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Characteristic Dihydroagarofuran Sesquiterpenoids with Neuroprotective Effects from the Celastraceae Plant Tripterygium wilfordii

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Chinese Journal of Chemistry 2021年第9期39卷 2547-2554页

作者： Fangyou Chen Jing Wang Yongming Luo Chuangjun li Jiwu Huang Jie Ma dongming Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicoChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchangJiangxi 330004China School of Pharmacy China Pharmaceutical UniversityNanjingJiangsu 211198China

Ten new characteristic dihydroagarofuran sesquiterpenoids and three known ones were acquired from the Celastraceae plant Tripterygium *** structure characterizations were done through spectroscopic data,while compounds 10-12 were further con firmed by single crystal *** dihydroagarofurans protected PC12 cells against H2O2-i nduced cytotoxicity as detected by CCK8 *** 5-7 and 13 sign ificantly in creased the levels of reactive oxyge n species(ROS)and superoxide dismutase(SOD),and decreased malondialdehyde(MDA)*** addition,compounds 5-7 and 13 activated the Nrf2 signaling pathway and increased Nrf2,NQO1,and HO1 expression levels in PC12 cells after H_(2)O_(2) treatment.

关键词： Tripterygium wilfordii Terpenoids Structure elucidation Neuroprotective effects X-ray diffraction

A comparison of flight energetics and kinematics of migratory Brambling and residential Eurasian Tree Sparrow

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Avian Research 2020年第3期11卷 215-223页

作者： Yang Wang Yuan Yin Zhipeng Ren Chuan Jiang Yanfeng Sun Juyong li Ghulam Nabi Yuefeng Wu dongming li Key Laboratory of Animal Physiology Biochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China Ocean College of Hebei Agricultural University Qinhuangdao 066003China

Background:Unlike resident birds,migratory birds are generally believed to have evolved to enhance flight efficiency;however,direct evidence is still scarce due to the difficulty of measuring the flight speed and mechanical ***:We studied the differences in morphology,flight kinematics,and energy cost between two passerines with comparable size,a migrant(Fringilla montifringilla,Brambling,BRAM),and a resident(Passer montanus,Eurasian Tree Sparrow,TRSP).Results:The BRAM had longer wings,higher aspect ratio,lower wingbeat frequency,and stroke amplitude compared to the TRSP despite the two species had a comparable body *** BRAM had a significantly lower maximum speed,lower power at any specific speed,and thus lower flight energy cost in relative to the TRSP although the two species had a comparable maximum vertical speed and ***:Our results suggest that adaptation for migration may have led to reduced power output and maximum speed to increase energy efficiency for migratory flight while residents increase flight speed and speed range adapting to diverse habitats.

关键词： Flight energy efficiency Flight kinematics Flight speed Maximum load-lifting capacity

Psiguamers A-C, three cytotoxic meroterpenoids bearing a methylated benzoylphloroglucinol framework from Psidium guajava and total synthesis of 1 and 2

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Chinese Chemical Letters 2021年第5期32卷 1721-1725页

作者： Jiwu Huang Chuangjun li Jie Ma Yingda Zang Xingyan Sun Xiaoguang Chen dongming Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicoChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Three sesquiterpene-based meroterpenoids psiguamers A-C(1-3)with new skeletons were isolated from Psidium guajava ***(±)-1 and(±)-2 were two pairs of humulene-de「ived meroterpenoids bearing a rare methylated benzoylphloroglucinol unit,while 3 was an unprecedented adduct of bicyclogermacrene and methylated *** structures were determined based on comprehensive analyses of spectroscopic data,calculated electronic circular dichroism(ECD)spectra,total synthesis,and X-ray crystallographic *** biomimetic synthesis of(±)-1 and(±)-2 was ***(+)-1 exhibited cytotoxic activities against five human tumor cell lines(HCT-116,HepG2,BGC-823,A549,and U251),with IC_(50) values of 2.94,9.01,6.45,5.42,and 5.33 μmol/L,respectively.

关键词： Psidium guajava Methylated benzoylphlorogiucinol Meroterpenoids Biomimetic synthesis Cytotoxic activities

Primary root and root hair development regulation by OsAUX4 and its participation in the phosphate starvation response

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Journal of Integrative Plant Biology 2021年第8期63卷 1555-1567页

作者： Rigui Ye Yunrong Wu Zhenyu Gao Hao Chen lixia Jia dongming li Xugang li Qian Qian Yanhua Qi State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou310058 China Key Laboratory of Herbage&Endemic Crop Biology of Ministry of Education Inner Mongolia Key Laboratory of Herbage&Endemic Crop BiotechnologySchool of Life SciencesInner Mongolia UniversityHohhot010000 China State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou310006 China State Key Laboratory of Crop Biology College of Life SciencesShandongAgricultural UniversityTai'an271018 China Sino-German Joint Research Center on Agricultural Biology College of Life SciencesShandong Agricultural UniversityTai'an271018 China

Among the five members of AUX1/LAX genes coding for auxin carriers in rice,only OsAUX1 and OsAUX3 have been *** understand the function of the other AUX1/LAX genes,two independent alleles of osaux4 mutants,osaux4-1 and osaux4-2,were constructed using the CRISPR/Cas9 editing *** osaux4-1 or osaux4-2 exhibited shorter primary root(PR)and longer root hair(RH)compared to the wild-type Dongjin(WT/DJ),and lost response to indoleacetic acid(IAA)***4 is intensively expressed in roots and localized on the plasma membrane,suggesting that OsAUX4 might function in the regulation of root *** decreased meristem cell division activity and the downregulated expression of cell cycle genes in root apices of osaux4 mutants supported the hypothesis that OsAUX4 positively regulates PR ***4 is expressed in RH,and osaux4 mutants showing longer RH compared to WT/DJ implies that OsAUX4 negatively regulates RH ***,osaux4 mutants are insensitive to Pi starvation(-Pi)and OsAUX4 effects on the-Pi response is associated with altered expression levels of Pi starvation-regulated genes,and auxin distribution/*** study revealed that OsAUX4 not only regulates PR and RH development but also plays a regulatory role in crosstalk between auxin and-Pi signaling.

关键词： OsAUX4 phosphate starvation primary root root hair development rice

Network-Assisted Full-Duplex Cell-Free mmWave Massive MIMO Systems with DAC Quantization and Fronthaul Compression

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China Communications 2024年第11期21卷 75-87页

作者： li Jiamin Fan Qingrui Zhang Yu Zhu Pengcheng Wang dongming Wu Hao You Xiaohu National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China Department of Electronic&Information Engineering Nanjing University of Information Science&TechnologyNanjing 210044China State Key Laboratory of Mobile Network and Mobile Multimedia Technology ZTE CorporationShenzhen 518055China

In this paper,we investigate networkassisted full-duplex(NAFD)cell-free millimeter-wave(mmWave)massive multiple-input multiple-output(MIMO)systems with digital-to-analog converter(DAC)quantization and fronthaul *** propose to maximize the weighted uplink and downlink sum rate by jointly optimizing the power allocation of both the transmitting remote antenna units(T-RAUs)and uplink users and the variances of the downlink and uplink fronthaul compression *** deal with this challenging problem,we further apply a successive convex approximation(SCA)method to handle the non-convex bidirectional limited-capacity fronthaul *** simulation results verify the convergence of the proposed SCA-based algorithm and analyze the impact of fronthaul capacity and DAC quantization on the spectral efficiency of the NAFD cell-free mmWave massive MIMO ***,some insightful conclusions are obtained through the comparisons of spectral efficiency,which shows that NAFD achieves better performance gains than cotime co-frequency full-duplex cloud radio access network(CCFD C-RAN)in the cases of practical limited-resolution ***,their performance gaps with 8-bit DAC quantization are larger than that with1-bit DAC quantization,which attains a 5.5-fold improvement.

关键词： cell-free massive MIMO DAC quantization millimeter-wave network-assisted full-duplex

Coping with extremes:lowered myocardial phosphofructokinase activities and glucose content but increased fatty acids content in highland Eurasian Tree Sparrows

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Avian Research 2021年第4期12卷 699-706页

作者： Boyang Ding Yuliang Zhao Yanfeng Sun Qian Zhang Mo li Ghulam Nabi Yuefeng Wu Chuan Jiang dongming li Key Laboratory of Animal Physiology Biochemistry and Molecular Biol-ogy of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuang 050010China Ocean College Hebei Agricultural University066003 QinhuangdaoChina College of life Science Cangzhou Normal University061001 CangzhouChina

Background:Efficient and selective utilization of metabolic substrates is one of the key strategies in high-altitude animals to cope with hypoxia and *** findings have shown that the energy substrate utilization of highland animals varies with evolutionary history and *** heart is a proxy for the cardiopulmonary system,and the metabolic substrate utilization in the myocardium is also under the strong selective pressure of chronically hypoxic and hypothermic ***,little information is available on the physiological adjustments in relation to metabolic substrate utilization in the myocardium for coping with high-altitude ***:We compared the metabolic enzyme activities,including hexokinase(HK),phosphofructokinase(PFK),pyruvate kinase(PK),citrate synthase(CS),carnitine palmitoyl transferase 1(CPT-1),lactic dehydrogenase(LDH),and creatine kinase(CK),and metabolic substrate contents including glucose(Glu),triglyceride(TG),and free fatty acid(FFA)in the myocardium of a typical human commensal species,Eurasian Tree Sparrows(Passer montanus)between the Qinghai-Tibet Plateau(the QTP,3230 m)and low altitude population(Shijiazhuang,80 m),and between ***:Among the seven metabolic enzymes and three substrates investigated,we identified no significant differences in PK,CPT-1,HK,CS,LDH,and CK activities and TG content of the myocardium between high and low altitude ***,the QTP sparrows had significantly lower Glu content and PFK activities but higher FFA content relative to their lowland *** addition,male sparrows had higher myocardial HK and CS activities relative to females,independent of ***:Our results showed that the QTP sparrows elevated fatty acid utilization rather than glucose preference in the myocardium relative to lowland counterpart,which contributes to uncovering both the physiological adjustments for adapting to the extreme conditions of the QTP,intraspe

关键词： Energy utilization Eurasian Tree Sparrow Metabolic enzyme Myocardium The Qinghai-Tibet Plateau

Hibernation with rhythmicity:the circadian clock and hormonal adaptations of the hibernating Asiatic toads(Bufo gargarizans)

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Integrative Zoology 2022年第4期17卷 656-669页

作者： Zhigang XIE Ibrahim M.AHMAD lirong ZUO Feng XIAO Yongpeng WANG dongming li Zhejiang Academy of Agricultural Sciences HangzhouChina College of Chemistry and life Science Zhejiang Normal UniversityJinhuaChina Ministry of Education Key Laboratory of Molecular and Cellular Biology Key Laboratory of Animal PhysiologyBiochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuangChina

Hibernation is one of the fundamental strategies in response to cold environmental *** hibernation,the endocrine and circadian systems ensure minimal expenditure of energy for *** circadian rhythms of key hormones,melatonin(MT),corticosterone(CORT),triiodothyronine(T3),and thyroxine(T4),and the underlying molecular regulatory mechanisms of hibernation have been well determined in mammals but not in ***,a terrestrial hibernating species,Asiatic toad(Bufo gargarizans),was employed to investigate the plasma CORT,MT,T3,and T4;and the retina,brain,and liver mRNA expression of the core clock genes,including circadian locomotor output cycles kaput(Clock),brain and muscle ARNT-like 1(Bmal1),cryptochrome(Cry)1 and 2,and period(Per)1 and 2,at 7-time points over a 24-h period under acute cold(1 day at 4℃),and hibernation(45 days at 4℃).Our results showed that the circadian rhythms of the core clock genes were rather unaffected by acute cold exposure in the retina,unlike the brain and *** contrast,during hibernation,the liver clock genes displayed significant circadian oscillations,while those in the retina and brain stopped ***,plasma CORT expressed circadian oscillations in both groups,and T3 in acute cold exposure group,whereas T4 and MT did *** results reveal that the plasma CORT and the liver sustain rhythmicity when the brain was not,indicating that the liver clock along with the adrenal clock synergistically maintains the metabolic requirements to ensure basic survival in hibernating Asiatic toads.

关键词： Asiatic toad circadian rhythm clock genes cold exposure hibernation metabolic hormones

FAST SOLUTION OF TRANSIENT SCATTERING FROM ELECTRICALLY LARGE COMPLEX OBJECTS BASED ON TIME DOMAIN INTEGRAL EQUATION SOLVERS

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Journal of Electronics(China) 2010年第1期27卷 99-104页

作者： li Ying Ren Meng Zhou dongming He Jianguo College of Electronics Science and Engineering National University of Defense Technology Changsha 410073 China

A fast Time Domain Integral Equation(TDIE) solver is presented for analysis of transient scattering from electrically large conducting complex *** numerical process of Marching-On-in-Time(MOT) method based TDIE encounters high computational cost and exorbitant memory requirements.A group-style accelerated method-Plane Wave Time Domain(PWTD) algorithm,which permits rapid evaluation of transient wave field generated by temporally bandlimited sources,is employed to reduce the computational cost of MOT-based TDIE *** efficient compressed storage technique for sparse matrix is adopted to decrease the enormous memory requirements of *** scheme of the Multi-Level PWTD(MLPWTD)-enhanced MOT with compressed storage for sparse matrix is presented for analysis of transient scattering from electrically large complex objects in this *** numerical simulation results demonstrate the validity and efficiency of the presented scheme.

关键词： Time Domain Integral Equation(TDIE) Marching-On-in-Time(MOT) Plane Wave Time Domain(PWTD) Compressed storage

Breath-by-breath measurement of exhaled ammonia by acetonemodifier positive photoionization ion mobility spectrometry via online dilution and purging sampling

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Journal of Pharmaceutical Analysis 2023年第4期13卷 412-420页

作者： Lu Wang Dandan Jiang Lei Hua Chuang Chen dongming li Weiguo Wang Yiqian Xu Qimu Yang Haiyang li Song Leng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Health Management Center The Second Affiliated Hospital of Dalian Medical UniversityDalian116023China University of Chinese Academy of Sciences Beijing100049China Dalian Key Laboratory for Online Analytical Instrumentation Dalian116023China Dalian Engineering Research Center of Breath Diagnostic Technology Dalian116023China

Exhaled ammonia(NH_(3))is an essential noninvasive biomarker for disease *** this study,an acetone-modifier positive photoionization ion mobility spectrometry(AM-PIMS)method was developed for accurate qualitative and quantitative analysis of exhaled NH_(3)with high selectivity and *** was introduced into the drift tube along with the drift gas as a modifier,and the characteristic NH_(3)product ion peak of(C_(3)H_(6)O)_(4)NH_(4)^(+)(K_(0)=1.45 cm^(2)/V·s)was obtained through the ion-molecule reaction with acetone reactant ions(C_(3)H_(6)O)_(2)H^(+)(K_(0)=1.87 cm^(2)/V·s),which significantly increased the peak-to-peak resolution and improved the accuracy of exhaled NH_(3)qualitative ***,the interference of high humidity and the memory effect of NH_(3)molecules were significantly reduced via online dilution and purging sampling,thus realizing breath-by-breath *** a result,a wide quantitative range of 5.87-140.92μmol/L with a response time of 40 ms was achieved,and the exhaled NH_(3)profile could be synchronized with the concentration curve of exhaled CO_(2).Finally,the analytical capacity of AM-PIMS was demonstrated by measuring the exhaled NH_(3)of healthy subjects,demonstrating its great potential for clinical disease diagnosis.

关键词： Photoionization ion mobility spectrometry Acetone modifier Exhaled ammonia Breath analysis