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老年患者脊柱手术术后谵妄发生的危险因素分析

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中国骨伤 2024年第7期37卷 700-705页

作者：张维平常雯茜刘卫义李振军毛建伟甘肃省中医院甘肃兰州730050 甘肃中医药大学甘肃兰州730030

目的:探讨老年患者脊柱手术后谵妄的危险因素。方法:回顾性分析自2021年1月至2023年1月在全麻下行脊柱手术566例患者的基本病例资料,其中男296例,女270例;年龄(71.58±4.21)岁;颈椎手术195例,胸椎手术26例,腰椎手术345例。根据术后是否... 详细信息

目的:探讨老年患者脊柱手术后谵妄的危险因素。方法:回顾性分析自2021年1月至2023年1月在全麻下行脊柱手术566例患者的基本病例资料,其中男296例,女270例;年龄(71.58±4.21)岁;颈椎手术195例,胸椎手术26例,腰椎手术345例。根据术后是否出现谵妄分为术后谵妄组41例与无谵妄组525例。对患者的性别、年龄、体重、吸烟史、饮酒史、手术部位、术前焦虑、术中低血压次数、失血量等可能影响因素进行单因素分析,并对P<0.05的单因素采用二元Logistic回归进行多因素分析。结果:术后谵妄者41例,单因素分析显示,年龄(P=0.000)、手术时间(P=0.039)、术前焦虑(P=0.001)、失血量(P=0.000)、阿片类药物使用史(P=0.003)、脑卒中病史(P=0.005)、术后C反应蛋白(P=0.000)、术后钠离子(P=0.000)在谵妄组与非谵妄组间差异有统计学意义。将上述因素纳入二元Logistic回归分析,结果显示:年龄[OR=0.729,95%CI(0.569,0.932),P=0.012]、阿片类药物使用[OR=21.500,95%CI(1.334,346.508),P=0.031]、失血量[OR=0.932,95%CI(0.875,0.993),P=0.029]、术后C反应蛋白[OR=0.657,95%CI(0.485,0.890),P=0.007]、术前焦虑[OR=23.143,95%CI(1.859,288.090),P=0.015]、术后钠离子[OR=1.228,95%CI(1.032,1.461),P=0.020]是老年患者脊柱手术术后发生谵妄的独立危险因素。结论:年龄、阿片类药物使用、失血量、术前焦虑、C反应蛋白升高、低钠血症是老年患者脊柱手术术后谵妄发生的独立危险因素。

关键词：脊柱手术谵妄危险因素

A Core Genome Multilocus Sequence Typing Scheme for Proteus mirabilis

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Biomedical and Environmental Sciences 2023年第4期36卷 343-352页

作者： CHEN Sheng lin KANG Yu Tong liANG Yi He QIU Xiao Tong li zhen jun School of Public Health Shanxi Medical UniversityTaiyuan 030001ShanxiChina State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective A core genome multilocus sequence typing(cgMLST)scheme to genotype and identify potential risk clonal groups(CGs)in Proteus *** In this work,we propose a publicly available cgMLST scheme for *** using chew *** total 72 complete *** genomes,representing the diversity of this species,were used to set up a cgMLST scheme targeting 1,842 genes,635 unfinished(contig,chromosome,and scaffold)genomes were used for its *** We identified a total of 205 CGs from 695 *** strains with regional distribution *** these,159 unique CGs were distributed in 16 ***20 and CG3 carried large numbers of shared and unique antibiotic resistance *** virulence genes(papC,papD,papE,papF,papG,papH,papI,papJ,and papK)related to the P fimbrial operon that cause severe urinary tract infections were only found in *** CGs require attention due to potential *** This research innovatively performs high-resolution molecular typing of *** using whole-genome sequencing technology combined with a bioinformatics pipeline(chewBBACA).We found that the CGs of *** showed regional distribution *** expect that our research will contribute to the establishment of cgMLST for ***.

关键词： Proteus mirabilis CgMLST Genotyping Clonal evolution ChewBBACA

Research on a Monte Carlo global variance reduction method based on an automatic importance sampling method

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Nuclear Science and Techniques 2024年第5期35卷 200-215页

作者： Yi-Sheng Hao zhen Wu Shen-Shen Gao Rui Qiu Hui Zhang jun-li li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging of Ministry of Education Beijing 100084China Nuctech Company limited Beijing 100084China

Global variance reduction is a bottleneck in Monte Carlo shielding *** global variance reduction problem requires that the statistical error of the entire space is *** study proposed a grid-AIS method for the global variance reduction problem based on the AIS method,which was implemented in the Monte Carlo program *** proposed method was validated using the VENUS-Ⅲ international benchmark problem and a self-shielding calculation *** results from the VENUS-Ⅲ benchmark problem showed that the grid-AIS method achieved a significant reduction in the variance of the statistical errors of the MESH grids,decreasing from 1.08×10^(-2) to 3.84×10^(-3),representing a 64.00% *** demonstrates that the grid-AIS method is effective in addressing global *** results of the selfshielding calculation demonstrate that the grid-AIS method produced accurate computational ***,the grid-AIS method exhibited a computational efficiency approximately one order of magnitude higher than that of the AIS method and approximately two orders of magnitude higher than that of the conventional Monte Carlo method.

关键词： Monte Carlo Global variance reduction Reactor shielding Automatic importance sampling

Normalized glandular dose coefficients for digital breast tomosynthesis using detailed Chinese breast models

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Nuclear Science and Techniques 2024年第5期35卷 42-59页

作者： Jia-Hao Wang Rui Qiu An-Kang Hu Ye-Qi liu zhen Wu Hui Zhang jun-li li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China Joint Institute of Tsinghua University Nuctech Company Limited BeijingBeijing 100084China

The rise in breast cancer diagnoses among Chinese women has necessitated the use of X-ray breast screening,which carries a radiation *** study aimed to provide a dosimetry protocol for the Chinese female population to replace the traditional standard that utilizes simplified breast models,for the accurate estimation of the mean glandular dose of a patient undergoing digital breast tomosynthesis(DBT).The first set of detailed Chinese female breast models and representative breast parameters was *** backscatter radiation and computational efficiency,we improved the combination of these models and the Chinese reference adult female whole-body voxel *** acquisition for four commercial DBT systems that are widely employed in China was simulated using the Monte Carlo method to obtain the normalized glandular dose coefficients of DBT(D_(gN)^(DBT))and the glandular depth dose(D_(g)^(dep)(z))for different breast characteristics and X-ray *** calculated a series of D_(gN)^(DBT) values for breasts with different percentage mass glandularities(5%,25%,50%,75%,and 100%)and compressed breast thicknesses(2,3,4,5,6,and 7 cm)at various tube potentials(25,28,30,32,35,and 49 kV)and target/filter combinations(W/Rh,W/Al,Mo/Mo,Rh/Rh,and Rh/Ag).The parameter dependence of the breast characteristics and beam conditions on D_(gN)^(DBT) in detailed breast models was *** D_(gN)^(DBT) results were 14.6-51.0%lower than those of the traditional dosimetry standard in *** difference in D_(gN)^(DBT) was mainly due to a decrease in the depth of the main energy deposition area caused by the glandular distribution along the depth *** results obtained in this study may be used to improve breast dosimetry in China and provide more detailed information on risk assessment during DBT.

关键词： Digital breast tomosynthesis Normalized glandular dose coefficients Detailed breast model Monte Carlo simulation

Reducing Operation Emissions and Improving Work Efficiency Using a Pure Electric Wheel Drive Tractor

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Engineering 2024年第6期37卷 230-245页

作者： Chang-Kai Wen Wen Ren Qing-zhen Zhu Chun-Jiang Zhao zhen-Hao Luo Sheng-li Zhang Bin Xie Zhi-jun Meng Research Center of Intelligent Equipment Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China State Key Laboratory of Intelligent Agricultural Power Equipment Beijing 100097China BYD Company limited Shenzhen 518118China College of Agricultural Engineering Jiangsu UniversityZhenjiang 212013China College of Engineering China Agricultural UniversityBeijing 100083China

In response to the problems of excessive greenhouse-gas and particulate emissions and the low traction efficiency of conventional diesel tractors in the field,a purely electric wheel-side drive tractor was studied,including an electric motor drive system,a battery ballast system,and an electro–hydraulic suspension *** paper develops a dynamics model of an electric tractor-ploughing unit under complex soil conditions,leading to the proposal of an active control method for drive wheel torque and a joint control method for the traction force of the suspension system and the front-and rear-axle loads of a ***,the tractor is prototyped and assembled,and ploughing tests are carried *** ploughing results show that the active torque-distribution control method proposed in this study reduces the tractor slip by 14.83%and increases the traction efficiency by 10.28%compared with the average torquedistribution *** with the conventional traction control mode,the joint control method for traction and ballast proposed in this paper results in a 3.7%increase in traction efficiency,a 15.05%decrease in slip,and a 4.9%reduction in total drive motor energy *** study will help to improve the operation quality and traction efficiency of electric tractors in complex soil conditions.

关键词： Electric tractor Ploughing unit Torque distribution Active ballast Traction performance

Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE

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Biomedical and Environmental Sciences 2013年第6期26卷 504-508页

作者： li zhen jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong State Key Laboratory for Communicable Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Hainan Provincial People's Hospital Guangdong Provincial Center for Disease Control and Prevention

Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hostsIll. In China, brucellosis is a national notifiable communicable disease both in animals and in human. In 2009, 35 816 brucellosis cases were reported. The annual incidence was 2.7 per 100 000 population.

关键词： MLVA Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE 2010

A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

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Nano-Micro Letters 2024年第7期16卷 31-45页

作者： Tao Zhang Cheng-Hui li Wenbo li zhen Wang Zhongya Gu Jiapu li junru Yuan jun Ou-Yang Xiaofei Yang Benpeng Zhu School of Integrated Circuit Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093People’s Republic of China National Institute of Dental and Craniofacial Research(NIDCR) National Institutes of Health(NIH)35A Convent DriveBethesdaMD 20892USA Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People’s Republic of China

Compared with traditional piezoelectric ultrasonic devices,optoacoustic devices have unique advantages such as a simple preparation process,anti-electromagnetic interference,and wireless long-distance power ***,current optoacoustic devices remain limited due to a low damage threshold and energy conversion efficiency,which seriously hinder their widespread *** this study,using a self-healing polydimethylsiloxane(PDMS,Fe-Hpdca-PDMS)and carbon nanotube composite,a flexible optoacoustic patch is developed,which possesses the self-healing capability at room temperature,and can even recover from damage induced by cutting or laser ***,this patch can generate high-intensity ultrasound(>25 MPa)without the focusing *** laser damage threshold is greater than 183.44 mJ cm^(-2),and the optoacoustic energy conversion efficiency reaches a major achievement at 10.66×10^(-3),compared with other carbon-based nanomaterials and PDMS *** patch is also been successfully examined in the application of acoustic flow,thrombolysis,and wireless energy *** findings in this study provides new insight into designing and fabricating of novel ultrasound devices for biomedical applications.

关键词： Optoacoustic Self-healing PDMS Acoustic flow Thrombolytic Wireless energy harvesting

Properties and microstructure of copper–titanium alloys with magnesium additions

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Rare Metals 2024年第5期43卷 2290-2299页

作者： Lue Huang li-jun Peng Jiang li Xu-jun Mi Gang Zhao Guo-Jie Huang Hao-Feng Xie Yi-Cheng Cao Wen-Jing Zhang zhen Yang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. LtdBejing 101407China School of Materials Science and Engineering Northeastern UniversityShenyang110000China General Research Institute for Nonferrous Metals Beijing 100088China China Academy of Space Technology Beijing 100094China China Nonferrous Metals Mining Group(Tianjin)Co.Ltd Tianjin 3001llChina

The volume fractions and morphology of precipitates in precipitation-strengthened Cu-Ti alloys,which precipitate mainly as continuous and discontinuous precipitates,are important for the application of the *** study employed hardness and electrical conductivity tests transmission electron microscopy(TEM),atom probe tomography(APT),and first-principles calculations to demonstrate that the addition of Mg is effective for accelerating nanosized continuousβ'-Cu_(4)Ti precipitation as well as for suppressing the precipitation of coarse lamellar discontinuousβ-Cu_(4)Ti precipitates along the grain boundaries,resulting in Cu-Ti alloys with high yield strength and good electrical *** results showed that the continuous precipitation ofβ'-Cu_(4)Ti was accelerated by the Mg additions,which reduced the supersaturation of the matrix,thereby reducing the chemical driving force for the discontinuous *** the other hand,Mg additions increased the mismatch between the discontinuousβ-Cu_(4)Ti precipitates and matrix decreased the nucleation rate of the discontinuous precipitates,and increased the spacing of the discontinuous precipitation layer,resulting in a lower growth rate of the discontinuous ***,the addition of Mg to Cu-Ti alloys enhances the strength and improves the resistance to over-ageing.

关键词： Cu-Ti-Mg alloy Precipitation hardening Discontinuous precipitation Continuous precipitation Microstructure formation mechanism

The dynamics beamline at SSRF

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Nuclear Science and Techniques 2024年第9期35卷 56-67页

作者： zhen liu li-Hua Wang Yong Jiang Ya-jun Tong Hua-Chun Zhu Te Ji Min Chen zheng Jiang Xiang-jun Wei Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China ShanghaiTech University Shanghai 201210China

The dynamics beamline(D-line),which combines synchrotron radiation infrared spectroscopy(SR-IR)and energy-disper-sive X-ray absorption spectroscopy(ED-XAS),is the first beamline in the world to realize concurrent ED-XAS and SR-IR measurements at the same sample position on a millisecond time-resolved *** combined technique is effective for investigating rapid structural changes in atoms,electrons,and molecules in complicated disorder systems,such as those used in physics,chemistry,materials science,and extreme ***,ED-XAS and SR-IR can be used independently in the two branches of the *** ED-XAS branch is the first ED-XAS beamline in China,which uses a tapered undulator light source and can achieve approximately 2.5×10^(12)photons/s·300 eV BW@7.2 keV at the sample *** exchange-able polychromator operating in the Bragg-reflection or Laue-transmission configuration is used in different energy ranges to satisfy the requirements for beam size and energy *** focused beam size is approximately 3.5μm(H)×21.5μm(V),and the X-ray energy range is 5–25 *** one-and two-dimensional position-sensitive detectors with frame rates of up to 400 kHz enables time resolutions of tens of microseconds to be *** distinctive techniques,such as the concurrent measurement of in situ ED-XAS and infrared spectroscopy,time-resolved ED-XAS,high-pressure ED-XAS,XMCD,and pump-probe ED-XAS,can be applied to achieve different scientific goals.

关键词： ED-XAS SR-IR Time-resolved D-line SSRF