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系统性红斑狼疮患者应用靶向B细胞治疗后发生中枢神经系统病变文献病例分析

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实用药物与临床 2024年第3期27卷 207-211页

作者：姜莉贾倩厉彦山王莉莉李红李尊忠临沂市人民医院风湿免疫科山东临沂276000 复旦大学风湿免疫过敏性疾病研究中心上海200040

目的探讨系统性红斑狼疮(SLE)患者经靶向B淋巴细胞生物制剂治疗后发生中枢神经系统不良反应的临床特征。方法检索国内外相关数据库(截至2023年5月),收集系统性红斑狼疮患者经贝利尤单抗、利妥昔单抗治疗后发生中枢神经系统病变的病例报... 详细信息

目的探讨系统性红斑狼疮(SLE)患者经靶向B淋巴细胞生物制剂治疗后发生中枢神经系统不良反应的临床特征。方法检索国内外相关数据库(截至2023年5月),收集系统性红斑狼疮患者经贝利尤单抗、利妥昔单抗治疗后发生中枢神经系统病变的病例报告类文献,提取患者的基本信息、贝利尤单抗或利妥昔单抗用药情况(用法用量、单用或联用、联用方案等)、中枢神经系统病变发生时间、临床表现、影像学特征、临床治疗及转归等,并进行描述统计分析。结果检索到进行性多灶性脑白质病(PML)患者14例,发病年龄(50.71±11.45)岁;可逆性后部脑病综合征(PRES)患者24例,发病年龄(30.67±14.93)岁。纳入有详细病例报道的患者共7例,7例患者均未合并HIV感染、恶性肿瘤及其他自身免疫性疾病。7例患者均经磁共振检查确诊,均未行脑组织活检。临床表现:癫痫5例,视物模糊或视力丧失3例,构音障碍或失语2例,头痛2例,昏迷1例,血压升高4例。最终7例患者中1例死亡。结论应用靶向B细胞治疗后,SLE患者中枢神经系统副作用多发生在疾病活动期且合并使用其他免疫抑制剂时。患者的临床表现容易与神经精神狼疮混淆,导致病情延误,提示在使用靶向B细胞生物制剂治疗时,应评估SLE患者发生中枢神经系统副作用的潜在风险。

关键词：靶向B细胞治疗系统性红斑狼疮进行性多灶性脑白质病可逆性后部脑病综合征药物不良反应

Fibre Metallurgy Characteristic of Short Cast Iron Fibre and Its Applications for Diamond Wheel

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Journal of Materials Science & Technology 1994年第4期10卷 246-250页

作者： Shizhen CHEN Dongli YU Julong HE Yongjun TIAN and Dongchun li (yanshan University, Qinhuangdao City, 066004, China) yanshan Univ Qinhuangdao China

A kind of diamond grinding wheel bonded by short cast iron fibres has been developed. ln comparison with high quality bronze bonded diamond grinding wheel. the new wheel was more suitable to grind hard and brittle materials like ceramics. For Si3N4, the grinding efficiency has been raised two times and the grinding ratio five times

关键词： Cast Fibre Metallurgy Characteristic of Short Cast Iron Fibre and Its Applications for Diamond Wheel MPa

An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration

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Bioactive Materials 2023年第9期27卷 181-199页

作者： Tao Yang Zhichao Hao Zhenzhen Wu Binxin Xu Jiangchen liu Le Fan Qinmei Wang yanshan li Dongying li Sangzhu Tang Chuanzi liu Weichang li Wei Teng Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Provincial Key Laboratory of StomatologyNo.56Lingyuan West RoadYuexiu DistrictGuangzhou510055China Department of Periodontology and Implantology Stomatological HospitalSchool of StomatologySouthern Medical UniversityGuangzhouChina Laboratory of Biomaterials Key Laboratory on Assisted CirculationMinistry of HealthCardiovascular DivisionThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Lamellar bone,compactly and ingeniously organized in the hierarchical pattern with 6 ordered scales,is the structural motif of mature *** hierarchical scale exerts an essential role in determining physiological behavior and osteogenic bioactivity of *** lamellar bone with full-scale hierarchy remains a longstanding ***,using bioskiving and mineralization,we attempt to engineer compact constructs resembling full-scale hierarchy of lamellar *** systematically investigating the effect of mineralization on physicochemical properties and bioactivities of multi-sheeted collagen matrix fabricated by bioskiving,the hierarchical mimicry and hierarchy-property relationship are *** prolongation of mineralization,hierarchical mimicry and osteogenic bioactivity of constructs are performed in a bidirectional manner,*** rising and then descending,which is supposed to be related with transformation of mineralization mechanism from nonclassical to classical *** mineralized 9 days can accurately mimic each hierarchical scale and efficiently promote *** analysis further reveals that this construct potently activates integrinα5-PI3K/AKT signaling pathway through mechanical and biophysical cues,and thereby repairing critical-sized bone *** present study provides a bioinspired strategy for completely resembling complex hierarchy of compact mineralized tissue,and offers a critical research model for in-depth studying the structure-function relationship of bone.

关键词： Full-scale hierarchy Lamellar bone Bioskiving Mineralization Integrinα5-PI3K/AKT signaling Pathway

Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions

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Molecular Plant 2015年第5期8卷 722-733页

作者： WenzhongXu Wentao Dai Huili Yan Sheng li Hongling Shen yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma Key Laboratory of Plant Resources Institute of Botany Chinese Academy of Sciences Beijing 100093 China

In Arabidopsis, the nodulin 26-like intrinsic protein （NIP） subfamily of aquaporin proteins consists of nine members, five of which （NIP1;1, NIP1;2, NIP5;1, NIP6;1, and NIP7;1） were previously identified to be perme- able to arsenite. However, the roles of NIPs in the root-to-shoot translocation of arsenite in plants remain poorly understood. In this study, using reverse genetic strategies, Arabidopsis NIP3;1 was identified to play an important role in both the arsenic uptake and root-to-shoot distribution under arsenite stress condi- tions. The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions. A promoter-β-glucuronidase analysis revealed that NIP3; 1 was ex- pressed almost exclusively in roots （with the exception of the root tips）, and heterologous expression in the yeast Saccharomyces cerevisiae demonstrated that NIP3;1 was able to mediate arsenite transport. Taken together, our results suggest that NIP3;1 is involved in arsenite uptake and root-to-shoot translocation in Arabidopsis, probably as a passive and bidirectional arsenite transporter.

关键词： Arabidopsis, arsenite, NIP3 1, root-to-shoot translocation, tolerance

Action Status Based Novel Relative Feature Representations for Interaction Recognition

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Chinese Journal of Electronics 2022年第1期 168-180页

作者： li yanshan GUO Tianyu liU Xing LUO Wenhan XIE Weixin ATR National Key Laboratory of Defense Technology Shenzhen University Guangdong Key Laboratory of Intelligent Information Processing Shenzhen University Tencent

Skeleton-based action recognition has always been an important research topic in computer vision. Most of the researchers in this field currently pay more attention to actions performed by a single person while there is very little work dedicated to the identification of interactions between two people. However, the practical application of interaction recognition is actually more critical in our society considering that actions are often performed by multiple people. How to design an effective scheme to learn discriminative spatial and temporal representations for skeleton-based interaction recognition is still a challenging problem. Focusing on the characteristics of skeleton data for interactions, we first define the moving distance to distinguish the action status of the participants. Then some view-invariant relative features are proposed to fully represent the spatial and temporal relationship of the skeleton sequence. Further, a new coding method is proposed to obtain the novel relative feature representations. Finally, we design a three-stream CNN model to learn deep features for interaction recognition. We evaluate our method on SBU dataset, NTU RGB+D 60 dataset and NTU RGB+D 120 dataset. The experimental results also verify that our method is effective and exhibits great robustness compared with current state-of-the-art methods.

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李军茹主任医师治疗高原慢性萎缩性胃炎临床经验总结

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中国医药导报 2024年第5期21卷 143-147页

作者：罗红英沈建武李军茹金登卫管昱鑫李燕杉青海省中医院中医药研究院青海西宁810099 广东省台山市中医院脾胃病科广东台山529200 青海省中医院急诊科青海西宁810099 青海省中医院治未病科青海西宁810099

慢性萎缩性胃炎是临床上难治的消化系统疾病,具有发病率高,反复发作性强等特点,发病原因与幽门螺杆菌感染、免疫因素、胆汁反流和遗传等有关。在各种因素相互作用下导致胃黏膜损伤,胃腺体萎缩。西医治疗可短期改善症状,但从长远来说容... 详细信息

慢性萎缩性胃炎是临床上难治的消化系统疾病,具有发病率高,反复发作性强等特点,发病原因与幽门螺杆菌感染、免疫因素、胆汁反流和遗传等有关。在各种因素相互作用下导致胃黏膜损伤,胃腺体萎缩。西医治疗可短期改善症状,但从长远来说容易复发。李军茹主任医师扎根高原30余载,治疗慢性萎缩性胃炎有独特的理论,她提出治疗应立足高原,采用“依天时-辨体质-辨病证-辨病症”结合的方式,重视患者舌象、脉象的变化,强调“皮膜同治”,时时顾护胃气,重调脾胃气机,从而制订临床方案。

关键词：慢性萎缩性胃炎高原气虚血瘀证舌脉

Grating　Angular－movement　Transducer　Using　a　Fabry－Perot　Structure

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Semiconductor Photonics and Technology 1996年第4期2卷 67-71,77页

作者： ① li Zhiquan (yanshan University,Qinghuangdao 066004,CHN)

A novel grating angular-movement transducer using a multiplex Fabry-Perot interference technology has been *** Fabry-Perot interferometer(FPI) has been traditionally used to examine either small spectral ranges or relatively simple ***,however,the studies have shown that the FPI can be competitive with the Michelson interferometer over extended spectral ranges.A relatively new FPI is described based on two gratings.

关键词： Angular-movement transducer Fabry-Perot Interferometer Grating Transducers

Three Beam interfering Pressure Gauge

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Semiconductor Photonics and Technology 1997年第1期3卷 44-49页

作者： WU Zhaoxia, TANG Xuhui, liU li, li Zhiquan(yanshan University, Qinhuangdao 066004, CHN)

Abstract: In order to solve the problem of high precision, complete electric insulating detection of the pressure measuring system, we have developed the three - beam interferometer. In this paper, the operation princ... 详细信息

关键词： Fourier Transformation Gauge Optical Path Difference Photodetec-tors Three Beam Interferometer

Biomolecular condensates and disease pathogenesis

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Science China(life Sciences) 2024年第9期67卷 1792-1832页

作者： Ke Ruan Ge Bai yanshan Fang Dan li Tingting li Xingguo liu Boxun Lu Qing Lu Zhou Songyang Shuguo Sun Zheng Wang Xin Zhang Wen Zhou Hong Zhang The First Affiliated Hospital&School of life Sciences Ministry of Education Key Laboratory for Membrane-less Organelles&Cellular DynamicsHefei National Research Center for Interdisciplinary Sciences at the MicroscaleCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Nanhu Brain-computer Interface Institute Hangzhou 311100China Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou 310058China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China CAS Key Laboratory of Regenerative Biology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Joint School of life Sciences Guangzhou Medical UniversityGuangzhou 510000China Neurology Department at Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceSchool of Life SciencesFudan UniversityShanghai 200433 China Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of EducationBio-X InstitutesShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Biocontrol MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging ResearchSchool of Life SciencesSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510275China Department of Human Anatomy Hist

Biomolecular condensates or membraneless organelles(MLOs)formed by liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific *** of LLPS or aberrant phase transition that disturbs the formation or material states of MLOs is closely correlated with neurodegeneration,tumorigenesis,and many other pathological ***,we summarize the recent progress in development of methods to monitor phase separation and we discuss the biogenesis and function of MLOs formed through phase *** then present emerging proof-of-concept examples regarding the disruption of phase separation homeostasis in a diverse array of clinical conditions including neurodegenerative disorders,hearing loss,cancers,and immunological ***,we describe the emerging discovery of chemical modulators of phase separation.

关键词： liquid-liquid phase separation biomolecular condensate membraneless organelle

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