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Hydrogen Bonding in Thermoplastic Polyurethane Elastomers:IR Thermal Analysis

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Chemical Research in Chinese Universities 2002年第1期18卷 84-87页

作者： CHEN Da-jun li yao-jun State Key Laboratory of Fiber Materials Modification Donghua UniversityShanghai 200051P.R.China

The hydrogen bond percentage and its temperature dependence of the three TPU samples synthesized from polytetrahydrofuran, 4,4'-diphenylmethane diisocyanate, N -methyl diethanol amine or 1,4-butane diol were studied by means of IR thermal analysis. The enthalpy and the entropy of the hydrogen bond dissociation were determined by the Van't Hoff plot.

关键词： Thermoplastic polyurethane elastomers IR thermal analysis Hydrogen Bond effect

Regional differences in global glacier retreat from 1980 to 2015

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Advances in Climate Change Research 2019年第4期10卷 203-213页

作者： li yao-jun DING Yong-Jian SHANGGUAN Dong-Hui WANG Rong-jun State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China Key Laboratory of Ecohydrology of Inland River Basin Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Beijing100049China

Global warming triggers shrinking and thinning of glaciers worldwide,with potentially severe implications for human ***,regional differences in glacier retreat and its relationship with climatic characteristics have not been conclusively *** this study,regional changes in global glaciers based on two primary features,area change and mass balance,were investigated on the basis of data collected from published research on glacier *** show that during the period 1980—2015,the rate of global glacier area shrinkage was 0.18%per year and that of global glacier mass loss was 0.25 m *** *** of glaciers located at low and middle latitudes was characterized by severe area shrinkage and mass ***,in the Arctic,deglaciation was characterized by ice thinning due to a low area reduction but relatively high mass loss ***,glaciers in high southern latitudes were in a relatively stable *** Mountain Asia exhibited the lowest rate of area shrinkage and mass loss among glaciers located at low and middle latitudes,and a slower rate of mass loss compared with the global *** in the Tropical Andes exhibited the fastest rate of glacier area shrinkage(—1.6%per year),whereas Antarctic and Subantarctic glaciers showed the lowest rate(—0.11%per year).For mass balance,the most negative occurred at Southern Andes(—0.81 m *** year),followed by Alaska(-0.74 m *** year).Only the Antarctic and Subantarctic experienced small mass gain(0.04 m *** year).High levels of correlation are found between the rates of glacier retreat and annual average temperature and annual total precipitation instead of their *** variability of the surface climate conditions in the glacier environment plays a key role in driving these regional differences in global glacier retreat.

关键词： Glacier retreat Regional differences Climate change

Molecular Mapping of a Gene for Resistance to Stripe Rust in Wheat Variety PIW138

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Agricultural Sciences in China 2010年第9期9卷 1285-1291页

作者： YUE Yan-li yao Zhan-jun REN Xin-xin WANG li College of Agronomy Agricultural University of Hebei Baoding 071001 P.R.China

Stripe rust, caused by Puccinia striiformis f. sp. tritici （Pst）, is one of the most damaging diseases of common wheat （Triticum aestivum L.）. Wheat variety PIW138 introduced from Pakistan is resistant to the currently prevailing Pst race CYR32 in China. In this study, the bulked segregant analysis （BSA） method and simple sequence repeat （SSR） markers were used to map the stripe rust resistance gene in PIW138. The resistant and susceptible DNA bulks were prepared from the segregating F2 population of the cross between Thatcher, a susceptible variety as the female parent, and PIW138 as the male parent. The segregation of resistant and susceptible F2 plants inoculated with CYR32 indicated that single dominant gene determined the reactions of PIW138 line and temporarily designated as YrP138. Total 200 SSR primers were screened, and 4 SSR markers, Xwmc52, Xbarc61, Xgwm268, and Xgwm153, on chromosome 1B were found to be polymorphic between the resistant and the susceptible DNA bulks as well as their parents. Genetic linkage was tested on the segregating F2 population with 259 plants, including 196 resistant and 63 susceptible plants. All 4 SSR markers were linked to the stripe rust resistance gene in PIW138. The genetic distances of Xwmc52, Xbarc61, Xgwm268, and Xgwm153 to the resistance gene were 29.8, 6.2, 6.8, and 8.2 cM, respectively.

关键词： wheat Puccinia striiformis f. sp. tritici resistance gene microsatellite marker

CFD SIMULATION OF 3D FLOW IN LARGE-BORE AXIAL-FLOW PUMP WITH HALF-ELBOW SUCTION SUMP

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Journal of Hydrodynamics 2006年第2期18卷 243-247页

作者： WANG Fu-jun li yao-jun CONG Guo-hui WANG Wen-e WANG Hai-song College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China

Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were perlbrmed by using CFD approach. The numerical model and velocity and pressure distributions in entire flow passage were presented. The obvious backflow in half-elbow suction sump and strong flow nonuniformity at suction sump outlet were observed, whereas these phenomena were not observed in existing studies performed for a separate suction sump by either experimental or numerical approach. This result indicates that the interaction between half-elbow suction sump and impeller has significant effect on the flow distribution in the pump passage. The change of pump efficiency caused by the interaction was discussed,

关键词： axial flow pump half elbow suction sump,CFD

Pseudothrombus deposition accompanied with minimal change nephrotic syndrome and chronic kidney disease in a patient with Waldenstrom’s macroglobulinemia: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2393-2400页

作者： Mercy Julian Mwamunyi Hong-Yan Zhu Chun Zhang Ya-Pei Yuan li-jun yao Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

BACKGROUND Waldenstr?m’s macroglobulinemia(WM) is a rare lymphoid neoplasia, which can have renal complications. These rarely occur, and most common renal manifestations are mild proteinuria and microscopic hematuria. Herein we describe a case of WM that presented with pseudothrombi depositing in capillaries associated with minimal change nephrotic syndrome and chronic kidney disease(CKD).CASE SUMMARY A 52-year-old man presented with features suggesting nephrotic *** workups were done, and there were elevated serum levels of interleukin-6 and vascular endothelial growth factor(VEGF), capillary pseudothrombus accumulation associated with minimal change nephrotic syndrome, CKD, and WM. Treatment was directed at the patient’s WM with bortezomib, thalidomide, and dexamethasone whereby serum immunoglobulin M(IgM) decreased. The damage of IgM on the kidney was corrected; thus, the patient’s proteinuria and serum creatinine had improved. The patient is still under clinical *** It is essential for clinicians to promptly pay more attention to patients presenting with features of nephrotic syndrome and do extensive workups to come up with a proper therapy strategy.

关键词： Waldenstrom’s macroglobulinemia Pseudothrombi Nephrotic syndrome Chronic kidney disease Case report

TOPK Activation Exerts Protective Effects on Cisplatin-induced Acute Kidney Injury

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Current Medical Science 2022年第4期42卷 742-753页

作者： Hui ZHANG Qing-qing DONG Hua-pan SHU Yu-chi TU Qian-qian liAO li-jun yao Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:T-LAK-cell-originated protein kinase(TOPK),a PSD95-Disc large-ZO1(PDZ)binding kinase(PBK),is a novel member of the mitogen-activated protein kinase(MAPK)*** have shown that TOPK plays a critical role in the function of tumor cells,including apoptosis and ***,little is known on the effect of TOPK in cisplatin-induced acute kidney injury(CP-AKI).This study aimed to investigate the role and mechanism of TOPK in ***:Cisplatin was administered to C57BL/6 mice and cultured kidney tubular epithelial cells(TECs)to establish the CP-AKI murine or cellular *** were then stimulated with the specific inhibitor of TOPK OTS514 or transfected with the recombinant-activated plasmid TOPK-T9E to inhibit or activate *** TECs were treated with AKT inhibitorⅧfollowing stimulation with OTS514 or *** blotting and flow cytometry were used to evaluate the cell cycle and apoptosis of ***:The analysis revealed that the TOPK activity was significantly suppressed by cisplatin,both in vivo and in ***,the pharmacological inhibition of TOPK by OTS514,a specific inhibitor of TOPK,exacerbated the cisplatin-induced cell cycle arrest in the G2/M phase and apoptosis of cultured ***,the TOPK activation via the TOPK-T9E plasmid transfection could partially reverse the cell cycle arrest at the G2/M phase and apoptosis of cisplatin-treated *** addition,AKT/protein kinase B(PKB),as a TOPK target protein,was inhibited by cisplatin in cultured *** pharmaceutical inhibition of AKT further aggravated the apoptosis of TECs induced by cisplatin or TOPK *** systematically mediated the apoptosis via the AKT pathway in the CP-AKI cell ***:These results indicate that TOPK activation protects against CP-AKI by ameliorating the G2/M cell cycle arrest and cell apoptosis.

关键词： acute kidney injury cisplatin cell cycle apoptosis T-LAK-cell-originated protein kinase/PSD95-Disc large-ZO1 binding kinase

热塑性聚氨酯弹性体中的氢键作用──动态力学分析

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高等学校化学学报 2001年第5期22卷 844-846页

作者：陈大俊李瑶君中国纺织大学纤维材料改性国家重点实验室上海200051

采用动态力学分析方法研究了一系列由聚四氢呋喃 (Mn=2 0 0 0 )、 4 ,4 -二苯基甲烷二异氰酸酯以及N-甲基二乙醇胺、 1 ,4 -丁二醇和 1 ,2 -丙二胺三种不同的扩链剂合成的 TPU中的氢键作用 .发现这种氢键作用符合 Arrhenius型的温度依... 详细信息

采用动态力学分析方法研究了一系列由聚四氢呋喃 (Mn=2 0 0 0 )、 4 ,4 -二苯基甲烷二异氰酸酯以及N-甲基二乙醇胺、 1 ,4 -丁二醇和 1 ,2 -丙二胺三种不同的扩链剂合成的 TPU中的氢键作用 .发现这种氢键作用符合 Arrhenius型的温度依赖性 .从弹性模量

关键词：热塑性聚氨酯弹性体氢键作用物理交联温度依赖性动态力学分析

cDNA cloning, prokaryotic expression and purification of rat α-synuclein

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Neuroscience Bulletin 2006年第1期22卷 29-33页

作者： Xin li yao-Hua li jun-Yan HAN Shun YU Biao CHEN Department of Neurobiology Beijing Institute of Geriatrics Xuanwu Hospital of Capital University of Medical Sciences Beijing 100053

Objective To clone the cDNA of rat α-Syn gene, investigate its prokaryotic expression and produce purified recombinant rat α-Syn protein. Methods Rat α-Syn cDNA was amplified from the rat brain total RNA by RT-PCR and was cloned into pGEX-4T-1, a prokaryotic expressing vector. The recombinant plasmid containing rat α-Syn gene was transformed into E. Coli BL21 to express a fusion protein with rat α-Syn protein tagged by glutathione-S-transferase （GST）. The fusion protein was then cleaved by thrombin during passing through the GST-agarose 4B column to release the recombinant rat α-Syn protein. The recombinant rat a-Syn protein was further purified using Superdex S200 gel filtration. Results DNA sequencing confirmed that the cloned cDNA contained 420 base pairs encoding 140 amino acids, which was identical to the reported amino acid sequence of rat α-Syn. After transformation, the recombinant plasmid pGEX-ra-Syn expressed a soluble protein that was inducible by IPTG. The purified recombinant protein was shown to be single band on SDS-PAGE, with a molecular size of around 18000, which was identical to the reported molecular size of rat α-Syn. Western blot analysis demonstrated that the recombinant protein was recognized by specific antibody against α-Syn. Conclusion The rat α-Syn gene was successfully expressed in prokaryotic expression system and highly purified rat α-Syn recombinant protein was produced.

关键词： α-synuclein rat recombinant protein purification

Short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune function

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World Journal of Clinical Cases 2024年第18期12卷 3395-3402页

作者： li-jun yao Xiao-Ding Zhu liu-Min Zhou li-li Zhang Na-Na liu Min Chen Jia-Ying Wang Shao-jun Hu Department of Oncology Suzhou Ninth People's HospitalSuzhou 215200Jiangsu ProvinceChina Department of Rehabilitation Suzhou Xiangcheng District Rehabilitation HospitalSuzhou 215132Jiangsu ProvinceChina

BACKGROUND Hepatectomy is the first choice for treating liver ***,inflammatory factors,released in response to pain stimulation,may suppress perioperative immune function and affect the prognosis of patients undergoing *** To determine the short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune *** Clinical data from patients with liver cancer admitted to Suzhou Ninth People’s Hospital from January 2020 to December 2023 were retrospectively ***-five patients underwent laparoscopic hepatectomy for liver cancer(liver cancer resection group)and 35 patients underwent medical image-guided microwave ablation(liver cancer ablation group).The short-term efficacy,complications,liver function,and immune function indices before and after treatment were compared between the two *** One month after treatment,19 patients experienced complete remission(CR),8 patients experienced partial remission(PR),6 patients experienced stable disease(SD),and 2 patients experienced disease progression(PD)in the liver cancer resection *** the liver cancer ablation group,21 patients experienced CR,9 patients experienced PR,3 patients experienced SD,and 2 patients experienced *** significant differences in efficacy and complications were detected between the liver cancer ablation and liver cancer resection groups(P>0.05).After treatment,total bilirubin(41.24±7.35 vs 49.18±8.64μmol/L,Pliver cancer ablation and liver cancer resection *** The short-term efficacy and safety of microwave ablation and laparoscopic surgery for the treatment of liver cancer are similar,but liver function recovers quickly after microwave ablation,and microwave ablation

关键词： Microwave ablation liver cancer Short-term efficacy liver function Immunologic function