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STUDIES ON THE PRENYLFLAVONOIDS PART X IX SYNTHESIS OF EXIGUAFLAVANONE K

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Chinese Chemical Letters 1996年第1期7卷 11-12页

作者： Xian Yong BU li xiao and yu lin li(State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University Lanzhou, 730000) State Key Lab. of Appl. Organ Institide Organic Chemistry Lanzhou University Lanzhou 730000

K was first synthesized via the Condensation of 2-hydroxy-3-prenyl-4, 6-dimethoxymethoxyacetophenone 3- methoxy-4methoxymethoxybenzaldehyde followed by cyclixation

关键词： IX STUDIES ON THE PRENYLFLAVONOIDS PART X IX SYNTHESIS OF EXIGUAFLAVANONE K

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao yu-Gui Peng Peng Wu Zong-lin li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

γ-Secretase Inhibitor, DAPT Inhibits Self-renewal and Stemness Maintenance of Ovarian Cancer Stem-like Cells In Vitro

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Chinese Journal of Cancer Research 2011年第2期23卷 140-146页

作者： li-yu Jiang xiao-lei Zhang Ping Du Jian-hua Zheng Department of Obstetrics and Gynecology the First Affiliated Hospital Harbin Medical University Harbin 150001 China

Objective: The Notch signaling pathway plays an important role in the stem cell signaling network and contributes to tumorigenesis. However, the functions of Notch signaling in ovarian cancer stem cells (OCSCs) are not well understood. We aimed to investigate the effects of Notch blockade on self-renewal and stemness maintenance of OCSCs. Methods: Ovarian cancer stem-like cells were enriched from ovarian cancer cell lines in serum-free medium. A γ-secretase inhibitor, (DAPT), was used to block Notch signaling. MTT assays were performed to assess self-renewal and proliferation inhibition, flow cytometry was performed to analyze cell surface marker and immunofluorescence, Western Blot and Real-time RT-PCR assays were performed to detect Oct4 and Sox2 protein and mRNA expression of the Ovarian cancer stem-like cells treated with DAPT. Results: Notch blockade markedly inhibits self-renewal and proliferation of ovarian cancer stem-like cells, significantly downregulates the expression of OCSCs-specific surface markers, and reduces protein and mRNA expression of Oct4 and Sox2 in OCSC-like cells. Conclusion: Our results suggest that Notch signaling is not only critical for the self-renewal and proliferation of OCSCs, but also for the stemness maintenance of OCSCs. The γ-secretase inhibitor is a promising treatment targeting OCSCs.

关键词： Ovarian cancer stem cells (OCSCs) Notch signaling pathway γ-secretase inhibitor

Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis

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World Journal of Gastroenterology 2011年第3期17卷 322-328页

作者： Shi-Bin Guo Zhi-Jun Duan Qing li xiao-yu Sun Department of Gastroenterology the First Affiliated Hospital of Dalian Medical University Dalian 116001 Liaoning Province China

AIM: To investigate the role of heme oxygenase-1 (HO-1) in pathogenesis of experimental hepatorenal syndrome (HRS). METHODS: Rats were divided into liver cirrhotic group, zinc protoporphyrin IX (ZnPP) treatment group, cobalt protoporphyrin (CoPP) treatment group and sham group. Biliary cirrhosis was established by bile duct ligation in the first three groups. Rats in the ZnPP and CoPP treatment groups received intraperitoneal injection of ZnPP and CoPP, respectively, 24 h before sample collection. Expression of HO-1 mRNA in kidney was detected by reverse-transcription polymerase chain reaction, while protein expression was determined by immunohis-tochemical analysis. Hematoxylin and eosin staining was performed to observe liver cirrhosis and renal structure. Renal artery blood flow, mean arterial pressure and portal vein pressure, 24 h total urinary volume, serum and urine sodium concentrations, and creatinine clearance rate (Ccr) were also ***: The HO-1 mRNA and protein expression levels in kidney, 24 h total urinary volume, renal artery blood flow, serum and urine sodium concentration and Ccr were lower in cirrhotic group than in sham group (P < 0.05). However, they were significantly lower in ZnPP treatment group than in cirrhotic group and significantly higher in CoPP treatment group than in cirrhotic group (P < 0.05). CONCLUSION: Low HO-1 expression level in kidney is an important factor for experimental HRS.

关键词： Heme oxygenase-1 Carbon monoxide Hepatorenal syndrome Zinc protoporphyrin IX Cobalt protoporphyrin Bile duct ligation Biliary cirrhosis

Experimental Observing Damage Evolution in Cement Pastes Exposed to External Sulfate Attack by in situ X-ray Computed Tomography

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 164-170页

作者： WU Min CAO Kailei xiao Weirong yu Zetai CAO Jierong DING Qingjun li Jinhui China Railway Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan liuheng Bridge Phase II Project Zhoushan 316000China China Railway Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key Laboratory of Silicate Material for Architecture(Wuhan University of Technology) Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate *** damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray computed tomography

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu xiao-li li xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Long-Term Outcome of A Large Series of Gastric Cancer Patients in China

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Chinese Journal of Cancer Research 2010年第3期22卷 167-175页

作者： Ai-wen Wu Jia-fu Ji Hong Yang Yan-ning li Shuang-xi li lian-hai Zhang Zi-yu li xiao-jiang Wu Xiang-long Zong Zhao-de Bu Ji Zhang Xiang-qian Su Yi Wang Guang-wei Xu Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department ofGastrointestinal Surgery Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing100142 China

Objective：The outcome of gastric cancer treatment in China is relatively poor compared with those in Japan and *** factors are not quite clear till *** aim of this study is to present data on gastric cancer patients from a single high volume cancer center of China and to illuminate relevant factors regarding unsatisfactory ***：A total of 2312 consecutive pathologically proven gastric carcinoma patients were treated in Beijing Cancer Hospital from January 1995 to December *** information including demographic information,tumor characteristics,therapeutic experience and survival was retrieved from the Database specially designed for Gastric Cancer Collaborative Group,Beijing Cancer ***：There were 1633 males and 679 females with a median age of 58.8 years（range 19-89）.Merely 181 patients were in the early stage（7.8%）.Curative resection was performed in less than 72% of the *** number of lymph nodes harvested varied from 0 to 71（average 9） while the median number of positive lymph node was 2（0-37）.Only in 650 patients the number of lymph nodes harvested was more than *** the end of follow-up,874 patients were still alive while 1132 *** 1,2,5,10-year overall survival were 68.50%,51.88%,36.83%,and 30.49%,*** analysis demonstrated that TNM stage,tumor location,tumor size,surgery,and vascular invasion were independent prognostic ***：The outcome of gastric cancer in China is not as good as *** detection and standardized curative resection should be prompted at present to improve the outcome.

关键词： Gastric cancer Management Outcome

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中国互联网内容监管策略结构与演化研究

情报科学 2014年第6期32卷 24-29页

作者：李小宇武汉大学信息资源研究中心湖北武汉430072

基于政策文本挖掘和内容分析,构建了中国互联网内容监管策略三层结构体系,分析了各类监管策略、措施的数量分布和演化历程,指出了不同政策领域偏好的监管策略。研究发现我国网络内容监管以前置审批、过程监控和事后追责三类策略构成的... 详细信息

基于政策文本挖掘和内容分析,构建了中国互联网内容监管策略三层结构体系,分析了各类监管策略、措施的数量分布和演化历程,指出了不同政策领域偏好的监管策略。研究发现我国网络内容监管以前置审批、过程监控和事后追责三类策略构成的制度化管理为基础,以专项整治行动为代表的运动式管理和企业自律为代表的代理式管理为突出特色。监管策略总体上经历了从倚重制度化管理转向在制度基础上综合运用运动式和代理式管理的演化历程。多种社会主体参与监管活动的趋势正在加强,而市场调控类策略的比重和效率还有待提高。

关键词：内容监管网络监管监管策略

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热塑性弹性体中的可逆共价交联反应

高分子材料科学与工程 2000年第6期16卷 24-27页

作者：殷红李效玉北京化工大学材料科学与工程学院北京100029

总结了热塑性弹性体中的 5类热可逆共价交联反应 ,介绍了其具体内容及研究进展。这类热塑性弹性体是将热可逆反应的活性基团引入高分子链通过交联和解交联反应 ,实现材料在常温时的强度及高温时的塑性。可逆共价交联是一种新的交联类型... 详细信息

总结了热塑性弹性体中的 5类热可逆共价交联反应 ,介绍了其具体内容及研究进展。这类热塑性弹性体是将热可逆反应的活性基团引入高分子链通过交联和解交联反应 ,实现材料在常温时的强度及高温时的塑性。可逆共价交联是一种新的交联类型。它克服了物理交联的缺点。

关键词：共价交联热塑性弹性体活性基团