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A Method for Identification of Selenoprotein Genes in Archaeal Genomes

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Genomics, Proteomics & Bioinformatics 2009年第1期7卷 62-70页

作者： Mingfeng li Yanzhao Huang yi xiao Biomolecular Physics and Modeling Group Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

The genetic codon UGA has a dual function： serving as a terminator and encoding selenocysteine. However, most popular gene annotation programs only take it as a stop signal, resulting in misannotation or completely missing selenoprotein genes. We developed a computational method named Asec-Prediction that is specific for the prediction of archaeal selenoprotein genes. To evaluate its effectiveness, we first applied it to 14 archaeal genomes with previously known selenoprotein genes, and Asec-Prediction identified all reported selenoprotein genes without redundant results. When we applied it to 12 archaeal genomes that had not been researched for selenoprotein genes, Asec-Prediction detected a novel selenoprotein gene in Methanosarcina acetivorans. Further evidence was also collected to support that the predicted gene should Asec-Prediction is effective be a real selenoprotein gene. for the prediction of archaeal The result shows that selenoprotein genes.

关键词： archaea selenocysteine selenoprotein SECIS SelB gene prediction

Study on pitting process of 316L stainless steel by means of staircase potential electrochemical impedance spectroscopy

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 48-52页

作者： Zhi-jun Jia Cui-wei Du Cheng-tao li Zou yi xiao-gang li School of Materials Science and Technology University of science and Technology Beijing Beijing 100083 China

Pitting corrosion of 316L stainless steel in NaCl solution was investigated by means of staircase potential electrochemical impedance spectroscopy（SPEIS）.The investigation focused on the transition of stainless steel from the passive state to pitting *** on the evolution of electrical parameters of the equivalent electrical circuit,it is suggested that the most probable mechanism of pit creation is the film breaking *** result demonstrates that staircase potential electrochemical impedance spectroscopy is an effective method for the investigation of pitting corrosion.

关键词： stainless steel passivation film steel corrosion pitting electrochemical impedance spectroscopy

Mechanism and prediction of failure of diamond films deposited on various substrates by HFCVD

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中国有色金属学会会刊：英文版 2004年第z1期14卷 229-233页

作者： ZHOU ling-ping SUN Xin-yuan li Shao-lu li De-yi CHEN xiao-hua College of Material Science and Engineering Hunan University Changsha 410082 China College of Material Science and Engineering Hunan University Changsha 410082 China College of Material Science and Engineering Hunan University Changsha 410082 China College of Material Science and Engineering Hunan University Changsha 410082 China College of Material Science and Engineering Hunan University Changsha 410082 China

Diamond films were deposited on the WC-Co cemented carbide and Si3N4 ceramic cutting tool substrates by hot-filament-assisted chemical vapour deposition. The adherence property of diamond films was estimated using the critical load (Pcr) in the indentation test. The adhesive strength of diamond films is related to the intermediate layer between the film and the substrate. Poor adhesion of diamond films to polished cemented carbide substrate is owing to the formation of graphite phase in the interface. The adhesion of diamond films deposited on acid etched cemented carbide substrate is improved, and the peeling-off of the films often happens in the loosen layer of WC particles where the cobalt element is nearly removed. The diamond films' adhesion to cemented carbide substrate whose surface layer is decarbonizated is strengthened dramatically because WC phase forms by reaction between the deposited carbon and tungsten in the surface layer of substrates during the deposition of diamond, which results in chemical combination in the film-substrate interface. The adhesion of diamond films to silicon nitride substrate is the firmest due to the formation of chemical combination of the SiC intermediate layer in the interfaces. In the piston-turning application, the diamond-coated Si3N4 ceramic and the cemented carbide cutting tools usually fail in the form of collapsing of edge and cracking or flaking respectively. They have no built-up edge(BUE) as long as coating is *** it wears through, BUE develops and the cutting force on it increases 1 - 3 times than that prior to failure. This can predict the failure of diamond-coated cutting tools.

关键词： diamond film cutting tool adhesion failure prediction cemented carbide

Investigation of Spontaneous Condensation of an Amino Acid Based Amphiphile on Cast Film by in situ Transmission FT-IR Spectroscopy

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Chinese Chemical Letters 2005年第12期16卷 1637-1640页

作者： Hai Yan WANG Yan Mei li yi xiao Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084

The spontaneous condensation of the amphiphilic N-（O,O-dihexadecyl）phosphorylalanine on the cast film was observed by in situ investigation of transmission infrared spectroscopy The particular orientation and ordered packing of the monomers within the multilayers of the cast film is concluded to attribute to the spontaneous condensation between the monomers.

关键词： Amphiphile cast film condensation FT-IR N-(O O-dihexadecyl)phosphoryl alanine

Concentrated Fluoride-medium Route to Synthesis of One-dimensional Fluoroaluminophosphate Chain (C_4H_(15)N_3)[AlPO_4F_2]

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Chemical Research in Chinese Universities 2010年第5期26卷 699-701页

作者： liU Yang HAN yi-de li yi SONG xiao-wei li Ji-yang YU Ji-hong XU Ru-ren State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

A new one-dimensional（ID） fluoroaluminophosphate chain（C4H15N3）[AlPO4F2]（denoted AIPO-CJ28） was synthesized in the concentrated fluoride synthetic medium with a gel composition of 1.0Al（OPr^1）a：1.0H3PO4： 5.4DETA：1.3HF：2.0H2O（DETA=diethylenetriamine）. The reagents were mixed directly without introducing additional water solvent. The 1D chain is constructed by alternating AlO2F2 arid doubly bridging PO4 tetrahedra to form the simplest serrate chain. AIPO-CJ28 can be transformed to another 1D aluminophosphate chain A1PO-CSC upon further crystallization at 230 ℃.

关键词： Fluoroaluminophosphate Concentrated fluoride-medium Phase transformation Chain structure

Screening Pathogenic Microorganism Standard Strains for Disinfection Efficacy Evaluation

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Biomedical and Environmental Sciences 2022年第11期35卷 1070-1073页

作者： li yi xiao SONG Yang MEI li JIANG Meng Nan WANG Duo Chun WEI Qiang National Pathogen Resource Center Chinese Center for Disease Control and PreventionBeijing 102206China Division of Infectious Disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionBeijing 102206China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Infectious diseases would always threaten human health,especially emerging infectious diseases(EIDs),such as the coronavirus disease-2019(COVID-19).In 2019,COVID-19 spread rapidly *** January 30,2020,World Health Orga... 详细信息

关键词： diseases Microorganism spread

The IAP family: endogenous caspase inhibitors with multiple biological activities

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Cell Research 2000年第3期10卷 169-177页

作者： YANG yi li, xiao MING li(Laboratory of Immune Cell Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) LaboratoryofImmuneCellBiology DivisionofBasicSciencesNationalCancerInstituteNationalInstitutesofHealthBethesdaMD20892USA.yiliyang@box-y.nih.gov

IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger *** found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the factthat IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination byiAPs on signal transduction, cell cycle, and apoptosis.

关键词： Apoptosis ubiquitination IAP caspase TNF

Heavy ion-induced single event upset sensitivity evaluation of 3D integrated static random access memory

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Nuclear Science and Techniques 2018年第3期29卷 31-41页

作者： Xue-Bing Cao li-yi xiao Ming-Xue Huo Tian-Qi Wang Shan-Shan liu Chun-Hua Qi An-Long li Jin-Xiang Wang Microelectronics Center Harbin Institute of TechnologyHarbin 150001China Harbin Institute of Technology Shenzhen Graduate School Shenzhen 518055China Research Center of Basic Space Science Harbin Institute of TechnologyHarbin 150001China

Heavy ion-induced single event upsets(SEUs)of static random access memory(SRAM), integrated with three-dimensional integrated circuit technology, are evaluated using a Monte Carlo simulation method based on the Geant4 simulation toolkit. The SEU cross sections and multiple cell upset(MCU) susceptibility of 3D SRAM are explored using different types and energies of heavy *** the simulations, the sensitivities of different dies of 3D SRAM show noticeable discrepancies for low linear energy transfers(LETs). The average percentage of MCUs of 3D SRAM increases from 17.2 to 32.95%, followed by the energy of ^(209)Bi decreasing from 71.77 to 38.28 MeV/u. For a specific LET, the percentage of MCUs presents a notable difference between the face-to-face and back-toface structures. In the back-to-face structure, the percentage of MCUs increases with a deeper die, compared with the face-to-face structure. The simulation method and process are verified by comparing the SEU cross sections of planar SRAM with experimental data. The upset cross sections of the planar process and 3D integrated SRAM are analyzed. The results demonstrate that the 3D SRAM sensitivity is not greater than that of the planar SRAM. The 3D process technology has the potential to be applied to the aerospace and military fields.

关键词： 3D integration Single event upset (SEU) Multiple cell upset (MCU) Monte Carlo simulation

Genome-Wide Analysis Regulatory Network of Photomorphogenesis Revealed the Complex Brassinosteroid Effects in

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Molecular Plant 2009年第4期2卷 755-772页

作者： li Song xiao-yi Zhou li li liang-Jiao Xue Xi Yang Hong-Wei Xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road 200032 Shanghai China

light and brassinosteroids （BRs） have been proved to be crucial in regulating plant growth and development; however, the mechanism of how they synergistically function is still largely unknown. To explore the underlying mechanisms in photomorphogenesis, genome-wide analyses were carried out through examining the gene expressions of the dark-grown WT or BR biosynthesis-defective mutant det2 seedlings in the presence of light stimuli or exogenous Brassinolide （BL）. Results showed that BR deficiency stimulates, while BL treatment suppresses, the expressions of lightresponsive genes and photomorphogenesis, confirming the negative effects of BR in photomorphogenesis. This is consistent with the specific effects of BR on the expression of genes involved in cell wall modification, cellular metabolism and energy utilization during dark-light transition. Further analysis revealed that hormone biosynthesis and signaling-related genes, especially those of auxin, were altered under BL treatment or light stimuli, indicating that BR may modulate photomorphogenesis through synergetic regulation with other hormones. Additionally, suppressed ubiquitin-cycle pathway during light-dark transition hinted the presence of a complicated network among light, hormone, and protein degradation. The study provides the direct evidence of BR effects in photomorphogenesis and identified the genes involved in BR and light signaling pathway, which will help to elucidate the molecular mechanism of plant photomorphogenesis.

关键词： brassinosteroid light photomorphogenesis hormone interplay ubiquitin.