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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-ze li Wen-li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Asymptotic stability of solitons to 1D nonlinear Schrodinger equations in subcritical case

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Frontiers of Mathematics in China 2020年第5期15卷 923-957页

作者： ze li School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

We prove the asymptotic stability of solitary waves to 1D nonlinear Schrodinger equations in the subcritical case with symmetry and spectrum *** of the main ideas is to use the vector fields method developed by ***,***,and ***[*** ***.,2013,6:957-980]to overcome the weak decay with respect to t of the linearized equation caused by the one dimension setting and the weak nonlinearity caused by the subcritical growth of the nonlinearity ***,we apply the polynomial growth of the high Sobolev norms of solutions to 1D Schrodinger equations obtained by ***[Duke Math.J.,1997,86(1):109-142]to control the high moments of the solutions emerging from the vector fields method.

关键词： Nonlinear Schrodinger equation(NLS) solitons weak nonlinearity asymptotic stability

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Cubic Diophantine Inequalities

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Acta Mathematica Sinica,English Series 2001年第1期17卷 153-160页

作者： Hong ze li Department of Mathematics Shandong University

Let λ1, λ2,...,λ7 be real numbers satisfying λi≥1. In this paper, we prove there are integers x1,...,x7 such that the inequalities |λ1x13+λ2x23+...+λ7x73|i|xi]3 （λ1λ2…λ7）89814) hold simultaneously.

关键词： Diophantine inequality Cubic equation Non-trivial solution

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Genus two correlation functions in CFTs with TT deformation

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 106-119页

作者： Song He Yun-ze li Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Am Mühlenberg 114476 GolmGermany

Since the definition of TT deformation in the curved Riemann surface is obstructive in the literature,we propose a way to do the deformation in the genus two Riemann surfaces by sewing *** construct the correlation functions of conformal field theories(CFTs)on genus two Riemann surfaces with the TT deformation in terms of the perturbative CFT *** to sewing construction to form higher genus Riemann surfaces from lower genus ones and conformal symmetry,we systematically obtain the first-order TT correction to the genus two correlation functions in the TT deformed CFTs,e.g.,partition function and one/higher-point correlation functions.

关键词： conformal field theory gauge/gravity duality TT deformation higher genus correlation function

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Small Prime Solutions of a Pair of linear Equations in Five Prime Variables

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Acta Mathematica Sinica,English Series 2010年第3期26卷 569-578页

作者： Zhen CUI Hong ze li Department of Mathematics Shanghai Jiao Tong University Shanghai 200240 P. R. China

Assume an additional congruent condition on the coefficients. We prove that the pair 5 of linear equations ∑j=1^5 αλjpj = bλ （λ= 1, 2） has solutions in primes pj satisfying pj 〈〈（｜b1｜＋｜b2｜＋1） maxλ,j ｜αλj｜^2318＋ε. This improves the exponent 79680 without assuming the additional condition of the second author＇s.

关键词： Diophantine equations Deuring-Heilbronn phenomenon large sieve inequality zero-free region

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Decision Support System for Adaptive Restoration Control of Transmission System

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Journal of Modern Power Systems and Clean Energy 2021年第4期9卷 870-885页

作者： ze li Yusheng Xue Haohao Wang lili Hao School of Electrical Engineering Southeast UniversityNanjingChina State Grid Electric Power Research Institute(NARI Group Corporation) NanjingChina State Grid Electric Power Research Institute(NARI Group Corporation) NanjingChinaand they are also with State Key Laboratory of Smart Grid Protection and Operation ControlNanjingChina School of Electrical Engineering and Control Science Nanjing Tech UniversityNanjingChina

The power system restoration control has a higher uncertainty level than the preventive control of cascading failures. In order to ensure the feasibility of the decision support system of restoration control, a decision support framework for adaptive restoration control of transmission system is proposed, which can support the coordinated restoration of multiple partitions, coordinated restoration of units and loads, and coordination of multi-partition decision-making process and actual restoration process. The proposed framework is divided into two layers, global coordination layer and partition optimization layer. The upper layer partitions the transmission system according to the power outage scenario, constantly and dynamically adjusts the partitions during the restoration process, and optimizes the time-space decision-making of inter-partition connectivity. For each partition, the lower layer pre-selects restoration targets according to the estimated restoration income, optimizes the corresponding restoration paths, and evaluates the restoration plans according to the expected net income per unit of power consumption. During the restoration process, if the restoration operation such as energizing the outage branch fails, the current restoration plan will be adaptively switched to the sub-optimal one or re-optimized if necessary. The framework includes two operation modes, i.e., the on-line operation mode and training simulation mode, and provides an information interaction interface for collaborative restoration with related distribution systems. The effectiveness and adaptability of the proposed framework is demonstrated by simulations using the modified IEEE 118-bus system.

关键词： Transmission system restoration two-layer decision support framework restoration risk and income restoration uncertainty sand table deduction

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Inhibition Mechanism of Cholinesterases by Carbamate: A Theoretical Study

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Chemical Research in Chinese Universities 2008年第6期24卷 778-781页

作者： YAO Yuan li ze-sheng State Key Laboratory of Theoretical and Computational Chemistry institute of Theoretical Chemistry Jilin University Changchun 130021 P R. China

The density functional theory at the B3LYP/6-311G（d, p） level was applied to exploring the inhibition mechanism of cholinesterases by carbamate. The results indicate that the inhibition reactions with or without the catalytic effect of the catalytic triad in eholinesterases underwent a two-step addition-elimination mechanism, which is in good agreement with the proposed mechanism. The solvent has a strong effect on the inhibition reactions and the reaction with the catalytic triad in the solvent phase is close to the real reaction under biological condition.

关键词： Carbamate Cholinesterase Inhibition mechanism Solvent effect

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A Solvability Criterion for Finite Groups

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Acta Mathematica Sinica,English Series 2016年第8期32卷 982-992页

作者： Guo Hua QIAN Tian ze li Department of Mathematics Changshu Institute of Technology

We show that if for every prime p, the normalizer of a Sylow p-subgroup of a finite group G admits a p-solvable supplement, then G is solvable. This generalizes a solvability criterion of Hall which asserts that a fin... 详细信息

关键词： Finite group solvable group Sylow normalizer supplement

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Analytic Invariant Curves for a Planar Mapping

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Acta Mathematica Sinica,English Series 2008年第4期24卷 623-630页

作者： Wen Rong li Han ze liU li YIN Department of Mathematics Binzhou University Binzhou 256600 P. R. China

This paper is concerned with the existence of analytic invariant curves for a planar mapping. By constructing a convergent power series solution of an auxiliary equation, analytic solutions of the original equation are obtained. In this paper, we discuss not only the general case, but also the critical cases as well, in particular, the case where β is a unit root is discussed.

关键词： planar mapping invariant curves analytic solution Majorant series

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Isometric Extension Problem Between Strictly Convex Two-dimensional Normed Spaces

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Acta Mathematica Sinica,English Series 2019年第4期35卷 513-518页

作者： Guang Gui DING Jian ze li School of Mathematical Sciences and LPMC Nankai University Electrical and Computer Engineering Ryerson University

In this paper, based on the smooth point of the unit ball and its support linear functional,we show two equivalent formulations of the isometric extension problem between the unit spheres of strictly convex two-dimens... 详细信息

关键词： Isometric extension strictly convex unit sphere smooth point additive map

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