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Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis

Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 201-208页

作者： li, zong-fang Xia, Xian-Ming Huang, Chen Zhang, Shu Zhang, Jian Zhang, Ai-Jun Xi An Jiao Tong Univ Sch Med Affiliated Hosp 2 Dept Surg Xian 710004 Peoples R China Xi An Jiao Tong Univ Minist Educ Key Lab Environm & Genes Related Dis Xian 710004 Peoples R China Wannan Med Coll Yijishan Hosp Dept Surg Wuhu 241001 Peoples R China

BACKGROUND: Stromal derived factor-1 (SDF-1) is an efficacious leukocyte chemoattractant, which can attract lymphocytes and mononuclear cells from bloodstream into the site of inflammation. Emodin., an anthraquinone derivative from Radix et Rhizoma Rhei, and baicalein, a flavone from Scutellaria baicalensis Georgi, both have been reported to possess anti-inflammatory activities. The expression pattern of SDF-1 in experimental acute pancreatitis (AP) and the effect of emodin or baicalein on that are not well defined. The present study aimed to investigate the effects of emodin and baicalein on pancreatic myeloperoxidase (MPO) activity (reflecting leukocyte sequestration) and cytokine production, as well as tissue SDF-1 expression in the setting of AP. METHODS: A :rat model of AP was induced by administration (of 5% sodium taurocholate through the biliopancreatic duct. The level of tumor necrosis factor-a (TNF-alpha), interleukin-6 (IL-6) and MPO in the pancreas, and serum amylase were tested by immunohistochemistry, EliSA and chromatometry. The expressions of SDF-1 alpha and SDF-1 beta were detected by real-time PCR, Western blotting, and immunohistochemistry. RESULT: Combination of emodin and baicalein significantly reduced pancreatic TNIP-alpha, IL-6 and MPO, and also inhibited pancreatic SDF-1 expression. CONCLUSIONS: The inhibition of SDF-1 expression by emodin and baicalein might contribute, in part at least, to the amelioration of pancreatic inflammation. The present study also shows benefits of simultaneous treatment of AP.

关键词： acute pancreatitis stromal derived factor-1 myeloperoxidase traditional Chinese medicine

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Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats

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Chinese Medical Journal 2009年第24期122卷 3043-3047页

作者： ZHANG Shu li zong-fang PAN Dun HUANG Chen ZHOU Rui liU Zhong-wei Department of Surgery Second Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an Shaanxi 710004 China Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University) Ministry of Education of China Xi'an Shaanxi 710004 China

Background It is generally accepted that spleen plays a complex role in the tumor immunity, which would change in the different periods of cancer. In this study, we investigated the changes in the function of splenic macrophage （Mφ） in different stages of liver cancer induced by diethylnitrosamine （DEN） in rats. The aim was to support the characteristics of ＂two-way＂ and ＂phase＂ of spleen in tumor immunity. Methods The model of pulmonary metastasis of liver cancer was established in forty male SD rats by DEN. In the 8th, 13th and 16th week, 10 rats were randomly chosen and sacrificed, and divided into cirrhosis, liver cancer and pulmonary metastasis groups depending on the pathological result, respectively. The other 10 rats were taken as control group. The Mφ was isolated by anchoring cultivation. The changes in ultrastructure, phagocytosis, cytokine secretion, antigen processing and presenting, and viability of splenic Mφ） were detected by transmission electron microscopy, VybrantTM Phagocytosis Assay, DQ^TM Ovalbumin, and rat TNF-α EliSpot kits. Results Under the electron microscope, the Mφ） in the control group had some pseudopodium-like prominences, and mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, and phagocytized RBC. In the liver cirrhosis and liver cancer group, Mφ had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, especially in the liver cancer group. In the pulmonary metastasis group, the Mφ was swelling, with few organelle. As compared to the control group, the function of splenic Mφ） increased in cirrhosis and cancer groups, but decreased in metastasis group （phagocytosis rate：（84.7±1.9）% （89.5±3.1）%, and （36.0±2.6）% vs （75.6±1.7）%, P〈0.05, P〈0.01; viability：（1.53±0.15）%, （1.56±0.14）%, and （1.12±0.29）% vs （1.48±0.17）%, P 〈0.05, P 〈0.01; TNF-α secretion：（741.0±52.9）%, （1126.2±174.5）%, and （313.8±50.8）% vs （626.6±24.6）%, P

关键词： liver cancer spleen macrophage ultrastructure cell function

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AI enhances drug discovery and development

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National Science Review 2024年第3期11卷 52-54页

作者： fang Bai Shiliang li Honglin li Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech University lingang Laboratory Innovation Center for AI and Drug Discovery East China Normal University

The advent of the third wave of artificial intelligence(AI) heralds a new era in drug discovery. AI-powered techniques can be characteristic of identifying features that are difficult for humans to interpret from big ...

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Neuroimaging Features of Pituicytomas

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Chinese Medical Journal 2016年第15期129卷 1867-1869页

作者： Wei Xie zong-fang li li Bian Bo He Wei Zhao Zhen-Guang Zhang Yi Lu Department of Radiology First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China Department of Pathology First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China

Pituicytoma is a distinct low-grade glioma arising from pituicytes of the neurohypophysis and infundibulum. Due to the rarity of this tumor, most of the reported cases in the literature were originally misdiagnosed as pituitary adenoma, meningiomas, and craniopharyngioma. It is of vital importance to accurately identify this tumor because this tumor, unlike pituitary adenomas, is prone to heavy bleeding during the surgical resection.

关键词： Dynamic Contrast Enhancement Magnetic Resonance Imaging Neurohypophyseal Tumor Pituicytoma

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Genetic analyses of ancient tea trees provide insights into the breeding history and dissemination of Chinese Assam tea(Camellia sinensis ***)

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Plant Diversity 2024年第2期46卷 229-237页

作者： Miao-Miao li Muditha K.Meegahakumbura Moses C.Wambulwa Kevin S.Burgess Michael Möller zong-fang Shen De-Zhu li lian-Ming Gao CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of ScienceKunming650201China Kunming College of life Science University of Chinese Academy of SciencesKunming650201YunnanChina Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla90000Sri Lanka Department of life Sciences School of Science and ComputingSouth Eastern Kenya University170-90200KituiKenya Department of Biology Columbus State UniversityUniversity System of GeorgiaColumbusGA31907-5645USA Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburghEH35LRScotlandUK lijiang Forest Biodiversity National Observation and Research Station Kunming Institute of BotanyChinese Academy of SciencesLijiang674100YunnanChina

Chinese Assam tea(Camellia sinensis ***)is an important tea crop with a long history of cultivation in Yunnan,*** its potential value as a genetic resource,its genetic diversity and domestication/breeding history remain *** address this issue,we genotyped 469 ancient tea plant trees representing 26 *** *** populations,plus two of its wild relatives(six and three populations of *** and ***,respectively)using 16 nuclear microsatellite *** showed that Chinese Assam tea has a relatively high,but comparatively lower gene diversity(H_(S)=0.638)than the wild relative ***(H_S=0.658).Clustering in STRUCTURE indicated that Chinese Assam tea and its two wild relatives formed distinct genetic groups,with considerable interspecific *** Chinese Assam tea accessions clustered into three gene pools,corresponding well with their geographic ***,New Hybrids analysis indicated that 68.48%of ancient Chinese Assam tea plants from Xishuangbanna were genetic intermediates between the Puer and lincang gene *** addition,10%of the ancient Chinese Assam tea individuals were found to be hybrids between Chinese Assam tea and *** results suggest that Chinese Assam tea was domesticated separately in three gene pools(Puer,lincang and Xishuangbanna)in the Mekong River valley and that the hybrids were subsequently selected during the domestication *** the domestication history of Chinese Assam tea in southwestern Yunnan remains complex,our results will help to identify valuable genetic resources that may be useful in future tea breeding programs.

关键词： Tea plant Hybrid origin Genetic diversity Domestication history Camellia sinensis var.assamica Camellia taliensis

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汉代羌人各部述论

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西南民族学院学报（哲学社会科学版） 2001年第6期22卷 51-62页

作者：李宗放西南民族学院文学院四川成都610041

汉代羌人分支和名称是历代最多的，本文收集了文献中可见的汉代各部分羌人名称，并对各部间的关系及其分布、出现时间、简要事迹进行了论述。以展示汉代无人各部全貌。

关键词：汉代羌人民族历史名称部落烧当羌滇那羌先霍羌卑和羌勒祖种凉州刺史部三辅益州刺史部

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Exploring battery material failure mechanisms through synchrotron X-ray characterization techniques

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Journal of Energy Chemistry 2024年第7期94卷 128-135页

作者： lingzhe fang Xiaozhao liu Tao li Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA X-ray Science Division and Joint Center forEnergy Storage Research Argonne National LaboratoryLemontIL6439UA

Rechargeable battery cycling performance and related safety have been persistent *** is crucial to decipher the capacity fading induced by electrode material failure via a range of *** these,synchrotron-based X-ray techniques with high flux and brightness play a key role in understanding degradation *** this comprehensive review,we summarize recent advancements in degra-dation modes and mechanisms that were revealed by synchrotron X-ray ***,an overview of X-ray absorption spectroscopy and X-ray scattering techniques is introduced for charac-terizing failure phenomena at local coordination atomic environment and long-range order crystal struc-ture scale,*** last,we envision the future of exploring material failure mechanism.

关键词： Battery failure Synchrotron-based techniques X-ray scattering X-ray absorption spectroscopy

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明代四川建昌地区的行政和军事建置及变化

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西南民族大学学报（人文社会科学版） 2006年第10期27卷 23-29页

作者：李宗放西南民族大学图书馆

明代建昌地区建置变化很大,有其特殊性。洪武二十五年前主要是行政建置,以当地民族为府州县卫所土官。洪武二十五年后,月鲁帖木儿等土官反明被平定,明王朝废除了行政建置,代以军事建置,增设四川行都司和卫所,驻军达五万多人。四川行都... 详细信息

明代建昌地区建置变化很大,有其特殊性。洪武二十五年前主要是行政建置,以当地民族为府州县卫所土官。洪武二十五年后,月鲁帖木儿等土官反明被平定,明王朝废除了行政建置,代以军事建置,增设四川行都司和卫所,驻军达五万多人。四川行都司辖六卫三十二千户所和五个长官司。行都司官员以流官为主,卫所官员有流有土,长官司为土官。明后期万历三年省建昌前卫后,才出现五卫八所。明前期,行都司及卫所、长官司有效地统治着建昌地区。明中期后,由于军民与夷人交往中的不良行为引起边衅,建昌卫土指挥使和邛部长官司土官衰落,原受土官抑制的彝族奴隶制扩张,掠夺劫杀卫所城镇军民,导致卫所萧条,控制范围大大缩小,军士减至五千多,靠从外地调入大批军队才能平定动乱。继之增置营戍,增派数千军士,分五大信地防守,但仍不能有效控制交通沿线,这种情况直到明朝灭亡。

关键词：明代建昌行政建置军事建置卫所土官

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Morphological changes of blood spleen barrier in portal hypertensive spleen

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Chinese Medical Journal 2008年第6期121卷 561-565页

作者： li zong-fang ZHANG Shu HUANG Ying XIA Xian-ming li Ai-min PAN Dun ZHANG Wei WANG Juan Department of General Surgery Second Affiliated Hospital School of Medicine Xi'anJiaotong University Xi'an Shaanxi 710004 China Department of Pathology Second Affiliated Hospital School of Medicine Xi'anJiaotong University Xi'an Shaanxi 710004 China

The pathogenesis of hypersplenism and the immune function of the spleen in patients with portal hypertension （PH） remain obscure. This study aimed to evaluate the morphological changes of blood spleen barrier in spleen with hypersplenism due to PH and provide evidence for an in-depth investigation of the immune function of the spleen with hypersplenism and the mechanism of hypersplenism. Methods Spleen samples from 12 portal hypertensive patients and 4 patients with traumatic ruptures of spleen were examined. The samples of spleen were made into pathological sections, stained with Masson trichrome stain, Gomori stain, and CD68, CD34 immunohistochemistry, and were examined microscopically for the changes in the distribution of collagen fibers, reticular fibers, macrophages, and vascular endothelial cells. The changes in ultrastructure of macrophages and endothelial cells in marginal zone were also evaluated by transmission electron microscopy. Results As compared to the normal spleen, the density of macrophage in the PH spleen was decreased, but the macrophages were mainly located in the marginal zone and distributed around the splenic corpuscle, with many villi and pseudopodium-like protrusion on the cell surface. The accrementition of collagen fibers was obvious around the splenic corpuscle and central artery. The increased reticulate fibers encircled the splenic corpuscle with more connection between the fibers. The vascular endothelial cells were in diffused distribution, without any regionality in PH spleen, but the vessel with enlarged lumina increased in red pulp. Conclusions The morphological changes of the blood spleen barrier can be one of the pathological fundaments for the abnormality of the immune function and the increased destruction of blood cells located in the spleens of patients with PH However. this still entails clarification.

关键词： hypertension, portal spleen blood spleen barrier hypersplenism

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Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats

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Chinese Medical Journal 2008年第11期121卷 1010-1014页

作者： DANG Shuang-suo ZHANG Xin JIA Xiao-li CHENG Yan-an SONG Ping liU En-qi HE Qian li zong-fang Department of Infectious Diseases the Second Hospital of Xi'an Jiaotong UniversityXi'an Shaanxi 710004 China Experimental Animal Center Medical College of Xi'an JiaotongUniversity Xi'an Shaanxi 710061 China Clinical Laboratory the Second Hospital of Xi'an Jiaotong UniversityXi'an Shaanxi 710004 China Department of Surgery the Second Hospital of Xi'an Jiaotong UniversityXi'an Shaanxi 710004 China

Background Chinese medicine plays an important role in hepatoprotective treatment. This study was conducted to investigate the protective effects of emodin and astragalus polysaccharides （APS） in a rat model of chronic hepatic injury. Methods Chronic hepatic injury was induced by hypodermic injection of an olive oil solution containing 40% carbon tetrachlodde （CCI4） twice a week, in addition to a diet of 79.5% maizena, 20% fat, 0.5% cholesterol, and 10% alcohol in the drinking water ad libitum for 12 weeks. Meanwhile, the rats were exposed to different concentrations of emodin （40 mg·kg^-1·d^-1）, APS （200 mg·kg^-1·d^-1）, combination drug （emodin 40 mg·kg^-1·d^-1 combined with APS 200 mg·kg^-1·d^-1） and colchicine （0.1 mg·kg^-1·d^-1） in parallel by oral gavage （once a day for 12 weeks）. At the end of 12 weeks, blood serum and liver tissue were taken. Serum was collected to determine the levels of total bilirubin （TBIL）, alanine transaminase （ALT）, aspartate transaminose （AST）, and albumin （ALB）. liver and spleen indexes were assayed, followed by the measurements of the liver associated enzyme superoxide dismutase （SOD） and malondialdehyde （MDA）. Histopathological changes were studied using optical microscopy. Results Splenohepatomegalia was alleviated and serum levels of TBIL and ALT were reduced in the groups treated with emodin and APS when compared to the control group. In addition, the ALB level in the APS and combination groups was higher. Similarly, the SOD activity of liver homogenates was significantly higher in the groups treated with emodin and APS, while administration of the herbal derivatives prevented the elevation in MDA levels. Histological analysis showed that the APS and combination groups significantly ameliorated the hepatic injury. Conclusions Co-administration of emodin and APS demonstrated a synergistic action in reducing ALT and restoring ALB in the serum from a rat model of chronic hepatic injury. Emodin and APS may ameliorate the CCI4-

关键词： emodin astragalus polysaccharides carbon tetrachloride hepatic injury

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