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Ultrasound-guided stellate ganglion blockade: an appealing tactic for cardiac electrical storm

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Journal of Geriatric Cardiology 2023年第5期20卷 376-382页

作者： Zi-Hao LAI li-hui zheng Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Ventricular arrhythmia(VA)is a life-threatening cardiac *** VA occurs three times or more within 24 h and interventions are required,it is defined as an electrical storm(ES)characterized by refractoriness and recurrence.[1]For patients with implantable cardioverter defibrillator(ICD),the notion is redefined as no fewer than three appropriate and separate(at least 5 min for each interval)ICD interventions given within 24 h.

关键词： cardiac storm electrical

Quantum Tunneling Radiation of Reissner-Nordstrom de Sitter Black Hole with a Global Monopole

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Communications in Theoretical Physics 2006年第3期45卷 457-460页

作者： JIANG Qing-Quan YANG Shu-zheng li hui-ling Institute of Theoretical Physics West China Normal University Nanchong 637002 China

Applying Parikh＇s quantum tunneling model, we study the quantum tunneling radiation of Reissne- Nordstrom de Sitter black hole with a global monopole. The result shows that the tunneling rates at the event horizon and the cosmic horizon are related to Bekenstein-Hawking entropy if we take the energy conservation into consideration, and the true radiate spectrum is not precisely thermal.

关键词： Reissner-Nordstrom de Sitter black hole global monopole energy conservation tunneling rate

Overexpression of polo-like kinase1 predicts a poor prognosis in hepatocellular carcinoma patients

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World Journal of Gastroenterology 2009年第33期15卷 4177-4182页

作者： Zi-li He He zheng hui lin Xiong-Ying Miao De-Wu Zhong Department of Hepatobiliary Surgery Xiangya Second Hospital Central South University Changsha 410011 Hunan Province China

AIM： To elucidate the role of overexpressed polo-like kinasel （PLK1）in hepatocellular carcinoma （HCC）. METHODS： We prospectively collected clinicopathological, immunohistochemical and semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR） data from 135 HCC patients undergoing successful hepatectomy. The correlations between PLK1 mRNA expression and clinicopathologic variables were analyzed by Mann-Whitney U test. Prognostic factors were identified by univariate and multivariate analyses. RESULTS： Immunohistochemical results showed overexpression of PLK1 was mainly found in tumor tissues compared with tumor-free tissue. A similar mRNA result was obtained by semi-quantitative RT-PCR. A total of 111 samples were positive for PLK1 mRNA expression. The positive expression was correlated with venous invasion, tumor nodules and Edmondson grade. Furthermore, 1, 3, 5-year survival rates in the positive expression group were significantly lower than the negative control group. Multivariate analysis showed that positive PLK1 expression was an independent risk factor for HCC. CONCLUSION： PLK1 could be a potential biomarker for diagnosis and therapy for HCC.

关键词： Hepatocellular carcinoma Immunohistochemistry Reverse transcription-polymerase chain reaction Survival analysis Polo-like kinase 1

Situational continuity-based air combat autonomous maneuvering decision-making

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Defence Technology（防务技术） 2023年第11期29卷 66-79页

作者： Jian-dong Zhang Yi-fei Yu li-hui zheng Qi-ming Yang Guo-qing Shi Yong Wu School of Electronics and Information Northwestern Polytechnical UniversityXi'an710129China Military Representative Office of Haizhuang Wuhan Bureau in Luoyang Region 471000China

In order to improve the performance of UAV's autonomous maneuvering decision-making,this paper proposes a decision-making method based on situational *** algorithm in this paper designs a situation evaluation function with strong guidance,then trains the Long Short-Term Memory(LSTM)under the framework of Deep Q Network(DQN)for air combat maneuvering *** the continuity between adjacent situations,the method takes multiple consecutive situations as one input of the neural *** reflect the difference between adjacent situations,the method takes the difference of situation evaluation value as the reward of reinforcement *** different scenarios,the algorithm proposed in this paper is compared with the algorithm based on the Fully Neural Network(FNN)and the algorithm based on statistical principles *** results show that,compared with the FNN algorithm,the algorithm proposed in this paper is more accurate and *** with the algorithm based on the statistical principles,the decision-making of the algorithm proposed in this paper is more efficient and its real-time performance is better.

关键词： UAV Maneuvering decision-making Situational continuity Long short-term memory(LSTM) Deep Q network(DQN) Fully neural network(FNN)

Experimental study on the degree and damage-control mechanisms of fuzzy-ball-induced damage in single and multi-layer commingled tight reservoirs

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Petroleum Science 2023年第6期20卷 3598-3609页

作者： Chinedu J.Okere James J.Sheng li-Kun Fan Xiao-Wei Huang li-hui zheng Pan-Feng Wei Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityTXUSA College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China China Changqing Oilfield Company CNPCXi'an710018ShaanxiChina Beijing lihuiLab Energy Technology Co. Ltd.Beijing102200China

Fuzzy-ball working fluids(FBWFs)have been successfully applied in different development phases of tight *** reports revealed that FBWFs satisfactorily met all the operational and reservoir damage control requirements during their ***,the damage-control mechanisms and degree of formation damage caused by fuzzy-ball fluids have not been investigated in lab-scale studies so *** this study,the degree of fuzzy-ball-induced damage in single-and double-layer reservoirs was evaluated through core flooding experiments that were based on permeability and flow rate ***,its damage mechanisms were observed via scanning electron microscope and energy-dispersive spectroscopy *** results show that:(1)For single-layer reservoirs,the FBWF induced weak damage on coals and medium-to-weak damage on sandstones,and the difference of the damage in permeability or flow rate index on coals and sandstones is below 1%.Moreover,the minimum permeability recovery rate was above 66%.(2)For double-layer commingled reservoirs,the flow rate index revealed weak damage and the overall damage in double-layer was lower than the single-layer reservoirs.(3)There is no significant alteration in the microscopic structure of fuzzy-ball saturated cores with no evidence of fines *** dissolution of lead and sulfur occurred in coal samples,while tellurium in sandstone,aluminum,and magnesium in ***,the precipitation of aluminum,magnesium,and sodium occurred in sandstone but no precipitates found in coal and *** temporal plugging and dispersion characteristics of the FBWFs enable the generation of reservoir protection layers that will minimize formation damage due to solid and fluid invasion.

关键词： Drilling Fracture Fuzzy-ball fluids Formation damage analysis Muti-layer tight reservoirs Permeability damage index Flow rate damage index

Relationship between red blood cell distribution width levels and atrial fibrillation in hypertensive patients

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Journal of Geriatric Cardiology 2020年第8期17卷 486-494页

作者： li-hui zheng Shang-Yu liU Feng HU Zhi-Cheng HU li-Shui SHEN ling-Min WU Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Information on the relationship between red blood cell distribution width(RDW)and atrial fibrillation(AF)in patients with essential hypertension are *** study aimed to assess the relationship between AF and RDW in hypertensive *** We enrolled 432 hypertensive patients,including 350 AF patients and 82 patients as ***'demographic,clinical,laboratory and echocardiographic characteristics were *** AF patients were further divided into the persistent and paroxysmal AF *** were monitored to identify the cardiac rhythm during blood sampling,and based on the rhythm,the paroxysmal AF group was categorized into the presence(with AF rhythm during blood sampling)and absence(with sinus rhythm during blood sampling)*** The AF group had elevated RDW levels than the controls(12.7%±0.8%vs.12.4%±0.7%,P=0.002),and the persistent AF subgroup had higher RDW levels than the paroxysmal AF subgroup(12.9%±0.8%vs.12.6%±0.8%,P=0.007).Furthermore,in the paroxysmal AF group,the presence group had higher RDW levels than the absence group(13.0%±0.6%vs.12.5%±0.9%,P=0.001).There was no significant difference in RDW levels between the persistent AF subgroup and presence group of the paroxysmal AF subgroup(P=0.533)and between the absence group of the paroxysmal AF subgroup and control group(P=0.262).In multivariate regression analysis,in hypertensive patients,the presence of AF rhythm is an independent predictor for increased RDW concentration(P=0.001).Conclusions The RDW may be associated with the presence of AF rhythm,which implies the importance of maintaining the sinus rhythm in hypertensive patients.

关键词： Atrial fibrillation Hypertension Inflammation Red blood cell distribution width

Ablation strategies for arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2020年第11期17卷 694-703页

作者： li-Shui SHEN li-Min liU li-hui zheng Feng HU Zhi-Cheng HU Shang-Yu liU Jin-Rui GUO Kush Kumar Bhagat Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Arrhythmia Center Yunnan Fuwai Cardiovascular HospitalKunmingChina Eternal hospital JaipurRajasthanIndia

Background Catheter ablation for ventricular tachycardia(VT) in patients with arrhythmogenic right ventricular cardiomyopathy(ARVC) has significantly evolved over the past decade. However, different ablation strategies showed inconsistency in acute and long-term outcomes. Methods We searched the databases of Medline, Embase and Cochrane library through October 17, 2019 for studies describing the clinical outcomes of VT ablation in ARVC. Data including VT recurrence, all-cause mortality, acute procedural efficacy and major procedural complications were extracted. A meta-analysis with trial sequential analysis was further performed in comparative studies of endo-epicardial versus endocardial-only ablation. Results A total of 24 studies with 717 participants were enrolled. The literatures of epicardial ablation were mainly published after 2010 with total ICD implantation of 73.7%, acute efficacy of 89.8%, major complication of 5.2%, follow-up of 28.9 months, VT freedom of 75.3%, all-cause mortality of 1.1% and heart transplantation of 0.6%. Meta-analysis of 10 comparative studies revealed that compared with endocardial-only approach, epicardial ablation significantly decreased VT recurrence(OR: 0.50;95% CI: 0.30–0.85;P = 0.010), but somehow increased major procedural complications(OR: 4.64;95% CI: 1.28–16.92;P = 0.02), with not evident improvement of acute efficacy(OR: 2.74;95% CI: 0.98–7.65;P = 0.051) or all-cause mortality(OR: 0.87;95% CI: 0.09–8.31;P = 0.90). Conclusion Catheter ablation for VT in ARVC is feasible and effective. Epicardial ablation is associated with better long-term VT freedom, but with more major complications and unremarkable survival or acute efficacy benefit.

关键词： Arrhythmogenic right ventricular cardiomyopathy Catheter ablation Ventricular tachycardia

The fracture network model of Shen 229 block buried hill:A case study from liaohe Basin,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1904-1910页

作者： XING Yu-zhong FAN Tai-liang zheng li-hui Energy Sources Department China University of Geosciences. Beijing 100083 China Exploration ＆ Exploitation Research Institute of liaohe Oil Field Company Petrochina. Panjin 124010. China

High oil production from the Proterozoic formation of Shen 229 block in Damingtun Depression, liaohe Basin, China, indicates the presence of natural fractured reservoir whose production potential is dominated by the structural fracture. A con- sistent structural model and good knowledge of the fracture systems are therefore of key importance in reducing risk in the de- velopment strategies. So data from cores and image logs have been collected to account for the basic characteristics of fracture, and then the analyzed results were integrated with the structural model in order to restrict the fracture network development during the structural evolvement. The structural evolution of the Proterozoic reservoir with time forms the basis for understanding the de- velopment of the 3D fracture system. Seismic interpretation and formation correlation were used to build a 3D geological model. The fault blocks that compose the Proterozoic formation reservoir were subsequently restored to their pre-deformation. From here, the structures were kinematically modeled to simulate the structural evolution of the reservoirs. At each time step, the dilatational and cumulative strain was calculated throughout the modelling history. The total strain which records the total spatial variation in the reservoir due to its structural history, together with core data, well data and the lithology distribution, was used to simulate geologically realistic discrete fracture networks. The benefit of this technique over traditional curvature analysis is that the structural evolution is taken into account, a factor that mostly dominates fracture formation.

关键词： Buried hill Fracture network In-situ stress Structural fracture

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue CHEN Zhi-Yuan WENG Si-Min CAI Zhu-Xin ZHANG li-Kun ZHOU li-hui zheng Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(Pline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC<8.4 ms had an 8.1(HR=8.1,95%CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-30.1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis