检索结果-南通市图书馆

间歇式发射对微泡超声空化损伤小血管的增强作用

在线全文

学校读者我要写书评

暂无评论

临床超声医学杂志 2007年第10期9卷 577-580页

作者：李佩倞左松刘政李秋颖王雅婕谭开彬高云华第三军医大学新桥医院超声科重庆400037

目的探讨不同的超声发射方式在微泡超声损伤肠系膜小血管中的效应。方法32只新西兰大白兔随机分为单纯微泡组、单纯超声辐照组、超声连续辐照微泡组和超声间歇辐照微泡组进行实验。静脉注射脂氟显微泡0.1ml/kg,用峰值声压2.6MPa的低占... 详细信息

目的探讨不同的超声发射方式在微泡超声损伤肠系膜小血管中的效应。方法32只新西兰大白兔随机分为单纯微泡组、单纯超声辐照组、超声连续辐照微泡组和超声间歇辐照微泡组进行实验。静脉注射脂氟显微泡0.1ml/kg,用峰值声压2.6MPa的低占空比治疗超声照射,照射后肉眼观察照射区域肠系膜小动静脉血管损伤情况,取辐照区小血管做病理检查。结果单纯微泡组和单纯超声辐照组照射区小血管未发现任何生物学效应,而由微泡超声辐照的两组均出现了小血管破裂出血、血栓形成等生物学效应。肉眼观察超声间歇辐照微泡组形成的血肿大于超声连续辐照微泡组;病理学检查表明超声间歇辐照微泡组血管内皮细胞损伤,基底膜断裂以及血栓栓塞情况均高于超声连续辐照微泡组。且超声连续辐照微泡组形成的血管损伤情况不稳定。间歇辐照组损伤面积显著高于连续辐照组(P<0.01)。结论在适宜参数条件下,微泡超声空化可引起肠系膜小血管壁破裂出血、形成血栓及栓塞血管;微泡再灌注增强了血管的损伤。

关键词：微泡空化效应肠系膜小血管

在线全文

学校读者我要写书评

暂无评论

载紫杉醇脂质微泡的改良制备研究

临床超声医学杂志 2008年第5期10卷 292-295页

作者：朱梅刘政张萍付赤学谭开彬李佩倞高云华昆明医学院第一附属医院超声科昆明市650032 第三军医大学新桥医院超声科第三军医大学西南医院超声科

目的探讨加入三醋酸甘油酯改良制备载紫杉醇脂质微泡的可行性,及其对载药微泡质量、载药量、包封率的影响。方法采用冷冻干燥法制备携带紫杉醇的脂质微泡,分别于制备过程中加入或不加入三醋酸甘油酯,测定载药微泡的包封率、载药量、粒... 详细信息

目的探讨加入三醋酸甘油酯改良制备载紫杉醇脂质微泡的可行性,及其对载药微泡质量、载药量、包封率的影响。方法采用冷冻干燥法制备携带紫杉醇的脂质微泡,分别于制备过程中加入或不加入三醋酸甘油酯,测定载药微泡的包封率、载药量、粒径大小、分布和Zeta电位、pH值。结果改良法(加入三醋酸甘油酯)制备的载紫杉醇脂质微泡与常规冻干法制备的载药微泡相比较,微泡粒径显著减小,二者的平均粒径分别是(1.1±0.4)μm和(2.8±0.4)μm,P<0.01;其表面电位显著增高(19.1±0.3)mV和(-5.9±0.2)mV,P<0.01;包封率和载药量显著增高,包封率分别为(95.0±1.2)%和(36.1±4.7)%,载药量为(5.60±0.10)%和(0.50±0.04)%,P<0.01。结论制备过程中加入三醋酸甘油酯可显著提高载药微泡的包封率和载药量。

关键词：紫杉醇脂质微泡三醋酸甘油酯

Electroacupuncture of Neiguan(PC 6) inhibits enhanced voltage-gated sodium currents in ischemic ventricular myocytes

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2014年第6期34卷 710-715页

作者： Baoqiang Dong Chunri li Xiaoqing Zhang Shudong Wang Zhedong Cheng peijing Rong College of Acumox and Tuina Liaoning University of Traditional Chinese Medicine Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences

OBJECTIVE: To examine the effect of electroacupuncture(EA) at bilateral Neiguan(PC 6) on voltage-gated Na+currents(INa) and channels(Nav) in ischemic ventricular ***: EA serum was prepared from six male adult Sprague-Dawley rats that had received EA at bilateral Neiguan(PC 6). Eighteen ventricular myocytes were prepared from six SD rats using an enzymolysis approach. Myocardial ischemia was mimicked by perfusion of ischemic solution. Whole-cell patch-clamping was used to record three currents evoked from isolated cells. The first current was the control, and recorded in absence of ischemic solution current. The second was the ischemic current,and recorded after perfusion of ischemic solution for 5 min, while the EA current was last, and recorded after perfusion of EA serum for 5 min. Navkinetic curves were fitted using related ***: Compared with those in controls, in the presence of ischemic solution, peak amplitudes of INasignificantly increased from ﹣40 m V to +30 m V,and half-maximal inactivation potentials of Navincreased significantly, while half-maximal activation potentials, slope factors and the recovery time from inactivation to activation of Navwere unchanged. Compared with those in the ischemic solution, in the presence of EA serum, peak ischemic current amplitudes significantly reduced from ﹣40m V to + 40 m V, and half-maximal inactivation potentials were restored, while half-maximal activation potentials, slope factors and the recovery time from inactivation to activation of Navwere ***: EA at bilateral Neiguan(PC 6) can reduce enhanced INavia restoration of delayed Navinactivation in ischemic ventricular myocytes.

关键词： Electroacupuncture Point PC 6 (Nei-guan) Myocardial Ischemia Voltage-gated SodiumCurrent Voltage-gated Sodium Channel

CO_(2)methanation boosted by support-size-dependent strong metal-support interaction and B-O-Ti component

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第2期9卷 321-332页

作者： Shaoyu Yuan Yushan Yang Zhangyi Xiong peijing Guo Sufang Sun Zejiang li Jianlong Du Yongjun Gao College of Chemistry and Environmental Science Hebei UniversityNo.180Wusidong RoadBaoding071002HebeiChina

Strong metal-support interaction(SMSI)has a great impact on the activity and selectivity of heterogeneous catalysts,which was usually adjusted by changing reduction temperature or processing catalyst in different ***,few researches concentrate on modulating SMSI through regulating the structure of the ***,we show how changing the surface environment of the anatase TiO_(2)(B–TiO_(2))can be used to modulate the *** moderate TiOx overlayer makes the Ni metal highly dispersed on the high specific surface area of support,resulting in a substantially enhanced CO_(2)methanation ***,a novel phenomenon was observed that boron dopants promote the for-mation of the B–O–Ti interface site,enhancing the catalytic performance of CO_(2)*** calculations confirm that the B–O–Ti structure facilitates the activation of CO_(2)and further hydrogenation to methane.

关键词： CO_(2)Methanation B-doped TiO_(2) SMSI Size-dependent

价值工程在高校后勤基建多项目投资评估中的应用

在线全文

学校读者我要写书评

暂无评论

价值工程 2010年第17期29卷 63-64页

作者：王晓红李培景毕忠臣刘丽平姚新宇中国农业大学后勤基建处北京100083

近年来随着国家教育投入加大,高等院校办学条件不断提高,高校后勤基建可做建设项目越来越多,怎样科学选择项目、使资金发挥最佳效益显得尤为重要。为更好地控制投资、加强管理,我们提出把价值工程相关理论应用到高校后勤基建管理的多项... 详细信息

近年来随着国家教育投入加大,高等院校办学条件不断提高,高校后勤基建可做建设项目越来越多,怎样科学选择项目、使资金发挥最佳效益显得尤为重要。为更好地控制投资、加强管理,我们提出把价值工程相关理论应用到高校后勤基建管理的多项目投资评估中,举实例说明其运用。

关键词：价值工程多项目投资评估应用

两种缩氨基硫脲衍生物的合成及其生物活性研究

在线全文

学校读者我要写书评

暂无评论

广东化工 2022年第2期49卷 26-28页

作者：曾福燃欧俊言李培静庄映芬游遨冯安生广东轻工职业技术学院生态环境技术学院广东广州510300

以4-羟基苯甲醛为起始化合物,通过酯化反应在苯甲醛的羟基位置引入两种不同的酯基,然后在化合物的醛基位置引入氨基硫脲基团,合成2种新型缩氨基硫脲衍生物。所有化合物均通过核磁共振氢谱、碳谱、质谱等进行表征。分别测试这类化合物对... 详细信息

以4-羟基苯甲醛为起始化合物,通过酯化反应在苯甲醛的羟基位置引入两种不同的酯基,然后在化合物的醛基位置引入氨基硫脲基团,合成2种新型缩氨基硫脲衍生物。所有化合物均通过核磁共振氢谱、碳谱、质谱等进行表征。分别测试这类化合物对酪氨酸酶的抑制活性,结果表明在化合物中引入缩氨基硫脲集团之后,2种化合物对蘑菇酪氨酸酶均表现出良好的抑制效果,其中活性最好的化合物为C1,其对酪氨酸酶的IC;值达到0.8μM,动力学研究表明这类化合物属于竞争型抑制剂。

关键词：酪氨酸酶抑制剂缩胺基硫脲衍生物合成动力学研究

Effect of PEG Addition on the Behavior of Aluminum Sol,Dry Gel,and Film

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2021年第6期36卷 825-829页

作者： TIAN peijing li Man YUAN Jian ZHENG Weihong WANG Jing School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Shahe Research Institute of Glass Technology Xingtai 054100China State Key Laboratory of Silicate Materials for Architectures Wuhan 430070China

Aluminum sol,dry gel,and film were prepared by sol-gel and a dipping-withdrawing *** effect of polyethylene glycol(PEG)on the behavior of aluminum sol,gel,and film was investigated by DLS,rotary viscometer,XRD,IR,EPMA,and light microscope,*** solid gels drying at room temperature was identified as amorphous phase,and the addition of PEG nearly has no effect on the structure of aluminum dry *** is indicated that the sol viscosity decreases with the PEG content increasing,while the micelle size in sol decreases first then *** uniformity and attached particles of the film are improved to a certain extent after PEG *** to the analytic results,we demonstrate that the improvement is caused by low viscosity and small micelle size of sol resulting from the PEG addition.

关键词： PEG alumina sol-gel film dipping-withdrawing

Transcutaneous auricular vague nerve stimulation improved brain connection activity on patients of disorders of consciousness: a pilot study

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2022年第3期42卷 463-471页

作者： WANG Yifei YANG Yi WANG Yu ZHANG Jinling ZHAI Weihang li Shaoyuan WU Mozheng HE Jianghong RONG peijing Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical University100700BeijingChina

OBJECTIVE:To evaluate the clinical effect of transcutaneous auricular vagus nerve nerve stimulation(ta VNS)on disorders of consciousness(DOC)patients with Coma Recovery Scale-Revised(CRS-R)and cerebral cortex activity by electroencephalogram(EEG)***:Randomized controlled methods were used to evaluate the clinical effect of ta VNS on patients with *** patients with initial CRS-R of 6-10 were randomly divided into the treatment group of ta VNS and control group of transcutaneous non-auricular vague nerve stimulation(tn VNS).According to clinical diagnosis,the treatment group was divided into vegetative state(VS)group and minimally conscious state(MCS)***:The energy of delta and beta bands is positively correlated with the brain activity of *** VNS has different regulatory effects on patients with different conscious *** ta VNS group,the energy of delta band in local brain regions changed *** changes in brain connection activity were limited to local brain *** in patients with MCS in the ta VNS group,delta and beta band energy significantly changed in multiple brain regions and crossbrain connection activity also changed ***:These findings suggest that ta VNS may be a related extra method for arousing patients’awakening by improving brain connection *** the effect is remarkable in MCS patients.

关键词： consciousness disorders electroencephalography treatment outcome transcutaneous auricular vagus nerve stimulation brain connection activity

经胸超声心动图诊断左冠状动脉异常起源于肺动脉的初步研究

在线全文

学校读者我要写书评

暂无评论

临床超声医学杂志 2021年第10期23卷 751-755页

作者：欧阳娜李晓瑜李佩倞左浩饶荣生高云华夏红梅陆军军医大学第二附属医院超声科重庆市400038

目的总结左冠状动脉异常起源于肺动脉(ALCAPA)的经胸超声心动图(TTE)特征及诊断思路。方法回顾性分析我院经手术证实的8例ALCAPA患者的临床及影像学资料,总结其TTE特征。结果8例ALCAPA患者左室收缩功能均正常,其中婴儿型1例,早期出现肺... 详细信息

目的总结左冠状动脉异常起源于肺动脉(ALCAPA)的经胸超声心动图(TTE)特征及诊断思路。方法回顾性分析我院经手术证实的8例ALCAPA患者的临床及影像学资料,总结其TTE特征。结果8例ALCAPA患者左室收缩功能均正常,其中婴儿型1例,早期出现肺炎、ST改变和心影增大;成人型7例,多无明显症状,因发现心脏杂音就诊。8例患者首诊超声仅确诊1例,高年资医师复诊检查确诊6例,1例误诊冠状动脉-肺动脉瘘。ALCAPA的典型TTE特征为左室增大,右冠状动脉内径增宽,心肌侧支血流丰富,肺动脉内见来自左冠状动脉的异常血流信号。结论婴儿期发现心力衰竭、ST改变、心影增大,以及儿童或成人期发现冠状动脉侧支血流丰富、右冠状动脉内径增宽,均需警惕ALCAPA;仔细扫查左冠状动脉的起源和血流方向,有助于提高TTE对ALCAPA的早期诊断准确率。

关键词：超声心动描记术,经胸先天性心脏病左冠状动脉异常起源于肺动脉