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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma yue Zhang Jinfeng li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng li Wei yue Nam‑Young Kim Yang li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

基于小波变换的抽取轻武器弹头曳光时间方法研究

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兵工学报 2008年第8期29卷 974-979页

作者：李岳霖闵碧蓉庞伟正叶剑锋哈尔滨工程大学中国白城兵器试验中心吉林白城137001

基于小波变换对连续波多普勒测速雷达的回波信号进行分析和研究,利用其对于表征信号的突变(瞬态)特征,对轻武器各种曳光弹头的曳光时间进行了抽取。试验结果表明,利用该方法能准确地抽取出曳光开始和结束时刻,且精度优于传统方法。

关键词：信息处理技术小波变换雷达信号突变曳光抽取

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汽油机燃烧过程模拟分析

内燃机学报 2000年第1期18卷 57-62页

作者：李岳林张志沛张雨郭晓汾长沙交通学院汽车工程系长沙410076 西安公路交通大学

建立了汽油机燃烧过程的双区和多区诊断及预测模型，其中包括火焰传播模型。在质量燃烧率的计算中，直接反映了紊流对燃烧过程的影响。编制了计算程序，进行了计算与试验的对比分析，计算结果与试验结果两者吻合良好。同时进行了变参... 详细信息

建立了汽油机燃烧过程的双区和多区诊断及预测模型，其中包括火焰传播模型。在质量燃烧率的计算中，直接反映了紊流对燃烧过程的影响。编制了计算程序，进行了计算与试验的对比分析，计算结果与试验结果两者吻合良好。同时进行了变参数性能预测计算。

关键词：汽油机燃烧过程模拟双区燃烧模型

基于规则的RBAC在Web信息系统中的实现

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四川大学学报（自然科学版） 2006年第6期43卷 1274-1278页

作者：李岳璘方勇邓远林陈其杉石稀林四川大学电子信息学院成都610064

针对Web资源访问的特点和安全问题,研究了传统的RBAC(Role-Based Access Con-trol)模型的缺陷,提出了一种适合大型Web资源访问系统的RBAC扩展模型,即利用用户属性制定相应的规则,根据规则为用户分配角色,以获得相应Web资源的访问权限.... 详细信息

针对Web资源访问的特点和安全问题,研究了传统的RBAC(Role-Based Access Con-trol)模型的缺陷,提出了一种适合大型Web资源访问系统的RBAC扩展模型,即利用用户属性制定相应的规则,根据规则为用户分配角色,以获得相应Web资源的访问权限.该扩展模型弥补了传统RBAC基于静态角色分配的不足,实现了角色的动态分配,并对规则和角色分配进行了约束,提高了Web资源访问的效率和安全性.

关键词：角色规则访问控制

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

lithium-ion batteries(liBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(liBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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汽油机燃烧循环变动的分岔特征

车用发动机 2005年第3期 13-17页

作者：刘志强徐小林李岳林长沙理工大学汽车与机械工程学院

对16种不同工况下的汽油机示功图进行了测量,以缸内峰值压力的试验数据为基础,应用符号时间序列分析方法,得到了汽油机燃烧循环变动的分岔特性,同时获得了汽油机燃烧循环变动随转速与负荷的变化规律。

关键词：汽油机燃烧循环变动符号时间序列分析分岔 Shannon熵

车用汽油机瞬态空燃比的混沌时序非线性组合辨识模型

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中国公路学报 2015年第4期28卷 109-115页

作者：李岳林解福泉徐东辉吴钢胡忠录长沙理工大学汽车与机械工程学院湖南长沙410076 河南交通职业技术学院河南郑州450005 宜春学院物理科学与工程技术学院江西宜春336000

为提高汽油机瞬态空燃比的辨识精度,提出了混沌时序非线性组合辨识模型。采用2种单项辨识方法,包括最小二乘支持向量机(LS-SVM)及径向基函数(RBF)前向型神经网络,分别对瞬态空燃比时间序列进行建模与辨识。采用非线性组合方法利用BP神... 详细信息

为提高汽油机瞬态空燃比的辨识精度,提出了混沌时序非线性组合辨识模型。采用2种单项辨识方法,包括最小二乘支持向量机(LS-SVM)及径向基函数(RBF)前向型神经网络,分别对瞬态空燃比时间序列进行建模与辨识。采用非线性组合方法利用BP神经网络对2种单项辨识方法的结果进行组合辨识,并与Elman神经网络模型及最小二乘辨识模型进行比较。结果表明:混沌时序非线性组合辨识模型的辨识精度优于Elman神经网络模型及最小二乘辨识模型,具有更强的非线性辨识能力,能提高瞬态空燃比的辨识精度,为空燃比反馈控制的成功实行提供了有力依据。

关键词：汽车工程混沌时序非线性组合辨识支持向量机 RBF神经网络