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Microplastics in sediment of the Three Gorges Reservoir:abundance and characteristics under different environmental conditions

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Journal of Oceanology and limnology 2024年第1期42卷 101-112页

作者： Wang li Bo ZU Yiwei liU Juncheng GUO jiawen li College of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Chongqing Research Academy of Ecology and Environmental Sciences Chongqing 401147China

Freshwater microplastic pollution is an urgent issue of global concern,and research on the distribution in reservoirs is lacking.We investigated the microplastic pollution levels in wet sediments collected from the Three Gorges Reservoir,the largest reservoir of China.Results show that microplastics were ubiquitous in the sediments of the Three Gorges Reservoir,and their abundance ranged from 59 to 276 pp/kg(plastic particles per kg,dry weight).Economic development and total population were important factors affecting the spatial heterogeneity of microplastic abundance,and the contribution of large cities along the reservoir to microplastic pollution should be paid with more attention.Fibrous microplastics were the most abundant type of microplastic particles in reservoir sediments,whereas polystyrene,polypropylene,and polyamide were the main types of polymers.The apparent spatial heterogeneity in morphology and color of microplastics is attributed to different anthropogenic or landbased pollution sources.Moreover,the accumulation of microplastics near the inlet of tributaries reflects the role of potential contributors of tributaries.More importantly,multiple bisphenols(BPs)and heavy metals detected at the microplastic surfaces indicate that microplastics can act as carriers of these pollutants in the environment in the same way as sediments did,which may alter the environmental fate and toxicity of these pollutants.Therefore,we conclude that the Three Gorges Reservoir had been contaminated with microplastics,which posed a stress risk for organisms who ingest them along with their associated pollutants(BPs,heavy metals).

关键词： microplastics Three Gorges Reservoir sediment bisphenol heavy metal

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Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention

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Neural Regeneration Research 2024年第2期19卷 316-323页

作者： Yiyang Chen Wenxuan Tang Xinqi Huang Yumei An jiawen li Shengye Yuan Haiyan Shan Mingyang Zhang Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of Justice(Academy of Forensic Science)ShanghaiChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe sequelae.However,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke subtypes.Recent studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral hemorrhage.Mitophagy,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged mitochondria.Mitophagy markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral hemorrhage.This review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral hemorrhage.In conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

关键词： intracerebral hemorrhage mitochondrial dysfunction mitophagy neuroinflammation neuroprotection reactive oxygen species secondary brain injury therapeutic target

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The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： jiawen li Xinqi Huang Yumei An Xueshi Chen Yiyang Chen Mingyuan Xu Haiyan Shan Mingyang Zhang Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life activities.Currently,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance.Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses.Recently,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain homeostasis.Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae.This article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain diseases.Additionally,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

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High-performance liquid metal electromagnetic actuator fabricated by femtosecond laser

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International Journal of Extreme Manufacturing 2024年第2期6卷 511-521页

作者： Yiyu Chen Hao Wu Rui li Shaojun Jiang Shuneng Zhou Zehang Cui Yuan Tao Xinyuan Zheng Qianqian Zhang jiawen li Guoqiang li Dong Wu Jiaru Chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China Key Laboratory of Testing Technology for Manufacturing Process of Ministry of Education Southwest University of Science and TechnologyMianyang 621010People’s Republic of China Department of Mechanical Engineering The University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Small-scale electromagnetic soft actuators are characterized by a fast response and simplecontrol,holding prospects in the field of soft and miniaturized robotics.The use of liquid metal(LM)to replace a rigid conductor inside soft actuators can reduce the rigidity and enhance the actuation performance and robustness.Despite research efforts,challenges persist in the flexible fabrication of LM soft actuators and in the improvement of actuation performance.To address these challenges,we developed a fast and robust electromagnetic soft microplate actuator based on a laser-induced selective adhesion transfer method.Equipped with unprecedentedly thin LM circuit and customized low Young’s modulus silicone rubber(1.03 kPa),our actuator exhibits an excellent deformation angle(265.25?)and actuation bending angular velocity(284.66 rad·s^(-1)).Furthermore,multiple actuators have been combined to build an artificial gripper with a wide range of functionalities.Our actuator presents new possibilities for designing small-scaleartificial machines and supports advancements in ultrafast soft and miniaturized robotics.

关键词： soft actuators femtosecond laser liquid metal

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Effects of Varying Copper Content on the Microstructure and Mechanical Properties of FeCoNiCu_(x)

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Journal of Wuhan University of Technology(Materials Science) 2022年第5期37卷 986-991页

作者：杨颜如 ZHANG Yichen li jiawen 朱和国 College of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

Five sets of high entropy alloys(HEAs)FeCoNiCu_(x)(x=0.5,1.0,1.5,2.0,2.5)were produced by vacuum induction smelting.The effects of Cu content on the microstructure and mechanical properties of the alloys were interrogated by X-ray diffractometer(XRD),field scanning electron microscope(FESEM)and tensile mechanical test.The result shows that the HEAs form single FCC solid solution phase.With the increase of Cu content,the diffraction peak first deviated to the right and then shifted to the left.The alloys changed from equiaxed crystal structure to refined dendritic crystal structure,as Cu content increased.A large number of Cu atoms are isolated in the inter-crystalline region.The tensile mechanical tests show that with the increase of Cu content,the ultimate tensile strength first increased and then decreased.When x is 2.0,the ultimate tensile strength reaches a maximum of 473 MPa,the percent elongation is 43.0%,and the fracture presents ductile behaviour.

关键词： FeCoNiCu alloy copper content microstructure elemental segregation mechanical properties

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面向道路养护车辆的铝蜂窝式防撞缓冲垫防撞性能研究

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机械强度 2024年第3期46卷 595-601页

作者：刘波李佳文郑硕北京首发公路养护工程有限公司北京100000

为了降低错误行驶车辆对养护施工作业区造成的人员伤亡,提出了一种安装在道路养护车辆尾部的铝蜂窝式防撞缓冲垫。目前针对该类型防撞缓冲垫的研究较少,为此搭建了高精度防撞缓冲垫碰撞有限元模型,并利用数值仿真的方法,从吸能性能、可... 详细信息

为了降低错误行驶车辆对养护施工作业区造成的人员伤亡,提出了一种安装在道路养护车辆尾部的铝蜂窝式防撞缓冲垫。目前针对该类型防撞缓冲垫的研究较少,为此搭建了高精度防撞缓冲垫碰撞有限元模型,并利用数值仿真的方法,从吸能性能、可导向性能和阻挡性能三方面对铝蜂窝式防撞缓冲垫的防撞性能展开研究。研究结果表明,铝蜂窝式防撞缓冲垫可有效降低碰撞过程中司乘人员受到的冲击力和加速度。另外,合理的铝蜂窝强度对提高防撞性能至关重要。

关键词：道路养护车防撞缓冲垫数值模拟防撞性能

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基于黏性等效的船舶顶浪运动降阶预报方法

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华中科技大学学报（自然科学版） 2024年第4期52卷 37-41页

作者：姜宜辰董宇张贺李嘉文大连理工大学船舶工程学院辽宁大连116024 大连海事大学航海学院辽宁大连116026

针对势流预报方法速度快但精度受黏性影响显著、黏流预报方法精度高但计算效率较低的问题,提出一种基于黏性等效的耐波性预报降阶预报方法.该方法首先基于一种强迫放大运动,快速获取船舶阻尼随运动幅度变化的特性;再根据黏性等效原则和... 详细信息

针对势流预报方法速度快但精度受黏性影响显著、黏流预报方法精度高但计算效率较低的问题,提出一种基于黏性等效的耐波性预报降阶预报方法.该方法首先基于一种强迫放大运动,快速获取船舶阻尼随运动幅度变化的特性;再根据黏性等效原则和船舶运动状态,对无黏耐波性预报模型的阻尼进行实时修正.为验证该方法的有效性,以DTMB 5415船模为研究对象,开展了顶浪环境下的水池模型试验.结果表明:该方法预报的纵摇运动响应误差低于6.2%,垂荡运动响应误差低于15.6%;在仿真时间方面,该方法预报效率比传统黏流模型高出10倍以上.

关键词：耐波性顶浪降阶模型黏性阻尼阻尼修正

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Effects of axial gap on aerodynamic force and response of shrouded and unshrouded blade

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Science China(Technological Sciences) 2017年第4期60卷 491-500页

作者： JIANG JinPeng li jiawen CAI GuoBiao WANG Jue School of Astronautics Beihang University System Engineering Division China Academy of Launch Vehicle Technology

Forced response analysis of a rocket engine turbine blade was conducted by a decoupled fluid-structure interaction procedure.Aerodynamic forces on the rotor blade were obtained using 3D unsteady flow simulations. The resulting aerodynamic forces were interpolated to the finite element(FE) model through surface effect elements prior to conducting forced response calculations.Effects of axial gap on aerodynamic forces were studied. In addition, influence of axial gap on the response of the shrouded blade was compared with that on the response of the unshrouded blade. Results demonstrated that as the axial gap increases,time-averaged pressure on the blade surface changes very little, while the pressure fluctuations decrease significantly. Pressure and aerodynamic forces on the blade surface display periodic variation, and the vane passing frequency component is dominant.Amplitudes of aerodynamic forces decrease with increasing axial gap. Restricted by the shroud, deformation and response of shrouded blade are much lower than those of the unshrouded blade. The response of unshrouded blade shows obvious beat vibration phenomenon, while the response of the shrouded blade does not have this characteristic because the shroud restrains multiple harmonics. Blade response in time domain was converted to frequency domain using fast Fourier transformation(FFT).Results revealed that the axial gap mainly affects the forced harmonic at the vane passing frequency, while the other two harmonics at natural frequency are hardly affected. Amplitudes of the unshrouded blade response decrease as the axial gap increases, while amplitudes of the shrouded blade response change very little in comparison.

关键词：涡轮叶片轴向间隙气动力半开式快速傅立叶变换带冠叶片谐波抑制压力变化

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史料的运用:以五四运动的史料为例

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历史教学（上半月） 2024年第5期 16-23页

作者：张汉林李嘉雯首都师范大学教师教育学院

史料运用的方式受制于其目标,而史料运用的目标又受制于史料观。按照史料观和目标导向的不同,史料的运用可分为把史料的信息等同于过去、把史料当作理解的对象、把史料当作问题的证据等三种方式。史料观与历史教育观的引入,让我们对史... 详细信息

史料运用的方式受制于其目标,而史料运用的目标又受制于史料观。按照史料观和目标导向的不同,史料的运用可分为把史料的信息等同于过去、把史料当作理解的对象、把史料当作问题的证据等三种方式。史料观与历史教育观的引入,让我们对史料运用的认识更为丰富与深刻。

关键词：史料理解证据

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福建方志所见王阳明行迹与年谱的对读--兼议方志中文学资料的纪实性与虚构性

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铜仁学院学报 2024年第3期26卷 9-17页

作者：李佳纹北京语言大学中华文化研究院北京海淀区100083

王阳明一生两次半入闽。他游历武夷、征战汀漳、驻军上杭、置县平和,不仅在福建进行社会治理和军事活动,还施行德政、传道讲学、兴办文教,用心学思想教化闽中文人,与闽地结下不解之缘。因此,福建地方志中就保存了大量王阳明在闽地的行... 详细信息

王阳明一生两次半入闽。他游历武夷、征战汀漳、驻军上杭、置县平和,不仅在福建进行社会治理和军事活动,还施行德政、传道讲学、兴办文教,用心学思想教化闽中文人,与闽地结下不解之缘。因此,福建地方志中就保存了大量王阳明在闽地的行迹、传记、诗文作品和后学信息。这些材料与《阳明先生年谱》《王阳明先生图谱》以及阳明后学的书写存在一定出入,尤其是关于王阳明在福建的第一次行迹的记载差异较大。对这些差异进行梳爬考证,一方面可以纠正和落实王阳明入闽的时间与路线,另一方面可以通过探知地方志在传人记事方面的特殊机制,揭示其中文学资料纪实与虚构并存的价值与不足。

关键词：王阳明福建地方志年谱

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