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S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds

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Chinese Chemical Letters 2024年第5期35卷 151-154页

作者： Ze-Yuan Ma Mei Xiao Cheng-Kun li Adedamola Shoberu Jian-Ping Zou Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical EngineeringSoochow UniversitySuzhou 215123China

An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP)is ***,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)_(2) moiety occurs were *** this manner,SDDP underwent facile SP(O)(OEt)_(2) transfer with electron-rich substrates such as ketones,indoles,and thiols to formα-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.

关键词： Electrophilic reagent Phosphorothiolation Electrophilic substitution

A systematic review of the role of TREM2 in Alzheimer’s disease

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中华医学杂志(英文版) 2024年第14期137卷 1684-1694页

作者： Yin Yunsi Yang Hanchen li Ruiyang Wu Guangshan Qin Qi Tang Yi Department of Neurology & Innovation Center for Neurological Disorders Xuanwu Hospital Capital Medical University National Center for Neurological Disorders Beijing China

Background: Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer’s disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a conflicting landscape of outcomes has emerged from bothin vivo andin vitro investigations. This study aimed to elucidate the multifaceted nuances and gain a clearer comprehension of the role of ***: PubMed database was searched spanning from its inception to January 2022. The search criteria took the form of ( "Alzheimer’s disease" OR "AD" ) AND ( "transgenic mice model" OR "transgenic mouse model" ) AND ( "Triggering receptor expressed on myeloid cells" OR "TREM2" ). Inclusion criteria consisted of the following: (1) publication of original studies in English; (2) utilization of transgenic mouse models for AD research; and (3) reports addressing the subject of ***: A total of 43 eligible articles were identified. Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function, Aβ accumulation, tau pathology, and inflammatory processes. However, the diverse inquiries posed yielded inconsistent responses. Nevertheless, the inconsistent roles of TREM2 within these AD mouse models potentially hinge upon factors such as age, sex, brain region, model type, and detection ***: This review substantiates the evolving understanding of TREM2’s disease progression-dependent impacts. Furthermore, it reviews the interplay between TREM2 and its effects across diverse tissues and temporal stages.

关键词： TREM2 Alzheimer’s disease Mouse model Microglia Amyloid-β accumulation Tau pathology Inflammation

A robust genomic-based prognostic model for the assessment ofcancer stemness and survival for patients with hepatocellularcarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 97-102页

作者： Cheng-li Du Shen-Yu Wei Yun-Hao Chen Kang-Jie Chen Division of Thoracic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang University School of Medicine Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characterization of novel prognostic and therapeutic strategies for HCC[3].

关键词： cancer prognosis liver

Carbon emission reduction: Contribution of geothermal energy and practice in China

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China Geology 2024年第1期7卷 161-164页

作者： liang Wang li-qiong Jia Natural Resources Integrated Survey Command Center China Geological SurveyMinistry of Natural ResourcesBeijing 100055China Development and Research Center China Geological SurveyMinistry of Natural ResourcesBeijing 100037China

As a kind of natural energy from the earth’s interior,geothermal energy is characterized by large reserve,wide distribution,good stability,high utilization coefficient,and positive effects of energy-saving and *** is of great significance for promoting green and low-carbon energy transition,reducing greenhouse gas emission,and achieving global climate goals and sustainable economic ***,it has been highly recognized and valued by lots of countries around the world,and has become one of the most important clean energy sources that countries are accelerating to develop and *** potential of the global geothermal energy resource is estimated to be 1.25×1027 J,equivalent to 4.27×10^(16) t of standard coal,among which the geothermal resource between 0 km and 5 km is 1.45×10^(26) J,equivalent to 4.95×1015 t of standard coal(China Geological Survey,2018).

关键词： energy utilize interior

An AIEgen nano-assembly for simultaneous detection of ATP and H_(2)S

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Chinese Chemical Letters 2024年第6期35卷 376-379页

作者： Jia-Mei Qin Xue li Wei Lang Fu-Hao Zhang Qian-Yong Cao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

A new aggregation-induced emission(AIE)-based fluorescence sensor,TPEPy-SS-C14,for simultaneous recognition of adenosine triphosphate(ATP)and hydrogen sulfide(H_(2)S)has been reported via the aggregation-disaggregation *** probe self-assembles nano-structure aggregations in aqueous *** shows fluorescence turn-on response toward ATP for the complexation-enhanced aggregation,but leads to fluorescence quenching of H_(2)S for cleavage the aggregations.

关键词： AIE-based ATP detection H_(2)S detection Fluorescent sensor Cell imaging

Recent Advances in Aqueous Zn||MnO_(2)Batteries

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Transactions of Tianjin University 2024年第1期30卷 27-39页

作者： Chuan li Rong Zhang Huilin Cui Yanbo Wang Guojin liang Chunyi Zhi Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloon 999077Hong KongChina Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Hong Kong Institute for Clean Energy City University of Hong KongKowloon 999077Hong KongChina Hong Kong Institute for Advanced Study City University of Hong KongKowloon 999077Hong KongChina

Recently,rechargeable aqueous zinc-based batteries using manganese oxide as the cathode(e.g.,MnO_(2))have gained attention due to their inherent safety,environmental friendliness,and low *** their potential,achieving high energy density in Zn||MnO_(2)batteries remains challenging,highlighting the need to understand the electrochemical reaction mechanisms underlying these batteries more deeply and optimize battery components,including electrodes and *** review comprehensively summarizes the latest advancements for understanding the electrochemistry reaction mechanisms and designing electrodes and electrolytes for Zn||MnO_(2)batteries in mildly and strongly acidic ***,we highlight the key challenges hindering the extensive application of Zn||MnO_(2)batteries,including high-voltage requirements and areal capacity,and propose innovative solutions to overcome these *** suggest that MnO_(2)/Mn^(2+)conversion in neutral electrolytes is a crucial aspect that needs to be addressed to achieve high-performance Zn||MnO_(2)*** approaches could lead to breakthroughs in the future development of Zn||MnO_(2)batteries,off ering a more sustainable,costeff ective,and high-performance alternative to traditional batteries.

关键词： Aqueous Zn||MnO_(2)batteries Zinc-ion batteries Zinc batteries MnO_(2)

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren Xiaobing Chen Mengmeng Xiao Xi li Zhe Xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang Zheng Quan Zhang Xiaogang Xia Peng li lingwei Gu Ting Wu Chenghua Luo Shu-Hai lin Wengang li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

Data Driven Vibration Control:A Review

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1898-1917页

作者： Weiyi Yang Shuai li Xin Luo Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714 Chongqing School University of Chinese Academy of SciencesChongqing 400714China Faculty of Information Technology and Electrical Engineering University of OuluOulu 90570 VTT-Technology Research Center of Finland Oulu 90570Finlan College of Computer and Information Science Southwest UniversityChongqing 400715China

With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests from both the industrial and academic *** shaping(IS),as a simple and effective feedforward method,is greatly demanded in DDVC *** convolves the desired input command with impulse sequence without requiring parametric dynamics and the closed-loop system structure,thereby suppressing the residual vibration *** on a thorough investigation into the state-of-the-art DDVC methods,this survey has made the following efforts:1)Introducing the IS theory and typical input shapers;2)Categorizing recent progress of DDVC methods;3)Summarizing commonly adopted metrics for DDVC;and 4)Discussing the engineering applications and future trends of *** doing so,this study provides a systematic and comprehensive overview of existing DDVC methods from designing to optimizing perspectives,aiming at promoting future research regarding this emerging and vital issue.

关键词： Data driven vibration control(DDVC) data science designing method feedforward control industrial robot input shaping optimizing method residual vibration

国外深度学习研究的现状与进展——基于WOS数据库中SSCI文献的分析

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数字教育 2019年第5期5卷 76-82页

作者：李嘉雯李玉斌辽宁师范大学计算机与信息技术学院

文章以Web of Science核心合集SSCI数据库近十年收录的343篇相关文献为研究对象,以文献计量和词频分析为研究方法,对国外深度学习研究的现状和进展进行分析。研究发现:从2010年开始,深度学习作为一个独特的研究领域受到越来越多的关注,... 详细信息

文章以Web of Science核心合集SSCI数据库近十年收录的343篇相关文献为研究对象,以文献计量和词频分析为研究方法,对国外深度学习研究的现状和进展进行分析。研究发现:从2010年开始,深度学习作为一个独特的研究领域受到越来越多的关注,当下正处于发展期;深度学习概念的形成大体分为两个阶段,总的来看依然缺乏一个清晰的理论框架来定义深度学习。文章最后对国外深度学习研究的特点进行了分析,并针对国内研究的不足提出了改进建议。

关键词：深度学习研究现状词频分析文献计量