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Oncosis in human esophageal squamous cell carcinoma and its relationship with apoptosis and microvessel density

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Chinese Medical Journal 2007年第22期120卷 1999-2001页

作者： ZHAO Gao-feng SENG Jing-jing ZHAO Song HU Wei li Ang li Xiang-nan qi Yu Department of Thoracic Surgery First Affiliated Hospital Zhengzhou University Zhengzhou 450052 China

Background Previous studies have shown that oncosis in malignant tumors might be related to cellular energy supply. The aim of this study was to detect oncosis in human esophageal squamous cell carcinoma （ESCC）, and to investigate its relationship with apoptosis and microvessel density （MVD）. Methods ESCC specimens were obtained from 30 patients with ESCC after surgery. Transmission electron microscopy TUNEL, and immunohistochemistry were used to detect oncosis, apoptosis, and MVD. The relation of oncosis to apoptosis and MVD was analyzed by ANOVA, t test, and q test using SPSS 10.0. Results Transmission electron microscopy revealed both oncosis and apoptosis in the ECSS tissues. About 10% of the TUNEL-positive cells, which were considered apoptotic cells, showed the characteristics of oncosis. In the areas, where oncotic cells accumulated, apoptotic cells were rare; contrarily, where apoptotic cells gathered, oncotic cells were sparse. Compared with the tissues with a high MVD, the number of oncotic cells was increased and that of apoptotic cells was decreased in the tissues with a low MVD. Conclusions Cellular oncosis can be detected in human ESCC tissues. The distribution of oncotic cells presents a close relationship with cellular apoptosis and MVD. Oncosis might be induced by poor blood supply.

关键词： oncosis esophageal carcinoma apoptosis microvessel density

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基于FARIMA的ARP欺骗入侵检测

计算机工程 2011年第2期37卷 139-140,142页

作者：李启南兰州交通大学电子与信息工程学院兰州730070

针对ARP网络流量具有自相似性,ARP欺骗会导致ARP网络流量局部突发的特征,在进行理论分析的基础上,提出一种ARP欺骗入侵检测方法。采用适合描述自相似性的FARIMA准确预测ARP网络流量,在线实时计算每个周期实测值和预测值的差值,比较差值... 详细信息

针对ARP网络流量具有自相似性,ARP欺骗会导致ARP网络流量局部突发的特征,在进行理论分析的基础上,提出一种ARP欺骗入侵检测方法。采用适合描述自相似性的FARIMA准确预测ARP网络流量,在线实时计算每个周期实测值和预测值的差值,比较差值变化率快速准确实现ARP欺骗入侵检测。运行结果证明FARIMA具有先进性,该方法可有效提高ARP欺骗实时入侵检测的检测率,实现追踪ARP欺骗攻击源主机。

关键词： ARP欺骗分形自回归滑动平均混合模型入侵检测网络安全自相似

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从编目途径提高西文文献的利用率

图书馆论坛 2005年第1期25卷 159-160,200页

作者：李祁平暨南大学图书馆广东广州510630

文献编目的主要目的之一是为了提供检索。提高文献的查全率或查准率, 一是基于文献著录时检索点的确定和标引; 二是基于文献著录时提供的增值服务。重视西文编目过程中每个检索点的确定和标引, 以及提供编目增值服务, 是提高西文编目效... 详细信息

文献编目的主要目的之一是为了提供检索。提高文献的查全率或查准率, 一是基于文献著录时检索点的确定和标引; 二是基于文献著录时提供的增值服务。重视西文编目过程中每个检索点的确定和标引, 以及提供编目增值服务, 是提高西文编目效用, 进而提高西文利用率的重要途径。

关键词：西文编目检索点文献著录标引高文查准率查全率增值服务效用途径

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu qi li Ruihua li qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

基于航空铸造钛合金Ti-6Al-4V高速铣削参数的表面质量及切削效率优化

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表面技术 2022年第2期51卷 331-337,346页

作者：王慧李南奇赵国超周国强辽宁工程技术大学机械工程学院辽宁阜新123000 佰斯特机械制造有限公司辽宁阜新123000

目的研究高速铣削参数对航空铸造钛合金Ti-6Al-4V表面质量的影响规律及交互作用,并基于高速铣削参数对表面质量和材料去除率进行优化。方法采用Box-Behnken设计和二次回归正交实验法,建立高速铣削参数与表面粗糙度的显著不失拟回归模型... 详细信息

目的研究高速铣削参数对航空铸造钛合金Ti-6Al-4V表面质量的影响规律及交互作用,并基于高速铣削参数对表面质量和材料去除率进行优化。方法采用Box-Behnken设计和二次回归正交实验法,建立高速铣削参数与表面粗糙度的显著不失拟回归模型,获得铣削参数影响表面粗糙度的显著性差异,挖掘高速铣削参数交互作用与表面粗糙度的关系;基于表面粗糙度回归模型及材料去除率,采用遗传算法(GA),对高速铣削参数进行多目标优化。结果铣削参数影响航空铸造钛合金Ti-6Al-4V试件表面粗糙度的显著性顺序为:切削深度>每齿进给量>切削宽度>主轴转速,其中切削宽度和主轴转速、每齿进给量和主轴转速的交互作用较为明显。利用遗传算法对铣削参数优化后,Ti-6Al-4V表面粗糙度较优化前提高44%,材料去除率提高70%,遗传算法优化后的试件表面粗糙度显著降低,表面刀路行距减小,纹理平均高度降低。结论由实验验证可知,通过响应曲面建立表面粗糙度显著不失拟回归模型具有较高的预测精度,基于遗传算法优化获得的铣削参数可有效提高表面质量和切削效率,对保证航空铸造钛合金Ti-6Al-4V表面质量具有较好的指导意义。

关键词：铸造钛合金表面粗糙度响应曲面交互作用参数优化铣削

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Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

GeO分子激发态的电子结构和跃迁性质的组态相互作用方法研究

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物理学报 2015年第12期64卷 120-128页

作者：刘晓军苗凤娟李瑞张存华李奇楠闫冰齐齐哈尔大学理学院齐齐哈尔161006 吉林大学吉林省应用原子与分子光谱重点实验室长春130012 齐齐哈尔大学通信与电子工程学院齐齐哈尔161006 吉林大学原子与分子物理研究所长春130012

应用多参考组态相互作用方法计算了GeO分子的第一解离极限(Ge(3Pg)+O(3Pg))对应的18个-S电子态的电子结构.计算中纳入了Ge原子的3d轨道电子的内壳层-价壳层电子关联效应、标量相对论效应和Davidson修正.基于计算的电子态的电子结构,通... 详细信息

应用多参考组态相互作用方法计算了GeO分子的第一解离极限(Ge(3Pg)+O(3Pg))对应的18个-S电子态的电子结构.计算中纳入了Ge原子的3d轨道电子的内壳层-价壳层电子关联效应、标量相对论效应和Davidson修正.基于计算的电子态的电子结构,通过求解径向Schrdinger方程获得了束缚电子态的光谱常数Re,Te,ωe,ωeχe,B e,理论计算给出的这些电子态的光谱常数与之前的实验结果符合得很好.计算了电子态的电偶极矩随核间距的变化,分析了电子态的组态成分的变化对电偶极矩的影响.计算的势能曲线表明,激发态A1∏,11,D1Σ,a3∏,a′3Σ+,d3△和e3Σ的绝热激发能密集地分布于26000—37000 cm 1范围内,这些密集分布的电子态之间的相互作用对振动波函数有明显扰动作用.借助于激发态之间的自旋-轨道耦合矩阵元,阐明了邻近的激发态对A1和a3的扰动作用.基于计算的A1∏—X1Σ+和A′1Σ+—X1Σ+跃迁的电偶极跃迁矩和Franck-Condon因子,给出了A1和A′1Σ+态的最低的六个振动能级的辐射寿命.

关键词： GeO 多参考组态相互作用方法激发态光谱常数

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二元主体结构的AIGC著作权归属研究

河南科技 2023年第18期42卷 117-122页

作者：李启南兰州交通大学电子与信息工程学院甘肃兰州730070

【目的】解决AIGC著作权归属问题,能够起到明晰权责、定纷止争的作用,促进AIGC发展。【方法】采用人工智能创作过程分析方法。【结果】应用投资者、创作者二元主体结构划分了AIGC著作权归属,并进行了AIGC著作权保护理论探索。【结论】... 详细信息

【目的】解决AIGC著作权归属问题,能够起到明晰权责、定纷止争的作用,促进AIGC发展。【方法】采用人工智能创作过程分析方法。【结果】应用投资者、创作者二元主体结构划分了AIGC著作权归属,并进行了AIGC著作权保护理论探索。【结论】投资者、算法所有者、算法使用者对AIGC创作无直接贡献或贡献微小,赋予其邻接权以鼓励其投资、生成、传播AIGC;算法设计者直接决定AIGC创作质量,赋予其署名权以鼓励其发展AIGC创作技术,提高AIGC质量;数据库开发者根据算法设计者要求付出劳动获得邻接权,鼓励其积极参与创作。

关键词：著作权归属 AIGC 著作权二元主体结构邻接权

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基于双重零水印的数据库版权保护

计算机工程 2012年第8期38卷 107-110页

作者：李启南李娇武让兰州交通大学电子与信息工程学院兰州730070 北京交通大学计算机与信息技术学院北京100044

数据库零水印具有二义性,可能引起数据库的版权纠纷。为此,提出一种数据库版权图像零水印算法。以零宽度不可见字符作为水印符号,将版权图像嵌入宿主数据库,构造一重数据库零水印,同时使用字符型数据Unicode编码提取二重数据库零水印。... 详细信息

数据库零水印具有二义性,可能引起数据库的版权纠纷。为此,提出一种数据库版权图像零水印算法。以零宽度不可见字符作为水印符号,将版权图像嵌入宿主数据库,构造一重数据库零水印,同时使用字符型数据Unicode编码提取二重数据库零水印。实验结果表明,该算法可以提高数据库版权保护能力。

关键词：数据库零水印零宽度不可见字符数据库版权保护汉明码信息隐藏