检索结果-南通市图书馆

Multi-scenario Simulation and Spatial-temporal Analysis of LUCC in china's Coastal Zone Based on Coupled SD-FLUS Model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

chinese Geographical Science 2024年第4期34卷 579-598页

作者： HOU Xiyong SONG Baiyuan zhang xueying WANG Xiaoli li Dong Yantai institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shanghai Fuxiong Environmental Technology Corporation Shanghai 200433China

Increased human activities in china's coastal zone have resulted in the depletion of ecological land ***,conducting current and future multi-scenario simulation research on land use and land cover change(LUCC)is crucial for guiding the healthy and sustainable development of coastal *** dynamic(SD)-future land use simulation(FLUS)model,a coupled simulation model,was developed to analyze land use dynamics in china's coastal *** model encompasses five scenarios,namely,SSP1-RCP2.6(A),SSP2-RCP4.5(B),SSP3-RCP4.5(C),SSP4-RCP4.5(D),and SSP5-RCP8.5(E).The SD model simulates land use demand on an annual basis up to the year ***,the FLUS model determines the spatial distribution of land use for the near term(2035),medium term(2050),and long term(2100).Results reveal a slowing trend in land use changes in china's coastal zone from 2000–*** these changes,the expansion rate of construction land was the highest and exhibited an annual *** 2100,land use predictions exhibit high accuracy,and notable differences are observed in trends across *** summary,the expansion of production,living,and ecological spaces toward the sea remains *** A emphasizes reduced land resource dependence,benefiting ecological land *** B witnesses an intensified expansion of artificial *** C sees substantial land needs for living and production,while Scenario D shows coastal forest and grassland ***,in Scenario E,the conflict between humans and land *** study presents pertinent recommendations for the future development,utilization,and management of coastal areas in *** research contributes valuable scientific support for informed,long-term strategic decision making within coastal regions.

关键词： land use and land cover change(LUCC) multi-scenario simulation system dynamic-future land use simulation(SD-FLUS)model SSP-RCP scenarios model coupling china's coastal zone

Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation

在线全文

学校读者我要写书评

暂无评论

Science china(life sciences) 2024年第5期67卷 1035-1050页

作者： Yaling Wang Jingwen Chen xueying Huang Bangguo Wu Peng Dai Feng zhang Jinsong li lingbo Wang State Key Laboratory of Genetic Engineering Shanghai Key Laboratory of Metabolic Remodeling and HealthInstitute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai institute for Biomedical and Pharmaceutical Technologies) School of PharmacyFudan UniversityShanghai 200433China Shanghai Key Laboratoryof Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchoolof Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Cytosine base editing achieves C·G-to-T·A substitutions and can convert four codons(CAA/CAG/CGA/TGG)into STOP-codons(induction of STOP-codons,iSTOP)to knock out genes with reduced *** enables direct phenotyping in founders’somatic cells,but it remains unknown whether this works in founders’germ cells so as to rapidly reveal novel genes for ***,we initially establish that iSTOP in mouse zygotes enables functional characterization of known genes in founders’germ cells:Cfap43-iSTOP male founders manifest expected sperm features resembling human“multiple morphological abnormalities of the flagella”syndrome(i.e.,MMAF-like features),while oocytes of Zp3-iSTOP female founders have no zona *** further illustrate iSTOP’s utility for dissecting the functions of unknown genes with Ccdc183,observing MMAF-like features and male infertility in Ccdc183-iSTOP founders,phenotypes concordant with those of Ccdc183-KO *** ultimately establish that CCDC183 is essential for sperm morphogenesis through regulating the assembly of outer dynein arms and participating in the intra-flagellar *** study demonstrates iSTOP as an efficient tool for direct reproductive disease modeling and phenotyping in germ cells of the founder generation,and rapidly reveals the essentiality of Ccdc183 in fertility,thus providing a time-saving approach for validating genetic defects(like nonsense mutations)for human infertility.

关键词： disease modeling infertility multiple morphological abnormalities of the flagella(MMAF) induction of STOP-codons(iSTOP CRISPR-STOP) sperm motility

Thermodynamic simulations of pellet internal target in CSRm

在线全文

学校读者我要写书评

暂无评论

Science china(physics,Mechanics & Astronomy) 2005年第5期48卷 529-540页

作者： li zhankui xu hushan zhang xueying institute of modern physics Chinese Academy of Sciences Lanzhou 730000 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

关键词： internal target, pellet target, evaporative cooling, luminosity.

The time and energy signals,counter plateau,energy resolution and gas gains performances of a new kind of micro-pattern gaseous detector-Micromegas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(Technological sciences) 2008年第12期51卷 2208-2212页

作者： zhang XiaoDong1,2,YANG HeRun1,xu hushan2,DUAN liMin2,HU BiTao1,li ChunYan2 & li ZuYu2 1 School of Nuclear Science and Technology,lanzhou University,lanzhou 730000,china 2 institute of modern physics,chinese academy of sciences,lanzhou 730000,china School of Nuclear Science and Technology Lanzhou University institute of modern physics Chinese Academy of Sciences

In present paper,a new Micromegas detector is developed,and its time and energy signals are obtained in the figure *** rising time of fast time signal is less than 2 ns due to the very fast collection of avalanche electrons,and the rising time of the energy pulse is about 100 ns,which is corresponding to the total collecting time of the electrons and ions in the avalanche *** counter plateau,energy resolution and the gas gains of the detector have been compared with other groups' experimental results and the Garfield simulation result.

关键词： micro-mesh gaseous structure time and energy signals energy resolution gas gain counter plateau

Speed of the internal pellet target in CSRm

在线全文

学校读者我要写书评

暂无评论

Science china(physics,Mechanics & Astronomy) 2009年第7期52卷 1047-1052页

作者： li zhankui RONG XinJuan xu hushan zhang xueying institute of modern physics Chinese Academy of SciencesLanzhou 730000China Graduate University of chinese academy of sciences Beijing 100049China

Pellet target is one of the main candidate targets in CSRm (cooler storage ring’s main ring) for hadron physics studies. Pellet speed is an important physical parameter for the target. Larger pellet speed could shorten the interacting time interval between the pellet and the cyclotron beam, and thus results in a small temperature variation for the pellet. This could make the pellet facility work in a stable condition. A fluid dynamic simulation was carried out for the pellet speed, and it was found that the maximum speed for the target pellet may be restricted to about 100 m/s even if all working parameters were set to their optimal values.

关键词： internal target pellet target pellet speed capillary fluid dynamics

The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in rice

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2024年第2期17卷 258-276页

作者： Yuqing He Yao Zhao Jitao Hu Lanlan Wang linying li xueying zhang Zhongjing Zhou lili Chen Hua Wangl Jiaoyu Wang Gaojie Hong State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Virology and BiotechnologyZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China Key Laboratory of Traceability for Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural AffairsHangzhou 310021P.R.China College of life sciences Zhejiang Sci-Tech UniversityHangzhou 310018P.R.China State Key Laboratory for Managing Biotic and Chemical Threats to the Qualty and Safety of Agro-products Zhejang Academy of Agricultural SciencesHangzhou 310021P.R.China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Key Labory of Biotechnology in Plant Protection of MOA of China and Zhejiang ProvinceInstitute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China

The growth-promoting hormones brassinosteroids(BRs)and their key signaling component BZR1 play a vital role in balancing normal growth and defense ***,we discovered that BRs and OsBZR1 up-regulated sakuranetin accumulation and conferred basal defense against Magnaporthe oryzae infection under normal *** shortages,including phosphate(Pi)deficiency,potentially disrupt this growth-defense ***1 and OsSPX2 have been reported to sense Pi concentration and interact with the Pi signal mediator OsPHR2,thus regulating Pi starvation *** this study,we discovered that OsSPX1/2 interacts with OsBZR1 in both Pi-sufficient and Pi-deficient conditions,inhibit-ing BR-responsive *** Pi is sufficient,OsSPX1/2 is captured by OsPHR2,enabling most of OsBzR1 to promote plant growth and maintain basal *** response to Pi starvation,more OsSPX1/2 is released from OsPHR2 to inhibit OsBZR1 activity,resulting in slower ***,our study reveals that the OsBZR1-SPX1/2 module balances the plant growth-immunity trade-off in *** Y.,Zhao Y.,Hu J.,Wang L.,li L.,zhang X.,Zhou Z.,Chen L.,Wang H.,Wang J.,and Hong G.(2024).The OsBZR1-OsSPX1/2 module fine-tunes the growth-immunity trade-off in adaptation to phosphate availability in esponse to Pi availability.

关键词： immunity maintain adaptation

Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第4期51卷 407-418页

作者： Yaling Wang xueying Huang Guoying Sun Jingwen Chen Bangguo Wu Jiahui Luo Shuyan Tang Peng Dai Feng zhang Jinsong li lingbo Wang Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai Key Laboratory of Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful *** deformities in flagella cause a male infertility syndrome,multiple morphological abnormalities of the flagella(MMAF),while acrosomal hypoplasia in some cases leads to sub-optimal embryonic developmental ***,evidence regarding the occurrence of acrosomal hypoplasia in MMAF is ***,we report the generation of base-edited mice knocked out for coiled-coil domain-containing 38(Ccdc38)via inducing a nonsense mutation and find that the males are *** Ccdc38-KO sperm display acrosomal hypoplasia and typical MMAF *** find that the acrosomal membrane is loosely anchored to the nucleus and fibrous sheaths are disorganized in Ccdc38-KO *** analyses reveal that Ccdc38 knockout causes a decreased level of TEKT3,a protein associated with acrosome biogenesis,in testes and an aberrant distribution of TEKT3 in *** finally show that intracytoplasmic sperm injection overcomes Ccdc38-related *** study thus reveals a previously unknown role for CCDC38 in acrosome biogenesis and provides additional evidence for the occurrence of acrosomal hypoplasia in MMAF.

关键词： Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) Infertility Sperm motility Asthenoteratozoospermia Disease modeling

A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 400-410页

作者： Han Chan Fenfen Ni Bo Zhao Huimin Jiang Juanjuan Ding li Wang Xiaowen Wang Jingjing Cui Shipin Feng Xiaojie Gao xueying Yang Huan Chi Hao Lee xuelan Chen Xiaoqin li Jia Jiao Daoqi Wu Gaofu zhang Mo Wang Yupeng Cun Xiongzhong Ruan Haiping Yang Qiu li Department of Nephrology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Nephrology Shenzhen Children's HospitalShenzhenGuangdong 518034China Department of Nephrology Kunming Children's HospitalKunming Medical UniversityKunmingYunnan 650228China Department of Nephrology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430015China Department of Nephrology Chengdu Women and Children Central HospitalChengduSichuan 610073China Pediatric Research institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Nephrology John Moorhead Research LaboratoryUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom

Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome(SSNS)using genome-wide association studies(GWAS)strategy is important for understanding the *** conducted a multicenter cohort study(360 patients and 1835 controls)combined with a GWAS strategy to identify susceptibility var-iants associated with the following two subphenotypes of ssNS:steroid-sensitive nephrotic syn-drome without relapse(SSNswR,181 patients)and steroid-dependent/frequent relapse nephrotic syndrome(SDNS/FRNS,179 patients).The distribution of two single-nucleotide poly-morphisms(SNPs)in ANKRD36 and ALPG was significant between SSNSWR and healthy controls,and that of two SNPs in GAD1 and HLA-DQA1 was significant between SDNS/FRNS and healthy ***,rs1047989 in HLA-DQA1 was a candidate locus for SDNS/FRNS but not for *** significant SNPs were observed between SSNSWR and SDNS/***,chromosome 2:171713702 in GAD1 was associated with a greater steroid dose(>0.75 mg/kg/d)upon relapse to first remission in patients with SDNS/FRNS(odds ratio=3.14;95%confidence interval,0.97-9.87;P=0.034).rs117014418 in APOL4 was significantly associated with a decrease in eGFR of greater than 20%compared with the baseline in SDNS/FRNS patients(P=0.0001).Protein-protein intersection network construction suggested that HLA-DQA1 and HLA-DQB1 function together through ***,SSNSWR belongs to non-HLA region-dependent nephropathy,and the HLA-DQA/DQB region is likely strongly associated with dis-ease relapse,especially in SDNS/*** study provides a novel approach for the GWAS strategy of SsNS and contributes to our understanding of the pathological mechanisms of SSNSWRandSDNS/FRNS.

关键词： Frequentrelapse Genome-wide association study Human leukocyte antigen region Steroid-sensitive nephrotic syndrome

Experimental research into the two-proton emissions from ^(17,18) Ne,^(28) P and ^(28,29)S

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(physics,Mechanics & Astronomy) 2011年第S1期54卷 73-80页

作者： liN ChengJian1, xu XinXing1, JIA HuiMing1, YANG Feng1, JIA Fei1, WU ZhenDong1, zhang ShiTao1, liU ZuHua1, zhang HuanQiao1, xu hushan2, SUN ZhiYu2, WANG JianSong2, HU ZhengGuo2, WANG Meng2, CHEN RuoFu2, zhang xueying2, li Chen2, LEI XiangGuo2, xu ZhiGuo2, XIAO GuoQing2 & ZHAN WenLong2 1china institute of Atomic Energy, P. O. Box 275(10), Beijing 102413, china 2 institute of modern physics, chinese academy of sciences, lanzhou 730000, china china institute of Atomic Energy Beijing China (GRID:grid.410655.3) (ISNI:***) chinese academy of sciences Institute of Modern Physics Lanzhou China (GRID:grid.9227.e) (ISNI:***)

Two-proton emissions from the excited states of 17,18Ne, 28P and 28,29S were investigated experimentally by the radioactive beams bombarding on the 197Au target via the Coulomb excitation. The complete-kinematics measurements were actualized by the stacks of silicon-strip detectors and CsI+PIN array detectors. The invariant mass of final systems as well as the relative momentum, opening angle, and relative energy of the two emitted protons was reconstructed under the framework of relativ istic kinematics. Visible proton-proton correlations were observed in these systems. The mechanisms of two-proton emission were analyzed in a simple schematic model, in which the extreme decay modes like He cluster emission, three-body 2 phase-space decay, and two-body sequential decay were taken into account. With the help of Monte-Carlo simulations, the two protons emitted from the 6.15 MeV excited state of Ne and the excited states in the energy region of 9.6–10.4 MeV of S, 18 29 respectively, exhibited prominent features of2 He cluster decay while for the other cases, no obvious diproton emissions were observed.

关键词： two-proton emission radioactive ion beam complete-kinematics measurement He cluster decay three-body 2 phase-space decay two-body sequential decay