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基础教育“减负”赋能综合素质评价改革:进展与启示——基于广东省的纵向数据研究

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广东第二师范学院学报 2024年第3期44卷 77-86页

作者：何铭欣李梦瑶方征华南师范大学教育科学学院广东广州510631

减负和综合素质评价是当前基础教育改革的重要议题。依据“双减”政策执行情况的调查结果,梳理减负、综合素质和综合素质评价三者间的关系,可发现“减负”的成效和不足均对综合素质评价改革起促进作用。“减负”在学生学业、睡眠和锻炼... 详细信息

减负和综合素质评价是当前基础教育改革的重要议题。依据“双减”政策执行情况的调查结果,梳理减负、综合素质和综合素质评价三者间的关系,可发现“减负”的成效和不足均对综合素质评价改革起促进作用。“减负”在学生学业、睡眠和锻炼、课后服务、评价体系等方面的成效为学生综合素质提升和综合素质评价改革提供发展基础,而作业量反弹、心理健康水平较低、家长焦虑转化为学生焦虑、城市地区学生综合素质发展基础优于农村地区等问题又为综合素质评价改进提供方向。基于此,未来综合素质评价改革可从作业和课堂、心理课程、家长政策认知和地方考评标准四个方面进行完善。

关键词：基础教育综合素质综合素质评价减负学业负担

Atmospheric Response to Mesoscale Ocean Eddies over the South China Sea

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Advances in Atmospheric Sciences 2018年第9期35卷 1189-1204页

作者： Haoya liU Weibiao li Shumin CHEN Rong fang Zhuo li School of Atmospheric Sciences Sun Yat-Sen University

The South China Sea（SCS） is an eddy-active area. Composite analyses based on 438 mesoscale ocean eddies during 2000–2012 revealed the status of the atmospheric boundary layer is influenced remarkably by such eddies. The results showed cold-core cyclonic（warm-core anticyclonic） eddies tend to cool（warm） the overlying atmosphere and cause surface winds to decelerate（accelerate）. More than 5% of the total variance of turbulent heat fluxes, surface wind speed and evaporation rate are induced by mesoscale eddies. Furthermore, mesoscale eddies locally affect the columnar water vapor, cloud liquid water, and rain rate. Dynamical analyses indicated that both variations of atmospheric boundary layer stability and sea level pressure are responsible for atmospheric anomalies over mesoscale eddies. To reveal further details about the mechanisms of atmospheric responses to mesoscale eddies, atmospheric manifestations over a pair of cold and warm eddies in the southwestern SCS were simulated. Eddy-induced heat flux anomalies lead to changes in atmospheric stability. Thus, anomalous turbulence kinetic energy and friction velocity arise over the eddy dipole, which reduce（enhance） the vertical momentum transport over the cold（warm） eddy, resulting in the decrease（increase） of sea surface wind. Diagnoses of the model＇s momentum balance suggested that wind speed anomalies directly over the eddy dipole are dominated by vertical mixing terms within the atmospheric boundary layer, while wind anomalies on the edges of eddies are produced by atmospheric pressure gradient forces and atmospheric horizontal advection terms.

关键词： mesoscale ocean eddies air-sea interaction atmospheric responses South China Sea

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中非铜钴矿带钴矿成矿特征和富集机理

矿物岩石地球化学通报 2024年第1期43卷 127-139页

作者：莫江平胡乔帆方科刘伟周守余李明君中国有色桂林矿产地质研究院有限公司广西桂林541004

中非铜钴矿带是世界上规模大、铜钴品位高的层控型铜钴矿带,以拥有大型超大型铜钴矿床和众多的世界级铜钴矿山而闻名于世。本文综述了该成矿带的基本地质特征和矿化类型,分析了Co的超常富集机理,指出了存在的问题。中非铜钴矿带位于非... 详细信息

中非铜钴矿带是世界上规模大、铜钴品位高的层控型铜钴矿带,以拥有大型超大型铜钴矿床和众多的世界级铜钴矿山而闻名于世。本文综述了该成矿带的基本地质特征和矿化类型,分析了Co的超常富集机理,指出了存在的问题。中非铜钴矿带位于非洲中南部的赞比亚和刚果(金)境内,全长700 km、宽150 km,包括赞比亚铜带省矿带、赞比亚西北省矿带和刚果(金)加丹加矿带。钴矿的形成经历了裂谷期成岩成矿作用(880~735 Ma)和造山期成矿作用(530~490 Ma),分别与新元古代加丹加沉积盆地的形成发展演化和卢富里安造山作用相对应。其成因类型包括同生沉积型钴矿床和热液改造型富钴矿床。沉积型钴矿在赞比亚境内发育,钴含量相对较低;热液改造型富钴矿床在刚果(金)境内更为发育,钴含量相对较高。钴与铜共生或伴生,主要含钴矿物为硫铜钴矿、方钴矿、硫钴矿、钴黄铁矿、水钴矿、钴华、菱钴矿等。Co的超常富集与由卤水在深部交代基底岩石(矿石)形成的富金属成矿流体通过迁移-富集-沉淀作用的多期次循环有关。矿床的氧化带、原生带分带明显,局部氧化深度达到300 m,表生氧化作用往往造成钴矿化富集。该区富钴矿床整体地质研究程度较低,原生铜钴矿的成矿物质来源、成矿环境特别是铜钴超常富集机理等方面的研究需要加强。

关键词：富钴矿床成矿特征富集机理中非铜钴矿带

Pb(Ⅱ)和Cd(Ⅱ)在人造沸石上竞争吸附位点的研究

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太原科技大学学报 2024年第2期45卷 182-186,192页

作者：刘富平刘宏芳刘润龙李江东李欣王瑞忻州市生态环境局东部区域监测技术保障中心代县分中心山西忻州034200 太原科技大学环境科学与工程学院太原030024

Pb(Ⅱ)和Cd(Ⅱ)是水中常见的重金属离子,其超标排放对人体健康和水体环境有较大危害,因此,水中Pb(Ⅱ)和Cd(Ⅱ)的去除尤为重要。首先采用机械球磨法制备人造沸石材料,然后研究了Pb(Ⅱ)和Cd(Ⅱ)在该材料上的吸附特性。研究结果表明:人造... 详细信息

Pb(Ⅱ)和Cd(Ⅱ)是水中常见的重金属离子,其超标排放对人体健康和水体环境有较大危害,因此,水中Pb(Ⅱ)和Cd(Ⅱ)的去除尤为重要。首先采用机械球磨法制备人造沸石材料,然后研究了Pb(Ⅱ)和Cd(Ⅱ)在该材料上的吸附特性。研究结果表明:人造沸石去除Pb(Ⅱ)和Cd(Ⅱ)的过程符合Langmuir模型,单一吸附时:Pb(Ⅱ)和Cd(Ⅱ)的吸附量分别为503.97和460.23 mg/g,竞争体系下,Pb(Ⅱ)和Cd(Ⅱ)的初始浓度比为1∶1、2∶1和1∶2时,Pb(Ⅱ)和Cd(Ⅱ)的吸附量分别为468.41、474.71、419.01 mg/g和437.13、365.39、420.31 mg/g.竞争体系下:Pb(Ⅱ)的选择系数为0.3668-83.3897,远大于Cd(Ⅱ)的选择系数,Pb(Ⅱ)为二元吸附体系的优势离子。由点位能量分布可知,Pb(Ⅱ)和Cd(Ⅱ)的初始浓度和吸附量与位点能量成负相关。单一体系时:Pb(Ⅱ)和Cd(Ⅱ)的E_(m)分别为45.50和47.58 kJ/mol竞争体系下,不同浓度比时:Pb(Ⅱ)和Cd(Ⅱ)的平均位点能量E_(m)和位点分布的均匀性不同,与具体的吸附体系相关。

关键词：人造沸石吸附模型位点能量分布竞争吸附

Cross-neutralizing Anti-hemagglutinin Antibodies Isolated from Patients Infected with Avian Influenza A(H5N1) Virus

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Biomedical and Environmental Sciences 2020年第2期33卷 103-113页

作者： SUN Ying CAO Yang li Zi BAI Tian ZHANG Hong HU Shi Xiong li fang Cai ZHAO Xiang CHEN Yong Kun LU Jian liU li Qi wang Da Yan SHU Yue Long ZHOU Jian fang National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionKey Laboratory for Medical VirologyNational Health and Family Planning CommissionBeijing 102206China Center of Growth Metabolism and AgingKey Laboratory of Bio-Resource and Eco-EnvironmentMinistry of EducationCollege of Life SciencesSichuan UniversityChengdu 610064SichuanChina Hunan Provincial Disease Control and Prevention Changsha 410000HunanChina School of Public Health(Shenzhen) Sun Yatsen UniversityShenzhen 510275GuangdongChina

Objective To recover broad-neutralizing monoclonal antibodies(Bn Abs)from avian influenza A(H5N1)virus infection cases and investigate their genetic and functional *** We screened the Abs repertoires of expanded B cells circulating in the peripheral blood of H5N1 *** genetic basis,biological functions,and epitopes of the obtained Bn Abs were assessed and *** Two Bn Abs,2-12 D5,and 3-37 G7.1,were respectively obtained from two human H5N1 cases on days 12 and 21 after disease *** Abs demonstrated cross-neutralizing and Ab-dependent cellular cytotoxicity(ADCC)*** derived from distinct Ab lineages,i.e.,V^H1-69-D2-15-JH^4(2-12D5)and V^H1-2-D3-9-JH^5(3-32 G7.1),the Bn Abs were directed toward CR6261-like epitopes in the HA stem,and HA2 I45 in the hydrophobic pocket was the critical residue for their *** motifs for binding with the HA stem,namely,IFY in VH1-69-encoded Abs and LXYFXW in D3-9-encoded Abs,were also observed in 2-12D5 and 3-32 G7.1,*** Cross-reactive B cells of different germline origins could be activated and re-circulated by avian influenza *** HA stem epitopes targeted by the Bn Abs,and the two Ab-encoding genes usage implied the VH1-69 and D3-9 are the ideal candidates triggered by influenza virus for vaccine development.

关键词： V^H1-69 D3-9 Avian influenza A(H5N1)virus Cross-neutralizing Antibody

c-CSN:Single-cell RNA Sequencing Data Analysis by Conditional Cell-specific Network

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 319-329页

作者： lin li Hao Dai Zhaoyuan fang Luonan Chen Key Laboratory of Systems Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Shanghai Research Center for Brain Science and Brain-Inspired Intelligence Shanghai 201210China CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Hangzhou Institute for Advanced Study Chinese Academy of SciencesHangzhou 310024China

t The rapid advancement of single-cell technologies has shed new light on the complex mechanisms of cellular ***,compared to bulk RNA sequencing(RNA-seq),single-cell RNA-seq(scRNA-seq)suffers from higher noise and lower coverage,which brings new computational *** on statistical independence,cell-specific network(CSN)is able to quantify the overall associations between genes for each cell,yet suffering from a problem of overestimation related to indirect *** overcome this problem,we propose the c-CSN method,which can construct the conditional cell-specific network(CCSN)for each cell.c-CSN method can measure the direct associations between genes by eliminating the indirect associations.c-CSN can be used for cell clustering and dimension reduction on a network basis of single ***,each CCSN can be viewed as the transformation from less“reliable”gene expression to more“reliable”gene–gene associations in a *** on CCSN,we further design network flow entropy(NFE)to estimate the differentiation potency of a single cell.A number of scRNA-seq datasets were used to demonstrate the advantages of our approach.1)One direct association network is generated for one cell.2)Most existing scRNA-seq methods designed for gene expression matrices are also applicable to c-CSN-transformed degree matrices.3)CCSN-based NFE helps resolving the direction of differentiation trajectories by quantifying the potency of each cell.c-CSN is publicly available at https://***/linli-0909/c-CSN.

关键词： Network flow entropy Cell-specific network Single-cell network Direct association Conditional independence

Electrodeposition of Ni–Co alloy films onto titanium substrate

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Rare Metals 2014年第4期33卷 442-447页

作者： Yu-fang Yang Zhao-Hui Wen Qiang-Guo li Department of Chemistry and life Science Xiangnan University library Xiangnan University

Binary bright Ni-Co alloy films were electro- deposited on titanium in the chloride-sulfate electrolytes. The influences of Co2＋ concentration, current density, and temperature on the Ni-Co alloy films electrodeposition were investigated. The films were analyzed by scanning electron microscope （SEM）, energy dispersive spectros- copy （EDS）, and X-ray diffraction （XRD）. Cathodic polarization for Ni-Co codeposition was performed on Ti working electrodes. With the increase of Co2＋ concentra- tion, the Ni content in the films decreases and the current efficiency increases slightly. The Ni content increases with the increase of temperature, while it decreases with the increase of current density to a minimum and then increases. The cathodic reduction peak potential is mea- sured to be -1.34 V. Anomalous deposition is found to occur in the Ni-Co codeposition. The SEM of Ni-Co alloy films shows that hydroxide particles are not present on the surface and fine grain, compact, smooth, and bright Ni--Co alloy films are obtained. The XRD result indicates that the deposited Ni-Co alloy film is Ni-solid solution with a face- centered cubic in structure.

关键词： Electrodeposition Ni-Co alloy Films Titanium substrate

Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss

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Bone Research 2022年第4期10卷 867-881页

作者： Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing wang Rui Chen Jia liu Xiangyue Meng Wei wang Guiling li Jiao Zhou Ya Zhang Wanbo Zhu Shiyuan fang Haiming Wei Hong Zheng Siying wang fang Ni Department of Pathophysiology School of Basic Medical SciencesAnhui Medical UniversityHefeiChina Department of Hematology The First Affiliated Hospital of USTCThe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Institute of Immunology University of Science and Technology of ChinaHefeiChina Department of Orthopaedics The First Affiliated Hospital of USTCHefeiChina Department of Orthopaedics Fuyang Hospital of Anhui Medical UniversityFuyangChina

Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal ***,the mechanisms linking HO pathogenesis with bone mass dysfunction remain ***,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with ***,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 *** immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass *** further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to *** with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass ***,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO.

关键词： PD1 therapeutic inhibited

右美托咪定联合纳布啡对腹腔镜胆囊切除术后患者的镇痛效果和血流动力学的影响

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海南医学 2024年第9期35卷 1270-1273页

作者：方丽林蔡晓玲张旭力武穴市第一人民医院麻醉科湖北武穴435400 武穴市第一人民医院手术室湖北武穴435400 武穴市第一人民医院科教科湖北武穴435400

目的探讨右美托咪定联合纳布啡对腹腔镜胆囊切除术后患者的镇痛效果、血流动力学的影响。方法选择2021年1~12月于武穴市第一人民医院接受腹腔镜胆囊切除术的100例患者纳入研究,按随机数表法分为观察组和对照组各50例。对照组患者腹腔镜... 详细信息

目的探讨右美托咪定联合纳布啡对腹腔镜胆囊切除术后患者的镇痛效果、血流动力学的影响。方法选择2021年1~12月于武穴市第一人民医院接受腹腔镜胆囊切除术的100例患者纳入研究,按随机数表法分为观察组和对照组各50例。对照组患者腹腔镜胆囊切除术后给予静脉推注纳布啡注射液,观察组患者在对照组基础上联合右美托咪定注射液静脉泵注。比较两组患者的围术期情况,术后2 h、12 h、24 h的视觉模拟评分(VAS)以及手术结束时(T0)、气管导管拔除前(T1)、气管导管拔除即刻(T2)、气管导管拔除后10 min(T3)、气管导管拔除后30 min(T4)的平均动脉压(MAP)和心率(HR),并比较两组患者的不良反应发生情况。结果观察组患者的苏醒时间、拔管时间分别为(20.02±4.72)min、(21.98±3.04)min,明显长于对照组的(15.68±3.11)min、(17.29±2.75)min,躁动发生率为12.00%,明显低于对照组的30.00%,差异均具有统计学意义(P0.05)。结论右美托咪定联合纳布啡对腹腔镜胆囊切除术后患者的镇痛效果明显,且能避免术后血流动力学波动,具有临床应用价值。

关键词：腹腔镜胆囊切除术纳布啡右美托咪定麻醉疼痛血流动力学

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