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A Bird’s Eye View of Quantitative Proteome of Tumor Tissues from Lung Cancer Patients by a High Precision Mass Spectrometry Method

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Chemical Research in Chinese Universities 2024年第1期40卷 136-144页

作者： du Xiaohui li Encheng WANG Qi YOU xin Lung Cancer Transitional Medicine Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Scientific Research Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China Department of Respiratory Medicine The Second Affiliated Hospital of Dalian Medical UniversityDalian116023P.R.China

Lung cancer produces a high incidence of malignant *** have been many studies on lung cancer using mass spectrometry(MS)***,most studies have focused on humoral *** this work,26 pairs of tissue samples(tumor ***-tumor)from patients with lung cancer were analyzed using liquid chromatography-tandem MS(LC-MS/MS)with data-independent acquisition *** total,3152 proteins were quantified from tissue samples with high confidence,including 189 up-regulated and 522 down-regulated proteins(tumor ***-tumor).In addition,79 and 690 proteins were identified only in para-cancerous samples and cancerous samples,*** results from bio-informatics tools indicated that altered proteins like PEBP1,HRG and LYZ could be ideal reservoirs for screening the potential biomarkers for lung *** is believed these tissue-specific proteomics results will assist in the studies of lung cancer.

关键词： Lung cancer Proteome Data-independent aquisition

Synthesis and Spectrum Characteristic of New Organic Fluorescence Dyes of Four Pyrazoline Compounds

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复旦学报（自然科学版） 2005年第5期44卷 887-888页

作者： Guan Bai Peihua lin Junfen li du xin li Chuan Dong College of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China

Pyrazoline derivatives are formed by benzeno-hydrazone cyclization. Because cyclization leads to double bond hindering , the compounds show stronger fluorescence. The pyrazoline has N atom which attends conjugation by donating electron, and it has higher hole-transport efficiency and some photoelectron characteristics,so it has been widely used as hole-transport materials in the electrophotography and Electroluminescence fields[1-4]. Pyrazoline derivatives are not only excellent hole-trasfer performance but also have excellent emitting blueness property[5].

关键词：邻二氮杂环戊烯光谱特性有机物荧光性环化作用

A genome scan of recent positive selection signatures in three sheep populations

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Journal of Integrative Agriculture 2016年第1期15卷 162-174页

作者： ZHAO Fu-ping WEI Cai-hong ZHANG li liU Jia-sen WANG Guang-kai ZENG Tao du li-xin National Center for Molecular Genetics and Breeding of Animal Institute of Animal Sciences Chinese Academy of Agricultural Sciences Institute of Animal Science Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences College of Animal Science and Technology Sichuan Agricultural University

Domesticated sheep have been exposed to artificial selection for the production of fiber, meat, and milk as well as to natural selection. Such selections are likely to have imposed distinctive selection signatures on the sheep genome. Therefore, detecting selection signatures across the genome may help elucidate mechanisms of selection and pinpoint candidate genes of interest for further investigation. Here, detection of selection signatures was conducted in three sheep breeds, Sunite （n=66）, German Mutton （n=159）, and Dorper （n=93）, using the Illumina OvineSNP50 Genotyping BeadChip array. Each animal provided genotype information for 43 273 autosomal single nucleotide polymorphisms （SNPs）. We adopted two complementary haplotype-based statistics of relative extended haplotype homozygosity （REHH） and the cross-popu- lation extended haplotype homozygosity （XP-EHH） tests. In total, 707,755, and 438 genomic regions subjected to positive selection were identified in Sunite, German Mutton, and Dorper sheep, respectively, and 42 of these regions were detected using both REHH and XP-EHH analyses. These genomic regions harbored many important genes, which were enriched in gene ontology terms involved in muscle development, growth, and fat metabolism. Fourteen of these genomic regions overlapped with those identified in our previous genome-wide association studies, further indicating that these genes under positive selection may underlie growth developmental traits. These findings contribute to the identification of candidate genes of interest and aid in understanding the evolutionary and biological mechanisms for controlling complex traits in Chinese and western sheep.

关键词： selection signature detection sheep genome REHH test XP-EHH test SNP chip

Genetic parameters for somatic cell score and production traits in the fi rst three lactations of Chinese Holstein cows

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Journal of Integrative Agriculture 2015年第1期14卷 125-130页

作者： ZHAO Fu-ping GUO Gang WANG Ya-chun GUO Xiang-yu ZHANG Yuan du li-xin National Center for Molecular Genetics and Breeding of Animal Institute of Animal SciencesChinese Academy of Agricultural Sciences Beijing Sanyuan Dairy Cattle Breeding Center College of Animal Science and Technology China Agricultural University

The objectives of this study were to estimate genetic parameters of lactation average somatic cell scores （LSCS） and examine genetic associations between LSCS and production traits in the first three lactations of Chinese Holstein cows using single-parity multi-trait animal model and multi-trait repeatability animal model. There were totally 273605 lactation records of Chinese Holstein cows with first calving from 2001 to 2012. Heritability estimates for LSCS ranged from 0.144 to 0.187. Genetic correlations between LSCS and 305 days milk, protein percentage and fat percentage were -0.079, -0.082 and -0.135, respectively. Phenotypic correlation between LSCS and 305 days milk yield was negative （-0.103 to -0.190）. Genetic correlation between 305 days milk and fat percentage or protein percentage was highly negative. Genetic correlation between milk fat percentage and milk protein percentage was highly favorable. Heritabilities of production traits decreased with increase of parity, whereas heritability of LSCS increased with increase of parity.

关键词： somatic cell score genetic parameters Chinese Holstein single-parity multi-trait animal model multi-traitrepeatability animal model

A novel carbazole-based fluorescent probe:3,6-B is-[(N- ethylcarb azole- 3-yl)-propene- 1-keto]-N-ethylc arb azole

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Chinese Chemical Letters 2010年第1期21卷 9-12页

作者： Hao, li ling li, Jun Fen lin, Pei Hua Dong, Rui Feng li, du xin Shuang, Shao Min Dong, Chuan Shanxi Univ Sch Chem & Chem Engn Res Ctr Environm Sci & Engn Taiyuan 030006 Peoples R China

A novel carbazole-based compound 5,3,6-bis[(N-ethylcarbazole-3-yl)-propene-1-keto]-N-ethylcarbazole has been designed, synthesized and *** absorption and fluorescence spectra in solvents of different polarities prove that the compound has a distinct intramolecular charge transfer *** 5 can be used as a new class of fluorescent probe or biosensor due to its sensitivity to the local microenvironment such as solvent polarity.

关键词： Carbazole Fluorescent probe Intramolecular charge transfer Synthesis

Process intensification for the synthesis and purification of battery-grade li_(2)CO_(3)with microfluidics

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Particuology 2024年第7期90卷 106-117页

作者： Haodu li Jie Zhang lin Dai Le du Jiqin Zhu The State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Battery-grade lithium carbonate(li_(2)CO_(3))with a purity of higher than 99.5 wt%is of great importance as a high value-added lithium ***,influences of different reaction systems and process control on product purity remain ***,a membrane dispersion microreactor was used to enhance the mass transfer of preparation and purification processes in homogeneous and heterogeneous *** systems of Na_(2)CO_(3)–liCl,NH_(4)HCO_(3)–liCl,and NH_(3)·H_(2)O−CO_(2)−liCl,CO_(2)purification based on carbonation and decomposition were *** li_(2)CO_(3)purity was increased by the improvement of mixing *** carbonation time was reduced by 62.5%and 58.3%for the NH_(3)·H_(2)O−CO_(2)and CO_(2)purification systems,*** the two ammonia-based systems,li_(2)CO_(3)particles with a purity of 99.7–99.8 wt%were one-step prepared with a size of 3–5μm,which also met the requirement of the battery-grade *** purity was further increased to 99.9 wt%by CO_(2)purification and liHCO_(3)*** investigation could provide a feasible alternative for the controllable preparation of battery-grade li_(2)CO_(3)in one or multiple steps.

关键词： Microfluidics Battery grade li_(2)CO_(3) Process intensification High purity

Molecular Cloning of IGFBP-1 Gene and Developmental Expression of Its mRNA in Different Tissues of Nanjiang Mongolian Gazelles

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畜牧兽医学报 2011年第B12期42卷 1-6页

作者： li li li Qiu WANG lin-jie CAO Jia-xuet ZHANG Hong-ping du li-xin Institute of Animal Genetics and Breeding Sichuan Agricultural University Ya＇ an 625014 China Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100193 China）

The objective of the present study was to investigate the developmental expression patterns of Insulin-like growth factor-binding protein 1 (IGFBP-1) gene in different tissues of postnatal Nanjiang Mongolian Gazelles. Samples of heart, liver, spleen, lung, longissimus dorsi, semimembranosus, m. triceps brachii and biceps muscle of thigh were collected from a total of 36 Nanjiang Mongolian Gazelles at the age of 0, 15, 30, 60, 90 and 120 days after birth (3 males and 3 females at each age). The CDS was sequenced and ontogeny of mRNA levels of IGFBP-1 were measured by real-time fluorescence quantitative RT-PCR. The size of IGFBP-1 ORF was 792 bp encoding 263 amino acid residues, and displayed higher nucleotide/amino acid sequence identities with other ruminants compared to non-ruminants. The levels of IGFBP-1 mRNA in liver were highest (P0.05). Three expression patterns of IGFBP-1 mRNA during postnatal growth from birth to day 60 were found: consistently decreasing (liver), fluctuating as increasing then decreasing (heart) or as decreasing then increasing then decreasing (spleen, lung and muscles). The results indicate that the IGFBP-1 gene is highly conserved among species, and liver has the highest expression. It was concluded that IGFBP-1 plays important roles in early postnatal growth and is expressed in a developmental-tissue-dependent manner.

关键词： IGF-1基因 mRNA水平组织发育分子克隆蒙古南疆胰岛素样生长因子结合蛋白实时荧光定量RT-PCR

A Modeling Study Recurrent Tuberculosis Towards End TB Strategy—China,2025-2035

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China CDC weekly 2024年第35期6卷 885-890页

作者： Tao li xin du Zhongwei Jia Yanlin Zhao Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Chinese Center for Disease Control and Prevention BeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Center for Intelligent Public Health Institute for Artificial IntelligencePeking UniversityBeijingChina Department of Global Health School of Public HealthPeking UniversityBeijingChina Center for Drug Abuse Control and Prevention National Institute of Health Data SciencePeking UniversityBeijingChina

Summary What is already known about this topic?The recurrence of tuberculosis(TB)following successful treatment presents a significant *** is added by this report?Achieving the global End TB Strategy milestones and targets with the current strategies in China is ***,interventions following recovery to prevent recurrence,in conjunction with preventive treatment for latent TB infection(LTBI),will aid in meeting these objectives.

关键词： Strategy tuberculosis treatment

Layer-by-layer assembly of chitosan and carbon nanotube on cotton fabric for strain and temperature sensing

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Journal of Materials Science & Technology 2024年第6期173卷 114-120页

作者： Ye-xin Zhang Yi-Dong li An-Ke du Yuanpeng Wu Jian-Bing Zeng Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Chongqing Academy of Science and Technology Chongqing 401123China School of New Energy and Materials State Key Laboratory of Oil and Gas Reservoir Geology and ExploitationSouthwest Petroleum UniversityChengdu 610500China

Layer-by-layer(LBL)assembly shows great potential in fabrication of flexible conductive cotton fabrics(FCCF)with carbon nanotubes(CNT)as conductive components but is limited because complicated chemical modification of CNT is usually ***,we reported a facile and eco-friendly LBL approach to fabricating FCCF by dipping in chitosan(CS)aqueous solution and poly(sodium 4-styrenesulfonate)(PSS)wrapped CNT aqueous dispersion *** FCCF with electrical conductivity higher than 30 S/m was achieved when 4 layers of CNT were coated on the cotton fabric(CF).The obtained FCCF possessed outstanding mechanical stability with electrical resistivity almost unchanged after exposure to 500 times mechanical abrasion and 500 circles of tape *** FCCF showed excellent strain sensing performance with high sensitivity(with a gauge factor up to 35.1)and a fast response time(70 ms).It can be used as a strain sensor to accurately detect various human deformations such as finger bending and joint *** FCCF could be used as a temperature sensor in that it exhibited stable and reproducible negative temperature sensing behavior in the temperature range of 30-100℃.

关键词： Flexible conductive cotton fabric Layer-by-layer Temperature sensing Strain sensing