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The Third China National Stroke Registry (CNSR-Ⅲ) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics

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Stroke & Vascular Neurology 2019年第3期4卷 158-164页

作者： Yongjun Wang Jing Jing Xia Meng yuesong Pan Yilong Wang Xingquan Zhao Jinxi lin Wei li Yong Jiang Zixiao li Xinmiao Zhang Xiaomeng Yang Ruijun Ji Chunjuan Wang Zhimin Wang Xinsheng Han Songdi Wu Zhengchang Jia Yongming Chen Hao li Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Center of Stroke Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Department of Neurology The First people's Hospital of TaizhouTaizhouChina Department of Neurology The Kaifeng Central HospitalKaifengChina Department of Neurology The First People's Hospital of Xi'anXi'anChina Department of Neurology The Second People’s Hospital of JinzhongJinzhongChina Department of Neurology WuYuan County People’s HospitalBayannurChina

Background and purpose Stroke is the leading cause of mortality and disability in *** aetiological classification,imaging and biological markers may predict the prognosis of *** Third China National Stroke Registry(CNSR-Ⅲ),a nationwide registry of ischaemic stroke or transient ischaemic attack(TIA)in China based on aetiology,imaging and biology markers,will be considered to clarify the pathogenesis and prognostic factors of ischaemic *** Between August 2015 and March 2018,the CNSR-Ⅲrecruited consecutive patients with ischaemic stroke or TIA from 201 hospitals that cover 22 provinces and four municipalities in *** data were collected prospectively using an electronic data capture system by face-to-face *** were followed for clinical outcomes at 3 months,6 months and 1-5 year *** imaging,including brain MRI and CT,were completed at *** samples were collected and biomarkers were tested at *** A total of 15166 stroke patients were enrolled,among which 31.7%patients were women with the average age of 62.2±11.3 *** stroke was predominant(93.3%,n=14146)and 1020(6.7%)TIAs were *** CNSR-Ⅲis a large scale nationwide registry in *** from this prospective registry may provide opportunity to evaluate imaging and biomarker prognostic determinants of stroke.

关键词： patients Blood transient

Effect of praseodymium additive on CeO2(ZrO2)/TiO2 for selective catalytic reduction of NO by NH3

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Journal of Rare Earths 2016年第11期34卷 1111-1120页

作者：金奇杰沈岳松祝社民刘青李喜红严巍 College of Materials Science and Engineering Jiangsu Collaborative Innovation Center for Advanced Inorganic Function CompositesJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 210009China Shandong Gemsky Environmental Technology Co. Zibo 255086China

A series of praseodymium added CeO2（ZrO2）/TiO2 catalysts separately prepared by methods of sol-gel and impregnation were tested for selective catalytic reduction of NO, and characterized by X-ray diffraction （XRD）, N2-brumauer-emmett-teller （N2-BET）, NH3-temperature programmed desorption （NH3-TPD）, H2-temperature programmed reduction （H2-TPR）, PL spectra, Ra-man spectra, electron paramagnetic resonance （EPR） and X-ray photoelectron spectroscopy （XPS）, respectively. Influence of prepara-tion method on catalytic performance was studied. Results showed that the influence of Pr addition on catalytic performance of the CeO2（ZrO2）/TiO2 catalysts was different between the sol-gel method and the impregnation method. The Pr addition tended to interact with TiO2 and formed the structure of Ti-O-Pr in the sol-gel method while it was more likely to interact with CeO2 forming the struc-ture of Ce-O-Pr in the impregnation method. The total acid amount and redox properties of the catalysts prepared by sol-gel method decreased with the addition of Pr element, which resulted in decrease of catalytic activity. In contrast, the Pr-added catalyst prepared by impregnation method was found to possess easier reducibility, more total acid amount and higher proportion of Ce3＋ species, which was favourable for higher catalytic activity.

关键词： praseodymium-added CeO2(ZrO2)/TiO2 preparation method selective catalytic reduction catalytic performance rare earths

Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis(INSPIRES)

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Stroke & Vascular Neurology 2023年第3期8卷 249-258,I0096-I0110页

作者： Ying Gao yuesong Pan Shangrong Han Weiqi Chen Jing Jing Chunjuan Wang Yingying Yang Tingting Wang Xia Meng Xingquan Zhao liping liu Hao li S Claiborne Johnston Pierre Amarenco Philip M Bath Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Dean's Office Dell Medical SchoolUniversity of Texas at AustinAustinTexasUSA Department of Neurology and Stroke Center Assistance Publique-Hôpitaux de Paris(APHP)Bichat HospitalINSERM LVTS-U1148University of ParisParisFrance Population Health Research Institute McMaster UniversityHamiltonOntarioCanada Stroke Trials Unit Mental Health&Clinical NeuroscienceUniversity of NottinghamNottinghamUK Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina National Center for Neurological Diseases BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Chinese Institute for Brain Research BeijingChina

Background It remains unclear if intensive antiplatelet and statin treatments begun within 24-72 hours of cerebral ischaemic events from intracranial or extracranial atherosclerosis is effective or *** The Intensive Statin and Antiplatelet Therapy for High-risk Intracranial or Extracranial Atherosclerosis(INSPIRES)trial is a randomised,double-blind,placebo-controlled,multicentre and 2×2 factorial trial.6100 individuals between the ages of 35 and 80 who have experienced a mild ischaemic stroke or high-risk transient ischaemic attack(TIA)within the previous 72 hours that is attributed to≥50%atherosclerotic stenosis of a major intracranial or extracranial artery or multiple infarctions of atherosclerotic origin will be enrolled in the *** subjects will be randomised 1:1:1:1 to one of four groups:(1)intensive antiplatelet therapy(combined clopidogrel and aspirin for days 1-21,then aspirin placebo and clopidogrel for days 22-90)plus immediate intensive statin therapy(atorvastatin at a dose of 80 mg daily for the first 21 days,then 40 mg daily for days 22-90);(2)intensive antiplatelet therapy plus delayed intensive statin therapy(atorvastatin placebo for days 1-3,followed by 40 mg per day of atorvastatin for days 4-90);(3)standard antiplatelet therapy(combination of clopidogrel placebo with aspirin for 90 days)plus immediate intensive statin therapy and(4)standard antiplatelet therapy plus delayed intensive statin *** primary efficacy endpoint is any new stroke(ischaemic or haemorrhagic)within 90 days after *** primary safety endpoint is moderate to severe bleeding at 90 *** The INSPIRES trial will assess the efficacy and safety of intensive antiplatelet therapy and immediate intensive statin therapy begun within 72 hours of onset in decreasing the recurrent stroke at 90 days in patients with acute mild ischaemic stroke or high-risk TIA of intracranial or extracranial atherosclerosis origin.

关键词： intracranial atherosclerosis random

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稀疏孔径双圆周阵列的成像性能研究

光学学报 2009年第10期29卷 2774-2779页

作者：刘丽江月松王长伟北京航空航天大学电子信息工程学院北京100191

针对传统稀疏孔径均匀圆周阵列的调制传递函数在截止频率区域内易出现零值而影响成像质量的问题,提出一种由两个均匀圆周阵列嵌套构成的无冗余的双圆周稀疏孔径结构。给出该阵列的光瞳函数以及调制传递函数的解析表达式。以5-3结构的双... 详细信息

针对传统稀疏孔径均匀圆周阵列的调制传递函数在截止频率区域内易出现零值而影响成像质量的问题,提出一种由两个均匀圆周阵列嵌套构成的无冗余的双圆周稀疏孔径结构。给出该阵列的光瞳函数以及调制传递函数的解析表达式。以5-3结构的双圆周阵列为例,以实际空间截止频率为像质评价准则,从子孔径直径、内环圆周半径以及内环旋转角度等几个方面详细分析了双圆周阵列的成像特性,给出不同情况下的实际截止频率值,并对双圆周阵列稀疏孔径系统进行模拟成像和图像复原。将该结构与均匀圆周阵列,Cornwell优化圆周阵列进行比较。结果表明,相同条件下,该阵列具有更大的实际空间截止频率,并且成像质量随着填充因子的减小而逐渐下降。

关键词：应用光学稀疏孔径调制传递函数成像特性

The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial

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Science Bulletin 2019年第2期64卷 101-107页

作者： Huaguang Zheng Yilong Wang Anxin Wang Hao li David Wang Xingquan Zhao Penglian Wang Haipeng Shen lijun Zuo yuesong Pan Zixiao li Xia Meng Xianwei Wang Weixiong Shi Yi Ju liping liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang Beijing Tiantan Hospital Capital Medical University China National Clinical Research Center for Neurological Diseases OSF Saint Francis Medical Center Peoria Faculty of Business and Economics University of Hong Kong The First Hospital Liao Ning Medical College The General Hospital Tianjin Medical University Guangzhou First People’s Hospital School of Medicine South China University of Technology The First Hospital of Shanxi Medical University The First Hospital Zhejiang Medical University Shenyang First People’s Hospital Shenyang Medical College Dementia Care & Research Center Peking University Institute of Mental Health

Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P line in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain.

关键词： Nimodipine Acute ischemic stroke Mild cognitive impairment Cognitive decline Prevention

Formation of Field Reversed Configuration (FRC) on the Yingguang-I device

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Matter and Radiation at Extremes 2017年第5期2卷 263-274页

作者： Qizhi Sun Xianjun Yang yuesong Jia Lulu li Dongfan Fang Xiaoming Zhao Weidong Qin Zhengfen liu Wei liu Jun li Yuan Chi Xiaoguang Wang Institute of Fluid Physics China Academy of Engineering PhysicsMiangyang 621900China Key Laboratory of Pulsed Power Technology and Science China Academy of Engineering PhysicsMiangyang 621900China Institute of Applied Physics and Computational Mathematics Beijing 100088China

As a hybrid approach to realizing fusion energy,Magnetized Target Fusion(MTF)based on the Field Reversed Configuration(FRC),which has the plasma density and confinement time in the range between magnetic and inertial confinement fusion,has been recently widely pursued around the *** investigate the formation and confinement of the FRC plasma injector for MTF,the Yingguang-I,which is an FRC test device and contains a multi-bank program-discharged pulsed power sub-system,was constructed at the Institute of Fluid Physics(IFP),*** paper presents the pulsed power components and their parameters of the device in detail,then gives a brief description of progress in experiments of FRC *** results of the pulsed power sub-system show that the peak current/magnetic field of 110 kA/0.3 T,10 kA/1.2 Tand 1.7 MA/3.4 Twere achieved in the bias,mirror and q-pinch circuits with quarter cycle of 80 ms,700 ms and 3.8 ms *** induced electric field in the neutral gas was greater than 0.25 kV/cm when the ionization bank was charged to 70 *** H_(2) gas of 8 Pa,the plasma target of density 10^(16) cm^(-3),separatrix radius 4 cm,half-length 17 cm,equilibrium temperature 200 eV and lifetime 3 ms(approximately the half pulse width of the reversed field)have been obtained through the q-pinch method when the bias,mirror,ionization and θ-pinch banks were charged to 5 kV,5 kV,55 kV and ±45 kV *** images from the high-speed end-on framing camera demonstrate the formation processes of FRC and some features agree well with the results with the two-dimension magneto hydrodynamics code(2D-MHD).

关键词： Magnetized Target Fusion(MTF) Field Reversed Configuration(FRC) Magnetized plasma Pulsed power

锆掺杂对Ti-Ce-Ox复合氧化物NH_3选择性催化还原NO的影响

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硅酸盐学报 2011年第6期39卷 989-994页

作者：李远沈岳松祝社民沈树宝南京工业大学材料科学与工程学院生物与制药工程学院南京210009

采用共混法制备Ti-Ce-Zr-Ox复合氧化物脱硝催化剂,主要研究Ti-Ce-Zr-Ox复合氧化物催化剂NH3选择性催化还原[selective catalytic reduction(SCR),NH3-SCR]NO的活性,重点考察锆掺杂对Ti-Ce-Ox复合氧化物催化剂NH3-SCR脱除NO的影响。用X射线衍射、氮气物理吸附、扫描电镜、能谱分析及氨气程序控温脱附等手段分别表征分析催化剂的晶型、表面积及孔分布、结构形貌、元素组成及固体酸量。结果表明:当摩尔比n(NH3):n(NO)=1:1、体积空间速率为5 000/h时,TiCe0.1Zr0.1O2.4复合氧化物的NH3-SCR脱除NO活性最高,达到92.70%,催化活性温度窗口为200～350℃;相比Ti-Ce-Ox复合氧化物,锆掺杂拓宽了催化活性温度窗口,使之向低温区偏移50℃;反应温度为300℃时,NO转化率提高了16.67%。锆掺杂可以细化催化剂晶粒,促进生成氧空位,明显提高催化剂固体酸量,使催化脱硝活性提高。

关键词：钛铈化合物复合氧化物催化剂氨选择性催化还原锆掺杂

Preparation of Carbon-coated Tourmaline and the Degradation of Methylene Blue

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矿物学报 2013年第S1期33卷 105-105页

作者： WANG yuesong CHUAN Xiuyun li lin HUANG Du-bin School of Earth and Space Science Peking University

An attempt was made to prepare carbon coated tourmaline by mixing tourmaline powders and polyvinyl alcohol (PVA), followed by heat treatment in argon atmosphere. All samples were characterized by powder X-ray diffraction, high-resolution transmission electron microscopy, UV diffuse reflectance spectroscopy. Results showed that the residual carbon content was influenced by heat treatment temperature and the amount of PVA. The degradation of methylene blue by Carbon-coated tourmaline was also studied. The experiments pointed out that the carbon coated effects are best when the heating temperature was 900℃ and the weight content of PVA was 70%. And the tourmaline prepared under 900℃ in the oxidation atmosphere has the best degrade efficiency. The results also proved that the infrared radiation of tourmaline is not effect in the degrade progress.

关键词： tourmaline carbon coated methylene blue degradation

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农地流转对农业碳排放的影响及空间特性

资源科学 2023年第1期45卷 77-90页

作者：吉雪强李卓群张跃松中国人民大学公共管理学院北京100872

【目的】农业碳排放问题对于碳达峰碳中和目标实现具有重要意义,农地流转是重大农业变革,对农业碳排放具有显著作用,然而现有研究未深入探索农地流转对农业碳排放的影响,影响了农业碳减排工作的进一步推进。【方法】本文在理论探讨基础... 详细信息

【目的】农业碳排放问题对于碳达峰碳中和目标实现具有重要意义,农地流转是重大农业变革,对农业碳排放具有显著作用,然而现有研究未深入探索农地流转对农业碳排放的影响,影响了农业碳减排工作的进一步推进。【方法】本文在理论探讨基础上结合2005—2020年中国30个省份面板数据,综合利用双固定效应回归模型、工具变量模型、中介效应模型、空间计量模型,在严格检验基础上实证分析了农地流转对农业碳排放的影响效应、中介路径及其空间特性。【结果】(1)农地流转对农业碳排放产生显著正向影响,即农地流转面积扩大会促进农业碳排放增加;(2)农业经营规模在农地流转促进农业碳排放增加过程中发挥部分中介效应,农地流转能通过提升农业经营规模进而增加农业碳排放;(3)考虑空间效应时,农地流转对本地区农业碳排放产生显著正向影响,对邻近地区农业碳排放产生显著负向影响,农业经营规模在农地流转对本地区农业碳排放的影响过程中发挥部分中介效应。【结论】农地流转对农业碳排放存在显著影响,农地流转推进过程应重视农业碳排放问题。

关键词：农地流转农业碳排放中介效应空间效应工具变量中国