检索结果-南通市图书馆

同方期刊数据库

Heavy atom-free triplet photosensitizer based on thermally activated delayed fluorescence material for NIR-to-blue triplet-triplet annihilation upconversion

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第2期34卷 403-406页

作者： hui liang Xiaoyu Liu Liting Tang Zafar Mahmood Zeduan Chen Guowei Chen Shaomin Ji Yanping Huo School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China

Triplet-triplet annihilation(TTA) upconversion-based materials have potential application in the broad range of research areas, including photocatalysis and life sciences. However, near-infrared(NIR)-to-blue upconverted emission is preferred for most of the practical applications, but developing a NIR-to-blue TTA upconversion system is a challenging task in photochemistry. In this work, a thermally activated delayed fluorescence(TADF) material with intense visible-to-NIR absorption is demonstrated that shows a longer triplet state lifetime(32 μs) and high triplet state energy(E_(T)= 1.55 e V). For the first time, a heavy atomfree NIR(λ_(ex)> 650 nm) to blue(λ_(em)< 460 nm) TTA upconversion system was devised, employing the dimeric borondifluoride curcuminoid TADF material as triplet photosensitizer(PS) and a large anti-Stokes shift(0.88 e V) along with moderate upconversion yield was achieved. Our work provides the solution and guidance for the future development of purely organic heavy atom-free NIR activating TTA upconversion system for a wide array of applications.

关键词： Heavy atom-free Triplet state Photosensitizer TTA-upconversion

Effect of stochastic electromagnetic disturbances on autapse neuronal systems

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2018年第11期27卷 349-357页

作者： liang-hui Qu Lin Du Zi-Chen Deng Zi-Lu Cao Hai-Wei Hu School of Natural and Applied Sciences Northwestern Polytechnical University Xi＇an 710129 China School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical University Xi ＇ an 710129 China College of Science Zhongyuan University of Technology Zhengzhou 450007 China

With the help of a magnetic flux variable, the effects of stochastic electromagnetic disturbances on autapse Hodgkin–Huxley neuronal systems are studied systematically. Firstly, owing to the autaptic function, the inter-spike interval series of an autapse neuron not only bifurcates, but also presents a quasi-periodic characteristic. Secondly, an irregular mixed-mode oscillation induced by a specific electromagnetic disturbance is analyzed using the coefficient of variation of inter-spike intervals. It is shown that the neuronal discharge activity has certain selectivity to the noise intensity, and the appropriate noise intensity can induce the significant mixed-mode oscillations. Finally, the modulation effects of electromagnetic disturbances on a ring field-coupled neuronal network with autaptic structures are explored quantitatively using the average spiking frequency and the average coefficient of variation. The electromagnetic disturbances can not only destroy the continuous and synchronous discharge state, but also induce the resting neurons to generate the intermittent discharge mode and realize the transmission of neural signals in the neuronal network. The studies can provide some theoretical guidance for applying electromagnetic disturbances to effectively control the propagation of neural signals and treat mental illness.

关键词： neuronal system electromagnetic disturbance autapse mixed-mode oscillations

Construction and Expression of Human Survivin and Preparation of Its Polyclonal Antibody

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2008年第6期24卷 767-770页

作者： ZHANG Hai-hong ZHANG Xi-zhen ZHAO Dong-hai SHI He-liang YU Yong-hui WU Yong-ge YU Xiang-hui KONG Wei Vaccine Research Center College of Life Science Jilin University Changchun 130012 P R. China

Survivin, a novel member of inhibitor of apoptosis（IAP） protein family, is aberrantly expressed in cancer but undetectable in normal, differentiated adult tissues. The cancer-specific expression of survivin, coupled with its importance in inhibiting cell death and in regulating cell division makes it a useful diagnostic marker of cancer and a potential target for cancer treatment. Survivin cDNA amplified from the total RNA of 293 cells through RT-PCR was cloned into prokaryotic expression vector pRSET-B. The recombinant plasmid pRSET-B-Surv was expressed in *** BL21, and the relative molecule mass（Mr） of expressed fusion protein was approximately 21000. The recombinant protein was purified through Ni^2＋ affinity chromatography column and characterized by SDS-PAGE and Western blot. The purified recombinant protein was then injected into rabbits, and antisurvivin polyclonal antibody with a high titer was obtained.

关键词： Clone Survivin Expression Polyclonal antibody

Mechanical Properties, Crystallization and Biodegradation Behavior of the Polylactide/Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/ Poly(butylene adipate-co-terephthalate) Blown Films

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第10期38卷 1072-1081,I0005页

作者： Xiang-Yu Wang Hong-Wei Pan Shi-Ling Jia Zeng-Wen Cao Li-Jing Han hui-liang Zhang Li-Song Dong Key Laboratory ofPolymer Ecomaterials Chinese Acadermy of SciencesChangchun Istitute of Applied ChemistryChangchun 130022 China University of Science and Technology of China Hefei 230026 China Zhejiang Zhongke Applied Chemistry Technology Co LtdHangzhou 30000 China

Polactide(PLA),poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P(3HB-CO-4HB)),and poly(butylene adipate co-terephthalate)(PBAT)ternary blends were prepared by extrusion *** biodegradable PLA/P(3HB-co 4HB)/PBAT films were successfully obtained by using blown films *** siffness-toughness balance was achieved for 55/10/35 PLA/P(3HB-co 4HB)/PBAT *** tensile strength reached 33.0 MPa(MD)and 23.5 MPa(TD).the elongation at break exceeded 1309%,and tear strength exceeded 110 kN/*** Young's modulus as low as about 1800 MPa also met packaging *** observations revealed rough and long ligaments,indicating that the tear specimens were broken *** addition of PBAT elastomers was the main reason for the improved toughness of the *** DMA and SEM analysis,it was demonstrated that PLA P(3HB co 4HB),and PBAT were prilly *** increasing P(3HB CO-4HB)content,the melt and cold crstallization of PLA was *** enzymatic degradation experiments indicated that the films had good *** findings gave important implications for designing and manufacturing biodegradation package of high biological carbon content.

关键词： Polylactide Poly(3 hydroxybutyrate co4-hydrxybutyrate) Blown flms Mechanical properties Biodegradability

RNAs in the testicular tissue of patients with non-obstructive azoospermia

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第6期24卷 660-665页

作者： Zhe Zhang Han Wu Lin Zheng Hai-Tao Zhang Yu-Zhuo Yang Jia-Ming Mao De-Feng Liu Lian-Ming Zhao hui liang hui jiang Department of Urology Peking University Third HospitalBeijing 100191China Department of Andrology Peking University Third HospitalBeijing 100191China Department of Reproductive Medicine Center Peking University Third HospitalBejing 100191China Department of Pathology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Circular RNAs(circRNAs)are highly conserved and ubiquitously expressed noncoding RNAs that participate in multiple reproductionrelated ***,the expression pattern and potential functions of circRNAs in the testes of patients with non-obstructive azoospermia(NOA)remain *** this study,according to a circRNA array,a total of 37881 circRNAs were identified that were differentially expressed in the testes of NOA patients compared with normal controls,including 19874 upregulated circRNAs and 18007 downregulated *** quantitative real-time polymerase chain reaction(qRT-PCR)analysis,we confirmed that the change tendency of some specific circRNAs,including hsa_circ_0137890,hsa_circ_0136298,and hsa_circ_0007273,was consistent with the microarray data in another larger *** structures and characteristics of these circRNAs were confirmed by Sanger sequencing,and fluorescence in situ hybridization revealed that these circRNAs were primarily expressed in the *** analysis was used to construct the competing endogenous RNA(ceRNA)network,and numerous miRNAs that could be paired with circRNAs validated in this study were reported to be vital for spermatogenesis *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses indicated that genes involved in axoneme assembly,microtubule-based processes,and cell proliferation were significantly *** data suggest that there are aberrantly expressed circRNA profiles in patients with NOA and that these circRNAs may help identify key diagnostic and therapeutic molecular biomarkers forNoA patients.

关键词： circular RNA microarray non-obstructive azoospermia spermatogenesis testicular tissue

Adjuvant chemotherapy after liver transplantation for hepatocellular carcinoma: a systematic review and a meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 236-245页

作者： Hua-Shan Lin Ren-Hua Wan liang-hui Gao Jian-Feng Li Ren-Feng Shan Jun Shi Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital College of Medicine Nanchang University

BACKGROUND： Hepatocellular carcinoma （HCC） is one of the most common tumors worldwide and liver transplanta- tion （LT） is considered as the best therapeutic option for patients with HCC combined with cirrhosis. However, tumor recurrence after LT for HCC remains the major obstacle for long-term survival. The present study was to evaluate the effi- cacy and necessity of adjuvant chemotherapy in patients with HCC who had undergone LT.

关键词： adjuvant chemotherapy liver transplantation hepatocellular carcinoma recurrence meta-analysis

Effect of HSPB9 on Apoptosis of DF-1 Cells

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2019年第2期32卷 107-120页

作者： XU Yong Jie HU Mei Ling ZHOU liang hui WANG Qi ZHANG Xi Quan LUO Qing Bin Department of Animal Genetics Breeding and Reproduction College of Animal Science/Key Laboratory of Chicken Genetics Breeding and Reproduction Ministry of Agriculture South China Agricultural University

Objective Our aim was to explore whether heat stress protein(HSP) 9 preferentially expresses under heat stress and affects the expression of other heat stress proteins as well as to explore the effect of HSPB9 overexpression and knockdown on apoptosis in DF-1. Methods We used gene cloning to construct an overexpression vector of the target gene, and synthesized the target gene interference fragment to transfect the chicken fibroblast cell line. Gene and protein expression, as well as apoptosis, were detected by RT-qPCR, Western blot, and flow cytometry. Results Chicken DF-1 cells showed an early state of apoptosis in the early stages of HSPB9 overexpression. In the later stages, as HSPB9 expression increased, the cells showed inhibition of apoptosis. When the cells were under heat stress, HSPB9 expression was much higher and earlier than the expression of HSPB1 and HSPA2. In addition, high expression of HSPB9 had a negative effect on HSPB1 and HSPA2 expression. This negative feedback decreased the percentage of early stages of apoptotic cells and promoted cell survival. Conclusion HSPB9 expression, although rapid, is detrimental to cell survival early during its overexpression. In heat stress, HSPB9 overexpression, while inhibiting the expression of HSPA2 and HSPB1, is beneficial to cell survival.

关键词： Heat stress HSPB9 HSPB1 HSPA2 Apoptosis

5-methoxytryptophan induced apoptosis and PI3K/Akt/FoxO3a phosphorylation in colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第47期29卷 6148-6160页

作者： Tian-Lei Zhao Yue Qi Yi-Fan Wang Yi Wang hui liang Ya-Bin Pu Department of General Surgery Naval Medical Center of PLAShanghai 200052China Department of Gastroenterology Naval Medical Center of PLAShanghai 200052China

BACKGROUND Colorectal cancer(CRC)is a highly prevalent malignancy worldwide,and new therapeutic targets urgently need to be found to prolong patient survival.5-methoxytryptophan(5-MTP)is a tryptophan metabolite found in animals and ***,the effects of 5-MTP on proliferation and apoptosis of CRC cells are currently *** To investigate the effects of 5-MTP on the proliferation,migration,invasion,and apoptosis abilities of CRC ***,we seek to explore whether 5-MTP has the potential to be utilized as a drug for the treatment of *** In order to evaluate the effect of 5-MTP on CRC cells,a series of experiments were conducted for *** formation assay and Cell Counting Kit 8 assays were used to investigate the impact of 5-MTP on the proliferation of CRC cell *** cycle assays were employed to examine the effect of 5-MTP on cellular *** addition,we investigated the effects of 5-MTP on apoptosis and reactive oxygen species in HCT-116 *** obtain a deeper understanding of how 5-MTP affects CRC,we conducted a study to examine its influence on the PI3K/Akt signaling pathway in CRC *** This article showed that 5-MTP promoted apoptosis and cell cycle arrest and inhibited cell proliferation in CRC *** many articles,it has been reported that PI3K/Akt/FoxO3a signaling pathway is one of the most important signaling pathways involved in internal regulating cell proliferation and differentiation. Nevertheless, 5-MTP combined with PI3K/Akt/FoxO3a signaling pathway inhibitors significantly promotedapoptosis and cell cycle arrest and inhibited cell proliferation in CRC cells compared with 5-MTP alone in ***, there is strong evidence that 5-MTP can be used as an effective medicine for CRC treatment.

关键词： Colorectal cancer 5-methoxytryptophan Apoptosis Cell cycle arrest PI3K/Akt signaling pathway

Evaluation of nine machine learning methods for estimating daily land surface radiation budget from MODIS satellite data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2022年第1期15卷 1784-1816页

作者： Shaopeng Li Bo Jiang Shunlin liang Jianghai Peng hui liang Jiakun Han Xiuwan Yin Yunjun Yao Xiaotong Zhang Jie Cheng Xiang Zhao Qiang Liu Kun Jia The State Key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing and Digital Earth of Chinese Academy of SciencesBeijingPeople’s Republic of China Beijing Engineering Research Center for Global Land Remote Sensing Products Institute of Remote Sensing Science and EngineeringFaculty of Geographical ScienceBeijing Normal UniversityBeijingPeople’s Republic of China Department of Geographical Sciences University of MarylandCollege ParkMDUSA Beijing Engineering Research Center for Global Land Remote Sensing Products College of Global Change and Earth System ScienceBeijing Normal UniversityBeijingPeople’s Republic of China

The all-wave net radiation(Rn)at the land surface represents surface radiation budget and plays an important role in the Earth's energy and water *** studies have been conducted to estimate from satellite top-of-atmosphere(TOA)data using various methods,particularly the application of machine learning(ML)and deep learning(DL).However,few studies have been conducted to provide a comprehensive evaluation about various ML and DL methods in *** on extensive in situ measurements distributed at mid-low latitudes,the corresponding Moderate Resolution Imaging Spectroradiometer(MODIS)TOA observations,and the daily from the fifth generation of European Centre for Medium-Range Weather Forecasts Reanalysis 5(ERA5)used as a priori knowledge,this study assessed nine models for daily estimation,including six classic ML methods(random forest-RF,adaptive boosting-Adaboost,extreme gradient boosting-XGBoost,multilayer perceptron-MLP,radial basis function neural network-RBF,and support vector machine-SVM)and three DL methods(multilayer perceptron neural network with stacked autoencoders-SAE,deep belief network-DBN and residual neural network-ResNet).The validation results showed that the three DL methods were generally better than the six ML methods except XGBoost,although they all performed poorly in certain conditions such as winter days,rugged terrain,and high *** had the most robust performance across different land cover types,elevations,seasons,and latitude zones,but it has disadvantages in practice because of its highly configurable implementation environment and low computational *** estimated daily values from all nine models were more accurate than the corresponding Global LAnd Surface Satellite(GLASS)product.

关键词： Net radiation energy balance mid-low latitude model comparison machine learning deep learning MODIS ERA5