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Virologica Sinica 2021年第6期36卷 1465-1474页

作者： Na li Zhen wang Rui wang Zhe-Rui zhang Ya-Nan zhang cheng-lin Deng bo zhang Lu-Qing Shang Han-Qing ye Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China College of Pharmacy and Drug Discovery Center for Infectious Diseases Nankai UniversityTianjin 300350China

Chikungunya virus(CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and enterovirus. In this study, we found that lycorine could inhibit CHIKV in cell culture at a concentration of 10 lmol/L without apparent cytotoxicity. In addition, it exhibited broad-spectrum anti-alphavirus activity, including Sindbis virus(SINV),Semliki Forest virus(SFV), and Venezuelan equine encephalomyelitis virus(VEEV). The time of addition studies indicated that lycorine functions at an early post-entry stage of CHIKV life cycle. The results based on two different CHIKV replicons provided further evidence that lycorine exerts its antiviral activity mainly by inhibiting CHIKV ***, our study extends the antiviral spectrum of lycorine.

关键词： Chikungunya virus(CHIKV) Alphavirus Lycorine Antiviral

Tuning Intermolecular Singlet Fission Efficiencies of Perylenediimide Derivatives through Bay Aromatic Substitution

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Chinese Journal of Chemistry 2023年第10期41卷 1170-1176页

作者： Chun-lin Sun Xiao-Zhen wang Hu-Hu Tian Qi-Wei Song bo-Yang zhang Xian Fei cheng zhang Jian-Rong Ma Juan ye Hao-li zhang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Special Function Materials and Structure DesignCollege of Chemistry and Chemical EngineeringFrontiers Science Center for Rare IsotopesLanzhou UniversityLanzhouGansu 730000China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistryTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin 300072China

Singlet fission(SF)has potential applications in high-efficiency photo-energy harvesting applications,but its practical application is hindered by the limited number of *** this work,we explored the bay aromatic substitution strategy for the design of new perylenediimide(PDI)based SF materials.A series of PDI derivatives with biphenyl or naphthalene units substituted at the bay posi-tions were designed and synthesized to investigate the effects of aromatic substitutes on their photodynamic *** bay substitutions do not shift the energy level of the PDI core significantly but give rise to different intermolecular coupling strengths in the thin films and affect the intermolecular SF *** transient absorption(fsTA)spectroscopy reveals that appro-priate spacing configuration from the bay aromatic substitution groups enhances the SF yields by promoting the interaction of neighbouring PDI *** exciton yields of up to 183%have been obtained from these new PDI derivatives,making them po-tential candidates in future SF-based optoelectronics.

关键词： Singlet fission Perylenediimide Femtochemistry Thin films Density functional calculations

Crystal phase-controlled growth of PtCu and PtCo alloys on 4H Au nanoribbons for electrocatalytic ethanol oxidation reaction

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Nano Research 2020年第7期13卷 1970-1975页

作者： Jie wang Jian zhang Guigao liu Chongyi ling bo Chen Jingtao Huang Xiaozhi liu Bing li An-liang wang Zhaoning Hu Ming Zhou ye Chen Hongfei cheng Jiawei liu Zhanxi Fan Nailiang Yang Chaoliang Tan lin Gu Jinlan wang Hua zhang Department of Chemistry City University of Hong KongHong KongChina Center for Programmable Materials School of Materials Science and EngineeringNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore School of Physics Southeast UniversityNanjing 211189China Institute of Physics Beijing National Laboratory for Condensed Matter PhysicsChinese Academy of SciencesBeijing 100190China Institute of Materials Research and Engineering(IMRE) Agency for Science Technology and Research(A*STAR)Singapore 138634Singapore Hong Kong Branch of National Precious Metals Material Engineering Research Center(NPMM) City University of Hong KongHong KongChina

Crystal phase can greatly affect the physicochemical properties and applications of ***,it stil remains a great challenge to synthesize nanostructures with the same composition and morphology but different phases in order to explore the phase-dependent properties and ***,we report the crystal phase-controlled synthesis of PtCu alloy shells on 4H Au nanoribbons(NRBs),referred to as 4H-Au NRBs,to form the 4H-Au@PtCu core-shell *** tuning the thickness of PtCu,4H-PtCu and face-centered cubic(cc)phase PICu(cc-PtCu)alloy shells are successtully grown on the 4H-Au NRB *** thickness-dependent phase-controlled growth strategy can also be used to grow PtCo alloys with 4H or fcc phase on 4H-Au ***,when used as electrocatalysts for the ethanol oxidation reaction(EOR)in alkaline media,the 4H-Au@4H-PtCu NRBs show much better EOR performance than the 4H-Au@fcc-PtCu NRBs,and both of them possess superior performance compared to the commercial Pt *** study provides a strategy on phase-contolled synthesis of nanomaterials used for crystal phase-dependent applications.

关键词： crystal phase 4H hexagonal face-ce ntered cubic ethanol oxidation reaction phase engineering of nanomaterials

Stability of QTL Across Environments and QTL-by-Environment Interactions for Plant and Ear Height in Maize

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Agricultural Sciences in China 2010年第10期9卷 1400-1412页

作者： zhang Yan li Yong-xiang wang wang liU Zhi-zhai liU cheng PENG bo TAN Wei-wei wang Di SHI Yun-su SUN Bao-cheng SONG Yan-chun wang Tian-yu li Yu Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China Institute of Food Crops Xinjiang Academy of Agricultural Sciences Urumqi 830000 P.R.China Maize Research Institute Southwest University Chongqing 400716 P.R.China

Better understanding of genotype-by-environment interaction （GEI） is expected to provide a solid foundation for genetic improvement of crop productivity especially under drought-prone environments. To elucidate the genetic basis of the plant and ear height, 2 F2：3 populations were derived from the crosses of Qi 319 × Huangzaosi （Q/H） and ye 478 × Huangzaosi （Y/H） with 230 and 235 families, respectively, and their parents were evaluated under 3 diverse environments in Henan, Beijing, and Xinjiang, China during the year of 2007 and 2008, and all the lines were also evaluated under water stress environment. The mapping results showed that a total of 21 and 12 QTLs were identified for plant height in the Q/H and Y/H population, respectively, and 24 and 13 QTLs for ear height, respectively. About 56 and 73% of the QTLs for 2 traits did not present significant QTL-by-environment interaction （QE1） in the normal joint analyses for Q/H and Y/H population, respectively, and about 73% of the QTLs detected did not show significant QEI according to joint analyses for stress condition in Q/H. Most of the detected major QTLs exhibited high stability across different environments. Besides, several major QTLs were detected with large and consistent effect under normal condition （Chr. 6 and 7 in Q/H; Chr. 1, 3 and 9 in Y/H）, or across 2 water regimes （Chr. 1, 8 and 10 for in Q/H）. There were several constitutive QTLs （3 for Q/H and 1 for Y/H） with no or minor QTL-by-environment for the 2 populations. Finally, we found several genomic regions （Chr. 1, 10, etc.） to be co-located across the populations, which could provide useful reference for genetic improvement of these traits in maize breeding programs. Comparative genomic analysis revealed that 3 genes/genetic segments associated with plant height in rice were orthologous to these 3 identified genomic regions carrying the major QTLs for plant and ear height on Chr. 1, 6, and 8, respectively.

关键词： maize (Zea mays L.) stability QTL QTL-by-environment plant height ear height

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

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Signal Transduction and Targeted Therapy 2023年第1期8卷 6-9页

作者： Hong-Qing zhang Ya-Nan zhang Zhe-Rui zhang Xiao-ling Chen Yan-Yan Hu Yu-Jia Shi Jing wang cheng-lin Deng bo zhang Xiao-Dan li Han-Qing ye Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences Beijing 100049China Hunan Normal University School of MedicineChangsha 410081China

Dear Editor,The prolonged outbreak and spread of coronavirus disease 2019(COVID-19),caused by SARS-CoV-2 poses a great threat to global economic and public *** protective efficacy of the vaccines based on the spike pr... 详细信息

关键词： protective stabilized particle

Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors

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World Journal of Gastroenterology 2014年第25期20卷 8253-8259页

作者： liu-ye Huang Jun Cui cheng-Rong Wu bo zhang li-Xin Jiang Xiang-Shu Xian Shu-Juan lin Ning Xu Xiao-ling Cao Zhi-Hua wang Department of Gastroenterology Yantai Yu Huang Ding Hospital Department of Abdominal Surgery Yantai Yu Huang Ding Hospital

AIM: To assess the effectiveness of endoscopic full-thickness resection (EFR) and laparoscopic surgery in the treatment of gastric stromal tumors arising from the muscularis propria.

关键词： Gastric stromal tumors Treatment Endoscopy Muscularis propria Full-thickness resection

Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months

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Virologica Sinica 2021年第5期36卷 869-878页

作者： Yang Zheng Qing zhang Ashaq Ali Ke li Nan Shao Xiaoli Zhou Zhiqin ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing wang Baidong Hou Min li Mengmeng Cui lihua Deng Xinyi Sun Qian zhang Qinfang Yang Yong li Hui wang Yake Lei bo Yu yegang cheng Xiaolin Tong Dong Men Xian-En zhang National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Guang’an Men Hospital China Academy of Chinese Medical SciencesBeijing 100053China Health Bureau of Wuchang District Wuhan 430070China Hubei University Wuhan 430074China Shenzhen Mindray Bio-Medical Electronics Co. LtdShenzhen 518057China Hubei Provincial Center for Disease Control&Prevention Wuhan 430079China University of Chinese Academy of Sciences Beijing 100049China

Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd *** retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to *** in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CliA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the ***,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th *** titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values *** contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of *** behavior of antibodies and their correlation in age,gender and severity groups were *** general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent *** a few patients with antibody reducing to an undetectable level which needs further *** humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity.

关键词： Coronavirus disease 2019(COVID-19) Humoral Responses Sustainability Convalescent

The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression

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Cancer Communications 2022年第9期42卷 868-886页

作者： ye Yuan li-Hong wang Xian-Xian Zhao Jiao wang Meng-Si zhang Qing-Hua Ma Sen Wei Ze-Xuan Yan Yue cheng Xiao-Qing Chen Hong-bo Zou Jia Ge Yan wang Xia zhang You-Hong Cui Tao Luo Xiu-Wu Bian Institute of Pathology and Southwest Cancer Center Southwest HospitalThird Military Medical University(Army Medical University)and Key Laboratory of Tumor ImmunopathologyMinistry of Education of ChinaChongqing 400038P.R.China Bio-Bank of Southwest Hospital Third Military Medical University(Army Medical University)Chongqing 400038P.R.China Department of Clinical Laboratory Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038P.R.China Department of Oncology the Third Affiliated Hospital of Chongqing Medical UniversityChongqing 401120P.R.China

Background:Elucidation of the post-transcriptional modification has led to novel strategies to treat intractable tumors,especially glioblastoma(GBM).The ubiquitin-proteasome system(UPS)mediates a reversible,stringent and stepwise post-translational modification which is closely associated with malignant processes of *** this end,developing novel therapeutic approaches to target the UPS may contribute to the treatment of this *** study aimed to screen the vital and aberrantly regulated component of the UPS in *** on the molecular identification,functional characterization,and mechanism investigation,we sought to elaborate a novel therapeutic strategy to target this vital factor to combat ***:We combined glioma datasets and human patient samples to screen and identify aberrantly regulated E3 ubiquitin *** database analysis and molecular and functional experiments in vivo and in vitro were used to evaluate the roles of HECT,UBA and WWE domain-containing E3 ubiquitin ligase 1(HUWE1)in ***9 synergistic activation mediator system and recombinant adeno-associated virus(rAAV)were used to endogenously overexpress full-length HUWE1 in vitro and in glioma orthotopic ***:Low expression of HUWE1 was closely associated with worse prognosis of GBM *** ubiquitination and subsequent degradation of N-Myc mediated by HUWE1,leading to the inactivation of downstream Delta-like 1(DLL1)-NOTCH1 signaling pathways,inhibited the proliferation,invasion,and migration of GBM cells in vitro and in vivo.A rAAV dual-vector system for packaging and delivery of dCas9-VP64 was used to augment endogenous HUWE1 expression in vivo and showed an antitumor activity in glioma orthotopic ***:The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress GBM *** activity of rAAV dual-vector delivering dCas9-HUWE1 system uncovers a promising therapeutic strategy for GBM.

关键词： DLL1 E3 ubiquitin ligase glioblastoma HUWE1 N-Myc NOTCH1 recombinant adenoassociated virus ubiquitin-proteasome system

Cancer metabolism and tumor microenvironment:fostering each other?

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Science China(life Sciences) 2022年第2期65卷 236-279页

作者： Yiyuan Yuan Huimin li wang Pu Leilei Chen Dong Guo Hongfei Jiang bo He Siyuan Qin Kui wang Na li Jingwei Feng Jing Wen Shipeng cheng Yaguang zhang Weiwei Yang Dan ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Molecular and Cell Biology Lab Institutes of Biomedical Sciences and School of Life SciencesFudan UniversityShanghai 200032China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China West China School of Basic Medical Sciences&Forensic Medicine Sichuan Universityand State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Centre for Excellence in Cell and Molecular Biology the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China School of Medicine Institutes for Life SciencesSouth China University of TechnologyGuangzhou 510006China Tsinghua University School of life Sciences and Tsinghua-Peking Center for Life SciencesBeijing 100084China

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells *** reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental *** evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling *** cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor *** cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of *** conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer ***,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer *** metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as *** them,cancer microenvironmental cells are immune cells which exert profound effects on cancer *** of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.

关键词： cancer metabolism cancer microenvironment epigenetics cancer immunology