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Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2565-2573页

作者： li-ming guo Zhi-Hui Jiang Hong-Zhen liu Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina

BACKGROUND Pediatric appendicitis is a common cause of abdominal pain in children and is recognized as a significant surgical emergency.A prompt and accurate diagnosis is essential to prevent complications such as perforation and *** To investigate the predictive value of the systemic immune-inflammation index(SII)combined with the pediatric appendicitis score(PAS)for the assessment of disease severity and surgical outcomes in children aged 5 years and older with *** Clinical data of 104 children diagnosed with acute appendicitis were *** participants were categorized into the acute appendicitis group and chronic appendicitis group based on disease presentation and further stratified into the good prognosis group and poor prognosis group based on *** SII and PAS were measured,and a joint model using the combined SII and PAS was constructed to predict disease severity and surgical *** Significant differences were observed in the SII and PAS parameters between the acute appendicitis group and chronic appendicitis *** analysis showed associations among the SII,PAS,and disease severity,with the combined SII and PAS model demonstrating significant predictive value for assessing disease severity[aera under the curve(AUC)=0.914]and predicting surgical outcomes(AUC=0.857)in children aged 5 years and older with *** The study findings support the potential of integrating the SII with the PAS for assessing disease severity and predicting surgical outcomes in pediatric appendicitis,indicating the clinical utility of the combined SII and PAS model in guiding clinical decision-making and optimizing surgical management strategies for pediatric patients with appendicitis.

关键词： Systemic immune-inflammation index Pediatric appendicitis score Disease severity Surgical outcomes Risk factor Logistic regression Receiver operating characteristic analysis

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Diagnostic significance of serum levels of serum amyloid A,procalcitonin,and high-mobility group box 1 in identifying necrotising enterocolitis in newborns

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2003-2011页

作者： li-ming guo Zhi-Hui Jiang Hong-Zhen liu Lei Zhang Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Qilu Hospital of Shandong University(Qingdao)Qingdao 260010Shandong ProvinceChina

BACKGROUND Necrotising enterocolitis(NEC)is a critical gastrointestinal emergency affecting premature and low-birth-weight *** amyloid A(SAA),procalcitonin(PCT),and high-mobility group box 1(HMGB1)have emerged as potential biomarkers for NEC due to their roles in inflammatory response,tissue damage,and immune *** To evaluate the diagnostic value of SAA,PCT,and HMGB1 in the context of NEC in *** The study retrospectively analysed the clinical data of 48 newborns diagnosed with NEC and 50 healthy newborns admitted to the ***,radiological,and laboratory findings,including serum SAA,PCT,and HMGB1 Levels,were collected,and specific detection methods were *** diagnostic value of the biomarkers was evaluated through statistical analysis,which was performed using chi-square test,t-test,correlation analysis,and receiver operating characteristic(ROC)*** The study demonstrated significantly elevated levels of serum SAA,PCT,and HMGB1 Levels in newborns diagnosed with NEC compared with healthy *** correlation analysis indicated strong positive correlations among serum SAA,PCT,and HMGB1 Levels and the presence of *** analysis revealed promising sensitivity and specificity for serum SAA,PCT,and HMGB1 Levels as potential diagnostic *** combined model of the three biomarkers demonstrating an extremely high area under the curve(0.908).CONCLUSION The diagnostic value of serum SAA,PCT,and HMGB1 Levels in NEC was *** biomarkers potentially improve the early detection,risk stratification,and clinical management of critical *** findings suggest that these biomarkers may aid in timely intervention and the enhancement of outcomes for neonates affected by NEC.

关键词： Serum amyloid A Procalcitonin High-mobility group box 1 Necrotising enterocolitis in newborns Serum biomarkers

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The First Reported Case of Co-Infection with Neisseria Meningitidis and Bordetella Pertussis in the Cerebrospinal Fluid Specimen of a Normal Four-Year-Old Child

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Biomedical and Environmental Sciences 2024年第4期37卷 432-435页

作者： XIA Xian li guo ming TANG Yi WANG Si Quan HE Fei JIANG Yong Zhong YANG Hong Mei JIANG Hong lin LYU Jing MAO ling Feng Hubei Key Laboratory of Edible Wild Plants Conservation&Utilization Hubei Normal UniversityHuangshi 430070HubeiChina Hubei Provincial Center for Disease Control and Prevention Wuhan 430079HubeiChina Joint Research Center for Molecular Diagnosis of Severe Infection in Children Binjiang Institute of Zhejiang UniversityHangzhou 310058ZhejiangChina

Pertussis is an acute and highly contagious respiratory disease caused by Bordetella pertussis(***),which occurs in people of all ages and is most dangerous for young children,especially *** introduction of whole-cell pertussis vaccines(wPVs)in the 1950s dramatically reduced the incidence of pertussis worldwide[1].However,over the past two decades,many studies have reported the resurgence of pertussis in different countries[2].Epidemiological surveillance in Hubei Province over the last 3 years revealed a clear increasing trend in the incidence of pertussis during the coronavirus disease 2019(COVID-19)epidemic.

关键词： Pertussis dangerous Hubei

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浅谈市政污水处理工程建设中存在的问题及解决措施

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建筑与装饰 2024年第5期 133-135页

作者：郭黎明陕西环保集团建筑工程有限公司陕西西安 710000

近些年,伴随着生态环境治理的高速发展,污水处理工程的数量和范畴也在不断增加.项目风险管理建设者既需要从整体的视角明确提出更为科学的改进措施,还要合理优化配置,防止对后续项目产生一定的影响.与此同时,管理者必须剖析以前工作上... 详细信息

近些年,伴随着生态环境治理的高速发展,污水处理工程的数量和范畴也在不断增加.项目风险管理建设者既需要从整体的视角明确提出更为科学的改进措施,还要合理优化配置,防止对后续项目产生一定的影响.与此同时,管理者必须剖析以前工作上存在的问题,明确指出更为科学的创新方案.本文讲述了污水处理工程建设和管理方面存在的问题、防范措施,以供参考.

关键词：污水处理工程管理建设管理应对建议

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市政工程施工中节能绿色环保技术的应用

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建筑与装饰 2024年第3期 130-132页

作者：郭黎明陕西环保集团建筑工程有限公司陕西西安 710000

现阶段,随着社会经济的快速发展,城镇化进程的不断加快,人们生活水平越来越高,对生态环境保护问题也越来越重视.建筑工程管理人员应积极将节能绿色环保工程施工理念应用在工程施工建设中,不断创新并持续优化节能绿色环保技术,有效提升... 详细信息

现阶段,随着社会经济的快速发展,城镇化进程的不断加快,人们生活水平越来越高,对生态环境保护问题也越来越重视.建筑工程管理人员应积极将节能绿色环保工程施工理念应用在工程施工建设中,不断创新并持续优化节能绿色环保技术,有效提升工程施工质量.基于此,本文首先阐述了市政工程施工中应用节能绿色环保技术的重要性,其次对市政工程施工中节能绿色环保技术的应用进行详细探析,以供参考.

关键词：市政工程施工节能绿色环保技术应用

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新型装配式可调钢拱架在复杂地质上承式拱桥中的应用

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建筑机械 2024年第6期 117-123页

作者：李国明郑燚中交城市建设(四川)有限公司四川成都611100

为解决传统“321桁架梁”、“六四式军用梁”等钢拱架施工风险高、拼装难度大、无法重复使用的缺陷,文章提出1套装配式可调钢拱架体系。可调钢拱架由基本节段与可调构造组成,其中可调构造包括跨径调节、幅宽调节与轴线调节构造,可适应... 详细信息

为解决传统“321桁架梁”、“六四式军用梁”等钢拱架施工风险高、拼装难度大、无法重复使用的缺陷,文章提出1套装配式可调钢拱架体系。可调钢拱架由基本节段与可调构造组成,其中可调构造包括跨径调节、幅宽调节与轴线调节构造,可适应不同特性的主拱圈施工,并基于Midas Civil软件验证了钢拱架的强度及稳定性。结果表明,装配式可调钢拱架整体强度、稳定性及调节螺杆强度均满足设计规范要求。结合大宁河大桥地质条件复杂、岩溶微发育、对拱架强度要求高的特性,研究了主拱圈施工、可调钢拱架安装、预压及拆除等施工关键技术。

关键词：可调钢拱架装配式上承式拱桥主拱圈钢拱架

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Breaking the final barrier in reproductive animal cloning: macaque monkeys cloned

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National Science Review 2018年第3期5卷 301-303页

作者： Hongjun Song guo-li ming Department of Neuroscience and Mahoney Institute for Neurosciences Department of Cell and Developmental Biology Institute for Regenerative Medicine University of Pennsylvania

Animal models are essential in research aiming to understand human biology and diseases,yet far too often clinical trials fail with drugs and therapeutic approaches that have been developed through,tested and built up... 详细信息

关键词： Breaking the final barrier in reproductive animal cloning macaque monkeys cloned

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Reprogram to pluripotency: a new logic and a chemical cocktail

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National Science Review 2014年第1期1卷 6-7页

作者： Hongjun Song guo-li ming Institute for Cell Engineering Departments of Neurology and Neuroscience Johns Hopkins University School of Medicine

Somatic cells rom animals and humans can be reprogrammed into pluripotent stem cells by pluripotency *** Deng and colleagues discovered that pluripotency can also be induced with exogenous lineage speciiers via balancing competing diferentiation *** a related study they achieved,for the irst time,restoration of pluripotency in adult somatic cells using a chemical cocktail alone.

关键词： GATA Reprogram to pluripotency a new logic and a chemical cocktail PSCs SOX

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Synthesis, Crystal Structure and Biological Activity of 2-Chloro-N-{2-fluoro-5-[N-(phenylsulfonyl) phenyl-sulfonamido]phenyl}benzamide

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Chemical Research in Chinese Universities 2008年第3期24卷 295-298页

作者： li Wen-ming WANG Jian-guo li Zheng-ming SONG Hai-bin Elemento-Organic Chemistry Institute State Key Laboratory of Elemento-Organic Chemistry National Pesticide Engineering Research Center Nankai University Tianjin 300071 P R. China

2-Chloro-N-{2-fluoro-5-[N-（phenylsulfonyl）phenylsulfonamido]phenyl}benzamide was synthesized and its crystal structure was also determined by X-ray single-crystal diffraction. The title compound（C25H18ClFN2O5S2） belongs to monoclinic, space group P21/n with a=0.7377（3） nm, b=1.2036（5） nm, c=2.6846（11） nm, β=90.895（9）°, V=2.3833（16） nm3, Mr=544.98, Z=4, Dc=1.519 g/cm3, μ=0.385 mm–1, F（000）=1120, R1=0.0632, and wR2=0.1438. Its crystal structure belongs to a novel class that has not been reported yet, and its preliminary herbicidal activity was also tested. Its inhibition rate to seedling growth of barnyard grass reaches 15.1% at 100 μg/mL.

关键词： X-ray diffraction Crystal structure Synthesis Biological activity

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Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support

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Chinese Chemical Letters 2008年第5期19卷 505-508页

作者： Chang Xie Hong Xia li ming guo liu ming Wu Ding Key Laboratory of Pesticide ＆ Chemical Biology of Ministry of Education Central China Normal University Wuhan 430079 China

4（3H）-Quinazolinones have been synthesized from poly（ethylene glycol）（PEG） supported aza-Wittig reaction. 2-Dialkylamino- 4（3H）-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.

关键词： 4(3H)-Quinazolinone Poly(ethylene glycol) supported Aza-Wittig reaction Carbodiimide Iminophosphorane

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