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Design of the Full-disk Magneto Graph (FMG) onboard the ASO-S

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Research in Astronomy and Astrophysics 2019年第11期19卷 11-22页

作者： Yuan-Yong Deng Hai-Ying Zhang Jian-Feng Yang Fu li Jia-Ben lin Jun-Feng Hou Zhen Wu Qian Song Wei Duan Xian-Yong Bai Dong-Guang Wang juan Lv Wei Ge Jia-Ning Wang Zhao-Ying zheng Chen-Jie Wang Nan-Ge Wang Hou-Kun Ni Yi-Zhong zeng Yang Zhang Xiao Yang Ying-Zi Sun zhi-Yong Zhang Xiao-Fan Wang Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

The Full-disk Magneto Graph(FMG),a payload onboard the Advanced Space Solar Observatory(ASO-S),will measure the vector magnetic field in the *** instrument consists of a frontwindow filter,a telescope,an LCVR polarimeter,an image-stabilization system,a seven-stage tunable Lyot filter,a CMOS camera with 4096×4096 pixels and a pair of calibration/focus *** this paper,we describe the design of the FMG instrument and provide a summary of test observations carried out with the FMG prototype.

关键词： Sun magnetic fields-space vehicles instruments-methods observational-techniques polarimetric

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细根分解研究及其存在的问题

植物学通报 2005年第2期22卷 246-254页

作者：张秀娟梅莉王政权韩有志东北林业大学林学院哈尔滨150040

细根分解是陆地生态系统C和养分循环的重要环节。主要包括淋溶和破碎等物理过程和以生物作用为主的化学过程。这些过程受复杂的细根化学成分及外部土壤因子的综合控制,如细根本身养分含量、木质素和纤维素含量、土壤温度、水分、养分的... 详细信息

细根分解是陆地生态系统C和养分循环的重要环节。主要包括淋溶和破碎等物理过程和以生物作用为主的化学过程。这些过程受复杂的细根化学成分及外部土壤因子的综合控制,如细根本身养分含量、木质素和纤维素含量、土壤温度、水分、养分的有效性以及土壤动物、真菌和细菌等。但是,细根分解发生在不能直接观测的地下部分,人为改变细根分解的自然环境是研究过程中存在的主要问题。埋袋法虽然应用最为普遍,但是它严重地干扰了细根分解环境,导致低估分解速率。最近提出的原状土芯法(intact-core)克服了埋袋法的主要缺陷,是目前细根分解研究中最接近自然分解过程的研究方法,但也存在一些问题。因此,如何设计有效且能够真实的反映细根自然分解过程的试验方法是今后该领域研究最重要和最具挑战性的课题。

关键词：细根陆地生态系统分解过程纤维素含量重要环节养分循环化学过程生物作用物理过程综合控制土壤因子化学成分养分含量土壤温度土壤动物地下部分研究过程自然环境分解速率研究方法接近自然试验方法木质素

基于计算机模拟研究雷公藤治疗类风湿关节炎的药效物质基础与分子作用机制

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中国组织工程研究 2016年第12期20卷 1818-1824页

作者：严培晶郑春松叶蕻芝郑丽秀鲍红娟福建生物工程职业技术学院经营管理系福建省福州市350002 福建中医药大学中西医结合研究院福建省福州市350122 厦门医学高等专科学校药学系福建省厦门市361008

背景:雷公藤及某些单体在治疗类风湿关节炎上临床效果确切,而较为系统探讨雷公藤药效物质基础与分子作用机制的研究较少。目的:探讨雷公藤治疗类风湿关节炎的药效物质基础与分子作用机制。方法:借助Discovery Studio 4.0模拟平台,构建... 详细信息

背景:雷公藤及某些单体在治疗类风湿关节炎上临床效果确切,而较为系统探讨雷公藤药效物质基础与分子作用机制的研究较少。目的:探讨雷公藤治疗类风湿关节炎的药效物质基础与分子作用机制。方法:借助Discovery Studio 4.0模拟平台,构建雷公藤化学成分分子数据集,比较其与Therapeutic Target Database中类风湿关节炎治疗药物分子的化学空间,在此基础上,采用网络药理学方法探讨其与类风湿关节炎治疗靶点的相互作用。结果与结论:雷公藤分子与类风湿关节炎药物分子具有相似的化学空间,其药效物质基础含有苯乙烯南蛇碱、表没食子儿茶精、雷公藤新碱和雷公藤甲素等46个化合物,可作用于肿瘤坏死因子α、JAK-1、基质金属酶1、基质金属酶3和基质金属酶9等10个靶点,来抗炎、调节免疫应答、抑制软骨和骨的破坏、改善类风湿关节炎血瘀证。计算机模拟直观展示了雷公藤治疗类风湿关节炎的多成分、多靶点、多途径作用。

关键词：关节炎,类风湿中草药计算机模拟生物材料材料相容性雷公藤类风湿关节炎软骨和骨损伤免疫系统血瘀证分子对接网络药理学

Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis

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Chinese Medical Journal 2016年第7期129卷 757-762页

作者： Ping liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U li Zhang Xu Yao Min zheng Yi-Wen Tang Xin-Xiano Lu xiu-juan xia You-Kun lin Yu-Zhen li Cai-Xia Tu zhi-Rong Yao Jin-Hua Xu Wei li Wei Lai Hui-Min Yang Hong-Fu Xie xiu-Ping Han zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang Department of Dermatology Peking University People's Hospital Beijing 100044 China Department of Dermatology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Dermatology Institute of Dermatology Chinese Academy of Medical Sciences Nanjing Jiangsu 210042 China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Dermatology Tianjin Changzheng Hospital Tianjin 300120 China Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Yantai Yuhuangding Hospital Yantai Shandong 264000 China Department of Dermatology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Dermatology The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China Department of Dermatology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Dermatology Shanghai Huashan Hospital Shanghai 200040 China Department of Dermatology Xijing Hospital Xi'an Shaanxi 710032 China Department of Dermatology The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Dermatology The Second Hospital of Heilongjiang Province Harbin Heilongjiang 150010 China Department of Dermatology Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Dermatology.Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Dermatology Peking University Third Hospital Beijing 100191 China Department of Dermatology The First Affili

Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is co

关键词： Adolescents and Adults Atopic Dermatitis Clinical Features Diagnostic Criteria Eczema

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川芎嗪噻唑烷二酮类化合物的合成

化学试剂 2011年第2期33卷 169-171页

作者：盛日正彭家志李家明陈增修周鹏安徽中医学院药学院安徽省现代中药重点实验室安徽合肥230031 蚌埠市第三人民医院药剂科安徽蚌埠233000

以具有活血化淤作用的中药有效成分川芎嗪为原料,经溴化、O-烷基化、与2,4-噻唑烷二酮缩合反应合成了两个川芎嗪噻唑烷二酮类化合物,其结构经IR、1HNMR1、3CNMR及MS确证。

关键词：川芎嗪 2,4-噻唑烷二酮川芎嗪噻唑烷二酮

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地震预警技术综述

自然灾害学报 2007年第6期16卷 216-223页

作者：袁志祥单修政徐世芳李金正李娟乔迎春陕西省地震局陕西西安710068

地震预警技术是为了适应减轻地震灾害的要求而产生的,其技术原理是利用电磁波与地震波的速度差,以及地震P波与S波的速度差来实现地震发生后的及时预警。论述了目前国内外应用地震预警技术、配置地震预警系统的情况,对应用该技术所产生... 详细信息

地震预警技术是为了适应减轻地震灾害的要求而产生的,其技术原理是利用电磁波与地震波的速度差,以及地震P波与S波的速度差来实现地震发生后的及时预警。论述了目前国内外应用地震预警技术、配置地震预警系统的情况,对应用该技术所产生的效益作了介绍,对其进一步的发展前景进行了展望。

关键词：地震灾害预警技术预警系统效益前景

应用CRISPR/Cas9技术构建miR-362敲除的95-D肺癌细胞株

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中国生物工程杂志 2017年第11期37卷 94-100页

作者：罗丹王莉娟孙秀璇张征陈志南北京交通大学理学院生命科学与生物工程研究院北京100044 空军军医大学(第四医科大学)细胞工程研究中心西安710032

目的:运用CRISPR/Cas9基因编辑技术,建立miR-362基因敲除的95-D肺癌细胞株,并研究miR-362在肿瘤中的调控作用。方法:针对人源miR-362基因序列设计gRNA,构建px330-gRNA载体;T7E1 assay确定gRNA的有效性。分别扩增miR-362上下游同源臂序... 详细信息

目的:运用CRISPR/Cas9基因编辑技术,建立miR-362基因敲除的95-D肺癌细胞株,并研究miR-362在肿瘤中的调控作用。方法:针对人源miR-362基因序列设计gRNA,构建px330-gRNA载体;T7E1 assay确定gRNA的有效性。分别扩增miR-362上下游同源臂序列构建donor载体。利用脂质体将CRISPR系统和donor载体共转至人肺癌细胞系95-D,通过同源重组方法将筛选标志基因整合至基因组中,通过流式分选以及q PCR方法检测筛选出的细胞中miR-362表达水平。利用Transwell分析miR-362对细胞运动能力的影响。结果:与95-D细胞相比,95-D-Knock Down细胞中miR-362表达水平显著降低,且迁移侵袭能力分别下降了53.1%(P=0.000 6)和48.3%(P=0.000 2)。结论:利用CRISPR/Cas9系统成功构建了miR-362基因敲除的95-D细胞,miR-362可促进细胞的运动能力,为后续研究miR-362在肿瘤中的作用机制和功能奠定了基础。

关键词： miR-362 95-D CRISPR/Cas9 侵袭迁移

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高支撑扣件式钢管脚手架体系的施工要点

山西建筑 2008年第24期34卷 29-30页

作者：李隽秀曾志兴华侨大学土木工程学院

结合工程实例,阐述了高支撑扣件式钢管脚手架体系的施工要点,从专项施工方案的编制、支撑施工的质量控制及混凝土浇捣的注意事项等方面,强调支撑设计应与施工实际有效结合,从而保证施工质量。

关键词：高大模板扣件式钢管支撑施工要点

Delivery room resuscitation and short-term outcomes of extremely preterm and extremely low birth weight infants: a multicenter survey in North China

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Chinese Medical Journal 2021年第13期134卷 1561-1568页

作者： Shuai-Jun li Qi Feng xiu-Ying Tian Ying Zhou Yong Ji Yue-Mei li Shu-Fen Zhai Wei Guo Fang Zhang Rong-xiu zheng Hai-Ying He Xia liu Jun-Yi Wang Hua Mei Hong-Yun Wang Hua Xie Chao-Mei zeng li Ma Ping-Ping Zhang Jin-Yu li Xiao-Ying Wang li-Hua li Hong Cui Shu-Lan Yang Lu Chen Xiao-Hong Gu Yan-Ju Hu Sheng-Shun Que li-Xia Sun Ming Yang Wen-li Zhao Qiu-Yan Ma Hai-juan Wang Jiu-Ye Guo Department of Pediatrics Peking University First HospitalBeijing 100034China Department of Neonatology Tianjin Central Hospital of Gynecology ObstetricsTianjin 300100China Department of Pediatrics Peking University Third HospitalBeijing 100191China Neonatal Intensive Care Unit Children's Hospital of ShanxiTaiyuanShanxi 030031China Department of Neonatology The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Neonatology Handan Central HospitalHandanHebei 056004China Department of Neonatology Xingtai People's HospitalXingtaiHebei 054031China Department of Neonatology Tangshan Maternal and Child Health HospitalTangshanHebei 071023China Department of Pediatrics Tianjin Medical University General HospitalTianjin 300052China Department of Pediatrics Baogang Third Hospital of HongCi GroupBaotouInner Mongolia Autonomous Region 014010China Department of Neonatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China Department of Pediatrics The First Hospital of Tsinghua UniversityBeijing 100016China Department of Neonatology The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotInner Mongolia Autonomous Region 010050China Department of Neonatology Inner Mongolia Maternal and Child Health HospitalHohhotInner Mongolia Autonomous Region 010020China Department of Neonatology Affiliated Hospital of Chifeng UniversityChifengInner Mongolia Autonomous Region 024005China Department of Pediatrics Peking University People's HospitalBeijing 100044China Department of Neonatology Hebei Children's HospitalShijiazhuangHebei 050000China Department of Neonatology Tianjin First Central HospitalTianjin 300384China Department of Pediatrics Peking Union Medical College HospitalBeijing 100730China Department of Neonatology Children's Hospital Capital Institute of PediatricsBeijing 100020China Department of Pediatrics Beijing Luhe Hospital.Capital Medical UniversityBeijing 101149China Department of Pediatrics Beijing Fri

Background:Delivery room resuscitation assists preterm infants,especially extremely preterm infants(EPI)and extremely low birth weight infants(ELBWI),in breathing support,while it potentially exerts a negative impact on the lungs and outcomes of preterm *** study aimed to assess delivery room resuscitation and discharge outcomes of EPI and ELBWI in ***:The clinical data of EPI(gestational age[GA]livery room resuscitation and risk factors for delivery room intubation(DRI).The secondary outcomes were survival rates,incidence of bronchopulmonary dysplasia(BPD),and risk factors for ***:A cohort of 952 preterm infants were *** incidence of DRI,chest compressions,and administration of epinephrine was 55.9%(532/952),12.5%(119/952),and 7.0%(67/952),*** analysis revealed that the risk factors for DRI were GAlivery room(OR,0.273;95%CI,0.160–0.467)were preventive factors for BPD(all Plivery room resuscitation and management of respiratory complications are imperative during early management of the health of EPI and

关键词： Extremely preterm Extremely low birth weight infants Delivery room resuscitation Survival rate BPD Risk factors