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Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor

Acta Pharmacologica Sinica 2004年第7期25卷 47-55页

作者： Jun-lin JIANG, De-jian JIANG, Yu-hai tang, Nian-sheng li, Han-wu DENG, Yuan-jian li1 Department of Pharmacology, Schoolof Pharmaceutic Sciences, Central South University, Changsha 410078, China Department of Pharmacology School of Pharmaceutic Sciences Central South University Changsha 410078 China

AIM: To investigate the effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthesis inhibitor asymmetric dimethylarginine (ADMA) in rats and cultured ECV304 cells. METHODS: Endothe- lial injury was induced by a single injection of low density lipoprotein (LDL) (4 mg/kg, 48 h) in rats or incubation with LDL (300 mg/L) or oxidative-modified LDL (100 mg/L) in cultured ECV304 cells, and vasodilator responses to acetylcholine (ACh) in the aortic rings and the level of ADMA, nitrite/nitrate (NO) and tumor necrosis factor- alpha (TNF-α) in the serum or cultured medium were determined. And the adhesion of the monocytes to endothe- lial cells and the activity of dimethylarginine dimethylaminohydrolase (DDAH) in the cultured ECV304 cells were measured. RESULTS: A single injection of LDL decreased endothelium-dependent relaxation to ACh, markedly increased the serum level of endogenous ADMA and TNF-α, and reduced serum level of NO. Pretreatment with simvastatin (30 or 60 mg/kg) markedly attenuated inhibition of vasodilator responses to ACh, the increased level of TNF-α and the decreased level of NO by LDL, but no effect on serum concentration of endogenous ADMA. In cultured ECV304 cells, LDL or ox-LDL markedly increased the level of ADMA and TNF-α and potentiated the adhesion of monocytes to endothelial cells, concomitantly with a significantly decrease in the activity of DDAH and serum level of NO. Pretreatment with simvastatin (0.1, 0.5, or 2.5 μmol/L) markedly decreased the level of TNF- α and the adhesion of monocytes to endothelial cells, butdid not affectthe concentration of endogenous ADMA and the activity of DDAH. CONCLUSION: Simvastatin protect the vascular endothelium against the damages induced by LDL or ox-LDL in rats or cultured ECV304 cells, and the beneficial effects of simvastatin may be related to the reduction of inflammatory cytokine TNF-α level.

关键词： simvastatin vasodilation tumor necrosis factor endogenous nitric oxide synthase inhibitor LDL lipoproteins

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Gas sensor array based on carbon-based thin-film transistor for selective detection of indoor harmful gases

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Rare Metals 2024年第9期43卷 4401-4411页

作者： Can liu Yu Sun Jia-Yi Guo Xiu-Lei li Lu Tao Jin-Yong Hu Jue-Xian Cao Ping-Hua tang Yong Zhang School of Electrical and Information Engineering Hunan Institute of EngineeringXiangtan 411104China Physics and Optoelectronics&Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

The identification of indoor harmful gases is imperative due to their significant threats to human health and *** achieve accurate identification,an effective strategy of constructing a sensor array combined with the pattern recognition algorithm is ***-based thin-film transistors are selected as the sensor array unit,with semiconductor carbon nanotubes(CNTs)within the TFT channels modified with different metals(Au,Cu and Ti)for selective responses to NH_(3),H_(2)S and HCHO,*** accurate gas species identification,an identification mode that combines linear discriminant analysis algorithms and logistic regression classifier is *** test results demonstrate that by preprocessing the sensor array’s sensing data with the LDA algorithm and subsequently employing the LR classifier for identification,a 100%recognition rate can be achieved for three target gases(NH3,H2S and HCHO).This work provides significant guidance for future applications of chip-level gas sensors in the realms of the Internet of Things and Artificial Intelligence.

关键词： Carbon-based thin-film transistors Gas sensor arrays Semiconductor carbon nanotubes Multi-gas detection linear discriminant analysis

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Magnitude,direction,and drivers of rhizosphere effect on soil nitrogen and phosphorus in global agroecosystem

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International Soil and Water Conservation Research 2023年第3期11卷 482-493页

作者： Andong Cai Shengnan tang Muhammad Ahmed Waqas Bin Wang Di Tian Yang Zhang Yu'e li Muhammad Nadeem Ashraf Tianjing Ren Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing100081China The Key Laboratory for Slviculture and Conervation of Ministry of Education College of ForestryBeijing Forestry UniversityBeijing100083China Department of Agroecology Aarhus UniversityBlichers Alle 20PO BOX 50DK-8830 TjeleDenmark Institute of Soil and Environmental Sciences University of Agriculture Faisalabad38000Pakistan Institute of Soil Science and Plant Cultivation State Research InstituteDepartment of Soil Science Erosion and Land ConservationCzartoryskich St.824-100PutawyPoland

The rhizosphere is the most active soil area for material transformation and energy flow of soil,root,and microorganism,which plays an important role in soil biochemical *** the rhizospheric nitrogen(N)and phosphorous(P)were easily disturbed in the agroecosystem,the effects of rhizosphere on the dynamics of soil N and P cycling have not yet been systematically quantified *** summarized the magnitude,direction,and driving forces of rhizosphere effects on agroecosystem's N and P dynamics by 1063 observations and 15 variables from 122 *** effects increased available N(AN,9%),available P(AP,11%),and total P(TP,5%),and decreased nitrate N(NO_(3)-N,18%)and ammonia N(NH_(4)-N,16%).The effect of rhizosphere on total N(TN)was not *** effects improved AN in tropical(12%)and subtropical(14%)*** effect of rhizosphere on TP was greater under subtropical conditions than in other *** most substantial effects of the rhizosphere on TP and AP were observed under humid *** effects increased AN and AP in vegetables more than in other crop *** of N>30o kg ha^(-1) had the most significant and positive rhizosphere effects on TN and AN.P application of 100-150 kg ha^(-1) had the greatest rhizosphere effects on TP and *** effects also improved the microbial(biomass N and P)and enzymatic aspects(urease,acid phosphatase,and alkaline phosphatase)of soil P and N *** equation modeling suggested that aridity indices,fertilizer application rate,soil pH,microbial biomass,and soil enzymes strongly influence the magnitude and direction of the rhizosphere's effect on the P and N ***,these findings are critical for improving soil nutrient utilization efficiency and modeling nutrient cycling in the rhizosphereforagricultural systems.

关键词： Rhizosphere effect Agriculture systems Nitrogen cycling Phosphorus cycling Climate Microbial biomass Soil enzymes

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Low lattice thermal conductivity and enhanced thermoelectric performance of SnTe via chemical electroless plating of Ag

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Rare Metals 2022年第1期41卷 86-95页

作者： Bang-Zhou Tian Xu-Ping Jiang Jie Chen Han Gao Ze-Gao Wang Jun tang Da-li Zhou Lei Yang Zhi-Gang Chen School of Materials Science&Engineering Sichuan UniversityChengdu 610064China Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Key Laboratory of Radiation Physics and Technology Ministry of EducationInstitute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Centre for Future Materials University of Southern QueenslandSpringfield CentralQLD 4300Australia

Interface engineering has been regarded as an effective strategy to manipulate the thermoelectric performance of ***,we use a facile chemical electroless plating and a spark plasma sintering process to fabricate Ag-plated SnTe *** sintering,a small amount of plated Ag can be doped into SnTe to suppress the Sn vacancies and the others form Ag precipitates with a size distribution from nanoscale to microscale,which introduces Ag/SnTe interfaces to enhance the Seebeck coefficient via energy filtering ***,these structures result in strong scattering to reach a low lattice thermal conductivity of-0.62 W·m^(–1)·K^(–1).Consequently,a maximum figure of merit(zT)of-0.67 at 823 K is achieved in 2 wt%Ag-plated SnTe,which is-60%higher than that of pristine ***,the microhardness indentation test results show that the mean microhardness of 2 wt%Ag-plated SnTe is HV 64.26,which is much higher than that of pristine SnTe,indicating that Ag electroless plating can improve the mechanical properties of *** work has provided a facile and eco-friendly method to realize the interface engineering for manipulating the thermoelectric and mechanical properties of SnTe.

关键词： Thermoelectric SnTe Electroless plating Energy filtering effect Interface engineering

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Co-occurrence of per- and polyfluoroalkyl substances, heavy metals and polycyclic aromatic hydrocarbons and their composite impacts on microbial consortium in soil: A field study

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Pedosphere 2024年第4期34卷 736-748页

作者： Meng ZHANG Qing WANG Xin SONG Mukhtiar Ali Zhiwen tang Xin liU Zhuanxia ZHANG Shurong MA Jinhui BI Zhongyuan li Key Laboratory of Saline-Alkali Vegetation Ecology Restoration Northeast Forestry UniversityHarbin 150040China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Center International Group Co. Ltd.Beijing 101160China China Construction Eighth Engineering Division Corp. Ltd.Shanghai 200122China

This is the first study to report the co-occurrence of per-and polyfluoroalkyl substances(PFASs),heavy metals,and polycyclic aromatic hydrocarbons(PAHs)and their impacts on the native microbial consortium in soil due to the long-term *** PFASs,heavy metals,and PAHs were detected in soil samples collected at 2–6 m below the ground surface at different sampling locations in a steel-making *** total concentrations of PFASs varied from 6.55 to 19.79 ng g^(-1),with perfluorooctane sulfonate(PFOS),perfluorobutane sulfonate,and 6:2 chlorinated polyfluorinated ether sulfonate(alternative of PFOS)being the predominant *** concentrations of arsenic,cadmium,and lead were detected in the ranges of 4.40–1270.00,0.01–8.67,and 18.00–647.00 mg kg^(-1),respectively,and the concentration of total PAHs was detected in the range of 1.02–131.60 mg kg^(-1).The long-term exposure to mixed contaminants of PFASs,heavy metals,and PAHs led to lower richness and diversity of microbial communities in *** soil bacterial communities were mainly composed of Pseudomonas,norank_p_GAL15,Leptothrix,norank_o_Rokubacteriales,and *** between soil environmental factors and microbial communities indicated that cation exchange capacity and total phosphorus were two key factors in shaping the composition of native microbial ***,Arthrobacter,Leptothrix,and Sphingobium were found to be significantly positively correlated with PFAS concentrations,indicating that these genera could tolerate the stress exerted by PFASs,along with the stress imposed due to the presence of heavy metals or/and PAHs.

关键词： arsenic cation exchange capacity mixed contaminant native microbial community perfuorooctane sulfonate total phosphorus

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Primary Cutaneous Gamma Delta T Cell Lymphoma: A Clinicopathological Analysis

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Journal of Biosciences and Medicines 2019年第5期7卷 22-26页

作者： li tang Yu li Department of Pathophysiology Chongqing Medical University Chongqing China Department of Pathology Institute of Neuroscience Chongqing Medical University Chongqing China

Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very uncommon and extremely aggressive tumor, and is described in the newly re-vised World health organization for research and treatment of cancer classification of cutaneous lymphomas. A 43-year-old male patient presented with a 4 months history of cutaneous lesion over upper lip, without plaque and any constitutional symptom. Histopathological examination of skin biopsy revealed infiltration of atypical lymphocytes with hyperchromatic irregular nuclei. Immunophenotyping pattern of skin biopsy was compatible with PCGD-TLC. It is a highly aggressive tumor resistant to chemotherapy, immunotherapy, and radiation therapy. The GDTCL is characterized by a worse prognosis with a median survival of 15 months. Early diagnosis is essential and aggressive therapy is necessary.

关键词： Cutaneous Gamma-Delta T-Cell Lymphoma Hematoxylin and Eosin Immunohistochemistry

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Exploring an eco-friendly approach to improve soil tensile behavior and cracking resistance

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第10期16卷 4272-4284页

作者： lin li Chao-Sheng tang Jin-Jian Xu Yao Wei Zhi-Hao Dong Bo liu Xi-Ying Zhang Bin Shi School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Civil and Environmental Engineering Nanyang Technological University639798Singapore Qinghai Provincial Key Laboratory of Geology and Environment of Salt Lake Qinghai Institute of Salt LakesChinese Academy of SciencesXining810008China

Soil tensile strength is a critical parameter governing the initiation and propagation of tensile *** study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey *** validate the feasibility and efficacy of the proposed approach,direct tensile tests were employed to determine the tensile strength of the compacted soil with different W-OH treatment concentrations and water *** tests were also performed to evaluate the effectiveness of W-OH treatment in enhancing soil tensile cracking *** this period,the effects of W-OH treatment concentration and water content on tensile properties,soil suction and microstructure were *** tensile tests reveal that W-OH treatment has a significant impact on the tensile strength and failure mode of the soil,which not only effectively enhances the tensile strength and failure displacement,but also changes the brittle failure behavior into a more ductile quasi-brittle failure *** suction measurements and mercury intrusion porosimetry(MIP)tests show that W-OH treatment can slightly reduce soil suction by affecting skeleton structure and increasing *** with the microstructural analysis,it becomes evident that the significant improvement in soil tensile behavior through W-OH treatment is mainly attributed to the W-OH gel's ability to provide additional binding force for bridging and encapsulating the soil ***,desiccation tests demonstrate that W-OH treatment can significantly reduce or even inhibit the formation of soil tensile *** the increase of W-OH treatment concentration,the surface crack ratio and total crack length are significantly *** study enhances a fundamental understanding of eco-polymer impacts on soil mechanical properties and provides valuable insight into their potential application for improving soil crack resistance.

关键词： Clayey soil Tensile strength Eco-friendly approach Direct tensile test Desiccation cracking Crack resistance

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Cav3.2 channel regulates cerebral ischemia/reperfusion injury:a promising target for intervention

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Neural Regeneration Research 2024年第11期19卷 2480-2487页

作者： Feibiao Dai Chengyun Hu Xue li Zhetao Zhang Hongtao Wang Wanjun Zhou Jiawu Wang Qingtian Geng Yongfei Dong Chaoliang tang Graduate School Wannan Medical CollegeWuhuAnhui ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Core Facility Center for Medical Sciences The First Affiliated Hospital of USTC(Anhui Provincial Hospital)HefeiAnhui ProvinceChina Department of Pharmacy The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion *** calcium channels are involved in cerebral ischemia/reperfusion ***3.2 channel is a main subtype of T-type calcium channels.T-type calcium channel blockers,such as pimozide and mibefradil,have been shown to prevent cerebral ischemia/reperfusion injury-induced brain ***,the role of Cav3.2 channels in cerebral ischemia/reperfusion injury remains ***,in vitro and in vivo models of cerebral ischemia/reperfusion injury were established using middle cerebral artery occlusion in mice and high glucose hypoxia/reoxygenation exposure in primary hippocampal *** results showed that Cav3.2 expression was significantly upregulated in injured hippocampal tissue and primary hippocampal *** further established a Cav3.2 gene-knockout mouse model of cerebral ischemia/reperfusion ***3.2 knockout markedly reduced infarct volume and brain water content,and alleviated neurological dysfunction after cerebral ischemia/reperfusion ***,Cav3.2 knockout attenuated cerebral ischemia/reperfusion injury-induced oxidative stress,inflammatory response,and neuronal *** the hippocampus of Cav3.2-knockout mice,calcineurin overexpression offset the beneficial effect of Cav3.2 knockout after cerebral ischemia/reperfusion *** findings suggest that the neuroprotective function of Cav3.2 knockout is mediated by calcineurin/nuclear factor of activated T cells 3 *** from this study suggest that Cav3.2 could be a promising target for treatment of cerebral ischemia/reperfusion injury.

关键词： calcineurin Cav3.2 channel cerebral ischemia/reperfusion hippocampus hypoxia/reoxygenation inflammatory response nuclear factor of activated T cells 3 oxidative stress primary hippocampal neurons stroke

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Performance Analysis for Multimedia Communication Systems with a Multilayer Queuing Network Model

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China Communications 2018年第8期15卷 67-76页

作者： Xuehua tang Zhongyuan Wang Xiaojun li Zhen Han Zheng He Youming Fu School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430079China Research Institute of Wuhan University in Shenzhen Shenzhen 518000China School of Computer Science Wuhan UniversityWuhan 430072China State Grid Economic and Technological Research Institute CO. LTDBeijing 102209China

Software performance evaluation in multimedia communication systems is typically formulated into a multi-layered client-server queuing network(MLCSQN) problem. However, the existing analytical methods to MLCSQN model cannot provide satisfactory solution in terms of accuracy, convergence and consideration of interlocking effects. To this end, this paper proposes a heuristic solving method for MLCSQN model to boost the performance prediction of distributed multimedia software systems. The core concept of this method is referred to as the basic model, which can be further decomposed into two sub-models: client sub-model and server sub-model. The client sub-model calculates think time for server sub-model, and the server sub-model calculates waiting time for client sub-model. Using a breadthfirst traversal from leaf nodes to the root node and vice versa, the basic model is then adapted to MLCSQN, with net sub-models iteratively resolved. Similarly, the interlocking problem is effectively addressed with the help of the basic model. This analytical solver enjoys advantages of fast convergence, independence on specific average value analysis(MVA) methods and eliminating interlocking *** experimental results on accuracy and computation efficiency verify its superiority over anchors.

关键词： multimedia communication system queuing network performance evaluation

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Self-oxygenated co-assembled biomimetic nanoplatform for enhanced photodynamic therapy in hypoxic tumor

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Chinese Chemical Letters 2023年第10期34卷 174-179页

作者： Bingchen Zhang ling lin Jizong Mao Weisheng Mo Zibo li Shengtao Wang Yan tang Chunhui Cui Yifen Wu Zhiqiang Yu Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Dongguan Institute of Clinical Cancer Research Dongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Department of General Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Affiliated Foshan Maternity&Child Healthcare Hospital Southern Medical University(Foshan Maternity&Child Healthcare Hospital)Foshan 528000China

Photodynamic therapy(PDT)has shown great application potential in cancer treatment and the important manifestation of PDT in the inhibition of tumors is the activation of immunogenic cell death(ICD)***,the strategy is limited in the innate hypoxic tumor *** are two key elements for the realization of enhanced PDT:specific cellular uptake and release of the photosensitizer in the tumor,and a sufficient amount of oxygen to ensure photodynamic ***,self-oxygenated biomimetic nanoparticles(CS@M NPs)co-assembled by photosensitizer prodrug(Ce6-S-S-LA)and squalene(SQ)were *** the treatment of triple negative breast cancer(TNBC),the oxygen carried by SQ can be converted to reactive oxygen species(ROS).Meanwhile,glutathione(GSH)consumption during transformation from Ce6-S-S-LA to chlorin e6(Ce6)avoided the depletion of *** co-assembled(CS NPs)were encapsulated by homologous tumor cell membrane to improve the tumor *** results showed that the ICD effect of CS@M NPs was confirmed by the significant release of calreticulin(CRT)and high mobility group protein B1(HMGB1),and it significantly activated the immune system by inhibiting the hypoxia inducible factor-1alpha(HIF-1α)-CD39-CD73-adenosine a2a receptor(A2AR)pathway,which not only promoted the maturation of dendritic cells(DC)and the presentation of tumor specific antigens,but also induced effective immune infiltration of ***,the integrated nanoplatform implements the concept of multiple advantages of tumor targeting,reactive drug release,and synergistic photodynamic therapy-immunotherapy,which can achieve nearly 90%tumor suppression rate in orthotopic TNBC models.

关键词： Photodynamic therapy Biomimetic nanoplatform Self-oxygenated co-assembly nanoparticles Immunogenic cell death HIF-1α-CD39-CD73-A2AR pathway

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