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Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases

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World Journal of Clinical Cases 2025年第6期13卷 14-23页

作者： Hang Shu Xiao-Yu Chen Jie zhao Pin li Zhen Sun Department of Traditional Chinese Medicine Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina Department of Convalescence Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air ForceNanjing 210000Jiangsu ProvinceChina

BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among *** pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune *** prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic ***,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and ***,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse *** To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune *** This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune *** and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western *** quality of the included studies was assessed using the Cochrane risk of bias assessment ***-analysis was performed using RevMan 5.4 *** The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune *** combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides

关键词： Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review Meta-analysis

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基于TRAIL的肿瘤治疗策略进展

生物技术通讯 2011年第5期22卷 733-737页

作者：隋臻尹帮旗李招发华侨大学分子药物学研究所福建泉州362021 分子药物教育部工程研究中心福建泉州362021

肿瘤坏死因子相关凋亡诱导配体(TRAIL)能选择性诱导肿瘤细胞凋亡,且对机体正常组织细胞无毒副作用,被认为是一种非常有潜力的抗癌药物。我们简要介绍TRAIL及其配体诱导细胞凋亡的机制、肿瘤细胞对TRAIL的耐受机制及其克服策略。

关键词：肿瘤坏死因子相关凋亡诱导配体死亡受体耐受机制肿瘤

丙酮酸激酶前mRNA可变剪接的调控在肿瘤代谢中的作用和意义

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生物技术通讯 2012年第1期23卷 132-135页

作者：许佳佳连文昌李招发华侨大学分子药物学研究所福建泉州362021 华侨大学分子药物教育部工程研究中心福建泉州362021

丙酮酸激酶是糖酵解的关键酶之一,丙酮酸激酶m基因前mRNA(pre-mRNA)通过可变剪接产生M1和M2型两种丙酮酸激酶异构体,2种异构体的选择性表达决定肿瘤细胞的代谢表型,改变肿瘤细胞的增殖和生长。因此,调控丙酮酸激酶可变剪接,对于控制肿... 详细信息

丙酮酸激酶是糖酵解的关键酶之一,丙酮酸激酶m基因前mRNA(pre-mRNA)通过可变剪接产生M1和M2型两种丙酮酸激酶异构体,2种异构体的选择性表达决定肿瘤细胞的代谢表型,改变肿瘤细胞的增殖和生长。因此,调控丙酮酸激酶可变剪接,对于控制肿瘤细胞的生长代谢十分重要。研究发现,核不均一核糖核蛋白(hnRNP)A1/A2及多聚嘧啶结合蛋白(PTB,又称hnRNPⅠ)具有调控丙酮酸激酶前mRNA可变剪接的作用,并且致癌转录因子c-Myc与hnRNP A1/A2及PTB在肿瘤细胞中的过表达密切相关。我们结合相关研究进展,简要综述丙酮酸激酶可变剪接调控机制。

关键词：丙酮酸激酶可变剪接调控前mRNA

广西扶绥县肝癌高发区HBV-DNA前S区变异与肝癌相关性研究

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广西医学 2015年第6期37卷 736-739,764页

作者：李曦亮邓伟黄天壬郑丹李召发广西医科大学南宁市530021

目的探讨广西扶绥县肝癌高发区HBV相关肝癌患者HBV-DNA前S区(Pre-S区)变异与肝癌发生的关系。方法采用病例对照研究的方法,选择HBV相关肝癌患者50例(肝癌组),HBV慢性携带者50例(对照组),提取受试者血清HBV-DNA,采用巢式PCR的方法扩增Pr... 详细信息

目的探讨广西扶绥县肝癌高发区HBV相关肝癌患者HBV-DNA前S区(Pre-S区)变异与肝癌发生的关系。方法采用病例对照研究的方法,选择HBV相关肝癌患者50例(肝癌组),HBV慢性携带者50例(对照组),提取受试者血清HBV-DNA,采用巢式PCR的方法扩增Pre-S区,测序并分析其核酸变异的情况。结果肝癌组患者Pre-S区缺失率、Pre-S2起始密码子变异率、T53C变异率分别为38.0%(19/50)、38.0%(19/50)和32.0%(16/50),均高于对照组的14.0%(7/50)、10.0%(5/50),4.0%(2/50)(P<0.05)。两组发生Pre-S区缺失26例,主要为Ⅱ类缺失,占69.2%;框内缺失24例占92.3%;Pre-S2 5'端缺失23例占88.5%。多因素非条件logistic分析结果显示,Pre-S区缺失、Pre-S2起始密码子变异以及T53C变异是肝癌发生的独立危险因素(P<0.05)。结论 HBV-DNA Pre-S区缺失、Pre-S2起始密码子变异和T53C变异与广西扶绥县HBV相关肝癌的发生密切相关。

关键词：乙型肝炎病毒肝癌前 S 区变异前 S2 起始密码子广西扶绥

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei Fu Yue-Jing li Ran Yu Rui-Qing Guo li-Xia Gao Sheng-Xia zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all Pfamily upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems family rearing Mediating effect

Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one

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World Journal of Diabetes 2025年第1期16卷 222-225页

作者： Zi-Yu zhao Pei-li Luo Xia Guo Zheng-Wei Huang State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative DrugsCollege of PharmacyJinan UniversityGuangzhou 511436Guangdong ProvinceChina

Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes *** condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express *** the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein ***,PCBP1 is small and ***,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed ***,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and ***,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.

关键词： Polycytosine RNA-binding protein 1 Protein nanoparticle Osteoblast Ferroptosis Diabetes

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SMARCA4缺失型鼻腔鼻窦癌1例报道

诊断病理学杂志 2024年第9期31卷 918-920页

作者：柯桥利台令华宋和雁李召发沂水县人民医院病理科山东临沂276400 菏泽市牡丹区人民医院病理科山东菏泽274000 沂水县第二人民医院内科山东临沂276400

目的探讨SMARCA4缺失型鼻腔鼻窦癌的临床病理特征、诊断要点、鉴别诊断及预后。方法收集沂水县人民医院诊治的1例SMARCA4缺失型鼻腔鼻窦癌患者临床资料,分析临床病理特征,复习相关文献,并对其治疗及预后进行探讨。结果患者男性,年龄60岁... 详细信息

目的探讨SMARCA4缺失型鼻腔鼻窦癌的临床病理特征、诊断要点、鉴别诊断及预后。方法收集沂水县人民医院诊治的1例SMARCA4缺失型鼻腔鼻窦癌患者临床资料,分析临床病理特征,复习相关文献,并对其治疗及预后进行探讨。结果患者男性,年龄60岁,以鼻塞入院,右侧鼻腔见球形肿物,肿瘤切除病理检查:大部分区域细胞上皮样类圆形,黏附性差,细胞核偏位,胞质弱嗜酸性,可见清晰核仁,少部分区域细胞梭形。肿瘤细胞具有上皮细胞分化CK(AE1/AE3)胞质阳性,SMARCA4/BRG1表达完全缺失,NUT阴性,INI-1表达阳性,SYN阳性,Melan A弱阳性,HMB45阴性,p63阴性,CK5/6阴性,CD56灶阳性,Cg A灶阳性,Vimentin阴性。结论SMARCA4缺失型鼻腔鼻窦癌是一种高度侵袭性恶性肿瘤,患者可能会从免疫治疗中获益。

关键词： SMARCA4 鼻腔鼻腔 BRG1 免疫组化SWI/SNF

西北绿洲灌区玉米叶片衰老特征对不同地膜覆盖利用方式的响应

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作物学报 2025年第1期51卷 233-246页

作者：王丽萍李盼赵连豪樊志龙胡发龙范虹何蔚柴强殷文甘肃农业大学农学院/省部共建干旱生境作物学国家重点实验室甘肃兰州730070

西北绿洲灌区玉米传统生产模式中大量使用地膜伴随着生态环境污染严重,且在极端高温下玉米出现叶片早衰。针对该现象,通过免耕一膜2年覆盖利用技术探讨延缓玉米叶片衰老并增加玉米产量的可行性,以期为构建西北绿洲灌区地膜减量玉米高效... 详细信息

西北绿洲灌区玉米传统生产模式中大量使用地膜伴随着生态环境污染严重,且在极端高温下玉米出现叶片早衰。针对该现象,通过免耕一膜2年覆盖利用技术探讨延缓玉米叶片衰老并增加玉米产量的可行性,以期为构建西北绿洲灌区地膜减量玉米高效生产技术提供理论支撑。2013年在西北绿洲灌区设置免耕一膜2年覆盖利用(NTP)、秋免耕春覆膜(RTP)和传统每年覆新膜(对照, CTP) 3种处理(本文采用2021-2023数据),探究玉米叶片光合源、持绿特性、细胞抗氧化酶活性和渗透调节物质含量对不同地膜覆盖利用方式的响应。结果表明,NTP和RTP可有效调节玉米生育期内光合源和叶片持绿性能的动态关系,维持生育后期较大的叶面积指数(LAI)、光合势(LAD)、叶片持绿性(SG)和叶绿素相对含量(SPAD),有利于延缓叶片衰老。与CTP相比, NTP玉米出苗后75~120 d的LAI、LAD、SG和SPAD分别提高15.1%~16.1%、14.8%~15.5%、7.2%~9.2%和11.3%~11.7%,RTP分别提高12.4%~13.0%、11.5%~12.4%、10.0%~17.6%和6.0%~6.7%。同时,通过单株绿色叶面积的拟合,发现NTP和RTP较CTP叶片衰老时间平均推迟了5.8~7.0d和6.2~7.7d,这可能是由于NTP和RTP有助于增强玉米大喇叭口期-灌浆期叶片的抗氧化能力和细胞渗透调节作用。玉米出苗后60~105 d, NTP较CTP叶片抗氧化酶(SOD、POD、CAT和APX)活性分别提高17.6%~20.0%、28.4%~34.4%、6.7%~8.4%和8.3%~10.9%, RTP较CTP分别提高11.3%~11.7%、16.9%~18.2%、4.4%~6.1%和5.8%~7.7%。此外,与CTP相比,NTP与RTP可溶性蛋白和脯氨酸含量分别提高35.9%~43.9%和29.5%~31.8%,20.7%~31.7%和17.4%~20.4%,丙二醛含量分别降低26.0%~27.8%和17.5%~25.9%。NTP对抗氧化酶和渗透调节物质的影响更大,NTP较CTP增产5.2%~6.0%。免耕一膜2年覆盖利用技术是西北灌区在实现资源减投条件下,有效延缓玉米叶片衰老且增加产量的适宜措施。

关键词：地膜覆盖光合源抗氧化酶活性细胞渗透调节能力籽粒产量

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma Ke Ye Xue zhao fangliang Ge Feifei Zheng Lulu liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation