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Wettability regulated gram-negative bacterial adhesion on biomimetic hierarchical structures

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Chinese Chemical Letters 2017年第4期28卷 813-817页

作者： You Jiang Yi-Jie Yin Xin-Cheng Zha Xiao-Qiu Dou chuan-liang Feng State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiaotong University Shanghai 200240 China

One of the critical issues in gram-negative bacterial adhesion is how wettability regulates adhesion as the surface wettability varies from superhydrophilic to superhydrophobic,and what is the relevant/contributing role of the lipopolysaccharide（LPS） outer layer of the gram-negative shell during this ***,by avoiding the unexpected influence induced by the varied topographies,control over gram-negative bacteria adhesion by wettability is achieved on biomimetic hierarchical surfaces,which is mainly mediated by LPS *** study provides a methodology to have a good control over bacteria cell adhesion by properly designing wettable surface *** design concept is helpful for developing new generations of biomaterials in order to control a variety of diseases induced by gramnegative bacteria,which still continue to be very important and necessary in the fields of biomedicine.

关键词： Wettability Gelator Self-assembly Hierarchical structures Bacteria adhesion

Circular RNA hsacirc0000745 may serve as a diagnostic marker for gastric cancer

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World Journal of Gastroenterology 2017年第34期23卷 6330-6338页

作者： Mei Huang Yi-Ren He Li-chuan liang Qiang Huang Zhi-Qiang Zhu Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery Department of General SurgeryAnhui Provincial Hospital Affiliated to Anhui Medical University Department of General Surgery Anhui Provincial Hospital Affiliated to Anhui Medical University

AIM To determine whether circular RNAs(circ RNAs) are involved in pathological processes of gastric cancer(GC).METHODS Three circ RNAs with differential expression in GC and colorectal cancer were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction(q RT-PCR), using 20 pairs of gastric tissues and normal tissues. Based on the predicted circ RNAmi RNA network, we then focused on hsa_circ_0000745, which was found to be down-regulated in 20 GC tissues compared with normal tissues. The hsa_circ_0000745 levels were further analyzed by q RT-PCR in 60 GC tissues and paired adjacent non-tumor tissues, as well as 60 plasma samples from GC patients and 60 plasma samples from healthy controls. The associations between the levels of hsa_circ_0000745 and the clinicopathological features of GC patients were statistically assessed. A receiver operating characteristic(ROC) curve was used to evaluate the diagnostic value of hsa_circ_0000745 in *** Hsa_circ_0000745 was down-regulated in GC tissues vs non-tumorous tissues(P < 0.001) and in plasma samples from patients with GC vs healthy controls(P < 0.001). The expression level of hsa_circ_0000745 in GC tissues correlated with tumor differentiation, while the expression level in plasma correlated with tumor-nodemetastasis stage. The area under the ROC curve(AUC) of hsa_circ_0000745 in plasma was 0.683, suggesting good diagnostic value. Plasma hsa_circ_0000745 level combined with carcinoembryogenic antigen(CEA) level increased the AUC to *** Hsa_circ_0000745 plays an important role in GC and its expression level in plasma in combination with CEA level is a promising diagnostic marker for this malignancy.

关键词： Circular RNA circ_0000745 Gastric cancer Diagnosis Noncoding RNA

Discovery of novel inhibitors of anti-apoptotic Bcl-2 proteins derived from Bim BH3 domain

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Chinese Chemical Letters 2017年第7期28卷 1523-1527页

作者： chuan-liang Zhang Shan Liu Xiao-Chun Liu Jiang-Ming Gao Shu-Lin Wang School of Medicine and Pharmacy Key Laboratory of Marine DrugsMinistry of EducationOcean University of ChinaQingdao 266003China Marine Biomedical Research Institute Qingdao 266071China

The BH3 mimetics targeting the interaction between the BH3-only proteins and their prosurvival Bcl-2family proteins have shown enormous potential as cancer therapeutics. Herein, seven analogues targeting anti-apoptotic Bcl-2 proteins derived from the Bim BH3 domain via sequence simplification and/or modification are described. The in vitro binding affinity on anti-apoptotic Bcl-2 proteins and cell killing activity were evaluated. The results showed that analogues could significantly bind to target proteins and exhibited anti-cancer effect against three cancer cell lines. Of particular interest were the analogue SM-5（KD= 9.48 nmol/L for Bcl-2） and SM-6（KD= 0.08 nmol/L for Bcl-xL）, which exhibited improved binding affinity compared with the lead Bim（KD= 16.90 nmol/L for Bcl-2 and 22.2 nmol/L for Bcl-xL, respectively）. These results indicated that the peptide sequence containing the four hydrophobic side chains occupying pockets within the BH3-recognition cleft of anti-apoptotic Bcl-2 proteins might be the minimum sequence required for the bioactivity and the active core region of Bim. Promising inhibitors of anti-apoptotic Bcl-2 proteins with high bioactivity might be designed based on the active core.

关键词： Apoptosis Anti-apoptotic Bcl-2 proteins Bim BH3 domain Binding affinity Anti-cancer activity

A Phase Ⅱ Study of Fotemustine Plus Dacarbazine with Dendritic Cell Vaccines as First-Line Therapy for Chinese Patients with Advanced Acral Lentiginous Melanoma

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Chinese Journal of Cancer Research 2009年第1期21卷 13-19页

作者： Lu Si Zhi-hong Chi Xiang-qing Yuan chuan-liang Cui Xi-nan Sheng Jun Guo Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Renal Cancer and Melanoma Center Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To investigate fotemustine plus dacarbazine （DTIC） with dendritic cell （DC） vaccines on patients with advanced acral lentiginous melanoma （ALM）. Fotemustine is a cytotoxic alkylating agent with a remarkable antitumor activity as single agent but also in association with （DTIC）. DC is the strongest antigen presenting cell which could induce durable clinical responses. Methods： This was a single-center study. Between July 2003 and June 2006, twenty-eight chemotherapy-naive patients of advanced ALM received fotemustine 100 mg/m^2, dr, 12, DTIC 400 mg/d d2-6, DC vaccines subcutaneously dT, 9, 13 repeated every 28 days. Ten HLA-A02＋24＋ patients received vaccines pulsed with melanoma antigen derived peptides, melanoma antigen recognized by T-cells 1 （Mart-i） and S-100. Eighteen patients received DC loaded with allogeneic melanoma lysate. The primary end-point was progression free survival （PFS）. Secondary end-points were overall survival （OS）, overall response rate （ORR） and toxicity. Tumor assessment was performed every 8 weeks and evaluated according to response evaluation criteria in solid tumors （RECIST）. Results： The 15 men and 13 women had a median age of 51 years. 16 patients had stage Mlc disease and 11/16 had liver metastasis. Patients received an average of 3.82±1.25 cycles. Follow-up for the 18 surviving patients ranged from 7-41 months with a median of 12 months. Median PFS was 8.5 months （95% CI： 7.86-15.21） with 12 patients remaining progression free. Only 10 patients died. Median OS was 12 months （95% CI： 10.33-18.24）. ORR （CR＋PR） was 35.7% including 3 complete response （CR） and 7 partial response （PR）. Six patients had disease stable. A total of 19 Grade Ⅲ/Ⅳ toxicities were observed including thrombocytopenia （n=8）, neutropenia （n=5）, fatigue （n=6） and hypersensitivity reaction （n=1）. One patient died of Grade IV thrombocytopenia. Conclusion： Fotemustine and dacarbazine plus DC vaccines are safe and tolerable to Chinese ALM patients. The regi

关键词： Fotemustine Dacarbazine Dendritic cell Melanoma

A New Chemiluminescent Triazine Reagent

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Chinese Chemical Letters 2001年第3期12卷 267-268页

作者： Quan Li MA Mei Hong SU Hui Min MA Zhi Hua WANG Shu chuan liang Center for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100080

A new chemiluminescent reagent 7-(4,6-dichloro-1,3,5-triazinylamino)-4-methylcoumarin-4-methylcoumarin (DTMC) was synthesized by linking 7-amino-4-methylcoumarin to cyanuric chloride at 0-5 degreesC, and with it a novel chemiluminescence method was developed for the determination of hydrogen peroxide. The selectivity of this method is high, and most of the transition metal ions have no effect on the determination of H2O2.

关键词： 7-(4 6-dichloro-1 3 5-triazinylamino)-4-methylcoumarin chemiluminescent reagent hydrogen peroxide.

基于RUSLE模型的利川市水土流失敏感性时空特征分析

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资源环境与工程 2024年第5期38卷 586-593页

作者：孙智杰王艺霖梁川龙少秋陈刚湖北省地质环境总站湖北武汉430034 资源与生态环境地质湖北省重点实验室湖北武汉430034 湖北省地质局第四地质大队湖北咸宁437100

水土流失是湖北省利川市面临的一项较为突出的生态问题,开展水土流失敏感性评估是制定水土保持措施的基础。采用RUSLE模型、热点分析、标准差椭圆分析和地理探测器等方法,对2002—2022年利川市水土流失敏感性的时空变化及其影响因素进... 详细信息

水土流失是湖北省利川市面临的一项较为突出的生态问题,开展水土流失敏感性评估是制定水土保持措施的基础。采用RUSLE模型、热点分析、标准差椭圆分析和地理探测器等方法,对2002—2022年利川市水土流失敏感性的时空变化及其影响因素进行分析。结果表明,利川市水土流失总体上以微度敏感为主,但不同年份和地区的敏感程度存在明显差异;2002年,水土流失敏感性普遍较高,高值区域广泛分布在柏杨坝、团堡和文斗等地;2012年和2022年,东城、都亭和汪营等地敏感性略有上升,其他地区则普遍下降;水土流失热点区域面积逐渐缩减,分布范围向心聚集,重心向中心城区迁移;植被覆盖度和土地利用类型是影响水土流失敏感性空间分布的主要因素,植被覆盖度与坡度、土地利用和地层岩性的交互作用具有显著的空间叠加效应。未来应进一步关注植被覆盖度低、地形破碎、岩体软弱等地区的水土保持工作。

关键词：水土流失 RUSLE模型时空格局地理探测器利川市

Silica encapsulated ZnO quantum dot-phosphor nanocomposites:Sol-gel preparation and white light-emitting device application

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Chinese Physics B 2018年第7期27卷 548-555页

作者： Ya-chuan liang Kai-Kai Liu Ying-Jie Lu Qi Zhao Chong-Xin Shan School of Physics and Engineering Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

ZnO quantum dots （QDs） as an eco-friendly and low-cost material has bright fluorescence, which makes it promising material for healthy lighting and displaying. However, the low fluorescence efficiency and poor stability of ZnO QDs impede their applications in lighting application. In this work, silica encapsulated ZnO QD-phosphors nanocomposites （ZSPN） have been prepared through a sol-gel synthesis process, where yellow-emitting ZnO QDs and blue-emitting BaMgAl10O17：Eu2＋ are employed as the luminescence cores and silica as link between two luminescence materials. Tunable photoluminescence of ZSPN and the white light emission have been achieved through changing mass ratio of both of ZnO QDs and commercial phosphors. The PLQY of the ZSPN can reach 63.7% and they can maintain high luminous in- tensity even the ambient temperature up to 110 ℃ and after 35 h of UV irradiation. In addition, they can keep stable for 40 days. By coating the ZSPN phosphors onto a ultraviolet chip, WLEDs with luminous efficiency of 73.6 lm/W and the color coordinate, correlated color temperature, and color rendering index can reach （0.32, 0.34）, 5580 K, and 87, respectively, indicating the bright prospect of the ZSPN phosphors used in healthy lighting.

关键词： ZnO QD-phosphors nanocomposites (ZSPN) phosphors light-emitting diodes

A Glycosylated and Catechol-crosslinkedε-Polylysine Hydrogel:Simple Preparation and Excellent Wound Hemostasis and Healing Properties

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Chinese Journal of Polymer Science 2022年第9期40卷 1110-1119页

作者： Lin Teng Zheng-Wei Shao Yu-Shi He Jia-Yu Lu De-Rong Zou chuan-liang Feng Chang-Ming Dong School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Department of Stomatology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China School of Chemistry and Chemical Engineering Shanghai Electrochemical Energy Devices Research CenterShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Commercial tissue adhesives have been widely applied in wound hemostats and dressings while enhancing the hemostasis and healing capabilities is challenging to meet clinical ***,we designed the glucose-and catechol-functionalized derivatives from commercialε-polylysine(EPL)and prepared the hydrogels by simple amidation and catechol-crosslinking reactions,which have larger swelling ratios of 220%–240%,suitable microporous size of about 6–8µm,and tissue adhesion strength of about 20–40 *** hemolysis,cytotoxicity,and cellular double-staining assays indicate that those hydrogels had good biocompatibility and the H-3 hydrogel with higher glucose content gave a lower hemolysis ratio of 0.73%±0.14%.The blood-clotting index,blood cell attachment and adhesion studies showed those hydrogels had fast blood-coagulation,resulting in excellent hemostasis performance with a short hemostatic time of 38–46 s and less blood loss of 19%–34%in a liver hemorrhage model.A full-thickness rat-skin defect model further demonstrates that the H-3 hydrogel achieved fast wound healing with a wound closure of 70.0%±2.7%on postoperative day 7 and nearly full closure on day ***,the hydroproline level that denotes the collagen production reached a higher one of 7.24±0.55µg/mg comparable to that in normal skins on day 14,evidencing the wound healing was close to completion in the H-3 ***,this work provides a simple method to construct a glycosylated and catechol-functionalized hydrogel platform from commercial EPL,holding translational potentials in wound hemostats and dressings.

关键词： Polylysine hydrogel Glycosylation Mussel-mimetic Hemostasis Wound dressing

一种Petri网合成方法及其在系统建模中的应用

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系统仿真学报 2006年第2期18卷 271-277页

作者：夏传良中国科学院数学与系统科学研究院计算机科学研究室

针对多个企业共用一个加工厂生产某种产品等这一类系统问题,提出了经由Petri网共享一种子网构成合成网的解决方案;用Petri网为系统建模,先为各企业租用加工厂生产某种产品的系统建立各自的Petri网模型,然后进行共享子网合成得到系统的整... 详细信息

针对多个企业共用一个加工厂生产某种产品等这一类系统问题,提出了经由Petri网共享一种子网构成合成网的解决方案;用Petri网为系统建模,先为各企业租用加工厂生产某种产品的系统建立各自的Petri网模型,然后进行共享子网合成得到系统的整体Petri网模型。运用这种整体Petri网模型,可达到同步操作和节省资源的目的。给出了自由选择网(FC){非对称选择网(AC)}的共享子网合成网仍为自由选择网(FC){非对称选择网(AC)}的条件和共享子网合成Petri网保持结构活性的条件;结果可为Petri网系统合成性质的考察提供有效途径,为复杂大系统建模提供有利手段,具有宽广的应用前景。

关键词： Petri网合成结构活性系统建模