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Kinetics of Specific and Non-Specific Copper Sorption on Aggregates of an Acidic Paddy Soil from the Taihu Lake Region in East China

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Pedosphere 2015年第1期25卷 37-45页

作者： liU Pei-Ya WEN Qin-liang li yu-jiao DONG Chang-Xun PAN Gen-Xing College of Sciences Nanjing Agricultural University Institute of Resource Ecosystem and Environment of Agriculture Nanjing Agricultural University

The Taihu Lake region in East China has become prone to soil acidification, which changes heavy metals such as copper(Cu) in soil into water-soluble species and increases the mobility and contamination risks of heavy metals in the biological environment. In this study, the kinetics of Cu2+sorption by the bulk soil and the aggregate size fractions of an acidic paddy soil collected from the Taihu Lake region, the effects of temperature on Cu2+sorption, and the p H changes of the solution were investigated by static sorption and magnetic stirring. The aggregate size fractions were prepared by low-energy ultrasonic dispersing and freeze-drying. The total sorption amounts of the bulk soil and the aggregate size fractions for Cu2+followed a descending order of clay > coarse sand > bulk soil > silt> sand, corresponding to those of organic matter content, free iron oxide content, free aluminum oxide content, and cation exchange capacity. The kinetic sorption curves of Cu2+by the bulk soil and the aggregates, which were divided into two stages(rapid and slow sequentially), were well fitted by the first-order equation, the diffusion equation, and the Elovich equation, showing significant correlations(P lightly during the non-specific sorption. When the specific sorption terminated, the p H of the solution was minimized nearly *** sorption progress of Cu2+by the bulk soil significantly preceded that by the aggregates. Therefore, heavy metal contamination may be another factor reducing soil p H and metal sorption forms should be taken into consideration in studies of mitigating soil heavy metal

关键词： bulk soil contamination heavy metal kinetic equation p H soil acidification temperature

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi lin Ruian Xu Lu liu yu Zhang Feng Tian jiao jiao li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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CB1 agonism prolongs time window for estrogen replacement therapy

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中国药理学与毒理学杂志 2018年第9期32卷 683-684页

作者： ZHANG Kun li Yan-jiao YANG Qi li yu-jiao YANG Le WANG Xin-shang DANG Rui-li GUAN Shao-yu GUO Yan-yan GE Xiang-wei SUN Ting WU yu-mei liU Shui-bing ZHAO Ming-gao Precision Pharmacy & Drug Development Center Department of Pharmacy Tangdu Hospital the Fourth Military Medical University Xi′an 710038 China′a710038China Institute of Clinical Pharmacy and Pharmacology Jining First People′ s Hospital Jining

OBJECTIVE To detect the underlying mechanism of time window for estrogen(E2)replacement treating cognitive *** E2 begun 1 week after the ovariectomy(OVXST)or 3 months after the ovariectomy(OVXLT).Learning and memory ability were examined by trace fear memory test and inhibitory avoidance *** and LTD were detected by *** throughput gene expression sequencing and microRNA(miR NA) sequencing were used to detecte the differently expressed genes between OVXSTand OVXLTafter estrogen *** Subcutaneous injection of E2 improved fear memory formation in both 1 week after ovariectomy(OVXST) mice or 3 months after ovariectomy(OVXLT) ***,for fear memory extinction,facilitated by E2 in OVXSTmice,but impaired by E2 in *** researches showed in medial prefrontal cortex(mPFC),estrogen facilitates LTD in OVXSTmice but impairs LTD in *** of highthroughput sequencings of mR NA and miRNA in mPFC from sham,OVXSTmice,E2 treated OVXST mice,OVXLTmice,and E2 treated OVXLTmice indicated decreased miR-221-5 p expression in OVXLTmice compared with *** OVXLT mice,miR-221-5 p could be further reduced by E2 ***,miR-221-5 p targeted neuralized E3 ubiquitin protein ligase 1 a/b(Neurl1 a/b) m *** miR-221-5 p will promotes cannabinoid receptor 1(CB1) ubiquitination through up-regulating Neurl1 a/b protein levels in E2 treated OVXLTmice,which disrupted the retrograde endocanabinoids *** miR-221-5 p or treating with CB1 agonist rescued the fear extinction impairment in E2 treated *** These results uncovered a epigenetic change after long term E2 responsible for failure of E2 improving cognitive performance in OVXLTmice,moreover miR-221-5 p and CB1 agonist as potential targets for prolonging the time window for E2 replacement therapy.

关键词： cannabinoid receptor1 estrogen time window miRNA epigenetic

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High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang Yan li libo Chen Handong jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (liMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** liMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of liMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of liMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable liMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Semiconductor doping

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing Wu Guang Yin Fan‑Zhen jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan jiao lingyan Meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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内格尔的目的论解释

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科学技术哲学研究 2014年第6期31卷 41-45页

作者：喻莉姣华南师范大学公共管理学院广州510006

生物学家在解释一些问题的时候会使用到目的论的语言,这种目的论语言到底有没有存在的必要呢?以内格尔为代表的一批学者认为这种语言是不必要的,其中内格尔试图用一个统一的D-N模型来替换目的论陈述,这种替换是否恰当呢?通过对其原著的... 详细信息

生物学家在解释一些问题的时候会使用到目的论的语言,这种目的论语言到底有没有存在的必要呢?以内格尔为代表的一批学者认为这种语言是不必要的,其中内格尔试图用一个统一的D-N模型来替换目的论陈述,这种替换是否恰当呢?通过对其原著的研究,笔者认为内格尔的这种替换是不恰当的,他对于目的论解释的消解也是不成功的。其次,内格尔没有注意到语境对于科学解释的重要性,这也造成他在用D-N模型对目的论解释进行消解时会出现无法处理的反例。

关键词：内格尔目的论解释目标归因功能归因

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Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein

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中国药理学与毒理学杂志 2019年第10期 765-766页

作者： ZHANG Kun li yu-jiao GUO Yan-yan ZHENG Kai-yin YANG Qi YANG Le CHEN Tao ZHUO Min ZHAO Ming-gao Department of Pharmacology School of PharmacyFourth Military Medical University Center for Neuron and Disease Frontier Institutes of Life Science and of Science and Technology Xi′an Jiaotong University Department of Anatomy Histology and Embryology and K.K.Leung Brain Research Center Fourth Military Medical University

OBJECTIVE Fragile X syndrome is an inheritable form of intellectual disability caused by loss of fragile X mental retardation protein(FMRP, encoded by the Fmr1 gene). METHODS Four protein level in brain homogenate were detected by EliSA. Morris water maze and novel object(location) were used to study changes of learning and memory. Golgi staining was used to study changes of dendritic spine density. Ed U staining was used to study number of neurogenesis in SGZ. Immunofluorescence staining was used to detect effects of exogenous protein on spine density and morphology. Patch clamp and Med64 electrophysiological technology were used to observe the effects of drugs on synaptic transmission and plasticity. Lentivirus expressing sh RNA was injected in medial prefrontal cortex(m PFC)to study gene function. RESULTS Absence of FMRP caused overexpression of progranulin(PGRN, encoded by Grn), a putative tumour necrosis factor receptor *** the present study, we found that PGRN m RNA and protein were upregulated in the of Fmr1 knock-out *** Fmr1 knock-out mice, elevated PGRN caused insufficient dendritic spine pruning and late-phase long-term potentiation in the m PFC of Fmr1 knock-out mice. Partial PGRN knock down restored spine morphology and reversed behavioural deficits, including impaired fear memory, hyperactivity, and motor inflexibility in Fmr1 knock-out mice. PGRN increased levels of phosphorylated glutamate ionotropic receptor Glu A1 and nuclear factor kappa B(NFκB) in cultured wild-type neurons. Tumour necrosis factor receptor 2(TNFR2) antibody perfusion blocked the effects of progranulin on Glu A1 phosphorylation; this result indicates that TNFR2 is required for PGRN mediated Glu A1 phosphorylation and late-phase long-term potentiation expression. However, high basal level of progranulin in Fmr1 knock-out mice prevented further facilitation of synaptic plasticity by exogenous PGRN. Partial downregulation of PGRN or TNFR2/NFκB signalling restored synaptic p

关键词： fragile X syndrome progranulin TNFR2 long-term potentiation synaptic plasticity

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政府扶持:现代农业阶段农民经济合作的必要条件——基于国际经验之上的思考和启示

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金融理论与实践 2011年第7期 65-69页

作者：李昱姣河南教育学院政治理论部河南郑州450046

从国际合作运动的实践来看,德、美、日等国政府都在农民经济合作组织的创立和发展过程中扮演着扶持者的角色。我国今天农民经济合作组织的建立和发展,无疑也应该借鉴发达国家的历史经验,采取扶持性的信贷和财政税收等优惠政策,以推动农... 详细信息

从国际合作运动的实践来看,德、美、日等国政府都在农民经济合作组织的创立和发展过程中扮演着扶持者的角色。我国今天农民经济合作组织的建立和发展,无疑也应该借鉴发达国家的历史经验,采取扶持性的信贷和财政税收等优惠政策,以推动农民经济合作组织的创立和发展。

关键词：农民经济合作相对贫困农民资金互助政府扶持

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对金融生态环境建设工作的理论思考

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金融理论与实践 2007年第2期 26-28页

作者：李昱姣华中师范大学政治学研究院湖北武汉473074

用马克思主义基本原理指导金融生态环境建设工作,必须准确地把握金融生态及金融生态环境的科学内涵,运用劳动价值学说阐述金融生态环境建设的必要性及其意义,在金融生态环境建设中学会抓主要矛盾及矛盾的主要方面,从内因与外因的关系上... 详细信息

用马克思主义基本原理指导金融生态环境建设工作,必须准确地把握金融生态及金融生态环境的科学内涵,运用劳动价值学说阐述金融生态环境建设的必要性及其意义,在金融生态环境建设中学会抓主要矛盾及矛盾的主要方面,从内因与外因的关系上看金融主观能动作用的发挥,用联系和发展的、对立统一的观点指导金融生态环境考核评价指标体系的建设和完善。

关键词：金融生态金融生态环境劳动价值学说主要矛盾能动性

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