检索结果-南通市图书馆

Inhibitory Activities on α-Glucosidase and Composition Analysis of Different Fractions of Ethanol Extracts from Actinidia chinensis Radix

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2019年第5期35卷 823-829页

作者： NIE Changping YANG Jun WU Dan WAN Luping liang guangping Department of Pharmacy Zunyi Medical and Pharmaceutical CollegeZunyi 563006P.R.China Department of Neurology the Fifth People's Hospital of Zunyi CityZunyi 563000P.R.China

Tlie inhibitory actions of ethyl acetate,n-butanol and water fractions from Actinidia chinensis Radix (A. chinensis Radix) ethanol extracts on glucosidase were investigated. We found that the inhibitory activity of different ethanol extract fractions on α-glucosidase is concentration-dependent. At the same concentration, the ethyl acetate and n-butaiiol fractions showed higher inliibitory activities on gglucosidase in comparison witli acarbose. We then determined the chemical constituents of tlie ethyl acetate and n-butanol fractions through ultra performance liquid cliromatography-triple-time of flight/mass spectrometry(UPLC-Triple-TOF/MS). Based on the mass spectrometry analysis and the databases Scitinder and Reaxys, 21 compoiinds(A1-A21) were identified from the ethyl acetate fraction. In addition, 11 of those compounds(A2, A3, A5, A6, A8, A10, A11, A13, A15, A19, A20) were identified for the first time from A. chinensis Radix. We also identified 14 compounds(A22-A32 and A4-A6) from tlie w-butanol fraction and compound A29 is a new natural product. From the n-butanol fraction, 7 additional compounds (A22, A25, A27, A28, A30-A32) were identified from A. chinensis Radix for the first time.

关键词： Actinidia chinensis Radix Extract /Glucosidase Ultra perfbnnance liquid chromatography-triple-time of flight/mass spectrometry(UPLC-Triple-TOF/MS)

A tubular focused sonochemistry reactor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2007年第14期52卷 1902-1905页

作者： ZHOU guangping liang ZhaoFeng LI ZhengZhong ZHANG YiHui Department of Electronic Engineering Shenzhen Polytechnic Shenzhen 518055 China

This paper presents a new sonochemistry reactor, which consists of a cylindrical tube with a certain length and piezoelectric transducers at tube’s end with the longitudinal vibration. The tube can effectively transform the longitudinal vibration into the radial vibration and thereby generates ultrasound. Furthermore, ultrasound can be focused to form high-intensity ultrasonic field inside tube. The reactor boasts of simple structure and its whole vessel wall can radiate ultrasound so that the electroacoustic transfer efficiency is high. The focused ultrasonic field provides good condition for sonochemical reaction. The length of the reactor can be up to 2 meters, and liquids can pass through it continuously, so it can be widely applied in liquid processing such as sonochemistry.

关键词：声化学反应堆聚焦圆柱形管道

Analysis of t-test misuses and SPSS operations in medical research papers

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2019年第1期7卷 290-294页

作者： guangping liang Wenliang Fu Kaifa Wang State Key Laboratory of Trauma Burnsand Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038People’s Republic of China School of Mathematics and Statistics Southwest UniversityChongq

In medical research papers,the selection of appropriate statistical methods serves as one of the pivotal premises to ensure the quality of papers and credibility of their results[1–3].To correctly perform the statistical analysis of quantitative data,two key points should be *** is to identify the type of experimental design correctly,and the other is to check whether data meets the preconditions of parameter test[2–4].Otherwise,it may cause different misuse in some situations and may even draw different or opposite conclusions about the same data.

关键词： app operations papers

Synthesis and Cytotoxic Activities of Spin-labeled Derivatives of Cinobufagin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2017年第4期33卷 581-586页

作者： GUO Jinhua TAN Bei YE Qingmei liang guangping YI Min JIANG Renwang Institute of Traditional Chinese Medicine & Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of Pharmacy Jinan University Guangzhou 510632 P. R. China Department of Pharmacy Hainan General Hospital Haikou 570311 P. R. China

Two series of novel spin-labeled derivatives of Cinobufagin（compounds 5 and 8a--8f in series 1 with five-membered ring nitroxyl free radical and compounds 6 and 9a-9f in series 2 with six-membered ring nitroxyl free radical） were synthesized. The cytotoxic activities in vitro against two tumor cell lines（HepG2 and HeLa） were evaluated, and the results indicate that all compounds display potent cytotoxicity against HepG2 and HeLa cells, and most compounds show better activities on HeLa cells than on HepG2 cells except for compounds 8a and 9d. Gene- rally, the compounds in series 2 have more potent cytotoxic activity against HepG2 than the compounds in series 1. Especially, compounds 6 and 9f in series 2 exhibit even more potent activities against the two tumor cell lines than Cinobufagin. Thus incorPoration of different L-amino acids as the linker changed the cytotoxic profile of the spin-labeled Cinobufagin. In addition, the representative compound 9f significantly changed the cell cycle distribution and led to HeLa cell cycle arrested at G2/M phase.

关键词： Cmobufagin Nitroxyl free radical Spin-labeled Cytotoxic activity

Epigenetic regulation of macrophage polarization in wound healing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2023年第1期11卷 105-121页

作者： Cheng Chen Tengfei Liu Yuanyang Tang Gaoxing Luo guangping liang Weifeng He State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Key Laboratory for Disease Proteomics Chongqing 400038China No.906 Hospital of Joint Logistic Support Force of PLA NingboZhejiangChina Academy of Biological Engineering Chongqing UniversityChongqingChina

The immune microenvironment plays a critical role in regulating skin wound ***,the main component of infiltrating inflammatory cells,play a pivotal role in shaping the immune microenvironment in the process of skin wound *** comprise the classic proinflammatory M1 subtype and anti-inflammatory M2 *** the early inflammatory phase of skin wound closure,M1-like macrophages initiate and amplify the local inflammatory response to disinfect the injured *** the late tissue-repairing phase,M2 macrophages are predominant in wound tissue and limit local inflammation to promote tissue *** biological function of macrophages is tightly linked with epigenomic *** factors are essential for macrophage *** modification of transcription factors determines the heterogeneity of *** contrast,transcription factors also regulate the expression of epigenetic *** transcription factors and epigenetic enzymes form a complex network that regulates the plasticity of ***,we describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.

关键词： Epigenetics Macrophage polarization Wound healing Immune microenvironment Signaling pathways

Novel Cinobufagin Oxime Ether Derivatives as Potential Na＋/K＋-ATPase Inhibitors： Synthesis, Biological Screening and Molecular Docking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2017年第3期33卷 378-383页

作者： liang guangping CHUNG Tseyu GUO Jinhua ZHANG Rongrong XU Wei TZEN Jason T.C JIANG Renwang College of Pharmacy Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University Guangzhou 510632 P. R. China Graduate Institute of Biotechnology 'National Chung-Hsing University ' Taichung 40227 China

Some cinobufagin oxime ether derivatives as potential Na＋/K＋-ATPase inkibitors were synthesized by following the side chain of istaroxime. These compounds inhibit Na＋/K＋-ATPase in a dose-dependent manner. Compound 3c with an oxyethylamine side chain that is the same as that of istaroxime showed the most potent inhibi- tion, which was stronger than compound 3a with only hydroxyoxime moiety at C3 and compound 3b with a methy-lated hydroxyoxime moiety. Molecular docking was used to explore the binding modes of the target compounds with Na＋/K＋-ATPase, which suggested that the longer ethyl amine group at C3 oxime moiety of compound 3c could make stronger interaction with Na＋/K＋-ATPase via intermolecular charge-charge and H-bond interaction as compared with other derivatives.

关键词： Cinobufagin Istaroxime Na+/K+-ATPase Molecular docking

Synthesis of Camptothecin-lO-O-glucoside Using an Engineered Oleandomycin Glucosyltransferase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2018年第3期34卷 423-427页

作者： ZHU Xuelin YE Qinmei WEN Chao CHEN Liping liang guangping ZENG Ting ZHANG Dongmei JIANG Renwang Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou 510632 P. R. China

Oleandomycin glycosyltransferase variant P67T/S132F/A242V（ASP） was used to convert 10-hydroxycamptothecin into camptothecin-10-O-glucoside, which was confirmed by spectral analysis. Compared to the previously reported results, the present study reached the conversion rate up to 80% through the optimization of reaction conditions. In addition, compared with 10-hydroxycamptotheein（HCPT）, camptothecin-10-O-glucoside inhibited the proliferation of Huh7 cells in a concentration-dependent manner and showed stronger antineoplastic effect but lower toxicity. Furthermore, camptothecin-10-O-glucoside induced more apoptotic cells as compared with the parent compound.

关键词： Camptothecin-10-O-glucoside 10-Hydroxycamptothecin Glycosylation Glucosyltransferase Antineoplastic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

第十九届全国烧伤救治与创面修复研讨会纪要

中华烧伤与创面修复杂志 2024年第7期40卷 699-700页

作者：吕艳玲莫愚梁光萍罗高兴彭毅志孙旦仇恺真武路遥李亭亭刘志欣中华烧伤与创面修复杂志重庆400038 陆军军医大学(第三军医大学)第一附属医院全军烧伤研究所创伤与化学中毒全国重点实验室重庆400038 佛山市第一人民医院烧伤整形创面修复外科佛山528000

第十九届全国烧伤救治与创面修复研讨会于2024年6月20—22日在广东省佛山市成功召开,共计700余名代表参加了此次学术盛会。本次会议以“拓展、融合与规范”为主题,旨在拓展烧伤相关学科的学术交流,实现多学科的交叉融合发展,推动烧伤临... 详细信息

第十九届全国烧伤救治与创面修复研讨会于2024年6月20—22日在广东省佛山市成功召开,共计700余名代表参加了此次学术盛会。本次会议以“拓展、融合与规范”为主题,旨在拓展烧伤相关学科的学术交流,实现多学科的交叉融合发展,推动烧伤临床救治与创面修复等规范化,助力学科发展。共有近200名知名专家学者在大会上进行了为期2天的主旨论坛及重症救治、创面修复、瘢痕防治、康复护理、交叉融合等专场学术研讨。学术交流紧凑全面、临床与基础兼备,会议成果丰硕。

关键词：烧伤会议学术创面修复

The progress of Chinese burn medicine from the Third Military Medical University—in memory of its pioneer,Professor Li Ao

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2017年第2期5卷 68-78页

作者： Haisheng Li Junyi Zhou Yizhi Peng Jiaping Zhang Xi Peng Qizhi Luo Zhiqiang Yuan Hong Yan Daizhi Peng Weifeng He Fengjun Wang guangping liang Yuesheng Huang Jun Wu Gaoxing Luo Institute of Burn Research State Key Laboratory of Trauma Burn and Combined Injury Southwest Hospital Third Military Medical UniversityGaotanyan Street no.29 Shapingba District Chongqing 400038 China

Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. The epidemiology and outcomes of admitted burn patients since 1958 were reviewed. Furthermore, main achievements of basic and clinical research for the past roughly 60 years were presented. These achievements mainly included the Chinese Rule of Nine, fluid resuscitation protocol, experience in inhalation injury, wound treatment strategies, prevention and treatment of burn infections, nutrition therapy, organ support therapies, and rehabilitation. The progress shaped and enriched modern Chinese burn medicine and promoted the development of world burn medicine.

关键词： Burn injury Chinese burn medicine Li Ao Third Military Medical University Inhalation injury