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On-demand engineerable visible spectrum by fine control of electrochemical reactions

National Science Review 2024年第3期11卷 239-249页

作者： Qirong liu Lei liu yongping Zheng Min li Baofu Ding Xungang Diao Hui-Ming Cheng Yongbing Tang Advanced Energy Storage Technology Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences School of Energy and Power Engineering North University of China School of Resource Environment and Safety EngineeringHunan University of Science and Technology School of Energy and Power Engineering Beihang University Shenzhen Key Laboratory of Energy Materials for Carbon Neutrality Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

Tunability of optical performance is one of the key technologies for adaptive optoelectronic applications,such as camouflage clothing, displays, and infrared shielding. High-precision spectral tunability is of great importance for some special applications with on-demand adaptability but remains challenging. Here we demonstrate a galvanostatic control strategy to achieve this goal, relying on the finding of the quantitative correlation between optical properties and electrochemical reactions within materials. An electrochromic electro-optical efficiency index is established to optically fingerprint and precisely identify electrochemical redox reactions in the electrochromic device. Consequently, the charge-transfer process during galvanostatic electrochemical reaction can be quantitatively regulated, permitting precise control over the final optical performance and on-demand adaptability of electrochromic devices as evidenced by an ultralow deviation of lications with strict demand on precise spectral tunability but also will promote in situ quantitative research in a wide range of spectroelectrochemistry, electrochemical energy storage, electrocatalysis, and material chemistry.

关键词： electrochromics fine control spectral tunability high precision galvanostatic control

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Identification of potential immune-related mechanisms related to the development of multiple myeloma

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Chinese Medical Journal 2024年第13期137卷 1603-1613页

作者： Yaomei Wang Wenli Zhang Tiandong li Mengmeng liu Mengya Gao Xinqing li Yufei Chen yongping Song Wei li Chunyan Du Fang Wang lina liu Department of Hematology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China The Academy of Medical Science College of MedicalZhengzhou UniversityZhengzhouHenan 450052China College of Public Health Zhengzhou UniversityZhengzhouHenan 450000China Department of Research and Foreign Affairs The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China Department of Clinical Medicine Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Laboratory Animal Center School of Medical SciencesZhengzhou UniversityZhengzhouHenan 450052China

Background:Although significant advances have been made in the treatment of multiple myeloma(MM),leading to unprecedented response and survival rates among patients,the majority eventually relapse,and a cure remains *** situation is closely related to an incomplete understanding of the immune microenvironment,especially monocytes/macrophages in patients with treatment-naïve *** aim of this study was to provide insight into the immune microenvironment,especially monocytes/macrophages,in patients with treatment-naïve ***:This study used the single-cell RNA sequencing(scRNA-seq)data of both patients with MM and heathy donors to identify immune cells,including natural killer(NK)cells,T cells,dendritic cells(DCs),and monocytes/*** data and flow cytometry analysis of monocytes/macrophages were used to further examine the effect of monocytes/macrophages in treatment-naïve MM ***:A significant difference was observed between the bone marrow(BM)immune cells of the healthy controls and treatment-naïve MM patients through *** is noteworthy that,through an scRNA-seq data analysis,this study found that interferon(IFN)-induced NK/T cells,terminally differentiated effector memory(TEMRA)cells,T-helper cells characterized by expression of IFN-stimulated genes(ISG^(+)Th cells),IFN-responding exhausted T cells,mannose receptor C-type 1(MRC1)^(+)DCs,IFN-responding DCs,MHCII^(+)DCs,and immunosuppressive monocytes/macrophages were enriched in patients with treatment-naïve ***,transcriptomic data of monocytes/macrophages demonstrated that"don’t eat me"-related genes and IFN-induced genes increase in treatment-naïve MM ***,scRNA-seq,transcriptomic data,and flow cytometry also showed an increased proportion of CD16^(+)monocytes/macrophages and expression level of ***-cell communication analysis indicated that monocytes/macrophages,whose related important signaling pathways include migration i

关键词： Multiple myeloma Monocytes/macrophages Single-cell RNA sequencing Immune cell Microenvironment Bone marrow Molecular characterization

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3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie liu Xuqiang liu Kaiyue He yongping Jian Yujia li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of life Sciences Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China Shenzhen Research Institute of Henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK Hepatocellular carcinoma

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Sparse convolutional model with semantic expression for waste electrical appliances recognition

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Science China Technological Sciences 2024年第9期67卷 2881-2893页

作者： HAN HongGui liU YiMing li FangYu DU yongping Faculty of Information Technology Beijing University of Technology Beijing Key Laboratory of Computational Intelligence and Intelligent System Engineering Research Center of Digital Community Ministry of Education Beijing Artificial Intelligence Institute and Beijing Laboratory for Intelligent Environmental Protection

Deep neural networks play an important role in the recognition of waste electrical appliances. However, deep neural network components still lack reliability in decision-making features. To address this problem, a sparse convolutional model with semantic expression(SCMSE) is proposed. First, a low-rank sparse semantic expression component, combining the benefits of residual networks and sparse representation, is adapted to enhance sparse feature extraction and semantic expression. Second, a reliable network architecture is obtained by iterating the optimal sparse solution, enhancing semantic expression. Finally, the results of visualization experiments on the waste electrical appliances dataset demonstrate that the proposed SCMSE can obtain excellent semantic performance.

关键词： sparse convolutional model deep neural network semantic expression visualization computer vision

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Reannotation of the cultivated strawberry genome and establishment of a strawberry genome database

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Horticulture Research 2021年第1期8卷 590-598页

作者： Tianjia liu Muzi li Zhongchi liu Xiaoyan Ai yongping li Institute of Fruit and Tea Hubei Academy of Agricultural Sciences/Fruit and Tea Subcenter of Hubei Innovation Center of Agricultural Science and TechnologyWuhanChina Department of Cell Biology and Molecular Genetics University of Maryland College ParkCollege ParkMDUSA School of life Sciences and State Key Laboratory of Agrobiotechnology Chinese University of Hong KongShatinHong KongChina

Cultivated strawberry(Fragaria×ananassa)is an important fruit crop species whose fruits are enjoyed by many *** octoploid of hybrid origin,the complex genome of this species was recently sequenced,serving as a key reference genome for cultivated strawberry and related species of the Rosaceae *** current annotation of the *** genome mainly relies on ab initio predictions and,to a lesser extent,transcriptome ***,we present the structure and functional reannotation of the *** genome based on one PacBio full-length RNA library and ninety-two Illumina RNA-Seq *** improved annotation of the *** genome,v1.0.a2,comprises a total of 108,447 gene models,with 97.85%complete *** models of 19,174 genes were modified,360 new genes were identified,and 11,044 genes were found to have alternatively spliced ***,we constructed a strawberry genome database(SGD)for strawberry gene homolog searching and annotation ***,the transcriptome of the receptacles and achenes of *** at four developmental stages were reanalyzed and qualified,and the expression profiles of all the genes in this annotation are also ***,this study provides an updated annotation of the *** genome,which will facilitate genomic analyses across the Rosaceae family and gene functional studies in cultivated strawberry.

关键词： straw Fragaria database

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Energy Planning of Beijing Towards Low-carbon,Clean and Efficient Development in 2035

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 913-928页

作者： Chengzhou li Ningling Wang Xiaohu Shen Yumeng Zhang Zhiping Yang Xiaofeng Tong François Maréchal ligang Wang yongping Yang Institute of Energy Power Innovation North China Electric Power UniversityBeijing 102206China School of Energy Power and Mechanical Engineering and National Research Center for Thermal Power Engineering and TechnologyNorth China Electric Power UniversityBeijing 102206China Industrial Process and Energy Systems Engineering Swiss Federal Institute of Technology in LausanneSionSwitzerland

Energy transition towards clean,efficient energy supply has been a common sense of the government and public in ***,lacking reasonable planning will lead to undisciplined development,resource waste,and excessive *** this context,this paper investigates potential pathways of Beijing energy transition towards a high-level low-carbon,clean and efficient energy system in 2035 with an extended energysocpe ***,based on available data,future energy demands are predicted by a newly proposed hybrid forecasting method,which combines the traditional regression model,grey model,and support vector machine model with an entropy-based weighted ***,the superstructure-based optimization model is employed to investigate the system configuration and operation strategy of the future Beijing energy ***,the uncertainty impact of electricity price,natural gas price,hydrogen price,and the capital expenditures of electrolyzer and steam methane reforming for hydrogen applications are *** forecasting results show that all walks of life will witness a continuously increasing energy demand in multiple sectors of Beijing towards *** planning results suggest that the imported electricity and natural gas will dominate the energy supply of Beijing in 2035 with a contribution of 86%of the energy resources consumption of 384 ***,the energy system presents a high end-use electrification level of 65%and high penetration of efficient technologies,which supply 119 TWh via combined heat and power,26 TWh via heat pump and 95 TWh via district heating *** energy use of various sectors of energy resources,technologies and end-use are closely *** will have an increased penetration in the private mobility sector,but the locally generated hydrogen is mainly from steam methane reforming technology.

关键词： Energy transition energy planning carbonneutral demand forecasting energyscope

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Establishment of Retinoblastoma Model in NOD-SCID Mice and Study of Metastasis

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Eye Science 2005年第3期21卷 185-191页

作者： Bo Zhang yongping li Zhonshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Purpose: To establish model of retinoblastoma subcutaneously in NOD-SCID mice and study rules of formation and distribution of retinoblastoma ***: Retinoblastoma cells SO-RB50 were inoculated subcutaneously in NOD-SCID mice. Animal acts and tumor formation, growth and metastasis in NOD-SCID mice were observed. Primary and metastatic tumors were studied pathohistologically by HE and immunohistochemical ***: The latent periods of tumor growth were 12～19 days and the taken rate of tumor was 100%. 32 days later, 5 NOD-SCID mice were found with tumors that had metastasized to areas mainly located in the abdominal cavity and the side of the kidney; the metastatic time of tumors in the mice also differed. The tumor cells of the primary nodules and the metastasis were similar with human retinoblastoma cells and positive in immunohistochemical staining of ***: The subcutaneous model of retinoblastoma in NOD-SCID mice showed a high taken rate and a short latent period of tumor, which had a high metastatic rate and was the best model in research of behaviors of retinoblastoma at present.

关键词：眼癌动物实验 NOD-SCID 小鼠肿瘤转移

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云南昭通市2021年草地贪夜蛾成虫种群动态及物理防控效益分析

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中国农学通报 2024年第8期40卷 132-139页

作者：周光信马永翠任佳昕盛亦伟李永萍彭明春冯正军李平松王崇云云南大学资源植物研究院/农学院昆明650228 昭通学院农学与生命科学学院云南昭通657000 云南大学生态与环境学院昆明650504 彝良县植保植检站云南昭通657000 昭阳区植保植检站云南昭通657000

草地贪夜蛾(Spodoptera frugiperda)自入侵以来就对中国粮食生产安全造成巨大的威胁,明晰昭通市草地贪夜蛾种群动态、采取有效防控措施是粮食生产安全的重要保障。2021年对云南省昭通市草地贪夜蛾成虫动态进行全年定点监测,并建立防控... 详细信息

草地贪夜蛾(Spodoptera frugiperda)自入侵以来就对中国粮食生产安全造成巨大的威胁,明晰昭通市草地贪夜蛾种群动态、采取有效防控措施是粮食生产安全的重要保障。2021年对云南省昭通市草地贪夜蛾成虫动态进行全年定点监测,并建立防控示范区对防控方案进行对比研究。结果表明:(1)昭通市的草地贪夜蛾成虫于3月1日起开始陆续出现;出现时序由西南向东北发展;(2)草地贪夜蛾成虫发生主要集中在巧家县、鲁甸县、永善县、彝良县、昭阳区和大关县;(3)昭通市西南部巧家县和永善县4—6月为草地贪夜蛾种群数量最多时期,鲁甸县、彝良县、昭阳区8月出现大量草地贪夜蛾迁入;(4)性诱、灯诱、性诱+灯诱混合防控的物理诱控方式能够显著降低草地贪夜蛾的危害,减少玉米产量损失,其中性诱+灯诱混合防控方式效果最为显著。

关键词：草地贪夜蛾成虫种群动态物理诱控云南昭通

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雪茄烟苗期钾素营养特征及干物质的积累

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山西农业科学 2024年第4期52卷 68-75页

作者：李禹姚恒孔光辉张光海赵高坤吴玉萍李薇李永平王戈白羽祥周鹏杜宇王娜云南农业大学烟草学院云南昆明650021 云南省烟草农业科学研究院云南昆明650021

为提高雪茄烟的品质,明确雪茄烟育苗阶段干物质积累及钾素吸收利用特性的很有必要,试验采用溶液培养方法,研究钾素供应水平(不供钾、正常供钾(1 L霍格兰氏营养液含有506 mg硝酸钾)、超量供钾(1 L霍格兰氏营养液含有506 mg硝酸钾+523.23... 详细信息

为提高雪茄烟的品质,明确雪茄烟育苗阶段干物质积累及钾素吸收利用特性的很有必要,试验采用溶液培养方法,研究钾素供应水平(不供钾、正常供钾(1 L霍格兰氏营养液含有506 mg硝酸钾)、超量供钾(1 L霍格兰氏营养液含有506 mg硝酸钾+523.23 mg硫酸钾)对雪茄烟烟苗生长状况、干物质积累量及钾素吸收利用特性的影响。结果表明,钾素显著影响雪茄烟苗期形态建成。就烟苗农艺性状而言,水培45 d时,株高、茎围、最大叶长和最大叶宽均以正常供钾处理最高,分别为31.67、2.30、21.17、11.17 cm;烟苗干物质积累而言,不供钾处理在水培过程中干物质积累较为缓慢,超量供钾处理在水培15~30 d时累积量很小且缓慢,而水培30~45 d时积累量急剧增加;在钾素方面,与CK相比,超量供钾处理提高了烟株钾素含量,但钾素利用率却有所降低,在水培15、30、45 d时分别降低了1.48%、18.24%、11.45%。综上,缺钾从开始即影响烟苗生长,根系生长受抑制,缺钾症状典型特征15 d后逐步显现;钾素过量时,烟株前期长势稍好,中后期增效不明显,干物质积累在烟苗生长前期积累量小且缓慢,且钾素利用率低于正常施钾处理。

关键词：雪茄烟钾素溶液培养法干物质积累钾素利用率

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Masculinizer gene controls sexual differentiation in Hyphantria cunea

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Insect Science 2024年第2期31卷 405-416页

作者： Xiaowei li Huihui liu Honglun Bi Yaohui Wang Jun Xu Sufang Zhang Zhen Zhang Ze Zhang yongping Huang Laboratory of Evolutionary and Functional Genomics School of Life SciencesChongqing UniversityChongqingChina CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Centerfor Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyShanghaiChina Key Laboratory of Forest Protection Research Institute of Forest EcologyEnvironment and ProtectionChinese Academy of ForestryState Forestry AdministrationBeijingChina

The Masculinizer gene,Masc,encodes a lepidopteran-specific novel CCCHtype zinc finger protein,which controls sex determination and dosage compensation in Bombyx *** the potential application of it in pest control,it is necessary to investigate the function of Masc gene in Hyphantria cunea,a globally invasive forest *** the present study,we identified and functionally characterized the Masc gene,HcMasc,in *** analysis revealed that HcMASC contained the conserved CCCH-type zinc finger domain,nuclear localization signal,and male determining domain,in which the last was confirmed to be required for its masculinization in BmN cell ***,expression data showed that unlike male-biased expression in ***,Hc-Masc gene expresses in main all developmental stages or tissues in both *** regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-based disruption of the common exons 1 and 3 of the HcMasc gene resulted in imbalanced sex ratio and abnormal external genitalia of both *** results suggest that the HcMasc gene is required for both male and female sexual differentiation and dosage compensation in *** and provide a foundation for developing better strategies to control this pest.

关键词： CRISPR/Cas9 dosage compensation Hyphantria cunea Masc sexual differentiation

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