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Short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune function

World Journal of Clinical Cases 2024年第18期12卷 3395-3402页

作者： li-jun yao Xiao-Ding Zhu liu-Min Zhou li-li Zhang Na-Na liu Min Chen Jia-Ying Wang Shao-jun Hu Department of Oncology Suzhou Ninth People's HospitalSuzhou 215200Jiangsu ProvinceChina Department of Rehabilitation Suzhou Xiangcheng District Rehabilitation HospitalSuzhou 215132Jiangsu ProvinceChina

BACKGROUND Hepatectomy is the first choice for treating liver ***,inflammatory factors,released in response to pain stimulation,may suppress perioperative immune function and affect the prognosis of patients undergoing *** To determine the short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune *** Clinical data from patients with liver cancer admitted to Suzhou Ninth People’s Hospital from January 2020 to December 2023 were retrospectively ***-five patients underwent laparoscopic hepatectomy for liver cancer(liver cancer resection group)and 35 patients underwent medical image-guided microwave ablation(liver cancer ablation group).The short-term efficacy,complications,liver function,and immune function indices before and after treatment were compared between the two *** One month after treatment,19 patients experienced complete remission(CR),8 patients experienced partial remission(PR),6 patients experienced stable disease(SD),and 2 patients experienced disease progression(PD)in the liver cancer resection *** the liver cancer ablation group,21 patients experienced CR,9 patients experienced PR,3 patients experienced SD,and 2 patients experienced *** significant differences in efficacy and complications were detected between the liver cancer ablation and liver cancer resection groups(P>0.05).After treatment,total bilirubin(41.24±7.35 vs 49.18±8.64μmol/L,Pliver cancer ablation and liver cancer resection *** The short-term efficacy and safety of microwave ablation and laparoscopic surgery for the treatment of liver cancer are similar,but liver function recovers quickly after microwave ablation,and microwave ablation

关键词： Microwave ablation liver cancer Short-term efficacy liver function Immunologic function

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NUMERICAL INVESTIGATION OF PERFORMANCE OF AN AXIAL-FLOW PUMP WITH INDUCER

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Journal of Hydrodynamics 2007年第6期19卷 705-711页

作者： li yao-jun WANG Fu-jun College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China

The interaction of flow through the inducer and impeller of an axial-flow pump equipped with an inducer has significant effect on its performance. This article presents a recent numerical investigation on this topic. The studied pump has an inducer with 3 blades mounted on a conical hub and a 6-blade impeller. The blade angle of the impeller is adjustable to generate different relative circumferential angles between the inducer blade trailing edge and the impeller blade leading edge. A computational fluid dynamics code was used to investigate the flow characteristics and performance of the axial-flow pump. For turbulence closure, the RNG k-ε model was applied with an unstructured grid system. The rotor-stator interaction was treated with a Multiple Reference Frame （MRF） strategy. Computations were performed in different cases： 7 different relative circumferential angles （ Δθ ） between the inducer blade trailing edge and the impeller blade leading edge, and 3 different axial gaps （G） between the inducer and the impeller. The variation of the hydraulic loss in the rotator was obtained by changing Δθ . The numerical results show that the pressure generated is minimum in the case of （ G = 3%D）, which indicates that the interference between inducer and impeller is strong if the axial gap is small. The pump performances were predicted and compared to the experimental measurements. Recommendations for future modifications and improvements to the pump design were also given.

关键词： axial-flow pump inducer CFD numerical simulation of flow

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Hydrogen Bonding in Thermoplastic Polyurethane Elastomers:IR Thermal Analysis

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Chemical Research in Chinese Universities 2002年第1期18卷 84-87页

作者： CHEN Da-jun li yao-jun State Key Laboratory of Fiber Materials Modification Donghua UniversityShanghai 200051P.R.China

The hydrogen bond percentage and its temperature dependence of the three TPU samples synthesized from polytetrahydrofuran, 4,4'-diphenylmethane diisocyanate, N -methyl diethanol amine or 1,4-butane diol were studied by means of IR thermal analysis. The enthalpy and the entropy of the hydrogen bond dissociation were determined by the Van't Hoff plot.

关键词： Thermoplastic polyurethane elastomers IR thermal analysis Hydrogen Bond effect

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万古霉素对新生儿细菌性感染疾病的疗效及不良反应相关指标的评价

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中国药物应用与监测 2024年第2期21卷 168-171页

作者：李俊瑶李琴刘定远黎亮遂宁市中心医院儿科遂宁629000

目的探索万古霉素对不同孕周新生儿细菌性感染的疗效和肾功能、听力损伤情况。方法回顾性收集2020年1月—2023年12月遂宁市中心医院新生儿科使用万古霉素新生儿41例,根据胎龄分为早产儿组(胎龄28~36周,n=23)和足月儿组(胎龄37~42周,n=1... 详细信息

目的探索万古霉素对不同孕周新生儿细菌性感染的疗效和肾功能、听力损伤情况。方法回顾性收集2020年1月—2023年12月遂宁市中心医院新生儿科使用万古霉素新生儿41例,根据胎龄分为早产儿组(胎龄28~36周,n=23)和足月儿组(胎龄37~42周,n=18),比较2组有效率,治疗前后肾功能和听力损害情况。结果2组新生儿病原学检查送检率100.0%,早产儿组有效率(86.96%)与足月儿组有效率(94.99%)比较差异无统计学意义(P>0.05);2组万古霉素谷浓度[分别为(12.30±6.30)μg·mL^(-1)和(9.88±5.87)μg·mL^(-1)]比较差异无统计学意义(P>0.05);用药后两组血肌酐(Scr)和血尿素氮(BUN)均升高,早产儿组血Scr浓度[(43.02±18.98)μmol·L^(-1)]高于足月儿组[(32.45±10.64)μmol·L^(-1)],差异有统计学意义(P<0.05);早产儿组听力损害发生率(13.04%)与足月儿组(16.67%)差异无统计学意义,随访期其余新生儿听力无异常。结论万古霉素治疗早产儿和足月儿的有效率差异无统计学意义,对早产儿Scr影响更大,建议早产儿密切监测肾功能指标。

关键词：万古霉素新生儿早产儿肾功能听性脑干反应

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高校推进全学段全链条心理育人责任体系建设的研究与实践

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湖北工业职业技术学院学报 2024年第4期37卷 28-31页

作者：徐瑛李俊瑶张鑫湖北工业职业技术学院心理健康教育中心

近年来，儿童青少年有心理问题、患精神疾病的占比不断攀升，越来越呈低龄化趋势，他们大多带“病”进入高校或步入社会，成为高校或基层单位“输入型”的高风险群体。为形成助人自助、“治未病”的良好社会风气，高校应充分发挥专业优... 详细信息

近年来，儿童青少年有心理问题、患精神疾病的占比不断攀升，越来越呈低龄化趋势，他们大多带“病”进入高校或步入社会，成为高校或基层单位“输入型”的高风险群体。为形成助人自助、“治未病”的良好社会风气，高校应充分发挥专业优势、条件优势、经验优势和教科研成果转化优势，不断推动大中小学“全学段”心理育人工作的纵向衔接，大力助推家庭、社会、医疗与学校的横向贯穿，以打通学校教育发展全脉络，构建纵横交错的全员、全方位、全过程、全覆盖的“全链条”心理育人工作大格局。

关键词：全学段全链条心理育人责任体系

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Regional differences in global glacier retreat from 1980 to 2015

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Advances in Climate Change Research 2019年第4期10卷 203-213页

作者： li yao-jun DING Yong-Jian SHANGGUAN Dong-Hui WANG Rong-jun State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China Key Laboratory of Ecohydrology of Inland River Basin Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Beijing100049China

Global warming triggers shrinking and thinning of glaciers worldwide,with potentially severe implications for human ***,regional differences in glacier retreat and its relationship with climatic characteristics have not been conclusively *** this study,regional changes in global glaciers based on two primary features,area change and mass balance,were investigated on the basis of data collected from published research on glacier *** show that during the period 1980—2015,the rate of global glacier area shrinkage was 0.18%per year and that of global glacier mass loss was 0.25 m *** *** of glaciers located at low and middle latitudes was characterized by severe area shrinkage and mass ***,in the Arctic,deglaciation was characterized by ice thinning due to a low area reduction but relatively high mass loss ***,glaciers in high southern latitudes were in a relatively stable *** Mountain Asia exhibited the lowest rate of area shrinkage and mass loss among glaciers located at low and middle latitudes,and a slower rate of mass loss compared with the global *** in the Tropical Andes exhibited the fastest rate of glacier area shrinkage(—1.6%per year),whereas Antarctic and Subantarctic glaciers showed the lowest rate(—0.11%per year).For mass balance,the most negative occurred at Southern Andes(—0.81 m *** year),followed by Alaska(-0.74 m *** year).Only the Antarctic and Subantarctic experienced small mass gain(0.04 m *** year).High levels of correlation are found between the rates of glacier retreat and annual average temperature and annual total precipitation instead of their *** variability of the surface climate conditions in the glacier environment plays a key role in driving these regional differences in global glacier retreat.

关键词： Glacier retreat Regional differences Climate change

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Molecular Mapping of a Gene for Resistance to Stripe Rust in Wheat Variety PIW138

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Agricultural Sciences in China 2010年第9期9卷 1285-1291页

作者： YUE Yan-li yao Zhan-jun REN Xin-xin WANG li College of Agronomy Agricultural University of Hebei Baoding 071001 P.R.China

Stripe rust, caused by Puccinia striiformis f. sp. tritici （Pst）, is one of the most damaging diseases of common wheat （Triticum aestivum L.）. Wheat variety PIW138 introduced from Pakistan is resistant to the currently prevailing Pst race CYR32 in China. In this study, the bulked segregant analysis （BSA） method and simple sequence repeat （SSR） markers were used to map the stripe rust resistance gene in PIW138. The resistant and susceptible DNA bulks were prepared from the segregating F2 population of the cross between Thatcher, a susceptible variety as the female parent, and PIW138 as the male parent. The segregation of resistant and susceptible F2 plants inoculated with CYR32 indicated that single dominant gene determined the reactions of PIW138 line and temporarily designated as YrP138. Total 200 SSR primers were screened, and 4 SSR markers, Xwmc52, Xbarc61, Xgwm268, and Xgwm153, on chromosome 1B were found to be polymorphic between the resistant and the susceptible DNA bulks as well as their parents. Genetic linkage was tested on the segregating F2 population with 259 plants, including 196 resistant and 63 susceptible plants. All 4 SSR markers were linked to the stripe rust resistance gene in PIW138. The genetic distances of Xwmc52, Xbarc61, Xgwm268, and Xgwm153 to the resistance gene were 29.8, 6.2, 6.8, and 8.2 cM, respectively.

关键词： wheat Puccinia striiformis f. sp. tritici resistance gene microsatellite marker

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生物有机肥施加对荒漠草原植被-土壤-微生物的影响

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草业学报 2024年第3期33卷 34-45页

作者：李俊瑶蒋星驰胡晋瑜魏栋光赵学勇王少昆中国科学院西北生态环境资源研究院甘肃兰州730000 中国科学院大学资源与环境学院北京101408 中国科学院大学生命科学学院北京101408 国营榆林市横山区二石磕林场陕西榆林719109 巴彦淖尔市林业和草原资源保护中心内蒙古巴彦淖尔015015

添加高效纤维素分解菌于农牧业有机冗余物中,通过有氧发酵制备出具有一定保水性、透气性和肥力的生物有机肥(MOF)。在乌拉特荒漠草原试验区进行MOF施加相关试验,施加量为1 kg·m^(-2)。结果表明,MOF的施加可以通过促进植被生长、改良土... 详细信息

添加高效纤维素分解菌于农牧业有机冗余物中,通过有氧发酵制备出具有一定保水性、透气性和肥力的生物有机肥(MOF)。在乌拉特荒漠草原试验区进行MOF施加相关试验,施加量为1 kg·m^(-2)。结果表明,MOF的施加可以通过促进植被生长、改良土壤理化性质以及增加微生物数量等方式对退化荒漠草原植被-土壤-微生物系统起到快速恢复作用。其中,植被盖度增加了33%;土壤黏粉粒含量增加了2%,土壤全碳含量增加了9%,土壤全氮含量增加了0.9%;土壤细菌中11个门类数量变化差异显著,土壤真菌中1个门类数量变化差异显著;植被盖度增加的92%可由MOF的施加和土壤含水率共同解释,物种丰富度增加的84%可由MOF施加、土壤含水率和土壤电导率共同解释。试验结果为施加生物有机肥在干旱区荒漠草原产生的恢复作用提供了理论依据、数据支持以及技术支撑。

关键词：生物有机肥荒漠草原植被特征土壤微生物

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CFD SIMULATION OF 3D FLOW IN LARGE-BORE AXIAL-FLOW PUMP WITH HALF-ELBOW SUCTION SUMP

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Journal of Hydrodynamics 2006年第2期18卷 243-247页

作者： WANG Fu-jun li yao-jun CONG Guo-hui WANG Wen-e WANG Hai-song College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China

Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were perlbrmed by using CFD approach. The numerical model and velocity and pressure distributions in entire flow passage were presented. The obvious backflow in half-elbow suction sump and strong flow nonuniformity at suction sump outlet were observed, whereas these phenomena were not observed in existing studies performed for a separate suction sump by either experimental or numerical approach. This result indicates that the interaction between half-elbow suction sump and impeller has significant effect on the flow distribution in the pump passage. The change of pump efficiency caused by the interaction was discussed,

关键词： axial flow pump half elbow suction sump,CFD

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2型糖尿病伴泌汗神经功能紊乱患者胰岛素分泌和血清25(OH)D3、NLR、SUA水平及临床意义分析

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河北医科大学学报 2024年第5期45卷 580-584页

作者：席巍姚丽君汪琳姣江苏省海安市人民医院内分泌科江苏海安2266000

目的探讨2型糖尿病伴泌汗神经功能紊乱患者胰岛素分泌和血清25羟维生素D3[25 hydroxyvitamin D3,25(OH)D3]、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血尿酸(serum uric acid,SUA)水平变化及临床意义。方法选... 详细信息

目的探讨2型糖尿病伴泌汗神经功能紊乱患者胰岛素分泌和血清25羟维生素D3[25 hydroxyvitamin D3,25(OH)D3]、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、血尿酸(serum uric acid,SUA)水平变化及临床意义。方法选取在我院治疗的2型糖尿病伴泌汗神经功能紊乱患者97例作为观察组,以性别配比1∶2选取2型糖尿病不伴泌汗神经功能紊乱患者194例作为对照组,分析比较2组临床资料、胰岛功能及25(OH)D3、NLR和SUA水平差异,通过Logistic回归分析分析2型糖尿病伴泌汗神经功能紊乱的影响因素。结果观察组年龄、糖尿病病程分别为(58.32±9.94)岁和(11.41±2.84)年,明显高于对照组(P<0.05);观察组糖负荷30 min净增C肽与葡萄糖比值(ΔC-P30/ΔG30)、净增胰岛素与葡萄糖比值(ΔI30/ΔG30)、胰岛素曲线下面积(I-AUC/G-AUC)和120 min血糖曲线下面积校正后的C肽(C-P-AUC/G-AUC)分别为(0.22±0.13)、(1.55±0.36)、(0.09±0.03)和(2.87±0.90),明显低于对照组(P<0.05)。观察组血清25(OH)D3为(22.12±6.01)μg/L,明显低于对照组(P<0.05),而NLR和SUA分别为(3.12±0.94)和(365.50±90.48)μmol/L,明显高于对照组(P<0.05)。Logistic回归分析显示:年龄、糖尿病病程、ΔC-P30/ΔG30、25(OH)D3、NLR和SUA是2型糖尿病伴泌汗神经功能紊乱的影响因素(P<0.05)。结论2型糖尿病伴泌汗神经功能紊乱患者胰岛素分泌功能受损,血清25(OH)D3降低,而NLR和SUA水平升高;2型糖尿病伴泌汗神经功能紊乱受早期相胰岛分泌功能以及血清25(OH)D3、NLR、SUA水平的影响,值得进一步研究。

关键词：糖尿病,2型胰岛素分泌泌汗神经功能紊乱

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