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大直径泥水盾构刀盘扭矩和推力分析与计算

建筑机械化 2024年第8期45卷 42-46页

作者：李玉梅段浚龙贾文宪兰浩钟一夫湖南师范大学工程与设计学院湖南长沙410000 中铁十四局集团大盾构工程有限公司江苏南京210000

总结归纳砾砂岩复合地层大直径盾构总推力和总扭矩预测公式,结合深江铁路珠江口隧道工程14.32m的大直径常压刀盘,针对344环前后刀盘总推力相对稳定下总扭矩剧增的异常情况,对325~363环的总扭矩、总推力采用了理论公式法和经验法进行测... 详细信息

总结归纳砾砂岩复合地层大直径盾构总推力和总扭矩预测公式,结合深江铁路珠江口隧道工程14.32m的大直径常压刀盘,针对344环前后刀盘总推力相对稳定下总扭矩剧增的异常情况,对325~363环的总扭矩、总推力采用了理论公式法和经验法进行测算并与实际数据对比。分析结果表明,刀盘刀具配置的变化对刀盘总扭矩和总推力影响不大,但刀盘前壁与泥浆摩阻扭矩占总扭矩比重达40%以上,刀盘面板的推进摩擦阻力对盾构总推力影响最大,占60%以上;理论公式法预测的刀盘总扭矩平均误差为12.9%、总推力平均误差为7.79%,同经验法相比,其预测的准确度有了极大的提高,对掘进参数的调整具有重要意义。

关键词：泥水盾构大直径刀盘推力刀盘扭矩工程案例分析

基于德尔菲法的手法诊疗膝骨关节病“筋骨评估”模式

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中国中医骨伤科杂志 2024年第6期32卷 57-61页

作者：张进霖李玉梅张昊奚小冰颜威王强胡劲松李飞跃上海交通大学医学院附属瑞金医院上海201810 上海中医药大学附属上海市中医医院

目的:构建手法诊疗膝骨关节病“筋骨评估”模式。方法:通过查阅文献资料、总结临床经验、研究小组讨论等方法制定专家咨询问卷,通过德尔菲法对20名专家进行两轮问卷调查,对问卷结果进行统计分析。结果:两轮专家积极系数均为100%。第一... 详细信息

目的:构建手法诊疗膝骨关节病“筋骨评估”模式。方法:通过查阅文献资料、总结临床经验、研究小组讨论等方法制定专家咨询问卷,通过德尔菲法对20名专家进行两轮问卷调查,对问卷结果进行统计分析。结果:两轮专家积极系数均为100%。第一轮肯德尔和谐系数为0.51,差异有统计学意义(P<0.05),专家权威系数为0.78,问卷信度为0.94;第二轮肯德尔和谐系数为0.30,差异有统计学意义(P<0.05),专家权威系数为0.82,问卷信度为0.91,且第二轮所有评估内容的变异系数均<0.5,故结束问卷调查。确立了中医手法治疗膝骨关节病时筋骨评估的五个方面内容:触诊检查、姿势体位、压痛点、肌张力、影像学检查。结论:手法诊疗膝骨关节病“筋骨评估”模式内容包含触诊检查(膝关节活动度、膝关节屈伸活动度、麦氏征、髌骨研磨试验、侧副韧带挤压试验、抽屉试验、股四头肌肌力、股二头肌肌力)、姿势体位(膝关节内翻、膝关节外翻、膝关节过伸)、压痛点(膝关节髌骨周围、膝关节间隙、膝关节腘窝)、肌张力(腘绳肌、股四头肌、腘肌、腓肠肌)、影像学检查(膝关节Q角、膝过伸角、下肢力线)。

关键词：膝骨关节病中医手法筋骨评估德尔菲法

Prognosis of synchronous endometrial and ovarian cancer based on the PROMISE molecular system

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中华医学杂志(英文版) 2024年第15期137卷 1870-1872页

作者： Wang Ming li Yue Xu Jianqing Xu Shuiqing Wu yumei Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital Beijing China

Selective cyclohexane oxidation enhancement by electronic structures regulation of metal-poly(ionic liquid)s

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Green Chemical Engineering 2024年第2期5卷 213-221页

作者： Ying Jin Shengxin Chen Ruirui Wang yumei liu Xinxin li Yingwei li Ruirui Zhang Ruixia liu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou450001China Beijing Key Laboratory of Ionic liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringInnovation Academy for Green ManufactureCASBeijing100190China

Poly(ionic liquids)(PILs)combined with the macromolecular structure and unique properties of ionic liquids show unlimited potential in *** this work,a series of metal-based PIL with different ionic ratios were prepared for the selective oxidation of *** analysis reveals that different degrees of ionization could adjust the Co-N sites of the catalysts efficiently,leading to significant changes in their electronic structure,which strongly relate to catalytic performance in oxidation.20.07%cyclohexane conversion and 13.06%cyclohexanone and cyclohexanol(KA oil)yield can be achieved by metal-based PILs that are better than other commercial *** with CoCl_(2),metal-based PILs perform well,with superior conversion and KA oil *** interestingly,the catalyst created in this study features a malleable Co-N site,which may potentially have an impact on how oxygen species adsorb and desorb from the ***,the catalyst studied in this work is used as molecular oxygen for the selective oxidation of cyclohexane to produce KA oil,and its application prospect is promising.

关键词： Metal-PILs Cyclohexane oxidation C-H activation Co-N sites

肺癌化疗患者住院期间体力活动水平和症状群的相关性分析

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结核与肺部疾病杂志 2024年第3期5卷 197-206页

作者：谌欣欣刘国凤杨英姿胡亚晨金瑛李玉梅同济大学附属上海市肺科医院护理部上海200433 同济大学医学院护理系上海200092 华东疗养院保健护理科无锡214100

目的:了解肺癌化疗患者的运动意愿及体力活动水平,并分析患者体力活动水平与症状群的相关性。方法:2022年6—8月,采用一般资料调查表、国际体力活动问卷、中文版安德森症状评估量表、修订版肺癌特异性症状模块对上海市肺科医院住院的23... 详细信息

目的:了解肺癌化疗患者的运动意愿及体力活动水平,并分析患者体力活动水平与症状群的相关性。方法:2022年6—8月,采用一般资料调查表、国际体力活动问卷、中文版安德森症状评估量表、修订版肺癌特异性症状模块对上海市肺科医院住院的232例肺癌化疗患者进行横断面调查。共回收有效问卷229份,有效回收率为98.71%。采用探索性因子分析提取症状群的种类,通过Spearman秩相关分析探讨体力活动水平与症状群的关系。结果:调查显示,肺癌化疗患者存在6个症状群,分别为:呼吸道症状群、睡眠相关症状群、心理症状群、消化道症状群、肺癌特异性症状群和恶病质症状群。中强度体力活动水平与心理症状群及恶病质症状群呈负相关(r=-0.153、-0.159,P值均<0.05);步行体力活动水平与呼吸道症状群、睡眠相关症状群、心理症状群及肺癌特异性症状群呈负相关(r=-0.257、-0.222、-0.284、-0.181,P值均<0.05);总体力活动水平与呼吸道症状群、睡眠相关症状群、心理症状群及恶病质症状群呈负相关(r=-0.252、-0.218、-0.304、-0.132,P值均<0.05)。结论:肺癌化疗患者的体力活动水平与症状群呈负相关,体力活动水平高的患者其症状群负担较轻,建议根据患者的体力活动水平及症状负担进行个性化运动处方设计,健康教育和运动指导,提高患者体力活动水平,从而减轻症状负担。

关键词：肺肿瘤物理治疗技术运动康复护理

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Clinical Study on Simultaneous Modulated Accelerated Radiotherapy and Concurrent Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma

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Clinical oncology and cancer researeh 2009年第5期6卷 354-358页

作者： Haiqun lin Baosheng li Zicheng Zhang yumei Wei limin Zhai Department of Radiotherapy Shandong Cancer Hospital Jinan 250117 Shandong Province. China.

OBJECTIVE To evaluate the clinical efficacy and toxicities of simultaneous modulated accelerated radiotherapy （SMART） and concurrent chemotherapy for locally advanced nasopharyngeal carcinoma. METHODS Eightyseven patients with nasopharyngeal carcinoma received SMART from April 2002 to September 2006. According to the UICC staging system, 30 patients were diagnosed as stage IIb, 42 patients stage III, 13 patients stage IVa and 2 patients stage IVb. The intensitymodulated radiotherapy was delivered with the ＂step and shoot＂ SMART technique with the prescribed dose of 66-76 Gy （2.2-2.4 Gy/day） to the gross tumor volume （GTV） and positive neck lymph nodes （GTVLN）, with 60 Gy （2.0 Gy/day） to the highrisk clinical target volume （CTV1）, encompassing the area around the nasopharynx and the upper neck, and with 54 Gy （1.8 Gy/day） to the lowrisk clinical target volume （CTV2）, including the lower neck and supraclavicular area. Among all the patients, 31 received 2 cycles of SMART concurrently with 5 fluorouracil （5-Fu） and cisplatin （the FP group） and 56 received 2 cycles of concurrent cisplatin. All the patients received 3 to 4 cycles of adjuvant combination chemotherapy of cisplatin and 5fluorouracil starting from the 1st month after completion of SMART. RESULTS With a median follow up of 59 months （ranging from 19 to 85 months）, the 1, 2 and 3year overall survival rates were 100%, 94.6% and 91.3% respectively. Acute mucositis and pharyngitis were more frequently observed in the FP group than in the cisplatin group. CONCLUSION SMART technique provides an excellent opportunity to spare normal tissue and is probably more biologically effective. Combination of single cisplatin was more tolerable.

关键词： simultaneous modulated accelerated radiotherapy (SMART) intensitymodulated radiotherapy nasopharyngeal carcinoma concurrent chemoradiotherapy.

Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model

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Bone Research 2014年第3期2卷 182-193页

作者： Xianrong Zhang Ji Zhu Fei liu yumei li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto ling Qin Department of Orthopaedic Surgery School of Medicine University of Pennsylvania Philadelphia PA USA Department of Physiology School of Basic Medical Sciences Wuhan University Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s Hospital Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Department of Physiology and Pharmacology Schulich School of Medicine and Dentistry University of Western Ontario London ONCanada Department of Surgery The Children’s Hospital of Philadelphia

Osteoarthritis （OA） is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor （EGFR） signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus （DMM） to induce OA in two mouse models with reduced EGFR activity, one with genetic modification （, was/＋ mice） and the other one with pharmacological inhibition （gefitinib treatment）. Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13 （MMP13）, the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2α （HIF2α）, a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation.

关键词： EGFR Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model

δ^13Csc values of the loess-paleosol sequence in Dali area, Shaanxi Province, China, and paleoenvironmental implications

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Chinese Science Bulletin 2003年第9期48卷 902-907页

作者： li yumei & liU Dongsheng (liU Tungsheng)Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029 (e-mail: liyrney@***) Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

The carbon isotopic ratios of carbonate in the two profiles of the Dali area were analyzed and some new understandings on the influencing factors of the δ13CSC value of the loess-paleosol sequence and its paleoenvironmental implications were discussed preliminarily in this report. The 13CSC value of the Dali loess-paleosol sequence is synchronizing with the variance of magnetic susceptibility basically and the negative peaks of the δ13CSC curves are corresponding to the different developmental periods of the paleosol. It is believed that the intervention of the CO2 produced by plants will cause the decrease of the δ13CSC value, the amplitude of which may be relevant to the paleovegetation density and the ancient humidity. The relative biomass of C4 plants in the vegetation will affect the sublevel change of the δ13CSC. Low δ13CSC value by and large indicates the environmental conditions of the relatively abundant vegetation and humid climate. During the last 250000 years, the period with the sparsest vegetation and the most arid climate is the phase of the loess in L2 depositing and the period with the most abundant vegetation and the most humid climate is the last interglacial period. The δ13CSC curves of Dali also show that the High Temperature and Large Precipitation Event of the Qinghai-Tibetan Plateau during 40-30 kaBP had affected the Central Shaanxi Plain with relatively humid climate, and had apparent influence on the local vegetation and humidity.

关键词：古环境大理地区黄土陕西湿润气候碳同位素植被高温天气

Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention

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Neural Regeneration Research 2024年第2期19卷 316-323页

作者： Yiyang Chen Wenxuan Tang Xinqi Huang yumei An Jiawen li Shengye Yuan Haiyan Shan Mingyang Zhang Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of Justice(Academy of Forensic Science)ShanghaiChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe ***,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke *** studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral ***,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged *** markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral *** review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral *** conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

关键词： intracerebral hemorrhage mitochondrial dysfunction mitophagy neuroinflammation neuroprotection reactive oxygen species secondary brain injury therapeutic target