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核电子学与探测技术 2010年第10期30卷 1303-1306,1314页

作者：李宝忠周辉何金良程引会马良李进玺吴伟西北核技术研究所西安710024 清华大学电机系电力系统国家重点实验室北京100084

介绍了一种非接触式脉冲电流注入装置,采用磁场耦合原理,对电缆、导线等电子部件进行脉冲电流注入,与被测试部件没有直接的电气物理接触,可以在电子设备正常工作时进行脉冲电流注入测试,实验表明,可以在4 m长两端接负载的导线上注入脉... 详细信息

介绍了一种非接触式脉冲电流注入装置,采用磁场耦合原理,对电缆、导线等电子部件进行脉冲电流注入,与被测试部件没有直接的电气物理接触,可以在电子设备正常工作时进行脉冲电流注入测试,实验表明,可以在4 m长两端接负载的导线上注入脉冲电流幅度高达150 A。

关键词：电磁脉冲感应电流脉冲电流注入

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外墙保温技术与能源节约

佳木斯大学学报（自然科学版） 2006年第2期24卷 317-318页

作者：李进喜哈铁建设集团五公司黑龙江佳木斯154002

外墙保温技术的迅猛发展的同时更要加强能源的合理利用,真正的做到节约能源、减少能耗、提高能源利用效率.

关键词：建筑节能外墙保温技术特点优点

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu li Mu xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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直流X射线模拟电缆X射线响应的可行性

原子能科学技术 2014年第3期48卷 500-505页

作者：马良周辉程引会吴伟李进玺赵墨郭景海西北核技术研究所强脉冲辐射环境模拟与效应国家重点实验室陕西西安710024

本文对电缆X射线辐照响应的机理和模拟方法进行了研究,分析了电缆直流和脉冲X射线辐照响应的异同。建立了带状电缆X射线辐照响应一维计算模型,该模型包含电缆屏蔽层和介质层间隙、介质层瞬态辐射感应电导率等计算模型,模拟了带状电缆直... 详细信息

本文对电缆X射线辐照响应的机理和模拟方法进行了研究,分析了电缆直流和脉冲X射线辐照响应的异同。建立了带状电缆X射线辐照响应一维计算模型,该模型包含电缆屏蔽层和介质层间隙、介质层瞬态辐射感应电导率等计算模型,模拟了带状电缆直流和脉冲X射线辐照电流响应。模拟结果表明,在X射线注量相同的条件下,电缆直流和方波脉冲X射线响应具有类似的波形特征及相同的间隙电压。因此,在该计算模型描述的电缆X射线辐照响应机制下,可利用直流X射线开展相应的脉冲X射线辐照响应机制模拟。

关键词：直流X射线电缆 X射线辐照响应脉冲X射线

骨科老年患者术后医院感染相关因素及预防策略分析

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中华医院感染学杂志 2018年第6期28卷 876-878,882页

作者：李坚张金喜李敏皋张海明曹娴华李锦锦杭州市大江东医院骨2科浙江杭州311225

目的探讨骨科老年患者术后医院感染相关因素及预防策略分析,以期为骨科术后医院感染预防提供依据。方法选取2013年1月-2015年12月医院骨科住院治疗老年骨折患者1377例,对所有病例资料进行查阅整理,分析患者术后医院感染率、感染部位及... 详细信息

目的探讨骨科老年患者术后医院感染相关因素及预防策略分析,以期为骨科术后医院感染预防提供依据。方法选取2013年1月-2015年12月医院骨科住院治疗老年骨折患者1377例,对所有病例资料进行查阅整理,分析患者术后医院感染率、感染部位及感染病原菌分布,分析影响因素,以制定预防策略。结果患者术后感染68例,感染率4.94%,以呼吸道感染率最高,占52.94%;送检标本128份,其中阳性标本96份,阳性率75.00%;阳性标本共分离病原菌106株,其中革兰阳性菌56株,革兰阴性菌50株;经logistis回归分析结果显示,年龄、手术时间、使用呼吸机、使用抗菌药物及住院时间与感染关系密切(P<0.05)。结论骨科老年患者术后医院感染部位主要为下呼吸道和切口,感染革兰阴性菌及阳性菌比例相当,术前术后给予饮食、环境调控,合理使用侵入性操作,术后合理使用抗菌药物可有效降低术后感染。

关键词：骨科老年术后医院感染预防策略

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基于MliR的数据流模型

计算机工程与科学 2024年第7期46卷 1151-1157页

作者：李金熹尹首一魏少军胡杨清华大学集成电路学院北京100084

在冯诺依曼架构下,指令集的使用让软硬件得以解耦并各自飞速发展。然而,近年来并行多核架构加速器的热潮为冯诺依曼架构下的顺序编程模型带来了挑战。在顺序编程模型下设计而成的指令集缺乏对并行硬件的抽象,因此仅仅使用指令集已不能... 详细信息

在冯诺依曼架构下,指令集的使用让软硬件得以解耦并各自飞速发展。然而,近年来并行多核架构加速器的热潮为冯诺依曼架构下的顺序编程模型带来了挑战。在顺序编程模型下设计而成的指令集缺乏对并行硬件的抽象,因此仅仅使用指令集已不能完全完成软硬件的解耦。人工智能软件编译栈领域需要新的编程模型,以对接顺序执行的编程平台和并行多核的硬件后端,并进一步探索并行硬件提供的优化机会。使用数据流模型作为编程模型,为顺序执行程序和并行硬件指令集的对接过程提供通用抽象,在指令集的基础上进一步实现软件前端与硬件后端的解耦。为确保项目的可复用性,将数据流模型以codelet dialect的形式实现在谷歌提出的编译器框架MliR上。MliR致力于整合碎片化的编译器生态,提高前后端对接流程的可复用性,在MliR上实现的数据流模型将进一步提升MliR系统的可复用性。

关键词：数据流模型端到端编译 MliR

Broadband low-frequency sound absorption of multifunctional composite metastructure

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Science China Technological Sciences 2025年

作者： Yilong YANG Shanshan liU Yan li Tong GAO Yongdong PAN Yong li Yabin jin School of Aerospace Engineering and Applied Mechanics Tongji University Institute of Acoustics School of Physics Science and Engineering Tongji University Shanghai Institute of Aircraft Mechanics and Control State International Joint Research Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical University Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science and Technology

In this study, we fabricated multifunctional metastructures from carbon fiber-reinforced plastic composites using additive manufacturing technology. These metastructures are characterized by their lightweight, load-bearing capacity, and broadband low-frequency sound absorption properties. The metastructure consists of 36 unit cells, and non-local coupling mechanism was considered for designing the sound absorption performance. We developed an acoustic impedance theory tailored for the metastructure, facilitating an analysis of thermal and viscous dissipation mechanisms. It is proven theoretically and experimentally that the proposed composite metastructure can achieve a noise reduction with an average sound absorption coefficient greater than 0.9 across frequencies in the rage of 330–1500 Hz. We also studied the metastructure’s quasi-static and cyclic compression performance, confirming its efficient absorption capabilities after cyclic compression. The proposed design and additive manufacturing method for composite metastructures provides a novel pathway for creating lightweight, multifunctional structures with diverse applications, such as aerospace engineering.

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Access在基层土地登记管理中的应用

山东国土资源 2009年第1期25卷 36-38页

作者：李金玺平度市国土资源局山东平度266700

针对基层土地登记管理信息化现状,利用Access数据库管理软件,开发了"土地登记管理系统",实现了土地登记发证、档案管理、宗地图管理自动化,信息检索自动化,提高了工作效率和工作质量。

关键词：土地登记管理 Access Auto CAD