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Enhancement of effect of risperidone on cognitive function of schizophrenic mice by fluoxetine

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上海交通大学学报（医学版） 2015年第10期35卷 1436-1442页

作者： QIAO Ying ZHANG Lei HE Shen SHENG Jian-hua WANG Hui-fang li hua-fang Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China Basic MedicineFaculty of Shanghai Jiao Tong University Shanghai 200025 China

Objective To explore the molecular mechanism of enhancing the effect of risperidone on the cognitive function of schizophrenic mice by fluoxetine. Methods Schizophrenic mice were injected with M K-801 and drugs( fluoxetine and / or risperidone) were adm inistrated orally 30 min before the injection of M *** of the control group adm inistrated the same dose of norm al saline. The cognitive function, distance of activity, and stereotyped behavior of mice were observed. The expressions of key param eters of MEK / ERK pathway in hippocam pus were detected by Western blotting or real-time qPCR. The participation of MEK / ERK pathway in isolated hippocam palneuron injuries induced by M K-801 mediation was also analyzed. Results The mice of M K-801 group showed prolonged activity distance, increased stereotyped behavior scores, and cognitive im pairm ent. Expressions of pMEK/MEK, pERK/ERK1 /2, MMP2 /9, and TIMP1 /2 of the MK-801 group increased. The aforem entioned proteins of drug adm inistration groups decreased dram atically. For schizophrenic m ice, fluoxetine enhanced effects of risperidone in norm alizing abnorm al behaviors, affecting cognitive function, and unusual protein expressions( P lizing the activated MEK / ERK signaling pathway.

关键词： schizophrenia cognitive dysfunction MK-801 MEK/ERK pathway matrix metaUoproteinase conncxins

Mechanism of apoptosis of human osteosarcoma M-G63 induced by arsenic trioxide

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Journal of Central South University of Technology 2005年第Z1期12卷 317-321页

作者： XIAO Tao li Kang-hua fang Jian-zhen WANG Wan-chun li Gui-yuan Cancer Research Institute Xiangya School of MedicineCentral South University Changsha 410078 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics Xiangya Hospital Central South University Changsha 410008 China Department of Central Laboratory the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Cancer Research InstituteXiangya School of MedicineCentral South University Changsha 410078 China

Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investigate the inducing apoptosis and inhibitative of As2O3 on osteosarcoma MG-63 cells. In order to study mechanism of apoptosis in MG-63 cells treated with As2 O3, microarray was performed. The down-regulated gene was confirmed by RT-PCR, Northern-blotting. Results After treated with As2O3, hypodiploid peak before G0/G1 phase was observed in MG-63 cells through FCM analysis. Loss of microvilli, condensation and fragmentation of nuclear chromatin, condensation of cytoplasmic organelles, dilatation of the endoplasmic reticulum shrinkage of cells and alterations in cell membranes and apoptosis bodies which were observed in MG-63 cells treated with As2O3 by transmission electronmicroscope. The results of microarray show that As2 O3 induced MG-63 cell apoptosis involves down-regulation of IEX-1 and the down-regulated gene is confirmed by RT-PCR and *** The results show that As2 O3 selectively inhibits growth of the solid tumor MG-63 cells by triggering apoptosis and indicates MG-63 induced by As2O3 cell apoptosis may through the IEX-1 pathway.

关键词： arsenic trioxide osteosarcorna MG-63 apoptosis IEX-1

Growing Out of Participation

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Fudan Journal of the Humanities and Social Sciences 2012年第4期5卷 145-151页

作者： li hua-fang

After decades of economic growth, China currently plays a critical role in the world＇s political stage. China has achieved its economic success under an authoritarian system, which will be democratized in the future according to some optimistic predictions. It is, however, hard to predict China＇s future democratization. The development of civil society, especially the boom in non-governmental organizations （NGOs）, along with economic growth, can provide a clue to understanding the relationship between state and society, which is key to understanding democracy. Therefore, an immediate and necessary task is to better understand the relationship between state and society before making any prediction.

关键词：经济增长非政府组织民主化中国预测社会 NGO 体制

THE 1-DIMENSIONAL COMPOSITION INCOMMENSURATE STRUCTURE OF Ce_(1+ε)Fe_4B_4

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Science China Mathematics 1989年第8期32卷 962-970页

作者：田静华梁敬魁杨大宇李方华李龙 Institute of Physics Academia Sinica Beijing Department of Physics Ningxia University Yinchuan

In this article the crystal structure of a B-rich phase Ce_(1+ε)Fe_4B_4 in the ternary alloy system of Ce-Fe-B has been studied by means of X-ray powder diffraction as well as electron diffraction. It is found that the structure of this phase is a kind of the so-called 'chimeny-ladder structure' consisting of 1-dlmensional composition incommensurate structure which is seldom observed in common alloys. The structure of this compound is composed of two interpenetrating structures, one being the (Fe-B) substructure and the other Ce-substructure, and both possessing tetragonal symmetry with the same lattice parameter α, but without the lowest common multiple relation between c_(Fe-B) and c_(Ce) parameters. The lattice parameters of Ce_(1+ε) Fe_4B_4 are as follows: α=0.7068 nm, C_(Fe-B)=0.3902 nm, c_(Ce)=0.3440 nm at room temperature and α=0.7065 nm, c_(Fe-B)=0.3887 nm and c_(Ce)=0.3563 nm after quenching from 950℃. The space groups of the substructure of Fe-B and that of Ce are P4_2/ncm and I4/mmm respectively.

关键词： crystal structure Ce-Fe-B X-ray diffraction electron diffraction.

A New Bipolar Type Transistor Created Based on Interface Effects of Integrated All Perovskite Oxides

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Chinese Physics Letters 2012年第10期29卷 198-203页

作者： XIA Feng-Jin WU Hao FU Yue-Ju XU Bo YUAN Jie ZHU Bei-Yi QIU Xiang-Gang CAO li-Xin li Jun-Jie JIN Ai-Zi WANG Yu-Mei li fang-hua liU Bao-Ting XIE Zhong ZHAO Bai-Ru National Laboratory for Superconductivity Institute of Physics and Center for Condensed Matter PhysicsChinese Academy of SciencesBeijing 100190 School of Physics and Microelectronic Science Hunan UniversityChangsha 410082 School of Physics and Technology Wuhan UniversityWuhan 430072 College of Physics Science and Technology Hebei UniversityBaoding 071002 Department of Materials Science Wuhan University of Science and TechnologyWuhan 430081

Oxide transistor is the basic device to construct the oxide electronic circuit that is the backing to develop integrated oxide electronics with high efficiency and low power *** growing the perovskite oxide integrated layers and tailoring them to lead semiconducting functions at their interfaces,the development of oxide transistors may be able to *** realize a kind of p-i-n type integrated layers consisting of an n-type cuprate superconductor,p-type colossal magnetoresistance manganite,and a ferroelectric barrier(i).From this,bipolar transistors were fabricated at the back-to-back p-i-n junctions,for which the Schottky emission and p-n junction barriers,as well as the ferroelectric polarization,were integrated into the interfaces to control the transport properties;a preliminary but distinct current gain greater than 1.6 at input current of microampers order was *** results present a real possibility to date for developing bipolar all perovskite oxide transistors.

关键词： bipolar polarization ferroelectric

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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乳腺导管原位癌116例临床病理分析

中华肿瘤防治杂志 2011年第8期18卷 620-621,630页

作者：李华芳德州市第二人民医院病理科山东德州253000

为了探讨乳腺导管原位癌(DCIS)各亚型的临床病理特点及其与预后的关系,对116例乳腺DCIS进行回顾分析,按照2003年WHO乳腺肿瘤组织学分类法进行组织学分级、分型并行雌激素受体(ER)、孕激素受体(PR)、c-erbB-2基因蛋白及p53等免疫表型分... 详细信息

为了探讨乳腺导管原位癌(DCIS)各亚型的临床病理特点及其与预后的关系,对116例乳腺DCIS进行回顾分析,按照2003年WHO乳腺肿瘤组织学分类法进行组织学分级、分型并行雌激素受体(ER)、孕激素受体(PR)、c-erbB-2基因蛋白及p53等免疫表型分析。结果:116例DCIS中,低级别36例,ER、PR均呈阳性表达,c-erbB-2及p53均为阴性。中级别60例,ER、PRc、-erbB-2及p53阳性表达分别为36、48、14和16例。高级别20例,多表现为ER、PR表达缺失,而过度表达c-erbB-2和p53。从组织结构来分,实体型、筛状型、微乳头型、贴壁型及粉刺型分别为28、48、12、8及4例混合型。实体型和筛状型多为低、中级别DCIS,临床随访6年未见复发;微乳头型、贴壁型易沿导管内播散,病变范围较大,保留乳房手术切缘不易切除干净,应慎选保留乳房手术;粉刺型为高级别DCIS,管腔高度扩张,易发生浸润,也是术后复发的重要因素。初步研究结果提示,高与低级别DCIS相比较,c-erbB-2阳性表达率高,粉刺型DCIS与其他亚型相比较易发生复发或浸润。

关键词：乳腺肿瘤癌,原位病理学,临床

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测定微小晶体结构的电子晶体学图像处理技术

物理 2007年第4期36卷 266-271页

作者：李方华中国科学院物理研究所北京凝聚态物理国家实验室北京100080

介绍了2005年国家自然科学奖二等奖获奖项目“微小晶体结构测定的电子晶体学研究”.研究目的是建立一种借助高分辨电子显微像测定晶体结构的新方法.为此提出了高分辨电子显微学与衍射晶体学相结合的思想,在实现此思想的过程中,研究了像... 详细信息

介绍了2005年国家自然科学奖二等奖获奖项目“微小晶体结构测定的电子晶体学研究”.研究目的是建立一种借助高分辨电子显微像测定晶体结构的新方法.为此提出了高分辨电子显微学与衍射晶体学相结合的思想,在实现此思想的过程中,研究了像衬的规律,得出实用的像衬公式和理论,阐明了不同种类原子像衬与晶体厚度的关系,而且用理论指导实验,观察到晶体中锂原子的像衬.以此理论为依据,把衍射晶体学中的多种分析方法特包是直接法引入到高分辨电子显微学中,建立了一套全新的电子晶体学图像处理技术,开发了相应的可视化专用软件包,并应用于测定多个未知晶体结构.文中逐一介绍了研究工作全过程的关键问题和研究结果.

关键词：电子晶体学晶体结构电子衍射高分辨电子显微学图像处理像衬理论直接法最大熵

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维拉唑酮在临床的应用状况

中国临床药理学杂志 2014年第9期30卷 862-864页

作者：王丽华李华芳上海交通大学医学院附属精神卫生中心上海201108

维拉唑酮是一种双重机制的新型抗抑郁药,它结合了选择性5-羟色胺(5-HT)转运体再摄取抑制和5-HT1A受体部分激动的作用。2011年,美国食品和药品管理局(FDA)批准维拉唑酮用于治疗抑郁症。口服维拉唑酮40 mg·d-1与安慰剂相比有较好的抗抑... 详细信息

维拉唑酮是一种双重机制的新型抗抑郁药,它结合了选择性5-羟色胺(5-HT)转运体再摄取抑制和5-HT1A受体部分激动的作用。2011年,美国食品和药品管理局(FDA)批准维拉唑酮用于治疗抑郁症。口服维拉唑酮40 mg·d-1与安慰剂相比有较好的抗抑郁效果,其耐受性好、不良反应轻,尤其对性功能影响小甚至有改善作用。但尚无足够的证据证明维拉唑酮比现有的其他抗抑郁药物具有优势。

关键词：维拉唑酮抑郁症临床评价抗抑郁药选择性5-HT再摄取抑制药