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融合继续预训练和分部池化的司法事件检测模型

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中文信息学报 2024年第4期38卷 99-107页

作者：张家诚孙媛媛李志廷杨亮林鸿飞大连理工大学计算机科学与技术学院辽宁大连116024 最高人民检察院检察技术信息研究中心北京100726

事件检测任务在自然语言处理领域中具有重要的研究价值,其主要目标是从文本中识别并分类触发词,实现高级文本分析与语义理解。随着智慧司法建设的推进,自然语言处理模型与司法领域的结合日益紧密。然而,由于司法领域数据较为稀缺且一个... 详细信息

事件检测任务在自然语言处理领域中具有重要的研究价值,其主要目标是从文本中识别并分类触发词,实现高级文本分析与语义理解。随着智慧司法建设的推进,自然语言处理模型与司法领域的结合日益紧密。然而,由于司法领域数据较为稀缺且一个句子大多包含多个触发词等问题,该研究在预训练阶段,通过收集的十二万条司法犯罪数据对BERT进行继续预训练,以提高预训练模型对司法领域知识的理解能力;在微调阶段提出了一种分部池化结构并融合PGD对抗训练的方法,以捕获触发词上下文和句子整体的语义特征。该模型在法研杯CAIL 2022事件检测赛道上取得了明显的性能提升,比基于BERT的基线模型平均F 1值提高了3.0%。

关键词：事件检测司法领域预训练模型

Upstream CRP-binding site is not essential for CRP-cAMP-mediated inhibition on the nifU promoter

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Chinese Science Bulletin 2002年第21期47卷 1821-1825页

作者： li zhiting ZHANG Weijia WANG Yiping National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life SciencesPeking UniversityBeijing 100871China

When the NifA-mediated activation of Kleb-siella pneumontae nifU promoter is recreated in Escherichia coli, it has been observed that CRP-cAMP has an inhibitory effect on the nifU promoter. Sequence analysis indicates that there is a strong CRP-binding site located upstream of the nifU promoter, overlapping completely with a previously identified Nif A-binding site. In vitro gel retardation analysis indicates that this putative CRP-binding site has similar affinity for CRP, when compared with that at the lac promoter, suggesting that CRP could effectively compete with NifA for such a binding site under physiological conditions. When this putative CRP-binding site on nifU was mutated, in vitro gel retardation analysis indicates that CRP can no longer bind to the mutant promoter. However, when constitutively expressed NifA is used as the activator, CRP-cAMP-mediated inhibitory effect on this mutant nifU promoter has no significant difference when compared with that obtained from its wild-type promoter.

关键词： CRP-cAMP the nifU promoter gene regulation.

cAMP receptor protein (CRP) downregulates Klebsiella pneumoniae nif promoters in Escherichia coli

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Chinese Science Bulletin 2002年第19期47卷 1622-1628页

作者： zhiting li Yicheng Sun Xianjun Mao Yiping Wang Peking Univ Coll Life Sci Natl Lab Prot Engn & Plant Genet Engn Beijing 100871 Peoples R China

In enteric bacteria, in response to the PTS system, the cAMP receptor protein (CRP) mediates the glucose effect, via regulating σ70-dependent catabolic genes at transcriptional level. In this study, it is observed that the nitrogen fixation capacity of Klebsiella pneumoniae varies strongly when cells are grown on different carbohydrates, and this carbon effect occurs at the level of nif gene expression. Here we show that CRP can repress σ54-dependent nif promoters (nifB, nifE, nifF, nifH, nifJ, nifLA and nifU), in a cAMP dependent fashion, in closed related E. coll background. Sequence analysis of these nif promoters indicates that there is no direct correlation between the fold of CRP-cAMP-mediated inhibition and the upstream cis elements at the promoters. In addition, the crp gene of K. pneumoniae has been isolated and sequenced, which is structural and functional highly homologous to that of E. coli. This suggests that CRP-cAMP-mediated inhibition on the nif promoters could be the reason for

关键词： CRP-cAMP nif promoter regulation of gene expression nitrogen fixation.

Effect of Cadmium and Herbicides on the Growth, Chlorophyll and Soluble Sugar Content in Rice Seedlings

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Wuhan University Journal of Natural Sciences 2006年第3期11卷 742-748页

作者： HUANG He XIONG zhiting li Minjing XIONG Shuanglian li Shenglan Felicite Obono Mba College of Resources and Environment Sciences Wuhan UniversityWuhan 430072 Hubei China

To investigate the combined effects of Cd^2＋（ 0,10,100,500 μmol/L） , acetochlor （AC）（0,1.6,4.0,8.0μmol/L）, and bensulfuronmethyl （BSM）（ 0,0.16,0.40,0.80 μmol/L） on the biomass,leaf soluble sugar, total chlorophyll （chl） content, chl a/b ratio, and Cd content in roots and shoots in the rice seedlings, pot culture experiments were conducted with rice （Oryza sativa L. ） cultivar Jinyou 402. The results showed that the Cd and AC combined treatment （Cd＋ AC treatment） significantly inhibited the growth of the roots and shoots. The root dry weight/shoot dry weight （RDW/SDW） ratio, total chlorophyll content and chl a/b ratio decreased by 41%, 50%, 56% , respectively, in comparison with the control, as well as the leaf soluble sugar content, plant dry weight /plant fresh weight （PDW/PFW） ratio increased by 284% and 44% , respectively. Cd content in the roots and shoots had a decreasing tendency with the increasing concentration of AC under the Cd＋AC treatment. The Cd and BSM combined treatment （Cd＋BSM treatment） had a similar result to the Cd＋AC treatment. The results suggest that the toxicity of Cd to rice seedlings has been enhanced due to its combination with herbicides.

关键词： cadmium herbicide chlorophyll soluble sugar rice

Systematic engineering of BiVO_(4)photoanode for efficient photoelectrochemical water oxidation

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Carbon Energy 2024年第4期6卷 12-21页

作者： zhiting liang Meng li Kai‐Hang Ye Tongxin Tang Zhan lin Yuying Zheng Yongchao Huang Hongbing Ji Shanqing Zhang Guangzhou Key Laboratory of Clean Transportation Energy Chemistry School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhouChina Chemical Engineering Guangdong Laboratory Jieyang Branch of ChemistryJieyangChina Key Laboratory for Water Quality and Conservation of the Pearl River Delta Institute of Environmental Research at Greater Bay AreaMinistry of EducationGuangzhou UniversityGuangzhouChina State Key Laboratory Breeding Base of Green‐Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhouChina School of Environment and Science Centre for Catalysis and Clean EnergyGriffith UniversityGold Coast CampusSouthportQueenslandAustralia

BiVO_(4)is one of the most promising photoanode materials for photoelectrochemical(PEC)solar energy conversion,but it still suffers from poor photocurrent density due to insufficient light‐harvesting efficiency(LHE),weak photogenerated charge separation efficiency(Φ_(Sep)),and low water oxidation efficiency(Φ_(OX)).Herein,we tackle these challenges of the BiVO_(4)photoanodes using systematic engineering,including catalysis engineering,bandgap engineering,and morphology *** particular,we deposit a NiCoO_(x)layer onto the BiVO_(4)photoanode as the oxygen evolution catalyst to enhance theΦ_(OX)of Fe‐g‐C_(3)N_(4)/BiVO_(4)for PEC water oxidation,and incorporate Fe‐doped graphite‐phase C_(3)N_(4)(Fe‐g‐C_(3)N_(4))into the BiVO_(4)photoanode to optimize the bandgap and surface areas to subsequently expand the light absorption range of the photoanode from 530 to 690 nm,increase the LHE andΦ_(Sep),and further improve the oxygen evolution reaction activity of the NiCoO_(x)catalytic ***,the maximum photocurrent density of the as‐prepared NiCoO_(x)/Fe‐g‐C_(3)N_(4)/BiVO_(4)is remarkably boosted from 4.6 to 7.4 mA cm^(−2).This work suggests that the proposed systematic engineering strategy is exceptionally promising for improving LHE,Φ_(Sep),andΦ_(OX)of BiVO_(4)‐based photoanodes,which will substantially benefit the design,preparation,and large‐scale application of next‐generation high‐performance photoanodes.

关键词： bismuth vanadate carbon nitride charge separation heterojunction water oxidation

Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress

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International Journal of Oral Science 2024年第3期16卷 553-562页

作者： Zhiyao Yuan Junjie li Fuyu Xiao Yu Wu zhiting Zhang Jiahong Shi Jun Qian Xudong Wu Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyState Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingChina

Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival *** therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative ***(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant *** study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular *** found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory *** Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in *** molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence *** immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor *** functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant ***,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative ***,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.

关键词： Bach1 period prompt

“大一统”与“华夷之辨”的理论对决——《大义觉迷录》解读

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历史档案 2021年第2期34卷 127-132页

作者：李治亭国家清史编纂委员会 100080

一个皇帝与一个囚徒展开书面理论对话,辩驳当时的治国方略与民族问题,这并非是天方夜谭,却是一桩实实在在的史事。这位皇帝,就是雍正帝。囚徒名叫曾静,是湖南永兴人,科举落第,在家收徒教书,自著两书,一曰《知几录》,一曰《知新录》,表... 详细信息

一个皇帝与一个囚徒展开书面理论对话,辩驳当时的治国方略与民族问题,这并非是天方夜谭,却是一桩实实在在的史事。这位皇帝,就是雍正帝。囚徒名叫曾静,是湖南永兴人,科举落第,在家收徒教书,自著两书,一曰《知几录》,一曰《知新录》,表达出“华夷之辨”的强烈意识。

关键词：华夷之辨治国方略雍正帝湖南永兴理论对话知新录大一统囚徒

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论“土司学”的独特性

吉首大学学报（社会科学版） 2017年第4期38卷 13-18页

作者：李治亭国家清史编纂委员会北京100080

任何一门专业研究领域,都有它的独特性。舍此,便不能称"学"。土司学的形成,不仅是土司研究长期发展的产物,更在于它有独特的学术内涵。这一独特的学术内涵源于独特的土司制度史。自元以来,土司制度就是西南地区重要的地方行政管理制度,... 详细信息

任何一门专业研究领域,都有它的独特性。舍此,便不能称"学"。土司学的形成,不仅是土司研究长期发展的产物,更在于它有独特的学术内涵。这一独特的学术内涵源于独特的土司制度史。自元以来,土司制度就是西南地区重要的地方行政管理制度,它对西南诸省的治乱兴衰,起着举足轻重的作用。因此,研究西南各省之历史,土司制度的研究是无可替代的。土司制度的独特性表现是代表了一种区域社会管理的新模式;土司作为世袭的地方官,其承袭、朝贡、征调等规定,也与流官完全不同。特别是作为边疆地区的管理制度,土司制度与明代东北的卫所制,清代蒙古的盟旗制、新疆的伯克制也是差异明显的。而现存众多的土司遗址、土司文化遗产更集中表现了土司制度、土司文化的独特性。可以说,没有独特性的土司制度,就没有土司学的独特性。

关键词：土司学土司制度独特性东北卫所制

从关注结果的“学会”,走向关注过程的“会学”——网络学习者在线学习力测评与发展对策研究

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开放教育研究 2017年第4期23卷 92-100页

作者：李宝敏祝智庭华东师范大学开放教育学院上海200062

在"互联网+"时代,成人学习者网络教育的目标不应仅关注其学会既定的知识与技能,更重要的是通过有效的支持让他们成为会学、有主动学习意识与学习能力的终身学习者。从"学会"到"会学",从关注结果走向兼顾过程,将过程与结果融为一体,帮助... 详细信息

在"互联网+"时代,成人学习者网络教育的目标不应仅关注其学会既定的知识与技能,更重要的是通过有效的支持让他们成为会学、有主动学习意识与学习能力的终身学习者。从"学会"到"会学",从关注结果走向兼顾过程,将过程与结果融为一体,帮助网络学习者具有终身学习力,适应学习型社会发展,是网络教育育人目标的发展与提升。本研究借鉴国外学习力测评工具,利用实证研究方法,对网络学习者在线学习力现状进行测评,针对当前网络学习者动机多元,问题意识弱、意志力缺乏,互惠性学习关系尚未真正建立等学习力现状,有针对性地提出重视学习体验,激发内源动力;加强学法指导,重视问题生成与解决过程;重视元学习过程,提高网络学习者的学习规划管理、评价反思与自主调节能力;构建激励性与支持性的学习共同体文化,促进互惠式学习等对策与建议。

关键词：网络学习者学习力测评发展