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On-chip boost regulator with projected off- and on-time control

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1223-1230页

作者： Xiao-ru XU meng-lian ZHAO Xiao-bo WU Institute of VLSI Design Zhejiang University Hangzhou 310027 China

The boost type power supplies are widely used in portable consumer electronics to step up the input voltage to adapt for the high voltage applications like light-emitting diode(LED) driving and liquid crystal display(LCD) *** these applications,a regulator with small volume,fewer external components and high efficiency is highly *** paper proposes a projected off-and on-time boost control scheme,based on which a monolithic IC with an on-chip VDMOS with 0.2 Ω on-state resistance RDS-ON was implemented in 1.5 μm bipolar-CMOS-DMOS(BCD) process.A 12 V,0.3 A boost regulator prototype is presented as *** projected off-time and modulated on-time in continuous conduction mode(CCM),a quasi fixed frequency,which is preferred for ripple control,is *** projected on-time and modulated off-time in discontinuous conduction mode(DCM),pulse frequency modulation(PFM) operation,which is beneficial to light load efficiency improvement,is achieved without extra control *** results show that an efficiency of 3% higher than that of a conventional method under 0.5 W output is achieved while a step load transient response comparable to that of current mode control is maintained as well.

关键词： Boost regulator Integrated circuits Pulse frequency modulation Projected off-time Projected on-time

Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

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World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： lian-meng Huang Ming-Jin Zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

基于干性指数模型对肉瘤预后、免疫浸润和铁死亡调控的分析

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中国组织工程研究 2025年第19期29卷 4151-4160页

作者：魏婧娴孟莲孙皓张田田刘春霞石河子大学医学院病理学系/石河子大学第一附属医院病理科新疆维吾尔自治区石河子市832000 广州医科大学附属第二医院病理科广东省广州市510260

背景:干性指数可能与肉瘤预后、免疫浸润有关,但具体调控机制与特征基因尚不清楚。目的:利用基因干性指数模型探究肉瘤干细胞与患者预后和免疫浸润的关系,并识别肉瘤干细胞铁死亡特征基因。方法:从癌症基因组图谱(TCGA)中获取肉瘤RNA测... 详细信息

背景:干性指数可能与肉瘤预后、免疫浸润有关,但具体调控机制与特征基因尚不清楚。目的:利用基因干性指数模型探究肉瘤干细胞与患者预后和免疫浸润的关系,并识别肉瘤干细胞铁死亡特征基因。方法:从癌症基因组图谱(TCGA)中获取肉瘤RNA测序数据及相关临床信息。利用肉瘤干性指数,对获取的肉瘤RNA测序数据进行分组。利用生存数据进行组间预后情况分析,获取组间差异表达基因后进行通路富集和免疫浸润分析。获得铁死亡相关差异基因,构建蛋白互作网络并进行预后相关性分析。培养横纹肌肉瘤细胞系,分为贴壁细胞组和干细胞组,贴壁细胞组不予任何干预,干细胞组通过无血清培养处理以诱导横纹肌肉瘤干细胞富集,qRT-PCR验证干细胞相关标志物、铁死亡相关差异基因以及铁死亡相关标志物的mRNA表达。结果与结论:①以干性指数中位数为界将患者分成高干性指数组和低干性指数组,通过患病风险预测显示高干性指数组患者的无进展生存期低于低干性指数组,提示预后不佳;②GO、KEGG分析显示肉瘤高、低干性指数组差异表达基因参与不同的细胞通路;高干性指数组和低干性指数组之间免疫浸润存在差异;差异基因中有23个铁死亡相关基因,其中9个可构成相关性较强的蛋白互作网络,其中IDO1、IFNG、AQP5高表达的肉瘤患者预后更好,CA9高表达的肉瘤患者预后不佳;③qRT-PCR结果显示,与贴壁细胞组相比,干细胞组干细胞相关标志物NANOG、SOX2和OCT4 mRNA表达显著升高(P<0.05);与贴壁细胞组相比,干细胞组铁死亡相关标志物SLC7A11的mRNA表达显著降低(P<0.05),ACSL4、GPX4、FTH1和COX2的mRNA表达显著升高(P<0.05);与贴壁细胞组相比,干细胞组差异基因CA9的mRNA表达显著降低,IDO1、IFNG、AQP5的mRNA表达显著升高(P<0.05)。经上述生物信息学分析与实验验证,干细胞与肉瘤生存、铁死亡过程密切相关,CA9、IDO1、IFNG、AQP5在肉瘤干细胞中异常表达,可能成为肉瘤诊断标志物和治疗新靶点。

关键词：肉瘤干细胞干性指数铁死亡生存预后免疫浸润

Multi-mode controller IC for soft-switched flyback converter with high efficiency over the entire load range

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1411-1419页

作者： Hai CHEN meng-lian ZHAO Xiao-bo WU Xiao-lang YAN Institute of VLSI Design Zhejiang University Hangzhou 310027 China

This paper presents a multi-mode control scheme for a soft-switched flyback converter to achieve high efficiency and excellent load regulation over the entire load range. At heavy load, critical conduction mode with valley switching (CCMVS) is employed to realize soft switching so as to reduce turn-on loss of power switch as well as conducted electromagnetic interference (EMI). At light load, the converter operates in discontinuous conduction mode (DCM) with valley switching and adaptive off-time control (AOT) to limit the switching frequency range and maintain load regulation. At extremely light load or in standby mode, burst mode operation is adopted to provide low power consumption through reducing both switching frequency and static power dissipation of the controller. The multi-mode control is implemented by an oscillator whose pulse duration is adjusted by output feedback. An accurate valley switching control circuit guarantees the minimum turn-on voltage drop of power switch. The pro-totype of the controller IC was fabricated in a 1.5-μm BiCMOS process and applied to a 310 V/20 V, 90 W flyback DC/DC converter circuitry. Experimental results showed that all expected functions were realized successfully. The flyback converter achieved a high efficiency of over 80% from full load down to 2.5 W, with the maximum reaching 88.8%, while the total power consumption in standby mode was about 300 mW.

关键词： Integrated circuit Multi-mode controller Soft-switched flyback converter Valley detection

Acoustic transmissive cloaking with adjustable capacity to the incident direction

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Microsystems & Nanoengineering 2022年第5期8卷 43-51页

作者： meng lian Linqiu Duan Junjie Chen Jingyuan Jia Ying Su Tun Cao School of Optoelectronic Engineering and Instrumentation Science Dalian University of Technology116024 DalianChina

Zero-refractive-index(ZRI)phononic crystals(PhCs),in which acoustic waves can be transmitted without phase variations,have considerable potential for engineering wavefronts and thus are applicable to invisibility ***,the creation of the transmissive cloaking achieved by ZRI-PhCs is challenging under an oblique incidence,which substantially hinders their practical ***,we experimentally demonstrate acoustic transmissive cloaking with the adjustable capacity to the incident *** transmissive cloaking of arbitrarily shaped obstacles can be obtained through a hybrid acoustic structure consisting of one outer layer of a programmable phaseengineered metasurface(PPEM)and one inner layer of a double zero-refractive-index(DZRI)-*** DZRI-PhC is functionally the same as an equiphase area and can guide acoustic waves around the obstacle,a process known as acoustic *** PPEM perpendicularly transfers the incident acoustic waves to the DZRI-PhC and allows the emergent waves from the DZRI-PhC to transmit along the original incident *** DZRI-PhC is made of an array of iron squares in the *** reciprocal of the effective bulk modulus and the effective mass density is approximately zero at a frequency of 3015 Hz(0.5187 v0/a)originating from the zeroth-order Fabry–Pérot(FP)resonance that possesses infinite phase *** meta-atom of the outer metasurface consists of a line channel and four shunted Helmholtz resonators,which have effective masses that are engineered by a mechanics *** amplitude and phase of the sound waves propagating through each meta-atom can be controlled continuously and dynamically,enabling the metasurface to obtain versatile wavefront manipulation *** cloaking is visually demonstrated by experimentally scanning the acoustic field over the hybrid structure at a frequency of 3000 Hz(0.5160 v0/a).Our work may provide applications with great potential,including underwater

关键词： incident Acoustic outer

Characterization of diffusion-bonded joint between Al and Mg using a Ni interlayer

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Rare Metals 2016年第7期35卷 537-542页

作者： Jian Zhang Guo-Qiang Luo Qiang Shen lian-meng Zhang Zhi-Jun Huang Research and Development Center of Wuhan Iron and Steel(Group)Corporation Wuhan 430080China State Key Laboratory of Advanced for Materials Synthesis andProcessing Wuhan University of TechnologyWuhan 430070China

Aluminum and magnesium were joined through diffusion bonding using Ni interlayer. The micro- structure and mechanical performance of the A1/Ni/Mg joints at different temperatures was investigated by means of scanning electron microscope （SEM）, electro-probe microanalyzer （EPMA）, X-ray diffraction （XRD）, Vickers hardness testing, and shear testing. The results show that the addition of Ni interlayer eliminates the formation of Mg-A1 intermetallic compounds and improves the bonding strength of the A1/Mg joints. The AI/Ni/Mg joints are formed by the diffusion of A1, Ni and Mg, Ni. The microstructure at the joint interface from A1 side to Mg side is A1 substrate/A1-Ni reaction layer/Ni interlayer/Mg-Ni reaction layer/Mg substrate multilayer structure. The mi- crohardness of the Mg-Ni reaction layer has the largest value of HV 255.0 owing to the existence of Mg2Ni phase. With the increase of bonding temperature, the shear strength of the joints increases firstly and then decreases. The A1/Ni/Mg joint bonds at 713 K for 90 min, exhibiting the maximum shear strength of 20.5 MPa, which is greater than that of bonding joint bonded directly or with Ag interlayer. The fracture of the joints takes place at the Mg- Ni interface rather than the A1-Ni interface, and the frac- ture way of the joints is brittle fracture.

关键词： A1-Mg Ni foil Diffusion bonding Microstructure Shear strength

A 20 μW 95 dB dynamic range 4th-order Delta-Sigma modulator with novel power efficient operational transconductance amplifier and resonator

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第6期12卷 486-498页

作者： Jian XU Xiao-bo WU meng-lian ZHAO Jun-yi SHEN Institute of VLSI Design Zhejiang University Hangzhou 310027 China

A low power high performance Delta-Sigma modulator for portable measurement applications is presented. To reduce power consumption while maintaining high performance, a fully feedforward architecture with a comprehensive system-level design is implemented. As a key building block, a novel power efficient current mirror operational transconductance amplifier (OTA) with a fast-settling less-error switched-capacitor common-mode feedback (SC CMFB) circuit is introduced, and the effects of both gain nonlinearity and 1/f noise of OTA are discussed. A new method to determine the voltage gain of an OTA is also proposed. The bottom terminal parasitic effect of poly-insulator-poly (PIP) capacitors is considered. About an extra 20% of capacitance is added to the total capacitance load. A power and area efficient resonator is adopted to realize a coefficient of 1/90 for 50% power and 75% area reduction compared with conventional designs. The chip is implemented in a low cost 0.35 μm complementary metal oxide semiconductor (CMOS) process. The total power consumption is 20 μW with a 1.5 V supply, and the measured dynamic range (DR) is 95 dB over a 1 kHz bandwidth. Experimental results show that a high figure-of-merit (FOM) is achieved for the designed modulator in comparison with those from the literature.

关键词： Low power High performance Power efficient OTA and resonator Delta-Sigma modulator

Wideband mid-infrared thermal emitter based on stacked nanocavity metasurfaces

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International Journal of Extreme Manufacturing 2022年第1期4卷 133-141页

作者： Tun Cao meng lian Kuan Liu Xianchao Lou Yaoming Guo Dongming Guo School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalianPeople’s Republic of China Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalianPeople’s Republic of China

Efficient thermal radiation in the mid-infrared(M-IR)region is of supreme importance for many applications including thermal imaging and sensing,thermal infrared light sources,infrared spectroscopy,emissivity coatings,and *** ability to control light makes metasurfaces an attractive platform for infrared ***,different metamaterials have been proposed to achieve high thermal *** date,broadening the radiation bandwidth of a metasurface emitter(meta-emitter)has become a key goal to enable extensive *** experimentally demonstrate a broadband M-IR thermal emitter using stacked nanocavity metasurface consisting of two pairs of circular-shaped dielectric(Si;N;)–metal(Au)stacks.A high thermal radiation can be obtained by engineering the geometry of nanocavity *** a meta-emitter provides wideband and broad angular absorptance of both p-and s-polarized light,offering a wideband thermal radiation with an average emissivity of more than 80%in the M-IR atmospheric window of 8–14μ*** experimental illustration together with the theoretical framework establishes a basis for designing broadband thermal emitters,which,as anticipated,will initiate a promising avenue to M-IR sources.

关键词： mid-infrared wideband perfect thermal radiation surface plasmon resonance metasurface nanocavity

Inhibitory Effects of 5-Aza-2'-Deoxycytidine and Trichostatin A in Combination with p53-Expressing Adenovirus on Human Laryngocarcinoma Cells

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Chinese Journal of Cancer Research 2012年第3期24卷 232-237页

作者： Ling-yan Jiang meng lian Hong Wang Ju-gao Fang Qi Wang Key Laboratory of Otorhinolaryngology Head and Neck Surgery(Ministry of Education) Beijing Institute of OtorhinolaryngologyBeijing 100005China Department of Otorhmolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective： To investigate the effects of 5-Aza-2＇-deoxycytidine （5-Aza-Cdr） and trichostatin A （TSA） combined with p53-expressing adenovirus （Ad-p53） on Hep-2 cell line in vivo and in vitro, in order to explore its possibility in biological treatment of laryngocarcinoma. Methods： Effects of 5-Aza-Cdr and TSA in combination with Ad-p53 on Hep-2 cell line in vivo were determined by Cell Counting Kit-8 （CCK-8） assay. The effect of drug combination was calculated by Jin＇s formula. Effects on the cell line in vitro were investigated by establishing the nude mice model. Results： 5-Aza-Cdr and TSA showed inhibitory effects on the proliferation of Hep-2 cells in dose- and time-dependent manner. Ad-p53 can inhibit the growth of Hep-2 cells in vivo and in vitro. However, the combination of epigenetic reagents （5-Aza-Cdr/TSA） and Ad-p53 was less effective than individual use of Ad-p53. 5-Aza-Cdr and Ad-p53 inhibited the growth of transplanted tumors and reduced the volume of tumors, and the tumor volume of Ad-p53 group was significantly smaller than that of the control group （P0.05）. Conclusion： Both epigenetic reagents （5-Aza-Cdr/TSA） and Ad-p53 can suppress cell proliferation on Hep-2 in vivo and in vitro and there may be some antagonistic mechanism between Ad-p53 and epigenetic reagents （5-Aza-Cdr/ TSA）.

关键词： 5-Aza-'-deoxycytidine trichostatin A p-expressing adenovirus Hep-2cell line