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中国广播电视学刊 2007年第7期 20-21页

作者：李英华天津电台

天津人民广播电台去年的广告经营由前年的153亿元大幅度提升到233亿元。许多人在问．一向默默无语、不事声张的天津电台何以突破两亿三？

关键词：天津人民广播电台广告经营广告整合创新思维

加味千金苇茎汤联合高压氧对急性呼吸窘迫综合征大鼠肺肠的保护作用及机制研究

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上海中医药杂志 2024年第3期58卷 58-64,71页

作者：马赞颂张蕾邵贵强贾圣洁朱行利江林昕尹雪吴春荣李英华杨春辉复旦大学附属上海市第五人民医院中医科上海200240 复旦大学附属上海市肿瘤医院闵行分院护理部上海200240 复旦大学附属上海市第五人民医院急诊科上海200240 复旦大学附属上海市第五人民医院中心实验室上海200240

目的基于肺肠相表里中医药经典腑脏理论,观察加味千金苇茎汤联合高压氧对急性呼吸窘迫综合征(ARDS)大鼠肺肠的保护作用及机制。方法选择Wistar大鼠40只,32只构建ARDS模型后随机分为4组,每组8只,即模型对照组、中药组、高压氧组及高压氧... 详细信息

目的基于肺肠相表里中医药经典腑脏理论,观察加味千金苇茎汤联合高压氧对急性呼吸窘迫综合征(ARDS)大鼠肺肠的保护作用及机制。方法选择Wistar大鼠40只,32只构建ARDS模型后随机分为4组,每组8只,即模型对照组、中药组、高压氧组及高压氧联合中药组,模型对照组不进行干预,高压氧组采用高压氧干预,高压氧联合中药组采用高压氧联合中药进行干预,剩余8只为正常对照组。观察各组的存活率并监测各组血氧饱和度和血气分析值,检测大鼠血浆D-乳酸、内毒素及二胺氧化酶(DAO)水平,同时光镜下观察肺、结肠组织的病理变化,采用酶联免疫吸附测定(EliSA)检测肺灌洗液中的肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)、白介素-10(IL-10)表达水平的变化,进行肺组织病理评分分析和计算肺湿/干重比(W/D),并测定肺组织脂质过氧化水平。结果高压氧组和高压氧联合中药组存活率为100%,模型对照组存活率为50%,中药组存活率为75%。正常对照组大鼠肺、结肠组织结构完整,模型对照组大鼠肺组织存在大量炎症细胞,高压氧联合中药组大鼠肺肠组织炎症水平显著低于中药组和高压氧组,其D-乳酸、内毒素、DAO水平、肺W/D、肺组织病理评分明显低于中药组和高压氧组,差异有统计学意义(P0.05)。结论加味千金苇茎汤联合高压氧能有效减轻ARDS大鼠的肺肠组织病理损伤,高压氧干预可以提高大鼠存活率,其机制可能与增强局部黏膜免疫和黏膜屏障功能有关;本研究结果可为中药联合高压氧在ARDS的临床应用提供理论依据和技术支持。

关键词：呼吸衰竭急性呼吸窘迫综合征高压氧加味千金苇茎汤肠-肺轴作用机制中药研究

项目教学法在艺术设计教学中运用新探——以中职《展示设计》课程为例

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职业技术教育 2016年第29期37卷 32-35页

作者：黎颖华上海市第二轻工业学校

《展示设计》是一门注重实际操作,培养学生设计能力、动手能力、团队合作能力,以及人际交流能力的课程。项目教学法将学生融于完成特定项目的有意义的过程中去,促进学生积极地自主学习、合作学习,主动地进行知识的建构,以学生的知识获... 详细信息

《展示设计》是一门注重实际操作,培养学生设计能力、动手能力、团队合作能力,以及人际交流能力的课程。项目教学法将学生融于完成特定项目的有意义的过程中去,促进学生积极地自主学习、合作学习,主动地进行知识的建构,以学生的知识获得和能力培养为最高目标,顺应了《展示设计》课程的要求。根据项目教学法的基本理论,在《展示设计》课程教学中总结出"九步项目教学法",取得了较好的效果。在项目教学中,教师必须转变角色,提高积极性,增强自主研究能力和社会实践能力。

关键词：展示设计项目教学法九步项目教学法中等职业教育

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数控机床辐射骚扰测试方法研究及整改应用

制造技术与机床 2021年第11期 110-113页

作者：李营花国家机床质量监督检验中心北京100102

数控机床的普及应用以及大规模车间生产的现状,使机床的电磁兼容性问题日益突出。以某自动切削机为例,进行了空间电磁辐射骚扰特性测试方法的研究及应用。经对自动切削机设计进行分析,提出了整改方案。经试验,验证了整改方案的可行性、... 详细信息

数控机床的普及应用以及大规模车间生产的现状,使机床的电磁兼容性问题日益突出。以某自动切削机为例,进行了空间电磁辐射骚扰特性测试方法的研究及应用。经对自动切削机设计进行分析,提出了整改方案。经试验,验证了整改方案的可行性、有效性和合理性。电磁辐射骚扰特性测试方法的研究为机电类产品的电磁兼容试验方法提供了基础理论支撑。整改方案的提出、验证及实施为数控机床电磁兼容性的设计提供了依据和经验,也为存在相似电磁兼容问题的数控机床提供了实例方案,对提高数控机床可靠性具有重要意义。

关键词：数控机床电磁兼容测试可靠性

Role of microbiota-gut-brain axis in neurodegenerative diseases and the potential of microbiome-targeted d ietary strategies: A review of current evidence and future perspective

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Food Science and Human Wellness 2024年

作者： Shuqing Zhang Wenjing Chen Chen Ma yinghua Luo li Dong Xiaosong Hu Fang Chen Daotong li College of Food Science and Nutritional Engineering， National Engineering Research Centre for Fruit and Vegetable Processing， Key Laboratory of Fruits and Vegetables Processing， Ministry of Agriculture， Engineering Research Centre for Fruits and Vegetables Processing， Ministry of Education， China Agricultural University

Neurodegenerative diseases (NDs)， mainly including Alzheimer’s disease， Parkinson’s disease， and Multiple sclerosis， represent a major public health challenge with the steady increase of aging population worldwide. Emerging evidence has revealed the key role of the microbiota-gut-brain axis in the pathogenesis of NDs. Diet is one of the most important environmental factors shaping the structure and function of gut microbiota. Manipulating the gut microbiota through specific diet patterns may represent a promising approach for NDs prevention. In this review， we highlight gut microbiota variations in NDs， outline several crucial signaling pathways of the gut-brain communication， and discuss the interplay of nutrients-microbes and biological effect of diet-derived microbial metabolites on neural physiology. In particular， we summarized the current knowledge about the application of dietary patterns in NDs to prevent disease progression via the modulation of the gut microbiota. Our study provides novel insights on the diet-microbiota-gut-brain axis in neurodegenerative disorders and highlights the potential of developing microbiome-targeted personalized dietary intervention for NDs management.

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汉水中游地区史前腰坑与瓮棺

江汉考古 2010年第1期 55-64页

作者：李英华湖北武汉 430072

本文首先介绍了汉水中游地区史前婴少儿瓮棺以腰坑形式与成人进行合葬的墓例情况,并对该地区史前腰坑材料进行了系统梳理,推断这些腰坑原本应是瓮棺的载体,并通过对我国史前瓮棺葬的具体特征的辨析对此作了进一步确认。然后,本文对汉水... 详细信息

本文首先介绍了汉水中游地区史前婴少儿瓮棺以腰坑形式与成人进行合葬的墓例情况,并对该地区史前腰坑材料进行了系统梳理,推断这些腰坑原本应是瓮棺的载体,并通过对我国史前瓮棺葬的具体特征的辨析对此作了进一步确认。然后,本文对汉水中游地区这类特殊合葬墓的形成作了初步解释;并从腰坑的形态与功能角度,对史前和夏商时期出土的腰坑材料进行了分析比较,论证了汉水中游地区史前腰坑葬俗的独特性,同时认为中原地区商周时期广泛流行的腰坑葬俗属于另一个系统,其源头应与汉水中游地区无关。

关键词：汉水中游地区腰坑瓮棺

The interaction between temperature and precipitation on the potential distribution range of Betula ermanii in the alpine treeline ecotone on the Changbai Mountain

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Forest Ecosystems 2024年第1期11卷 42-51页

作者： Yu Cong Yongfeng Gu Wen J.Wang Lei Wang Zhenshan Xue Yingyi Chen yinghua Jin Jiawei Xu Mai-He li Hong S.He Ming Jiang Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China Key Laboratory of Geographical Processes and Ecological Security in Changbai Mountains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun 130024China School of Natural Resources University of MissouriColumbiaMO 65211USA Swiss Federal Institute for Forest Snow and Landscape Research WSLCH-8903 BirmensdorfSwitzerland School of life Science Hebei UniversityBaoding 071000China

Alpine treeline ecotones are highly sensitive to climate *** low temperature-determined alpine treeline is expected to shift upwards in response to global ***,little is known about how temperature interacts with other important factors to influence the distribution range of tree species within and beyond the alpine treeline ***,we used a GF-2 satellite image,along with bioclimatic and topographic variables,to develop an ensemble suitable habitat model based on the species distribution modeling algorithms in *** investigated the distribution of suitable habitats for *** under three climate change scenarios(i.e.,low(SSP126),moderate(SSP370)and extreme(SSP585)future emission trajectories)between two consecutive time periods(i.e.,current-2055,and 2055-2085).By 2055,the potential distribution range of *** will expand under all three climate *** medium and high suitable areas will decline under SSP370 and SSP585scenarios from 2055 to ***,under the three climate scenarios,the uppermost altitudes of low suitable habitat will rise to 2,329 m a.s.l.,while the altitudes of medium and high suitable habitats will fall to 2,201 and2,051 m *** 2085,*** promotes the expansion of *** distribution range in Changbai Mountain,and this expansion will be modified by precipitation as climate warming *** interaction between temperature and precipitation plays a significant role in shaping the potential distribution range of *** in the alpine treeline *** study reveals the link between environmental factors,habitat distribution,and species distribution in the alpine treeline ecotone,providing valuable insights into the impacts of climate change on high-elevation vegetation,and contributing to mountain biodiversity conservation and sustainable development.

关键词： Biomod2 Birch Climate change Climate scenarios Habitat suitability Range shift Treeline species

Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy:a novel delivery system candidate for tumor vaccines

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Science China(life Sciences) 2024年第4期67卷 680-697页

作者： Nan li Yun Zhang Miaomiao Han Tian liu Jinjia Wu Yingxia Xiong Yikai Fan Fan Ye Bing Jin yinghua Zhang Guibo Sun Xiaobo Sun Zhengqi Dong State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Chinese Academy of Medical Sciences&Peking Union Medical College(CAMS)Institute of Medicinal Plant Development(IMPLAD)Beijing 100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine(Natural Medicine)and Translational MedicineKey Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription from Chinese Academy of Medical SciencesCAMSIMPLADBeijing 100193China Department of Pharmaceutics School of Pharmaceutical SciencesHeilongjiang University of Chinese MedicineHarbin 150036China Jilin Academy of Chinese Medicine Sciences Changchun 130012China Joint Research Center for Chinese Medicinal Herbs IMPLADABRC&ACCLBeijing 100193China

The study of tumor nanovaccines(NVs)has gained interest because they specifically recognize and eliminate tumor ***,the poor recognition and internalization by dendritic cells(DCs)and insufficient immunogenicity restricted the vaccine ***,we extracted two molecular-weight Astragalus polysaccharides(APS,12.19 k D;APSHMw,135.67 k D)from Radix Astragali and made them self-assemble with OVA257–264directly forming OVA/APS integrated nanocomplexes through the microfluidic *** nanocomplexes were wrapped with a sheddable calcium phosphate layer to improve *** in the formed nanocomplexes served as drug carriers and immune adjuvants for potent tumor *** optimal APS-NVs were approximately 160 nm with uniform size distribution and could remain stable in physiological saline *** FITC-OVA in APS-NVs could be effectively taken up by DCs,and APS-NVs could stimulate the maturation of DCs,improving the antigen cross-presentation efficiency in *** possible mechanism was that APS can induce DC activation via multiple receptors such as dectin-1 and Toll-like receptors 2 and *** accumulation of APS-NVs both in draining and distal lymph nodes were observed following *** APS-NVs could easily access the lymph ***,APS-NVs could markedly promote antigen delivery efficiency to DCs and activate cytotoxic T *** addition,APS-NVs achieve a better antitumor effect in established B16-OVA melanoma tumors compared with the OVA+Alum treatment *** antitumor mechanism correlated with the increase in cytotoxic T cells in the tumor ***,the poor tumor inhibitory effect of APS-NVs on the nude mouse model of melanoma also confirmed the participation of antitumor adaptive immune response induced by ***,this study developed a promising APS-based tumor NV that is an efficient tumor immunotherapy without systemic side effects.

关键词： Astragalus polysaccharides nanovaccines OVA immunotherapy self-adjuvant

等相关峰综合鉴别函数的编码方法及计算机生成

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微计算机信息 2006年第8S期22卷 299-300页

作者：李英华军械工程学院光学与电子工程系

对于光学相关识别畸变问题常用到的等相关峰综合鉴别函数(ECPSDF)进行了原理论述并利用计算机实现了该算法。在此基础上对程序进行了改进,提高了运算效率。

关键词：光学相关识别等相关峰综合鉴别函数畸变不变

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求解期权定价问题的熵保险精算方法

辽宁工程技术大学学报（自然科学版） 2010年第3期29卷 513-516页

作者：李英华李兴斯大连理工大学应用数学系辽宁大连116023 大连理工大学工业装备结构分析国家重点实验室辽宁大连116023

为了求解不完全市场的期权价格,提出了基于熵的保险精算方法。方法考虑期权卖方的最大权益、分析了保险精算期权定价执行条件,结合标的资产价格的历史信息,运用最大熵原理求出标的资产的概率密度,以此为基础计算损失变量的概率密度,依... 详细信息

为了求解不完全市场的期权价格,提出了基于熵的保险精算方法。方法考虑期权卖方的最大权益、分析了保险精算期权定价执行条件,结合标的资产价格的历史信息,运用最大熵原理求出标的资产的概率密度,以此为基础计算损失变量的概率密度,依据保险精算方法可知,损失变量在此概率密度下的期望值即为期权的价格。经HSI指数和S&P500指数的部分指数作为标的资产的期权实证检验,可发现新方法不仅比B-S公式蕴含更平坦的隐含波动率,而且进一步印证了传统保险定价过低和B-S定价偏高的情况。

关键词：期权定价最大熵原理保险精算方法