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Molecular profiling of hepatocellular carcinomas by cDNA microarray

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World Journal of Gastroenterology 2005年第4期11卷 463-468页

作者： lian-HaiZhang Jia-FuJi PekingUniversitySchoolofOncology BeijingCancerHospitalBeijingInstituteforCancerResearchBeijing100034China

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. Conventional diagnosis and treatment of this malignancy have been dismal and should be complemented by novel tools. The development and progress of HCC are believed to be caused by the accumulation of genetic changes resulting in altered expression of thousands of cancer-related genes, which can be measured by globe genetic analysis. Gene expression profiling of HCC has been employed to elucidate hepatocarcinogenesis and disclose molecular mechanisms underlying complex clinical *** phenotype-associated genes/profiles has impacts on current diagnosis and management strategy of HCC. In spite of some pitfalls of this technology and challenges in improving the research process, scrutinous validation of profiling data of HCC combined with other approaches will eventually benefit the patients.

关键词： Hepatocellular carcinomas cDNA microarray Gene expression profiling

Effects of fabricated error on transmission performance of double layer frequency selective surface configuration

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光学精密工程 2005年第5期13卷 599-603页

作者： HE Bin SUN lian-chun Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033China

Based on the experimental results, in which the fabricated error of the double layer frequency selective surface (FSS) leads to the transmission loss and the resonant frequency leaves away the design resonant frequency, the inter-layer separation distance (ISD) and the unit cell aligning error (UAE) were used as main variables to study the transmission performance attenuation of the double layer FSS configuration. The numerical analysis model for ISD and UAE was established and also was used to simulate the ring unit cell FSS transmission performance by the finite element and periodic moment methods. The double layer ring aperture FSS configuration designed was used as the numerical model. As a result of the numerical analysis, it is shown that both ISD and UAE produce insertion transmission loss (ITL) and insertion phase distortion (IPD) directly. Furthermore, ISD results in more loss of the amplitude of the transmitted signal for the FSS than UAE. It is significant for the designer of the multiplayer FSS to assign the fabricated error of the FSS dielectric layers. The UAE introduces the insertion phase variation badly.

关键词： FSS 平衡性 ISD 结构设计 UAE 光学机械

A Non-Intrusive Reduced Basis EKI for Time Fractional Diffusion Inverse Problems

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Acta Mathematicae Applicatae Sinica 2020年第1期36卷 183-202页

作者： Feng-lian YANG liang YAN College of Science Hohai UniversityNanjing 210098China School of Mathematics Southeast UniversityNanjing210096China

In this study,we consider an ensemble Kalman inversion(EKI)for the numerical solution of time fractional diffusion inverse problems(TFDIPs).Computational challenges in the EKI arise from the need for repeated evaluations of the forward *** address this challenge by introducing a non-intrusive reduced basis(RB)method for constructing surrogate models to reduce computational *** this method,a reduced basis is extracted from a set of full-order snapshots by the proper orthogonal decomposition(POD),and a doubly stochastic radial basis function(DSRBF)is used to learn the projection *** DSRBF is carried out in the offline stage with a stochastic leave-one-out cross-validation algorithm to select the shape parameter,and the outputs for new parameter values can be obtained rapidly during the online *** to the complete decoupling of the offline and online stages,the proposed non-intrusive RB method–referred to as POD-DSRBF–provides a powerful tool to accelerate the EKI approach for *** demonstrate the practical performance of the proposed strategies through two nonlinear time-fractional diffusion inverse *** numerical results indicate that the new algorithm can achieve significant computational gains without sacrificing accuracy.

关键词： fractional differential equations ensemble Kalman inversion surrogate modeling reduced basis method

Characterization and Crystal Structure of Bis(N'-ethyl-N-piperazinly-carbodithioato-S,S') Nickel(II) Complex:Ni(S_2CNC_4H_8NC_2H_5)_2

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1260-1264页

作者： WANG Ying YAN lian-He School of Chemical Engineering Nanjing University of Science and Technology Nanjing Jiangsu 210094 China

The title compound has been prepared and characterized by elemental analysis, infrared and FT-Raman spectra, and thermal analysis. The crystal and molecular structures of bis（N＇-ethyl-N-piperazinly-carbodithioato-S,S＇） nickel（Ⅱ） complex （Ni（S2CNC4H8NC2H5）2） were determined by X-ray diffraction methods. The crystal crystallizes in the triclinic system, space group PI^- with a = 0.66770（15）, b = 0.85066（12）, c = 0.8973（2） nm,α= 84.97（2）, β =78.71（2）,γ= 80.12（2）°, Mr = 437.34, V= 0.49160（17） nm^3, Z = 1, Dc = 1.477 g/cm^3, F（000） = 230, R = 0.0422 and wR = 0.1290. In the structure, the central Ni atom is coordinated in a slightly distorted square plane by four S atoms from two bidentate S2CNC4H8NC2H5 ligands with the four Ni-S bond distances in the range of 0.22065（10）～0.22076（9） nm. The IR and FT-Raman spectral data are in agreement with the structural data. Thermal analysis indicates that the title compound decomposes completely at the temperature of 799.88℃, leaving NiS.

关键词： crystal structure N-ethylpiperazine nickel complex FT-Raman

Advances in Research on Anticancer Properties of Salidroside

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Chinese Journal of Integrative Medicine 2021年第2期27卷 153-160页

作者： SUN An-qi JU Xiu-lian Key Laboratory for Green Chemical Process of Ministry of Education School of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan(430073)China The College of Post and Telecommunication Wuhan Institute of TechnologyWuhan(430073)China

Salidroside is a phenolic secondary metabolite present in plants of the genus Rhodiola,and studies investigating its extensive pharmacological activities and mechanisms have recently attracted increasing *** review summarizes the progress of recent research on the antiproliferative activities of salidroside and its effects on breast,ovarian,cervical,colorectal,lung,liver,gastric,bladder,renal,and skin cancer as well as gliomas and ***,it provides a reference for the further development and utilization of salidroside.

关键词： salidroside anticancer mechanism antiproliferative Chinese medicine review

Comparative study of four QSAR models of aromatic compounds to aquatic organisms

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Journal of Environmental Sciences 2002年第4期14卷 552-557页

作者： YURui-lian HUGong-ren ZHAOYuan-hui CollegeofMaterialsScienceandEngineering HuaqiaoUniversityQuanzhou362011China DepartmentofEnvironmentalScience NortheastNormalUniversityChangchun130024China

Quantitative structure activity relationships(QSARs)were developed for 43 aromatic compounds toxicity to Photobacterium phosphoreum and Daphnia magna based on four methods: octanol/water partition coefficient, linear solvation energy relationship, molecular connectivity index and group contribution. Through the evaluation of four QSAR methods, LSER was proved to be the best. And it applied to the widest range of chemicals with the greatest accuracy.

关键词： aromatic compounds Photobacterium phosphoreum Daphnia magna QSAR models

The synergism of sequential paired electrosynthesis with halogen bonding activation for the cyclization of organochlorides with olefins

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Science China Chemistry 2023年第2期66卷 540-547页

作者： Fei lian Kun Xu Chengchu Zeng Faculty of Environment and Life Beijing University of TechnologyBeijing100124China

Reported herein is the design of a new catalytic paradigm by synergistically combining sequential paired electrosynthesis with halogen-bonding(XB)activation for the cyclization of organochlorides with *** dual activation strategy enables rapid access to densely functionalized 2-alkylidene-tetrahydrofurans with exclusive Z-selectivities,which are challenging to be synthesized by other methods.4,4′-Di-tert-butyl-2,2′-bipyridine(dtbbpy)showed an unprecedented reactivity as a XB acceptor to activate C-Cl bond by shifting its reduction potential positively by 220 m *** different from previous electroreductions of C-Cl bonds relying upon high electrode potentials or matched redox properties between mediators and organochlorides,the XB activator employed herein has no limit on the abovementioned redox property matching but can lower the applied electrode *** decreased operating potential allows broad functional group tolerance,which was highlighted by the late-stage functionalization of 11 examples of drugs and natural products-derived alkenes.

关键词： electrochemistry cross-electrophile coupling electrocatalysis paired electrolysis

Impacts of reforestation on woody species composition,species diversity and community structure in dry-hot valley of the Jinsha River,southwestern China

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Journal of Mountain Science 2016年第12期13卷 2182-2191页

作者： GONG Zhi-lian TANG Ya Department of Environment College of Architecture and Environment Siehuan University Chengdu 510065 China Department of Environment Engineering College of Energy and Environment Xihua University Chengdu 610039 China

To understand the impacts of reforestation on woody species composition,species diversity and community structure,seven plantation forests in dryhot valley of the Jinsha River in Southwest China were investigated,with adjacent wastelands,natural shrub grassland and a natural forest as *** importance value,species richness,species heterogeneity and Sorenson similarity index between plantations and the natural forest were *** indicated that compared to wastelands and natural shrub grassland,reforestation improved species diversity and community structure,and more forest woody species found suitable habitats in *** diversity in understory of plantations and Sorenson similarity index were significantly negatively correlated with stem density in mature plantations(26-31 years old).Higher species diversity and Sorenson similarity index existed in mature sparse plantations due to lower stem density and more tree species planted *** contrast,reference natural forest,with species heterogeneity of 2.28 for shrub layer,showed the highest species *** would take a long time for species composition and diversity to recover through reforestation in a dry-hot ***,it was essential to protect remnant natural forests strictly and reforest with suitable management such as lower stem density and increasing genetic diversity of trees planted.

关键词： Biodiversity Plantations Dry hot valley Genetic resources Natural forest Reforestation

Genesis of the 2014–2016 El Nio events

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Science China Earth Sciences 2017年第9期60卷 1589-1600页

作者： lian Tao CHEN DaKe TANG YouMin State Key Lab of Satellite Ocean Environment Dynamics Second Institute of Oceanography Environmental Science and Engineering University of Northern British Columbia

The 2015/2016 El Nio was one of the strongest El Nio events in history, and this strong event was preceded by a weak El Nio in 2014. This study systematically analyzed the dynamical processes responsible for the genesis of these events. It was found that the weak 2014 El Nio had two warming phases, the spring-summer warming was produced by zonal advection and downwelling Kelvin waves driven by westerly wind bursts(WWBs), and the autumn-winter warming was produced by meridional advection, surface heating as well as downwelling Kelvin waves. The 2015/2016 extreme El Nio, on the other hand, was primarily a result of sustained zonal advection and downwelling Kelvin waves driven by a series of WWBs, with enhancement from the Bjerknes positive feedback. The vast difference between these two El Nio events mainly came from the different amount of WWBs in 2014 and 2015. As compared to the 1982/1983 and 1997/1998 extreme El Nio events, the 2015/2016 El Nio exhibited some distinctive characteristics in its genesis and spatial pattern. We need to include the effects of WWBs to the theoretical framework of El Nio to explain these characteristics, and to improve our understanding and prediction of El Nio.

关键词： El Nio WWBs Upper ocean heat content