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Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 4-13页

作者： Ji-yao Sheng Zi-Fan Meng Qiao li yong-Sheng Yang Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun 130041China Jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases the Second Hospital of Jilin UniversityChangchun 130041China

Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with cirrhosis.Although primary prevention drugs,including non-selectiveβ-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related contraindications.With recent advances in precision medicine,precise drug treatment provides better treatment efficacy.Data sources:literature search was conducted in PubMed,MEDliNE and Web of Science for relevant articles published up to May 2022.Information on clinical trials was obtained from https://clinicaltrials.gov/and http://***/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising drugs.According to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and others.All these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.Conclusions:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

关键词： Cirrhotic portal hypertension Target drug Primary prevention Bleeding

Association between Serum Ferritin Levels and Metabolic-associated Fatty liver Disease in Adults:a Cross-sectional Study Based on the NHANES

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Current Medical Science 2024年第3期44卷 494-502页

作者： Jiang-hui li Xue-yao MA Yun YI Lu-rao li Zhi-yong XU Ying CHANG Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan430071China Endoscopy Center The People’s Hospital of YingshanHuanggang438799China

Objective Ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic diseases.Our study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of America.Methods A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 cycles.Hepatic steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive indexes.Multiple regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver fibrosis.Results The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),Pliver index(Fli);Q4 vs.Q1:OR=3.13(1.91,5.13),Pli].Additionally,participants with the highest serum ferritin levels(Q4 group)displayed a higher prevalence of liver fibrosis[Q4 vs.Q1:OR=2.59(1.19,5.62),Pliver stiffness measurement;OR=5.06(1.12,22.94),Pliver fibrosis in patients.Elevated serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

关键词： serum ferritin liver fibrosis metabolic-associated fatty liver disease National Health and Nutrition Examination Survey

A novel topology with controllable wideband baseband impedance for power amplifiers

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 308-315页

作者： yao yao Zhijiang DAI Mingyu li School of Intelligent Technology and Engineering Chongqing University of Science and TechnologyChongqing400065China School of Microelectronics and Communication Engineering Chongqing UniversityChongqing400065China

This paper presents a novel topology to control the baseband impedance of a power amplifier(PA)to avoid performance deterioration in concurrent dual-band mode.This topology can avoid pure resonance of capacitors and inductors LC,which leads to a high impedance at some frequency points.Consequently,it can be applied to transmitters that are excited by broadband signals.In particular,by adjusting the circuit parameters and increasing stages,the impedance of the key frequency bands can be flexibly controlled.A PA is designed to support this design idea.Its saturated output power is around 46.7 dBm,and the drain efficiency is>68.2%(1.8-2.3 GHz).Under concurrent two-tone excitation,the drain efficiency reaches around 40%even under 5.5 dB back-off power with the tone spacing from 10 MHz to 500 MHz.These results demonstrate that the proposed topology is capable of controlling wideband baseband impedance.

关键词： Baseband impedance Concurrent dual-band Power amplifier

The BEL1-like transcription factor GhBLH5-A05 participates in cotton response to drought stress

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The Crop Journal 2024年第1期12卷 177-187页

作者： Jing-Bo Zhang yao Wang Shi-Peng Zhang Fan Cheng yong Zheng Yang li Xue-Bao li Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina College of life Sciences Xinjiang Normal UniversityUrumqi 830017XinjiangChina

Drought stress impairs crop growth and development.BEL1-like family transcription factors may be involved in plant response to drought stress,but little is known of the molecular mechanism by which these proteins regulate plant response and defense to drought stress.Here we show that the BEL1-like transcription factor GhBLH5-A05 functions in cotton(Gossypium hirsutum)response and defense to drought stress.Expression of GhBLH5-A05 in cotton was induced by drought stress.Overexpression of GhBLH5-A05 in both Arabidopsis and cotton increased drought tolerance,whereas silencing GhBLH5-A05 in cotton resulted in elevated sensitivity to drought stress.GhBLH5-A05 binds to cis elements in the promoters of GhRD20-A09 and GhDREB2C-D05 to activate the expression of these genes.GhBLH5-A05 interacted with the KNOX transcription factor GhKNAT6-A03.Co-expression of GhBLH5-A05 and GhKNAT6-A03 increased the transcription of GhRD20-A09 and GhDREB2C-D05.We conclude that GhBLH5-A05 acts as a regulatory factor with GhKNAT6-A03 functioning in cotton response to drought stress by activating the expression of the drought-responsive genes GhRD20-A09 and GhDREB2C-D05.

关键词： Cotton(Gossypium hirsutum) BEL1-like transcription factor Drought stress Transcriptional regulation Drought tolerance

Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance li-ion battery anodes

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Rare Metals 2024年第2期43卷 599-611页

作者： Xue-Ru Zhang Qiong Wu yong Zhang Xi-Fei li Ting Xie Yu-Cheng Wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox couples.However,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical applications.To overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization process.In a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon layer.The integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer binders.While MnCo_(2)O_(4)@C/Cu possesses slightly longer li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in li-ion cycles.The rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase films.As a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials lithium-ion batteries

In-situ polymerized PEO-based solid electrolytes contribute better li metal batteries:Challenges,strategies,and perspectives

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Journal of Energy Chemistry 2024年第5期92卷 548-571页

作者： Zhihui Jia yong liu Haoming li Yi Xiong Yingjie Miao Zhongxiu liu Fengzhang Ren School of Materials Science and Engineering Henan Key Laboratory of Non-Ferrous Materials Science&Processing TechnologyHenan University of Science and TechnologyLuoyang 471023HenanChina Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal new Materials and Advanced Processing Technology Henan University of Science and TechnologyLuoyang 471023HenanChina

Polyethylene oxide(PEO)-based solid polymer electrolytes(SPEs)with good electrochemical stability and excellent li salt solubility are considered as one of the most promising SPEs for solid-state lithium metal batteries(SSLMBs).However,PEO-based SPEs suffer from low ionic conductivity at room temperature and high interfacial resistance with the electrodes due to poor interfacial contact,seriously hindering their practical applications.As an emerging technology,in-situ polymerization process has been widely used in PEO-based SPEs because it can effectively increase li-ion transport at the interface and improve the interfacial contact between the electrolyte and electrodes.Herein,we review recent advances in design and fabrication of in-situ polymerized PEO-based SPEs to realize enhanced performance in LMBs.The merits and current challenges of various SPEs,as well as their stabilizing strategies are presented.Furthermore,various in-situ polymerization methods(such as free radical polymerization,cationic polymerization,anionic polymerization)for the preparation of PEO-based SPEs are summarized.In addition,the application of in-situ polymerization technology in PEO-based SPEs for adjustment of the functional units and addition of different functional filler materials was systematically discussed to explore the design concepts,methods and working mechanisms.Finally,the challenges and future prospects of in-situ polymerized PEO-based SPEs for SSLMBs are also proposed.

关键词： In-situ polymerization Polyethylene oxide Solid polymer electrolytes lithium metal anodes

limits of Uneven Battery Power in Modular Multilevel Converter-based Battery Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 686-695页

作者： yao Pan Xiaofeng Sun Wei Zhao Xin li yao Cai Institute of Electrical Engineering Yanshan UniversityQinhuangdao 066004China

For modular multilevel converter-based battery energy storage systems (MMC-BESS), uneven power among batteries of SMs will be deduced by battery aging, battery fault, etc., which will degrade performance and even lead to system failure. For maintaining the balance of capacitor voltage, this paper analyzes the limits of the uneven power of batteries, which are presented as the current limits in this paper. According to analysis, an analytical method is proposed that only the dc and fundamental frequency components of the arm current are used to calculate current limits. With the current limits it is able to evaluate the reasonability of power distribution among batteries. Meanwhile, increase of fundamental frequency component will enhance the current limits, and the dc component determines the size relationship between the absolute values of the upper and lower current limits. Finally, simulation model and experiment prototype are built for verifying the theoretical analysis and current limits calculation method, and satisfactory results are provided.

关键词： Arm current balance of capacitor voltage current limits MMC-BESS uneven power

Rhyscotus subrisus li&Jiang,sp.nov.,representing a new record family Rhyscotidae from China(Isopoda:Oniscidea)

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Zoological Systematics 2024年第2期49卷 181-183页

作者： Chonghui yao Chao Jiang Weichun li College of Agronomy Jiangxi Agricultural UniversityNanchang 330045China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs National Resource Center for Chinese MateriaMedicaChina Academy of Chinese Medical SciencesBeijing 100700China

The family Rhyscotidae Budde-Lund,1904 contains two genera:Rhyscotoides Schmalfuss&Ferrara,1978 and Rhyscotus Budde-Lund,1885.To date,twenty-one species within the family are known,occurring in the subtropic and tropic regions(Schmalfuss,2003;Schmidt,2003;Boyko et al.,2022).The members of the family can be recognized by the cephalon with a strongly inflated frons,the antennae with two-jointed flagellum,the maxillae are almost semicircular,the maxillipeds have short palpus and endite,and pleopod exopodites without pseudotracheae(Schmalfuss&Ferrara,1978).Before this study,the members of Rhyscotidae were unknown in China.The present research describes a new species of the genus Rhyscotus from Hainan Island,representing a new record of the family Rhyscotidae from China.

关键词： record family

Polyimide covalent organic frameworks as efficient solid-state li^(+) electrolytes

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Science China Chemistry 2024年第5期67卷 1647-1652页

作者： Xu liu Shi Wang Siqi liu Chengfang liu Xiangchun li Jian Wu Dazhi li Shihao Xu Chongyang liu Wen-yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&TelecommunicationsNanjing 210023China

Covalent organic frameworks(COFs) are attractive porous crystalline materials with extremely high stability, easy functionalization, and open channels, which are expected to be unique ion conductors/transporters in lithium ion batteries(liBs). Despite recent advances, low ion conductivity and low transference number, resulting in low charging/discharging rate, low energy density, and short battery life, are the main issues that limit their direct application as solid electrolytes in liBs. Here, we designed and synthesized a novel polyimide COF, namely, TAPA-PDI-COF, with abundant C=O groups, which has been successfully employed as high-performance solid electrolytes by doping TAPA-PDI-COF and succinonitrile(SN). Both the well-defined nanochannels of COFs and SN confined in the well-aligned channels restricted the free migration of anions, while C=O on COFs and CN groups of SN enhanced li^(+) transport, thus achieving a high ion conductivity of 0.102 m S cm^(-1)at 80 °C and a high lithium-ion transference number of 0.855 at room temperature. According to density functional theory(DFT)calculations, li-ion migration mainly adopted in-plane transport rather than the axial pathway, which may be due to the shorter hopping distances in the planar pathway. The results suggest an effective strategy for the design and development of all-solidstate ionic conductors for achieving high-performance liBs.

关键词： lithium ion batteries(liBs) covalent organic frameworks(COFs) solid-state ion conductors solid-state electrolytes ion conductivity