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子宫内膜癌组织中紧密连接蛋白6、紧密连接蛋白9的表达及临床意义

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中国性科学 2022年第12期31卷 80-84页

作者：栾婕刘霞李凤月程海燕青岛大学附属青岛市中心医院疾病控制科山东青岛266042 青岛大学附属青岛市中心医院妇科山东青岛266042

目的分析子宫内膜癌(EC)患者癌组织中紧密连接蛋白6(CLDN6)、紧密连接蛋白9(CLDN9)的表达水平及临床意义。方法选取2016年6月至2018年7月于青岛大学附属青岛市中心医院行手术治疗的68例EC患者作为研究对象,术中取其癌组织及癌旁组织,另... 详细信息

目的分析子宫内膜癌(EC)患者癌组织中紧密连接蛋白6(CLDN6)、紧密连接蛋白9(CLDN9)的表达水平及临床意义。方法选取2016年6月至2018年7月于青岛大学附属青岛市中心医院行手术治疗的68例EC患者作为研究对象,术中取其癌组织及癌旁组织,另将同期57例因宫颈病变切除全子宫、全子宫加双附件的患者的正常子宫内膜组织作为对照。检测不同组织中CLDN6、CLDN9蛋白表达情况,分析CLDN6、CLDN9表达与患者临床病理特征及预后的关系,并采用Ualcan数据库分析EC组织中CLDN6、CLDN9 mRNA表达情况及二者水平对患者预后的影响。结果CLDN6、CLDN9高表达患者的生存率均低于CLDN6、CLDN9低表达患者(P<0.05);癌组织中CLDN6、CLDN9蛋白阳性率均高于癌旁组织及正常子宫内膜组织(P<0.05),CLDN6、CLDN9蛋白水平与国际妇产科联盟(FIGO)分期、病理分级及淋巴结转移有关(P<0.05),CLDN6、CLDN9阳性患者3年生存率均低于CLDN6、CLDN9阴性患者(P<0.05)。结论CLDN6、CLDN9在EC患者癌组织中呈高表达,二者水平可预测患者预后情况。

关键词：子宫内膜癌紧密连接蛋白6 紧密连接蛋白9 临床意义

颈动脉支架植入术联合规范脑血管病二级预防对颈内动脉颅外段重度狭窄患者的效果观察

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临床研究 2024年第1期32卷 4-7页

作者：李秉龙韩丰月刘琳郭鹏济南市第三人民医院神经内科山东济南250000

目的探究颈动脉支架植入术联合规范脑血管病二级预防对颈内动脉颅外段重度狭窄患者认知功能影响的效果。方法选取2021年9月至2023年3月期间在济南市第三人民医院收治的68例颈内动脉颅外段重度狭窄患者,根据治疗方式不同将其分为对照组... 详细信息

目的探究颈动脉支架植入术联合规范脑血管病二级预防对颈内动脉颅外段重度狭窄患者认知功能影响的效果。方法选取2021年9月至2023年3月期间在济南市第三人民医院收治的68例颈内动脉颅外段重度狭窄患者,根据治疗方式不同将其分为对照组和观察组各34例。基础疾病治疗基础上,对照组采取规范的脑血管病二级预防,观察组完成颈动脉支架植入术,并坚持规范的脑血管病二级预防,比较两组精神状态、认知功能、不良情绪、日常生活活动能力及神经功能缺损评分情况。结果治疗后,两组患者的简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分均有所提高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分均有所下降,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的日常生活能力评定量表(ADL)评分均有所提高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的神经功能缺损(NIHSS)评分均有所降低,观察组低于对照组,差异有统计学意义(P<0.05)。结论颈动脉支架植入术联合规范脑血管病二级预防能够显著改善颈内动脉颅外段重度狭窄患者的精神状态、认知功能、不良情绪、日常生活活动能力和神经功能缺损。这一治疗策略有助于提升患者的生活质量和康复效果。

关键词：颈动脉支架植入术规范脑血管病二级预防颈内动脉颅外段重度狭窄认知功能

Zircon U–Pb age and geochemical constraints on the origin and tectonic implication of the Tuotuohe Cenozoic alkaline magmatism in Qinghai–Tibet Plateau

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Acta Geochimica 2020年第1期39卷 67-84页

作者： Ye Qian Shengnan Tian Yujin li fengyue Sun College of Earth Sciences Jilin UniversityChangchunChina Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural Resources of the People's Republic of ChinaChangchunChina

A large number of Eocene-Oligocene alkaline/alkali-rich igneous rocks were developed in the Tuotuohe region of the Qinghai-Tibetan *** this study,we present zircon U-Pb ages,Hf isotope data,and major and trace element compositions of the Cenozoic alkaline rocks from the Tuotuohe region in order to constraint the petrogenesis and tectonic evolution history of Qiangtang *** U-Pb ages were measured via LA-ICP-MS to be39.6,37.6 and 32.0 *** 39.6 Ma trachyte was characterized by low SiO2 and high K2O and MgO *** 37.6 and 32.0 Ma orthophyres show enrichment in SiO2 and K2O,but deficient in *** of the samples belong to the alkaline *** rocks display enrichment in REE,LREE,and liLE,depletion in HFSE,and no obvious Eu *** and geochemical features suggest that there were two possible mechanisms for the origin of the alkaline rocks in the Tuotuohe region:(1)the removed mafic lower crust dropped into the asthenosphere,forming the mix magma(Nariniya trachyte);(2)the upwelling asthenosphere triggered the crustal melting(Nariniya and Zamaqu orthophyre).The Eocene-Oligocene alkaline rocks in the study and adjacent areas are likely to be the result of the same tectonic-magmatic event of deep lithospheric evolution that is the crustal material melting triggered by lithospheric *** conclusion extends the influence scope of lithospheric delamination eastward to the Tuotuohe region(*92°E)from Banda Co(*82°E).

关键词： Zircon U-Pb chronology Zircon Hf isotopic Delamination Tuotuohe region Qinghai–Tibetan Plateau

U-Pb dating and geochemistry of granite porphyry dykes in the Xicha gold-(silver)deposit,southern Jilin Province,China,and their metallogenic significance

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Acta Geochimica 2020年第4期39卷 574-586页

作者： Jian Wang fengyue Sun Bile li lihui Tian School of Mining Engineering.Heilongjiang University of Science and Technology No.2468 Puyuan StreetHarbin 150022People's Republic of China College of Earth Sciences Jilin UniversityChangchun 130061People's Republic of China

We report U-Pb dating of zircon,as well as geochemical and Hf isotope data,in order to constrain the formation time,magma source,and tectonic setting of granite porphyry dykes in the Xicha gold-(silver)district in southern Jilin Province,Northeast *** zircon grains are euhedral-subhedral,display oscillatory growth zoning and have Th/U ratios varying between 0.11 and 0.78,which together imply a magmatic *** dating results indicate the porphyry formed in the Early Cretaceous(122±1 Ma)and it contains SiO2=70.64-72.31 wt%,Al2O3-=13.99-14.64 wt%,K2O+Na2O=6.96-7.81 wt%K2O/Na2O=1.24-2.10,and A/CNK=***,the porphyry belongs to a high-K calc-alkaline S-type ***-normalized rare earth elements(REE)patterns show LREE enrichment,light rare earth elements(LREE)/heavy rare earth elements(HREE)=9.93-11.97(La/Yb)N=11.08-15.16,and d Eu=*** the trace element spider diagram,large ion lithophile elements such as Rb,Ba,K,Th,and U are enriched,whereas the high field strength elements Ti and P are *** e Hf(t)values of zircon from the granite porphyry vary between-17.1 and-13.2,and their Hf two-stage model ages vary from 2.01 to 2.26 Ga,implying that the magma was derived from partial melting of old lower *** granite porphyry dykes and many A-type granites in the region formed at the same time,suggesting an extensiona *** combination of the occurrence of strong magmatism,large-scale mineralization,and extensiona tectonics throughout much of Eastern China indicate that the Early Cretaceous was a period of significant lithospheric *** southern Jilin Province,therefore,experienced lithospheric thinning during the Early Cretaceous.

关键词： Southern Jilin Province Syn-mineralization dykes Jinchanggou Zircon U-Pb geochronology Geochemistry Hf isotopes

多酶法提取高温菜籽粕中蛋白质的工艺及其优化

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中国粮油学报 2012年第8期27卷 69-72页

作者：刘晓庚高梅陈梅梅曹祟江孔令艳吴珂李凤月彭冬梅南京财经大学食品科学与工程学院南京210046

通过比较菜籽蛋白的各种提取方法,设计了以高温压榨菜籽粕为原料,采用多酶解法与碱提酸沉法相结合的新工艺提取菜籽粕蛋白质。在单因素试验的基础上,着重研究酶解过程,并用L9(34)正交优化试验得到了多酶酶解最佳工艺条件为:pH为9.0,温度... 详细信息

通过比较菜籽蛋白的各种提取方法,设计了以高温压榨菜籽粕为原料,采用多酶解法与碱提酸沉法相结合的新工艺提取菜籽粕蛋白质。在单因素试验的基础上,着重研究酶解过程,并用L9(34)正交优化试验得到了多酶酶解最佳工艺条件为:pH为9.0,温度为50℃,料液比为1∶10,多酶以α-淀粉酶+纤维素酶为宜,且加入量为α-淀粉酶90 U/g粕、纤维素酶45 U/g粕;在此最优条件下的验证实验所得蛋白质提取率为98.96%,菜籽蛋白产品的蛋白质含量为99.04%,产品为无特殊气味浅黄色的细晶粒和粉末固体。

关键词：高温菜籽饼粕蛋白质提取酶解法紫外分光光度法

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水热法制备陶瓷粉体的研究现状及进展

山东陶瓷 2016年第4期39卷 16-20页

作者：梁晓夏李凤月邢文文沈毅李锋锋华北理工大学材料科学与工程学院河北省无机非金属材料重点实验室河北唐山063009 华北理工大学轻工学院唐山市环境功能材料重点实验室河北唐山063000

本文从对水热法制备陶瓷粉体的研究现状及发展进行了综述。分别从水热法制备压电陶瓷粉体、水热法制备微波陶瓷粉体和水热法制备形貌可控的纳米陶瓷粉体的研究进程来简述水热法制备陶瓷粉体的研究现状及发展,并介绍了水热法制备陶瓷粉... 详细信息

本文从对水热法制备陶瓷粉体的研究现状及发展进行了综述。分别从水热法制备压电陶瓷粉体、水热法制备微波陶瓷粉体和水热法制备形貌可控的纳米陶瓷粉体的研究进程来简述水热法制备陶瓷粉体的研究现状及发展,并介绍了水热法制备陶瓷粉体的原理、特点,并且展望了其发展前景。

关键词：水热法陶瓷粉体纳米材料发展

Early Permian–Late Triassic Magmatism in the Tuotuohe Region of the Qinghai–Tibet Plateau: Constraints on the Tectonic evolution of the Western Segment of the Jinshajiang Suture

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Acta Geologica Sinica(English Edition) 2014年第2期88卷 498-516页

作者： QIAN Ye SUN fengyue li Bile li Shijin ZHAO Junwei College of Earth Sciences Jilin University Qinghai Geological Survey No.5 Geological and Mineral Survey Institute of Qinghai Province

In this paper we present new zircon U-Pb ages,whole-rock major and trace element analyses,and zircon Hf isotopic data for magmatic rocks in the Tuotuohe region of the western segment of the Jinshajiang *** aim is to constrain the Early Permian-Late Triassic tectonic evolution of the *** from the magmatic rocks of the Tuotuohe region are euhedralsubhedral in shape and display fine-scale oscillatory zoning as well as high Th/U ratios （0.4-4.6）,indicating a magmatic *** zircon U-Pb ages obtained using LA-ICP-MS are 281 ± 1 Ma,258 ± 1 Ma,244 ± 1 Ma,and 216 ± 1 Ma,which indicate magmatism in the Early Permian-Late Triassic.A diorite from Bashihubei （BSHN） has SiO2 =57.18-59.97 wt％,Al2O3=15.70-16.53 wt％,and total alkalis （Na2O ＋ K2O） =4.46-6.34 wt％,typical of calc-alkaline and metaluminous series.A gabbro from Bashibadaoban （BSBDB） belongs to the alkaline series,and is poor in SiO2 （45.46-54.03 wt％） but rich in Al2O3 （16.19-17.39 wt％） and total alkalis （Na2O ＋ K2O =5.48-6.26 wt％）.The BSHN diorite and the BSBDB gabbro both display an enrichment of LREEs and liLEs and depletion of HFSEs,and they have no obvious Eu anomaly; they have relatively low MgO contents （2.54-4.93 wt％）,Mg# values of 43 to 52,and low Cr and Ni contents （8.07-33.6 ppm and 4.41-14.2 ppm,respectively）,indicating they differentiated from primitive mantle *** have low Nb/U,Ta/ U,and Ce/Pb ratios （1.3-9.6,0.2-0.8,and 0.1-18.1,respectively）,and their initial Hf isotopic ratios range from ＋9.6 to ＋16.9 （BSHN diorite） and ＋6.5 to ＋12.6 （BSBDB gabbro）,suggesting their primary magmas were derived mainly from the partial melting of a mantle wedge that had been metasomatized by subduction *** all the new data together,we conclude that the western and eastern segment of the Jinshajiang suture regions underwent identical processes of evolution in the Early Permian-Late Triassic：oceanic crust subduction before the Early Permian,continental collision during the Early-Middle T

关键词： zircon U-Pb chronology zircon Hf isotopes geochemistry tectonic setting Tuotuohe region Jinshajiang suture Qinghai-Tibet Plateau

Geochronology, geochemistry and Hf isotopes of andesites in the Sandaowanzi gold deposit(Great Xing’an Range, NE China): implications for petrogenesis, tectonic setting,and mineralization

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Acta Geochimica 2021年第2期40卷 251-270页

作者： Runtao Yu Bile li fengyue Sun Zhihua li Huawei li Yufan Shi College of Earth Science Jilin UniversityNo.2199 Jianshe StreetChangchun 130061China

The Sandaowanzi gold deposit is an extremely Au-rich deposit in the Northern Great Hinggan Range in recent *** U-Pb geochronology,Hf isotope analysis,and the geochemistry of andesites of the Longjiang Formation from the Sandaowanzi gold deposit were used to investigate the origin,magmatic evolution as well as mineralization and tectonic setting of the Early Cretaceous epithermal gold deposits in the northern Great Hinggan Range *** U-Pb dating reveals an emplacement age of 123.4±0.3 Ma,indicating that the andesites of the Sandaowanzi gold deposit was formed during the Early *** andesites are enriched in light rare earth elements relative to heavy rare earth elements and have weak negative Eu anomalies(δEu=0.76-0.90).The rocks are also enriched in large-ion lithophile elements,such as Rb,Ba,Th,U,and K,and depleted in the high-field-strength elements,such as Nb,Ta,and *** characteristics are typical of volcanic rocks related to *** zircons from the andesite samples have relatively homogeneous Hf isotope ratios,176Hf/177Hf values of 0.282343-0.282502,εHf(t)values of-12.58 to-6.95,and two-stage model ages(TDM2)of 1743-1431 *** characteristics of the andesites of the Longjiang Formation are consistent with derivation from partial melting of enriched mantle wedge metasomatized by subducted-slab-derived *** rocks formed in an extensional environment associated with the closure of the Mongol-Okhotsk Ocean and subduction of the Paleo-Pacific *** occurred towards the end of volcanism,and the magmatic activity and mineralization are products of the same geodynamic setting.

关键词： Andesites of longjiang formation Zircon U–Pb geochronology Hf isotope Geochemistry Sandaowanzi gold deposit

典型化学制品企业OVOCs排放特征及环境影响

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环境科学学报 2024年第10期44卷 111-120页

作者：翟增秀李佳音杨伟华闫凤越武婷崔焕文韩萌天津市生态环境科学研究院天津 300191 生态环境部恶臭污染控制重点实验室天津 300191 天津迪兰奥特环保科技开发有限公司天津 300191 天津市生态环境科学研究院天津 300191 生态环境部恶臭污染控制重点实验室天津 300191

为充分了解化学制品行业挥发性含氧有机物(OVOCs)排放情况和环境影响,以16家典型化学制品企业为研究对象,同时采用气相色谱-质谱法、高效液相色谱法和气相色谱法等检测方法识别化学制品企业排放的OVOCs,研究企业OVOCs排放特征及产生的... 详细信息

为充分了解化学制品行业挥发性含氧有机物(OVOCs)排放情况和环境影响,以16家典型化学制品企业为研究对象,同时采用气相色谱-质谱法、高效液相色谱法和气相色谱法等检测方法识别化学制品企业排放的OVOCs,研究企业OVOCs排放特征及产生的臭氧和恶臭污染影响.结果表明,16家企业共检出128种OVOCs,涵盖了酯类、醇类、醛类、酮类、呋喃类、酸类、醚类等物种,OVOCs总浓度范围为0.29～200.83 mg·m-3.16家企业OVOCs的臭氧生产潜势(OFP)相差较大,OFP范围为0.22～188.47 mg·m-3,整体来看,醇类、酯类和醛类对OFP的贡献较高,但不同企业主要贡献物质存在差异.化学制品企业OVOCs恶臭物质组成复杂,16家企业差异较大,日化-A、日化-C、日化-G、涂料-A和肥料-A等5家企业气味活度值(OAV)总和在1000以上,恶臭污染潜在风险较大,主要恶臭物质分别为甲基叔丁基醚、戊酸乙酯、2-甲基丁酸乙酯、丁醛和异丁醛.研究显示,OVOCs是化学制品企业主要的VOCs物种,会产生一定的臭氧和恶臭污染影响,是需要重点关注的一类VOCs物质,建议加强对OVOCs物质的全面检测和深入研究.

关键词：化学制品企业含氧挥发性有机物(OVOCs) 臭氧生成潜势(OFP) 恶臭