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Effects of Chinese Medicine on Symptoms,Syndrome Evolution,and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge:A Prospective Cohort and Nested Case-Control Study

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Chinese Journal of Integrative Medicine 2021年第4期27卷 245-251页

作者： li li GOU Chun-yan li Xue-mei SONG Wen-yan WANG Xiao-jun li hong-ying li hong-yan li Xiu-hui Integrated Traditional Chinese and Western Medicine Center Beijing Youan HospitalCapital Medical UniversityBeijing(100069)China Chronic Disease Management Center Beijing Youan HospitalCapital Medical UniversityBeijing(100069)China Department of Radiology Beijing Youan HospitalCapital Medical UniversityBeijing(100069)China

Objective:To observe the changes of symptoms,Chinese medicine(CM)syndrome,and lung inflammation absorption during convalescence in patients with coronavirus disease 2019(COVID-19)who had not totally recovered after hospital discharge and whether CM could promote the improvement ***:This study was designed as a prospective cohort and nested case-control study.A total of 96 eligible patients with COVID-19 in convalescence were enrolled from Beijing Youan Hospital and Beijing Huimin Hospital and followed up from the hospital discharged *** were divided into the CM(64 cases)and the control groups(32 cases)based on the treatment with or without CM and followed up at 14,28,56,and 84 days after *** the CM group,patients received the 28-day CM treatment according to two types of CM *** in clinical symptoms,CM syndrome,and absorption of lung inflammation were ***:All the 96 patients completed the 84-day follow-up from January 21 to March 28,*** the 84th day of follow-up,respiratory symptoms were less than 5%.There was no significant difference in the improvement rates of symptoms,including fatigue,sputum,cough,dry throat,thirst,and upset,between the two groups(P>0.05).Totally 82 patients(85.42%)showed complete lung inflammation absorption at the 84-day *** day 14,the CM group had a significantly higher absorption rate than the control group(P<0.05)and the relative risk of absorption for CM *** group was 3.029(95%confidence interval:1.026-8.940).The proportions of CM syndrome types changed with time prolonging:the proportion of the pathogen residue syndrome gradually decreased,and the proportion of both qi and yin deficiency syndrome gradually ***:Patients with COVID-19 in convalescence had symptoms and lung inflammation after hospital discharge and recovered with time *** could improve lung inflammation for early *** types of CM syndrome can be transformed wi

关键词： COVID-19 convalescent patient Chinese medicine syndrome evolution pneumonia absorption

Comparison of an SMS text messaging and phone reminder to improve attendance at a health promotion center:A randomized controlled trial

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 34-38页

作者： Zhou-wen CHEN li-zheng FANG li-ying CHEN hong-lei DAI Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective: To compare the efficacy of a short messaging service (SMS) text messaging and phone reminder to im-prove attendance rates at a health promotion center. Methods: A total of 1 859 participants who had scheduled appointments in the health promotion center of our hospital from April 2007 to May 2007 were enrolled in the study and randomly assigned into 3 groups: control (no reminder) group,SMS text messaging reminder group and telephone reminder group. Attendance rates and costs of interventions were collected. Results: A total of 1848 participants were eligible for analysis. Attendance rates of control,SMS and telephone groups were 80.5%,87.5% and 88.3%,respectively. The attendance rates were significantly higher in SMS and telephone groups than that in the control group,with odds ratio 1.698,95% confidence interval 1.224 to 2.316,P=0.001 in the SMS group,and odds ratio 1.829,95% confidence interval 1.333 to 2.509,P<0.001 in the telephone group. However,there was no difference between the SMS group and the telephone group (P=0.670). The cost effectiveness analysis showed that the cost per attendance for the SMS group (0.31 Yuan) was significantly lower than that for the telephone group (0.48 Yuan). Conclusion: SMS and telephone are effective reminders for improving attendance rate at a health promotion center. SMS reminder may be more cost-effective compared with the telephone reminder.

关键词： Reminder Short messaging service (SMS) Telephone Failure to attend (FTA) Randomized controlled trial (RCT)

Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 616-622页

作者： Zhou-wen CHEN li-ying CHEN hong-lei DAI Jian-hua CHEN li-zheng FANG Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results：（1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.

关键词： Nonalcoholic fatty liver disease (NAFLD) Alanine aminotransferase (ALT) Metabolic syndrome (MS)

Analysis of Vitamin K_3 by a Fluorescent Spectroelectrochemistry Method

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Chemical Research in Chinese Universities 2010年第5期26卷 742-745页

作者： ZHAO Chang-zhi li ying DU hong XU Hua-jun JIAO Kui Key Laboratory of Eeo-Chemical Engineering Ministry of Education College of Chemistry ＆ Molecular Engineering Qingdao University of Science ＆ Technology Qingdao 266042 P. R. China

A simple and sensitive spectroelectrochemistry method for the determination of vitamin K3 was developed by combining electrolysis and fluoremetry. This method was based on that vitamin K3 was reduced at a glassy carbon electrode, and its product with characteristic fluorescence at 420 nm was determined with excitation wavelength at 309 nm. Under optimized electrochemical reaction conditions and fluorescent experiment parameters, the fluorescence intensity was proportional to the concentration of vitamin K3 in a range from 3.50×10^-7 to 1.05×10^-5 mol/L with a correlation coefficient of 0.9991, and detection limit was estimated to be 7.50× 10^-8 mol/L at a signal/noise ra- tio of 3. The relative standard deviation was less than 4.3%（n=5） and the recovery was in a range of 97%-105% for the determination of vitamin K3 in pharmaceutical preparations. The result is satisfactory for the determination of vitamin K3 as comparison to that from HPLC method.

关键词： Spectroelectrochemistry Fluorescence Electro-reduced Vitamin K3

Preparation of Anhydrous LnCl_3(Ln=Eu, Er, Lu) by Chemical Vapor Transport

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Journal of Rare Earths 2000年第2期18卷 152-154页

作者： WANG lin shan, li ying, WANG Yu hong (Department of Chemistry, Northeastern University, Shenyang 110006, China) Department of Chemistry Northeastern University Shenyang 110006 China

Anhydrous lanthanide chlorides LnCl 3(Ln=Eu, Er, Lu) which are not easy to prepare in other ways were prepared by chemical vapor transport(CVT) method. Ln 2O 3 reacted with an excess of Al 2Cl 6 at 300 ℃ to produce LnCl 3. LnCl 3 reacted with Al 2Cl 6 at high temperature to form the gaseous complexes which decomposed at low temperature. LnCl 3 was then separated from other solids by controlling a proper temperature gradient. Residual Al 2Cl 6(g) was removed by the carrier of dry Cl 2 N 2 gases at 200 ℃. The yield rates are >90%, and the purity of products is >99 5%. The high purity of anhydrous lanthanide chlorides can be obtained by CVT method.

关键词： rare earths preparation chemical vapor transport

Neuroprotective Effect of Fructus broussonetiae on APP/PS1 Mice via Upregulation of AKT/β-Catenin Signaling

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Chinese Journal of Integrative Medicine 2021年第2期27卷 115-124页

作者： li ying-hong JIN Yu WANG Xu-sheng CHEN Xiao-ling CHEN hong-bo XU Ji DUAN li-hong WANG Yu-long LUO Xun WANG Qing-mei WU Zheng-zhi The First Affiliated Hospital of Shenzhen University(the Second People's Hospital of Shenzhen) ShenzhenGuangdong Province(518035)China The Shenzhen Key Laboratory of Health Sciences and Technology Graduate School at ShenzhenTsinghua UniversityBeijing(518055)China Graduate School Guangzhou Medical UniversityGuangzhouGuangdong(510182)China Stroke Biological Recovery Laboratory Spaulding Rehabilitation HospitalHarvard Medical SchoolCharlestownBostonMassachusetts(02129)USA Shenzhen Sanming Group Spaulding Rehabilitation HospitalHarvard Medical SchoolCharlestownBostonMassachusetts(02129)USA Kerry Rehabilitation Medicine Research Institute ShenzhenGuangdong Province(518048)China

Objective:To evaluate the mechanisms underlying the protective effect of Chinese herbal medicine Fructus broussonetiae(FB)in both mouse and cell models of Alzheimer’s disease(AD).Methods:APP/PS1 mice treated with FB for 2 months and vehicle-treated controls were run through the Morris water maze and object recognition test to evaluate learning and memory ***-Seq,Western blotting,and immunofluorescence staining were also conducted to evaluate the effects of FB treatment on various signaling pathways altered in APP/PS1 *** further explore the mechanisms underlying FB’s protective effect,PC-12 cells were treated with Aβ25–35 in order to establish an in vitro model of ***:FB-treated mice showed improved learning and memory capacity on both the Morris water maze and object recognition ***-seq of hippocampal tissue from APP/PS1 mice showed that FB had effects on multiple signaling pathways,specifically decreasing cell apoptotic signaling and increasing AKT and β-catenin ***,FB up-regulated both AKT and β-catenin signaling in PC-12 cells pre-treated with Aβ25–35,in which AKT positively regulated β-catenin *** study showed that AKT promoted β-catenin signaling via enhancing β-catenin(Ser552)***,AKT and β-catenin signaling inhibition both resulted in the attenuated survival of FB-treated cells,indicating the AKT/β-catenin signaling is a crucial mediator in FB promoted cell ***:FB exerted neuroprotective effects on hippocampal cells of APP/PS1 mice,as well as improved cell viability in an in vitro model of *** protective actions of FB occurred via the upregulation of AKT/β-catenin signaling.

关键词： Alzheimer disease Chinese medicine neuroprotective agent apoptosis regulatory proteins Fructus broussonetiae

Selection of Parents for Breeding Edible Varieties of Sweetpotato with High Carotene Content

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Agricultural Sciences in China 2009年第10期8卷 1166-1173页

作者： MA Dai-fu li Qiang li Xiu-ying li hong-min TANG Zhong-hou HU ling CAO Qing-he XIE Yi-ping WANGXin Sweetpotato Research institute Chinese Academy of Agricultural Sciences~National Sweetpotato Improvement Center Xuzhou 221121P.R. China

Sweetpotato varieties with high carotene content have high value for human health. This work aims to improve the breeding efficiency of special varieties with high carotene content by combining molecular markers and agronomic traits to evaluate and screen the parents. The cluster analysis was carried out to identify and screen promising parents by utilizing phenotypic results of the agronomic and characteristic traits, and RAPD and ISSR markers of 15 parents and their offspring by group crossing. Among different parental materials, greater variations were observed in two important traits, the carotene content and the storage root yield. Negative correlation was found between the carotene content and both fresh and dried root yields. The most significant positive correlation was between the carotene content of parents and that of their offspring, with the coefficient of correlation value of 0.7932＊＊. The relationship based on the agronomic characters of the trial materials was not in agreement with the known genealogy, while that based on the molecular marker data showed better result. Each primer amplified 13.8 bands oflSSR markers on average, in which the rate of polymorphic loci was 89.6%. 9.4 bands of RAPD markers were arnplified per primer, in which the rate of polymorphic bands was 74.46%. Large genetic variation of carotene content was found among the parents. For analyzing the genetic diversity of sweetpotato, the molecular marker methods were better than morphological traits; ISSR markers were more efficient than RAPD markers. The combination of molecular markers and agronomic trait analysis may provide valuable theoretic basis for selection of parents to breed new varieties with high carotene content.

关键词： sweetpotato carotene selection of parents RAPD ISSR cluster analysis

Determination of Dopamine in the Presence of Ascorbic Acid on the IrO2-Ta2O5 Type DSA Electrode

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Chinese Chemical Letters 2005年第1期16卷 64-66页

作者： Yang liU, Zhi ying li, Jing hong li? State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

IrO2/Ta2O5 (70%: 30%, molar ratio) electrodes (ITEs) were prepared by the thermal decomposition method. Typical “mud-cracked” surface and surface enrichment of Ta were observed. The determination of dopamine (DA) was carried out in the presence of ascorbic acid (AA). The detection limit of DA was 5×10-5 mol/L without the interference of AA.

关键词： Dopamine ascorbic acid determination DSA.

A Visual Attention Model for Robot Object Tracking

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International Journal of Automation and computing 2010年第1期7卷 39-46页

作者： Jin-Kui Chu Rong-Hua li Qing-ying li hong-Qing Wang School of Mechanical Engineering, Dalian University of Technology, Dalian 116024, PRC School of Mechanical Engineering Dalian University of Technology Dalian PRC

Inspired by human behaviors, a robot object tracking model is proposed on the basis of visual attention mechanism, which is fit for the theory of topological perception. The model integrates the image-driven, bottom-up attention and the object-driven, top-down attention, whereas the previous attention model has mostly focused on either the bottom-up or top-down attention. By the bottom-up component, the whole scene is segmented into the ground region and the salient regions. Guided by top-down strategy which is achieved by a topological graph, the object regions are separated from the salient regions. The salient regions except the object regions are the barrier regions. In order to estimate the model, a mobile robot platform is developed, on which some experiments are implemented. The experimental results indicate that processing an image with a resolution of 752 × 480 pixels takes less than 200 ms and the object regions are unabridged. The analysis obtained by comparing the proposed model with the existing model demonstrates that the proposed model has some advantages in robot object tracking in terms of speed and efficiency.

关键词： Object tracking visual attention topological perception salient regions weighted similarity equation