检索结果-南通市图书馆

基于网络药理学研究玉屏风颗粒调节IgA肾病模型小鼠Th1/Th2平衡的作用机制

在线全文

学校读者我要写书评

暂无评论

中医药导报 2024年第3期30卷 1-8页

作者：李雅静杜宇白雅雯王烁卜凤跃孙丽宁边春艳内蒙古医科大学中医学院内蒙古呼和浩特010110 包头市第八医院内蒙古包头014040 包头医学院第一附属医院内蒙古包头014017 克什克腾旗蒙医中医医院内蒙古赤峰025378

目的:基于网络药理学预测玉屏风颗粒治疗IgA肾病(IgAN)的作用机制并进行机制验证。方法:通过中药系统药理学数据库与分析平台(TCMSP)数据库检索玉屏风颗粒有效成分;从GeneCards、OMIM、TTD数据库获取IgAN靶点,运用Venny2.1.0、Cytoscape... 详细信息

目的:基于网络药理学预测玉屏风颗粒治疗IgA肾病(IgAN)的作用机制并进行机制验证。方法:通过中药系统药理学数据库与分析平台(TCMSP)数据库检索玉屏风颗粒有效成分;从GeneCards、OMIM、TTD数据库获取IgAN靶点,运用Venny2.1.0、Cytoscape 3.7.2软件分别获取玉屏风颗粒与IgAN两者交集靶点,构建“活性成分-交集靶点-疾病”关系网络;使用String数据库构建蛋白互作网络图,运用DAVID数据库进行GO、KEGG富集分析;通过AutoDock Vina软件对玉屏风颗粒中的主要活性成分与关键靶点进行分子对接验证。选取60只雄性昆明小鼠随机分为正常组10只,造模组50只,造模成功后随机分为玉屏风颗粒高、中、低剂量组及西药对照组,给药8周。免疫荧光法检测IgA在肾组织中的沉积情况;HE染色、糖原染色观察肾组织病理学改变;生化法检测24 h-UTP、BUN、Scr;EliSA法检测血清中IgA,Th1相关因子TNF-α、INF-γ、IL-2表达,以及Th2相关因子IL-4、IL-6表达。结果:网络药理学部分,筛选出玉屏风颗粒活性成分34个,药物靶点222个;疾病靶点1436个;交集靶点102个;主要活性成分为槲皮素、山柰酚、汉黄芩素等;关键靶点有TNF、IL-6、IL-4、IL-2等。分子对接结果表明,主要活性成分与关键靶点均能较好的结合,所有结合能均≤-6.0 kJ/mol;GO富集分析得到生物过程689条、细胞组分54条、分子功能115条;KEGG富集分析得到IL-17、NF-κB等信号通路。动物实验部分,肾组织IgA免疫荧光显示,与正常组比较,模型组肾小球系膜区可见强绿色团块状IgA荧光信号;与模型组比较,各治疗组IgA沉积情况均有所改善,其中玉屏风颗粒高剂量组改善较明显。HE染色显示,与正常组比较,模型组可见肾小球肿胀,系膜细胞、内皮细胞增生,细胞外基质增多,系膜区扩张;与模型组比较,各治疗组肾组织病理损伤均有所减轻;糖原染色显示,与正常组比较,模型组可见系膜细胞增生,细胞外基质增多,给予药物治疗后,各治疗组肾组织病变程度由中重度变为中轻度。与正常组比较,模型组24 h-UTP、BUN、Scr明显升高(P<0.01);与模型组比较,各治疗组肾功能均有所改善(P<0.01或P<0.05)。与正常组比较,模型组血清中IgA表达明显升高,与模型组比较,各治疗组血清中IgA表达均有所降低(P<0.05)。与正常组比较,模型组血清中Th1相关因子TNF-α、INF-γ、IL-2表达水平明显降低(P<0.05),各治疗组血清中Th1相关因子TNF-α、INF-γ、IL-2均有所上调。与正常组比较,模型组血清中Th2相关因子IL-4、IL-6表达水平明显升高(P<0.05),使用药物治疗后,各治疗组血清中Th2相关因子IL-4、IL-6表达水平均有所下调。与正常组比较,模型组血清中Th1/Th2比值明显下降(P<0.05),各治疗组血清中Th1/Th2比值均有所上调(P<0.05)。结论:玉屏风颗粒对IgAN模型小鼠具有较好的治疗作用,其机制可能与纠正Th1/Th2失衡有关。

关键词： IgA肾病玉屏风颗粒 Th1/Th2 网络药理学实验验证小鼠

Zircon U-Pb geochronology and geochemistry of granite in Huoluotai area of northern Great Hinggan Range

在线全文

学校读者我要写书评

暂无评论

Global Geology 2019年第3期22卷 141-151页

作者： CAO Zi'ang SUN fengyue li liang JIA Xiaoyu li Jianzhi College of Earth Sciences Jilin UniversityChangchun 130061China The 3rd Oil Production Plant of Daqing Oilfield Daqing 163318HeilongjiangChina

Zircon LA-ICP-MS U-Pb geochronology of Huoluotai granite in the studied area shows that the weighted mean age of the rock is 148.12±0.85 Ma, which is of Early Cretaceous. The composition of elementary geochemistry indicates that the granite has high content of SiO2(66.53%--68.92%), K2O+Na2O(8.80%--9.02%) and Al2O3 (15.16%--16.09%), but low MgO(0.72%--0.91%) and Mg^#(23.59-29.51). The aluminum saturation index(A/CNK) is 0.87-0.95, with high Sr content of(466.00-688.00)×10^-6 and low Y of(4.65-6.22)×10^-6. It is indicated that the granite is a set of adakitic rocks with the characteristics of high-K calc-alkaline series. Fraction of light and heavy rare earth elements is obvious, with(La/Yb)N=58.22--117.91, and anomaly of Eu is feeble(δEu=0.83--0.99). The samples are also enriched in light rare earth elements and large ion elements(Rb, K), depleted in heavy earth elements and high field strength elements(Nb,Ti, P, Zr). Combined with the characteristics of regional tectonic evolution, it is suggested that the fine granite originated from the partial melting of the thickened lower crust, which should be related to the collision compression orogeny after the closure of the Mongolia-Okhotsk Ocean.

关键词： Great Hinggan Range granite U-Pb geochronology adakite Huoluotai area

发电机组低负荷下的SVG无功补偿技术应用分析

在线全文

学校读者我要写书评

暂无评论

电工技术 2024年第8期 106-109页

作者：罗浩刘守豹汪凤月曾恕嘉袁洋侯俊宏李宏博赵国亚大唐水电科学技术研究院有限公司四川成都610036 嘉陵江亭子口水利水电开发有限公司四川苍溪628400

低负荷运行容易导致发电机组无功功率不足、电压不稳定等问题,影响电力系统的稳定性和可靠性。探讨了在发电机组低负荷条件下应用静止无功发生器(SVG)技术进行无功补偿的途径。分析了SVG在维持电压稳定、改善功率因数以及减轻低负荷运... 详细信息

低负荷运行容易导致发电机组无功功率不足、电压不稳定等问题,影响电力系统的稳定性和可靠性。探讨了在发电机组低负荷条件下应用静止无功发生器(SVG)技术进行无功补偿的途径。分析了SVG在维持电压稳定、改善功率因数以及减轻低负荷运行对发电机组的不良影响等方面的表现和有效性,并通过实验和仿真开展评估验证。

关键词：低负荷无功补偿 SVG技术电压稳定

Geochronology,geochemistry and Hf isotope of monzogranite in Niubiziliang of Qinghai

在线全文

学校读者我要写书评

暂无评论

Global Geology 2016年第3期19卷 153-163页

作者： JIANG Hefang SUN fengyue li liang li Ruihua YU Lu WANG Fei SHEN Dali College of Earth Sciences Jilin University Changchun 130061 China MLR Key Laboratory of Metallogeny and Mineral Resources Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences Beijing 100037 China School of Earth and Space Sciences Perking University Beijing 100871 China Qinghai Nuclear Industrial Geology Bureau Xining 810008China

Zircon U-Pb dating, whole-rock geochemical analyses and Hf isotope are undertaken for the monzogranite in Niubiziliang area with the aim of constraining its formation time,petrogenesis and the regional tectonic setting. The zircons from monzogranite are euhedral-subhedral in shape,and display rhythm growth zoning,indicating a magmatic origin. LA-ICP-MS zircon U-Pb dating indicates the monzogranite formed most probably in the Late Devonian( 359. 0 ± 2. 6 Ma). The monzogranite has Si O2= 74. 69%--76. 11%,Al2O3=12. 07%--12. 81%,Na2 O + K2 O = 8. 24%--8. 70%,Na2 O / K2 O = 0. 60--0. 68,A / CNK > 1,which shows that it belongs to high-Si and high-K weakly peraluminous calc-alkaline series. The monzogranite is enriched in K,Rb,Th( liLEs) and La,Ce,Sm,Nd( LREEs); and depleted in Ba,U( HREEs) and Ta,Nb( HFSEs).Their zircon εHf( t) values range from 1. 21 to 3. 46,in response to their two-stage Hf model ages( TDM2) ranging from 1 034 Ma to 1 159 Ma,respectively,indicating that the primary magma was derived from the young crust in Meso-Neoproterozoic. Combined with the regional geological evolution background,it is considered that the Niubiziliang monzogranite formed the closure of North Qaidam ocean,which was the stretching stage product after the collision between Qaidam block and Qilian block.

关键词： magmatic zircon geochemistry dating isotope depleted enriched crust probably geochemical

Thoughts and effects for substituted resource prospecting in Laozuoshan gold deposit in Heilongjiang

在线全文

学校读者我要写书评

暂无评论

Global Geology 2013年第2期16卷 75-81页

作者： WEI lianxi SUN fengyue li Bile DING Qingfeng SUN Naiquan ZHAO Haipeng College of Earth Sciences Jilin University Research Institute of Geological Exploration for Nonferrous Metals in Heilongjiang Province College of Geological Engineering and Geomatics Chang'an University No. 701 Team of Geological Exploration for Nonferrous Metals of Heilongjiang Province

According to the Geological settings and the distributed laws of ore bodies and previous research re- suits, combining with latest theories and new methods of geological prospecting, the authors proposed prospec- ting thoughts for substituted resources in Laozuoshan gold deposit. After ore prospecting in two years, nine new blind ore bodies were found, among which four ore bodies contain 4218. 1 kg inferred intrinsic economic re- sources （ 333 ）, and mitigate the crisis situation of mine reserves. At the same time, lots of significant geophysi- cal and geochemical anomalies were found in the peripheral, which provide a basis for further prospecting.

关键词： Laozuoshan gold deposit substituted resource prospecting

免人工肾积水在超声引导经皮肾镜取石术中的应用

在线全文

学校读者我要写书评

暂无评论

中华临床医师杂志（电子版） 2023年第7期17卷 798-803页

作者：张曦才曹先德高建萍沈大庆曹现祥郭诗杰李凤岳肖琳 272002　山东济宁，济宁医学院临床医学院250011　济南，山东省中医药大学附属医院泌尿外科272029　山东济宁，济宁医学院附属医院手术室272029　山东济宁，济宁医学院附属医院泌尿外科

目的探讨超声引导经皮肾镜取石术中不制造人工肾积水的安全性及有效性。方法回顾性分析2019年1月至2021年12月济宁医学院附属医院泌尿外科收治的395例行经皮肾镜取石术的患者的临床资料。将395例患者根据术前CT中肾积水的程度分3层(无... 详细信息

目的探讨超声引导经皮肾镜取石术中不制造人工肾积水的安全性及有效性。方法回顾性分析2019年1月至2021年12月济宁医学院附属医院泌尿外科收治的395例行经皮肾镜取石术的患者的临床资料。将395例患者根据术前CT中肾积水的程度分3层(无肾积水层、轻度肾积水层、中重度肾积水层)进行比较,每层按照手术方法分为人工肾积水组与免人工肾积水组,比较2组患者的一针穿刺成功率、手术时间、术中出血、一期结石清除率、术后发热发生率、术后住院时间的差异。结果2组患者一般资料差异无统计学意义(P>0.05)。无肾积水层,人工肾积水组与免人工肾积水组的手术时间分别为[(54.8,95.5)min vs(25.0,56.0)min,P0.05)。结论超声引导经皮肾镜取石术术中不建立人工肾积水是一种治疗不同积水程度的肾结石安全有效的手术方式,具有手术时间短、术后恢复快等优势。

关键词：尿路结石经皮肾镜取石术人工肾积水输尿管导管

Geochronology and geochemistry of Baicaogou tuff in Yanji,NE China and its tectonic implications for Early Cretaceous

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Geology 2018年第1期21卷 14-25页

作者： WANG Yingchao SUN fengyue li liang XIN Wei YAN Jiaming TIAN lidan College of Earth Sciences Jilin University

The authors studied zircon U-Pb age and geochemical data of Baicaogou tuff in Yanji,Jilin *** results indicate that the rocks formed in Early Cretaceous( 125. 6 ± 2. 3 Ma). Geochemically,these tuffs have high Si O2 and total Na2 O + K2 O,low Mg O and Fe O,and they belong to metaluminous series,the rock are enriched in LREEs and liLEs,depleted in HREEs and HFSEs such as Nb,Ta,Ti,and P,exhibiting an affinity to I-type granite. All these characteristics implied that the volcanic rocks were derived from partial melting of lower crust. Combined with the geochronology and geochemical features of the coeval igneous rocks within NE China,it is concluded that Yanji area was in a back-arc extensional setting in response to the subduction of the Paleo-Pacific Plate beneath the Eurasian Plate.

关键词： Baicaogou tuff zircon U-Pb age I-type granite subduction Paleo-Pacific Yanji

Zircon U-Pb geochronology and geochemistry of diorite dikes from Nancha ore deposit in Tonghua area of Jilin and its geological significance

在线全文

学校读者我要写书评

暂无评论

Global Geology 2017年第1期20卷 21-31页

作者： WU Qiong SUN fengyue WANG li liU Jinlong TIAN lidan WANG Fei College of Earth Sciences Jilin UniversityChangchun 130061China

The authors presented geochronology and geochemical data of diorites from Nancha gold deposit in Tonghua region, with the aim to constraining its formation age, magma source and tectonic setting. LA-ICP-MS U-Pb dating results of zircons from the diorites indicate that the rocks were formed in the Middle Jurassic （171 ±2 Ma, MSWD = 1. 19）. Geochemically, these rocks have Si02 concentrations of 52. 52%-54. 90%,K20 of 2. 14%-3.84% , Na20 of 3. 17%-3. 35% , MgO of 7. 43%-9. 34% and high Mg# of 68. 57-72. 57. These rocks are characterized by enrichment in large ion lithophile elements（ liLE,such as K, Ba, Rb and Sr） and light rare earth elements （ LREE） , relatively depletion in high field strength elements （ HFSE, such as Ta, Nb, Ti and Zr） , and heavy rare earth elements （HREE）. These characteristics suggest that primary magma of the rocks were derived from the partial melting of mantle with miner crustal contamination, which may related to partial melting of mantle wedge by addition of sediment melt from subducting oceanic crust. Based on former and present studies, the authors consider that the Nancha ore deposit high-Mg diorites were formed in compres- sional structural setting which is similar to volcanic arc. It could be related to the subduction of the Paleo-Paci- fic plate beneath the Eurasian continent.

关键词： zircon U-Pb chronology geochemistry diorite Nancha gold deposit Tonghua Jilin

Zircon U-Pb geochronology and geochemistry of syenogranitesin western Niubiziliang,northwestern Qaidam,Qinghai

在线全文

学校读者我要写书评

暂无评论

Global Geology 2017年第2期20卷 69-79页

作者： YU Lu SUN fengyue li Bile li liang li Ruihua JIANG Hefang WANG Fei SHAO Ji SHEN Dali College of Earth Sciences Jilin UniversityChangchun 130061China MLR Key Laboratory of Metallogeny and Mineral Resources Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China School of Earth and Space Sciences Peking UniversityBeijing 100871China Qinghai Nuclear Industrial Geology Bureau Xining 810008China

The study presents the results of U-Pb dating of zircons and whole-rock geochemical analyses of a syenogranite located in the western Niubiziliang area,China with the aim of determining its formation time,petrogenesis and the regional tectonic setting. Zircons within the syenogranite are euhedral-subhedral and display rhythmic growth zoning,indicating a magmatic origin. Zircon U-Pb data obtained by LA-ICP-MS indicate the syenogranite formed in the Late Permian (260.7±1.5 Ma). The w(SiO_2) of syenogranites is 70.82%--73.59%,w(Al_2O_3) is 13.49%--14.82%,and w(Na_2O + K_2O) is 7.85%--8.52%,and yield K_2O/Na_2O ratios of 1.06--1.26. Therefore,the syenogranites belong to the high-K calc-alkaline and metaluminous (A/CNK 1) series which display I-type granites similarly. The syenogranites also show the geochemical characteristics of volcanic arc rocks,being enriched in large-ion lithophile elements (liLEs; K,Rb) and light rare-earth elements (LREEs; La,Ce,Sm,Nd),but depleted in high field strength elements( HFSEs; Ta,Nb,P,Ti). On the whole,trace element ratios are close to the mean of the Earth's crust,indicating a lowercrust magma source. The low Sr (161--214) ×10^(-6) and Yb (1.08--1.80)×10^(-6) concentrations indicate that plagioclase and hornblende are residual mineral phases in the source. The regional geology and whole-rock geochemistry suggest that the formation of the syenogranites was related to subduction of the Zongwulong Ocean crust,and the north margin of Qaidam Block during the Late Permian was in an active continental margin tectonic setting.

关键词： syenogranite zircon U-Pb dating geochemistry tectonic setting Zongwulong Ocean Niubiziliang