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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian li Mengxin Xu Jingyi Yang li Zhou lin liu Min li Shasha Wang Mei-Qin liu zhixiang Huang Zhen Zhang Shuning liu Yunqi Hu Haofeng lin Bowen liu Ying Sun Qingguo Wu Zheng-li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode *** this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery *** mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this *** leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/***,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami *** interaction of Al and F is advantageous to realize the defluoridation to some *** is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

Genetic parameters and response to selection for body weight in turbot(Scophthalmus maximus, linnaeus)

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Acta Oceanologica Sinica 2018年第6期37卷 47-51页

作者： LYU Ding WANG Weiji LUAN Sheng HU Yulong GUAN Jiantao li zhixiang WU Huanhuan KONG Jie liU Shoutang Wuxi Fisheries College Nanjing Agricultural University Wuxi 214081 China Key Laboratory for Sustainable Utilization of Marine Fisheries Resources of Ministry of Agriculture Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071 China Yellow Sea Fisheries limited Company Haiyang 265122 China

Genetic parameters and response to selection were estimated for harvest body weight in turbot. The data consisted of 10 952 individuals of 508 full-sib families from three generations（G0, G1, and G2）. The heritability estimates for G0, G1, and G2 were 0.11±0.08, 0.18±0.09, and 0.17±0.07, respectively. Over three generations, the heritability estimate was 0.19±0.04. Maternal and common environmental effects were 0.10±0.04, 0.14±0.04, and0.13±0.03 within each generation and 0.12±0.01 across generations. The selection differential in growth was 18.24 g in G0 and 21.19 g in G1 corresponding to an average of 19.72 g per generation. The genetic gains were also calculated, they were 22.06 g in G1 and 11.93 g in G2, corresponding to 6.36% and 3.52% body weight. The total genetic gain after two generations was 10.10% body weight, which indicated that the selective breeding program for the body weight trait in turbot was successful.

关键词： turbot genetic parameter selective breeding body weight Scophthalmus maximus

Wide frequency phonons manipulation in Si nanowire by introducing nanopillars and nanoparticles

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Chinese Physics B 2024年第4期33卷 78-84页

作者：李亚涛刘英光李鑫李亨宣王志香张久意 Hebei Key Laboratory of Low Carbon and High Efficiency Power Generation Technology North China Electric Power UniversityBaoding 071003China

The combination of different nanostructures can hinder phonons transmission in a wide frequency range and further reduce the thermal conductivity(TC).This will benefit the improvement and application of thermoelectric conversion,insulating materials and thermal barrier coatings,*** this work,the effects of nanopillars and Ge nanoparticles(GNPs)on the thermal transport of Si nanowire(SN)are investigated by nonequilibrium molecular dynamics(NEMD)*** analyzing phonons transport behaviors,it is confirmed that the introduction of nanopillars leads to the occurrence of lowfrequency phonons resonance,and nanoparticles enhance high-frequency phonons interface scattering and *** results show that phonons transport in the whole frequency range can be strongly hindered by the simultaneous introduction of nanopillars and *** addition,the effects of system length,temperature,sizes and numbers of nanoparticles on the TC are *** work provides useful insights into the effective regulation of the TC of nanomaterials.

关键词： resonant structure nanoparticles nanopillars phonon transport thermal conductivity

Fate of BHC in the terrestrial ecosystem

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Journal of Environmental Sciences 1989年第2期1卷 48-53页

作者： Huang Shizhong and li zhixiang National Agroenviromental Protection Institute,Tianjin,China

The fate of BHC in the terrestrial ecosystem was investigated under both laboratory and field conditions. The uptake, accumulation and degradation of BHC in earthworms and corn plants were studied. Earthworms could absorb and accumulate BHC residues from soil. Statistically, significant correlation existed between the amounts of BHC in soil and in earthworms. Different species of earthworms appeared to concentrate BHC in their bodies to different extents. In a terrestrial ecosystem, the uptake, accumulation of BHC residues by soil animals and plants had an effect on each other.

关键词： BHC terrestrial ecosystem absorption accumulation.

Heteroclinic orbits and heteroclinic chains for a discrete Hamiltonian system

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Science China Mathematics 2010年第6期53卷 1555-1564页

作者： ZHANG Hao & li zhixiang Department of Mathematics and Systems Science,College of Science,National University of Defense Technology,Changsha 410073,China Department of Mathematics and Systems Science College of Science National University of Defense Technology

In the present work we prove some existence results of heteroclinic orbits and heteroclinic chains for a second order discrete Hamiltonian system of the form Δ2q(t-1)+V(q(t))=0,t∈*** methods we use are variational in *** results show that under general conditions,for each maximum point β of V,the above system possesses multiple heteroclinic orbits joining β and some other maximum points of *** also prove that for any pair of distinct maximum points η and ξ of V,there exists at least one heteroclinic chain from η to ξ.

关键词： difference equation heteroclinic orbit heteroclinic chain variational method

Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia

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Food Science and Human Wellness 2024年

作者： Jiaojiao Han Jiayi Xiong zhixiang Bai Yang Qin Chenyang Lu Jun Zhou Ye li Tinghong Ming Zhen Zhang Xiurong Su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo University School of Marine Science Ningbo University

Iron deficiency anemia (IDA) is a nutritional deficiency disease with a high incidence rate worldwide. Bioactive peptides are safe and effective， have multiple functions and can serve as potential candidates for alleviating IDA. In this study， the anti-anemia effects of tuna dark muscle peptides were explored in a diet-induced IDA mouse model. The results showed that tuna dark muscle peptides alleviated the IDA phenotype， oxidative stress and iron metabolism. In addition， tuna dark muscle peptides reversed gut microbiota dysbiosis in IDA mice. Furthermore， the transplanted fecal microbiota from tuna dark muscle peptide-treated mice also alleviated IDA symptoms and regulated iron metabolism and the gut microbiota， indicating that the anti-anemic effects were at least partially mediated by the gut microbiota. Thus， we identified a new and safe prebiotic material to alleviate IDA and provided ideas for the development of peptides. At the same time， these data also provided a theoretical basis for fecal microbiota transplantation (FMT) to alleviate IDA.

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基于注意力分布参数回归的遥感图像配准

激光杂志 2023年第9期44卷 135-142页

作者：李志翔宋智礼上海应用技术大学计算机科学与信息工程学院上海201418

针对传统的遥感图像配准算法的鲁棒性差,且深度学习的配准算法的精度有待提高的问题,提出了一种基于注意力分布参数回归的遥感图像配准算法。首先,采用卷积神经网络和全局上下文融合获得针对性的特征;其次,进行特征互相关匹配并结合相... 详细信息

针对传统的遥感图像配准算法的鲁棒性差,且深度学习的配准算法的精度有待提高的问题,提出了一种基于注意力分布参数回归的遥感图像配准算法。首先,采用卷积神经网络和全局上下文融合获得针对性的特征;其次,进行特征互相关匹配并结合相互最近邻原则过滤错误匹配;然后,提出了一种注意力分布的参数回归网络估计仿射变换参数;最后,利用循环一致性损失函数正则化整体算法的训练过程以提高图像配准的性能。实验结果表明,相比于其他算法,所提算法能够提高遥感图像配准的精度,正确匹配率达到96.3%,同时对于多视角、多时相和多模态的遥感图像具有较强的鲁棒性。

关键词：遥感图像图像配准深度学习循环一致性注意力分布

PERIODIC CHARACTER OF A DIFFERENCE EQUATION WITH MAXIMUM

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Annals of Differential Equations 2005年第3期21卷 362-365页

作者： liu Yicheng li zhixiang Dept. of Math. and System Science Science School National University of Defence Technology Changsha 410073

We study the periodicity of the positive solutions of a class of difference equations with maximum. We prove that every positive solutions of these equations are eventually periodic.

关键词： periodic solutions nonlinear difference equation