiota *** intestine-originated exosomes mediate the gut’s influence on liver steatosis remains ***,we aimed to determine whether intestinal epithelium-derived exosomes(intExos)contribute to the regulation of hepatic lipid *** found that mouse intExos could be taken up by hepatic *** fed high-fat diet(HFD)received intExos showed strong resistance to liver *** sequencing of intExos indicated the correlation between miR-21a-5p/miR-145a-5p and hepatic lipid *** liver overexpression of miR-21a-5p and intExos containing miR-21a-5p alleviated hepatic steatosis in mice fed with ***,miR-21a-5p suppressed the expression of Ccl1(C-C motif chemokine ligand 1)in macrophages,as well as lipid transport genes Cd36(cluster of differentiation 36)and Fabp7(fatty acid binding protein 7)in ***-specific inhibition of miR-145a-5p significantly reduced hepatic lipid accumulation in mice fed with HFD through negatively regulating the expression of Btg1(BTG anti-proliferation factor 1),leading to an increase of stearoyl-CoA desaturase-1 and *** study demonstrates that intExos regulate hepatic lipid metabolism and non-alcoholic fatty liver dis-ease(NAFLD)progression via miR-21a-5p and miR-145a-5p pathways,providing novel mediators for the gut-liver crosstalk and potential targets for regulating hepatic lipid metabolism.

关键词： exosome non-alcoholic fatty liver disease miR-21a-5p miR-145a-5p lipid metabolism

体育公益活动对在校体育类大学生实践能力的影响研究

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体育科技文献通报 2024年第4期32卷 227-229页

作者：冼颖欣尹清秀梁传玺艾凤奇王佳杰郭海峰河南科技大学河南洛阳471023

目的:探讨体育公益活动对在校体育类大学生实践能力的影响。方法:运用文献资料法、问卷调查法、数理统计法和深度访谈法等研究方法。结论:参加体育公益活动对在校体育类大学生的实践能力有明显提升作用。建议:高校应多组织开展体育公益... 详细信息

目的:探讨体育公益活动对在校体育类大学生实践能力的影响。方法:运用文献资料法、问卷调查法、数理统计法和深度访谈法等研究方法。结论:参加体育公益活动对在校体育类大学生的实践能力有明显提升作用。建议:高校应多组织开展体育公益活动;高校教师应当多引导学生参与体育公益活动;在校体育类大学生应积极看待体育公益活动。

关键词：体育公益活动体育类大学生实践能力

YR36/WKS1-Mediated Phosphorylation of PsbO,an Extrinsic Member of Photosystem Ⅱ,Inhibits Photosynthesis and Confers Stripe Rust Resistance in Wheat

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Molecular Plant 2019年第12期12卷 1639-1650页

作者： Shuai Wang Qiu-Ping Li Jianfeng Wang Yan Yan Guo-liang Zhang Yan Yan Huifei Zhang jiajie Wu Feng Chen Xiaojie Wang Zhensheng Kang Jorge Dubcovsky Jin-Ying Gou State Key Laboratory of Genetic Engineering MOE Key Laboratory for Biodiversity Science and Ecological EngineeringMOE Engineering Research Center of Gene TechnologyInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityYanglingShaanxi 712100China Agronomy College/National Key Laboratory of Wheat and Maize Crop Science Henan Agricultural UniversityZhengzhouHenan 450046China State Key Laboratory of Crop Biology/College of Agronomy Shandong Agricultural UniversityTai^nShandong 271018China Department of Plant Sciences University of CaliforniaDavisCA 95616USA Howard Hughes Medical Institute Chevy ChaseMD 20815USA

Wheat stripe rust,due to infection by Puccinia striiformis ***(Pst),is a devastating disease that causes significant global grain yield ***36,which encodes Wheat Kinase START1(WKS1),is an effec-tive high-temperature adult-plant resistance gene and confers resistance to a broad spectrum of Pst *** previously showed that WKS1 phosphorylates the thylakoid ascorbate peroxidase protein and reduces its ability to detoxify peroxides,which may contribute to the accumulation of reactive oxygen species(ROS).WKS1-mediated Pst resistance is accompanied by leaf chlorosis in Pst-infected regions,but the un-derlying mechanisms remain ***,we show that WKS1 interacts with and phosphorylates PsbO,an extrinsic member of photosystem Ⅱ(PS Ⅱ),to reduce photosynthesis,regulate leaf chlorosis,and confer Pst resistance.A point mutation in PsbO-A1 or reduction in its transcript levels by RNA interference resulted in chlorosis and reduced Pst *** analyses revealed that WKS1 phosphorylates PsbO at two conserved amino acids involved in physical interactions with PS Ⅱ and reduces the binding affinity of PsbO with PS Ⅱ.Presumably,phosphorylated PsbO proteins dissociate from the PS Ⅱ complex and then un-dergo rapid degradation by cysteine and aspartic *** together,these results demonstrate that perturbations of wheat PsbO by point mutation or phosphorylation by WKS1 reduce the rate of photo-synthesis and delay the growth of Pst pathogen before the induction of ROS.

关键词： wheat stripe rust PsbO WKS1 chlorosis photosynthesis rate

Ionic liquid engineering enabled in-plane orientated 1D perovskite nanorods for efficient mixed-dimensional perovskite photovoltaics

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InfoMat 2023年第8期5卷 81-93页

作者： Fei Wang Dawei Duan Kang Zhou YZBXue Xiao liang Xianfang Zhou Chuangye Ge Chao Zhou Jin Xiang jiajie Zhu Quanyao Zhu Haoran Lin Yumeng Shi Yonghua Chen Gang Li Hanlin Hu Hoffmann Institute of Advanced Materials Shenzhen PolytechnicShenzhenthe People's Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhanthe People's Republic of China Oxford Instruments Technology(Shanghai)Co.Ltd. Shanghaithe People's Republic of China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhenthe People's Republic of China School of Physics Science and Engineering Tongji UniversityShanghaithe People's Republic of China Key Laboratory of Flexible Electronics(KLoFE)&Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjingthe People's Republic of China Department of Electronic and Information Engineering Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityKowloonHong Kongthe People's Republic of China

Mixed-dimensional engineering of perovskite material has been demonstrated as a facile and promising strategy to improve both photovoltaic performance and long-term stability of perovskite solar cells(PSCs).In this study,we report an in-plane preferred orientation of 1D perovskite induced by an ionic liquid(IL)of 1-(3-cyanopropyl)-3-methylimidazolium chloride(CPMIMCl)for the first time via sequential deposition approach,leading to a mixed dimensional perovskite thin *** generated one-dimensional(1D)CPMIMPbI3 with in-plane orientation resides at the grain boundaries of three-dimensional(3D)perovskite can be appreciably observed from the morphology level,leading to creation of high-quality films with large grain size with more efficient defect ***,the dispersion of IL in the bulk phase of perovskite material allows for the formation of 1D perovskite for multiple level passivation to inhibit non-radiative recombination and optimize carrier *** IL engineering strategy not only yields a mixed-dimensional perovskite heterostructure with in-plane orientation 1D perovskite nano-rods but also significantly improves the opto-electronic property with suppressed trap *** a result,the CPMIMCl-treated PSCs show an enhanced photovoltaic performance with a champion power conversion efficiency(PCE)up to 24.13%.More importantly,benefiting from the hydrophobicity of formed 1D perovskite and defects suppression,the corresponding PSC demonstrates an excellent longterm stability and maintain 97.1%of its pristine PCE at 25C under 50%RH condition over 1000 *** research provides an innovative perspective for employing the low dimensional engineering to optimize the performance and stability of photovoltaic devices.

关键词： 1D/3D perovskite ionic liquid perovskite solar cells stability

深圳市盐田海滨栈道碧道区域鸟类资源初步调查

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绿色科技 2024年第16期26卷 59-64页

作者：赵一阳肖嘉杰林石狮黄丹丹梁晓彤罗连丁明艳李远航广东省野生动物监测救护中心广东广州510520 广东环境保护工程职业学院广东佛山528216 顺德职业技术学院广东佛山528300

鸟类多样性研究是我国自然保护区保护工作的重要组成部分,也是实现可持续发展的重要工作之一。2021年5-9月,鸟类抽样调查采用固定距离样线法和固定半径样点法,调查了深圳市盐田滨海栈道碧道区域鸟类,共记录到鸟类15目36科76种,其中国家... 详细信息

鸟类多样性研究是我国自然保护区保护工作的重要组成部分,也是实现可持续发展的重要工作之一。2021年5-9月,鸟类抽样调查采用固定距离样线法和固定半径样点法,调查了深圳市盐田滨海栈道碧道区域鸟类,共记录到鸟类15目36科76种,其中国家二级重点保护鸟类12种,CITES附录Ⅱ鸟类8种,国家“三有”保护鸟类54种。盐田滨海栈道碧道区域丰富的鸟类资源是自然资源的有机组成部分,其生存与发展维系着生态系统的平衡与稳定,影响着人类社会的生存和发展。建议结合鸟类生境建设、生态景观提升等工作,开展鸟类多样性保护工作。

关键词：鸟类资源多样性保护滨海栈道深圳市

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左侧卧位腹腔镜肝右叶部分切除术临床分析

肝胆胰外科杂志 2024年第5期36卷 282-286,293页

作者：袁汉坤游声林梁文祥周嘉杰陆礼柏罗宗将马嘉盛李鸿飞汪建初右江民族医学院附属医院百东院区肝胆胰外科广西百色533099 河池市人民医院肝胆外科广西河池547099

目的探讨左侧卧位腹腔镜肝右叶各肝段部分切除的可行性及疗效。方法回顾性分析右江民族医学院附属医院百东院区2022年5月至2023年4月期间39例行左侧卧位腹腔镜肝右叶部分切除术的病例资料。结果39例中有腹部手术史者13例;肿瘤1个34例,肿... 详细信息

目的探讨左侧卧位腹腔镜肝右叶各肝段部分切除的可行性及疗效。方法回顾性分析右江民族医学院附属医院百东院区2022年5月至2023年4月期间39例行左侧卧位腹腔镜肝右叶部分切除术的病例资料。结果39例中有腹部手术史者13例;肿瘤1个34例,肿瘤2个3例,肿瘤3个2例,肿瘤最大径37.0(24.0,58.0)mm。其中行非解剖性肝切除20例,解剖性肝切除19例;单一肝段切除术28例,两部位肝部分切除术10例,三部位肝部分切除术1例;联合腹腔镜胆囊切除24例;无血流阻断9例,行Pringle法血流阻断30例。平均手术时间(143.5±56.8)min;中位术中出血量100.0(50.0,300.0)mL,4例术中输血(合计29.50 U),无中转开腹。35例放置引流管,引流管留置时间(6.3±3.7)d;术后平均住院时间(10.1±4.0)d,住院总费用(41121.8±18978.3)元。术后23例患者出现少量胸腔积液;1例患者并发急性呼吸窘迫综合征(ARDS)及肝功能不全,经ICU复苏治愈;1例出现少量气胸;无感染、出血、胆漏等并发症发生;无非计划性再次手术发生。所有患者均通过门诊或电话的方式获得随访,所有病例近期无复发。结论左侧卧位行腹腔镜肝右叶部分切除术操作简单,暴露好,手术时间相对较短,出血少。

关键词：左侧卧位腹腔镜手术肝右叶肝部分切除术肝细胞瘤肝血管瘤肝转移瘤

Fusarium graminearum FgPLC1 regulates growth,development,stress response,and pathogenicity

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Fusarium graminearum FgPLC1 regulates growth,development,str...

Anti-fatigue Effect of Water Extract from Centella asiatica(L.)Urban on Mice

中国植物病理学会第十二届青年学术研讨会

作者： Ling Sun Qili Zhu jiajie Lian Houjuan Xu Jin Lin Yuancun liang College of Plant Protection Shandong Agricultural University

Phospholipase C（PLC） is an important phospholipid hydrolase that plays critical roles in various cellular processes in eukaryotic *** date,little is known about the functions of PLC in morphogenesis and pathogenesis in Fusarium *** constructed deletion mutants for all six FgPLC genes in this *** FgPLC1 deletion mutant（Δplc1） generated by gene replacement showed significant defects in hyphal growth,conidiation,sexual reproduction,pathogenicity,and responses to abiotic ***,complementation of the Δplc1 mutant with the full-length FgPLC1 gene restored all the defects of the *** addition,analysis of gene expression profile showed that deletion of the FgPLC1 gene altered the expression patterns of 1619 genes compared with the wild type *** contrast to theΔplc1 mutant,the deletion mutants of other five genes did not show aberrant phenotypic features including colony morphology and *** together,our results revealed the functions of FgPLC1 in *** biology and the potential applications of these findings in development of an effective FHB management protocol.

关键词： Fusarium graminearum FgPLCl growth pathogenicity

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Medicinal Plant 2023年第1期14卷 48-49,54页

作者： Chunmei MO Jinye LIN Yanfang MA jiajie ZHOU Ling liang Nian LIN Suoyi HUANG Gang XIAO Youjiang Medical University for Nationalities College of Clinical MedicineBaise 533000China Youjiang Medical University for Nationalities College of PharmacyBaise 533000China Youjiang Medical University for Nationalities Key Laboratory of Guangxi Universities for National Medicine Research in Youjiang River BasinBaise 533000China

[Objectives]To study the anti-fatigue effect of water extract from Centella asiatica(L.)Urban on mice.[Methods]After intragastric administration of low,medium and high concentration of water extract from Centella asiatica(L.)Urban for 14 d,the rotarod time and the content of serum lactic acid in mice were determined,respectively.[Results]Compared with the control group,the rotarod time of mice in the low and medium concentration groups was significantly prolonged(P<0.05),but there was no significant difference between the control group and the high concentration group;the content of serum lactic acid in the medium concentration group was significantly lower than that in the control group(P<0.01),but there was no significant difference between low concentration group and high concentration group and the control group.[Conclusions]A certain concentration of water extract from Centella asiatica(L.)Urban had a good anti-fatigue effect.

关键词： Centella asiatica(L.)Urban Mice Anti-fatigue

Stress and strain analysis of Si-based Ⅲ-V template fabricated by ion-slicing

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Chinese Physics B 2020年第7期29卷 481-488页

作者： Shuyan Zhao Yuxin Song Hao liang Tingting Jin jiajie Lin Li Yue Tiangui You Chang Wang Xin Ou Shumin Wang State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049 China Department of Microtechnology and Nanoscience Chalmers University of TechnologyGothenburg 41296Sweden

Strain and stress were simulated using finite element method(FEM)for threeⅢ-V-on-Insulator(Ⅲ-VOI)structures,i.e.,InP/SiO2/Si,InP/Al2O3/SiO2/Si,and GaAs/Al2O3/SiO2/Si,fabricated by ion-slicing as the substrates for optoelectronic devices on *** thermal strain/stress imposes no risk for optoelectronic structures grown on InPOI at a normal growth temperature using molecular beam *** grown on GaAsOI are more dangerous than those on InPOI due to a limited critical *** intermedia Al2O3 layer was intended to increase the adherence while it brings in the largest *** simulated results reveal thermal stress on Al2O3 over 1 GPa,which is much higher than its critical stress for interfacial *** without an Al2O3 layer is more suitable as the substrate for optoelectronic integration on Si.

关键词： Ⅲ-VOI template finite element method(FEM) critical thickness