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依洛尤单抗联合阿替普酶治疗急性脑梗死的临床研究

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现代药物与临床 2024年第1期39卷 106-110页

作者：常虹李雁翔王琳吴小玉天津市北辰医院神经内科天津300400

目的探讨依洛尤单抗联合阿替普酶治疗大动脉粥样硬化性、Fazekas量表评分为重度的急性脑梗死患者的临床疗效。方法选取2021年1月—2022年11月天津市北辰医院脑神经科收治的112例大动脉粥样硬化性、Fazekas量表评分为重度的急性脑梗死... 详细信息

目的探讨依洛尤单抗联合阿替普酶治疗大动脉粥样硬化性、Fazekas量表评分为重度的急性脑梗死患者的临床疗效。方法选取2021年1月—2022年11月天津市北辰医院脑神经科收治的112例大动脉粥样硬化性、Fazekas量表评分为重度的急性脑梗死患者,按随机数字表法将所有患者分为对照组和治疗组,每组各56例。对照组患者给予注射用阿替普酶,按照0.9 mg/kg计算,最高剂量不超过90 mg,总剂量的10%静脉慢推1 min,其余90%药物静脉点滴1 h。治疗组在对照组的基础上皮下给药依洛尤单抗注射液,140 mg/次,1次/2周。两组治疗2周。观察两组的临床疗效和症状缓解时间,比较两组治疗前后血脂指标和血清细胞因子的变化情况。结果治疗后,治疗组患者总有效率是92.86%,显著高于对照组的80.36%(P<0.05)。治疗后,治疗组偏侧肢体无力、口角歪斜、吞咽异常、偏侧肢体麻木缓解时间均显著短于对照组(P<0.05)。治疗后,两组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)水平均较同组治疗前显著降低,而高密度脂蛋白(HDLC)水平显著升高(P<0.05);治疗后,治疗组血脂水平改善优于对照组(P<0.05)。治疗后,两组神经损伤100β蛋白(S100β)、血清细胞间黏附因子-1(ICAM-1)、神经元特异性烯醇化酶(NSE)、肿瘤坏死因子α(TNF-α)水平均低于同组治疗前(P<0.05);且治疗后,治疗组S100β、ICAM-1、NSE、TNF-α水平低于对照组(P<0.05)。结论依洛尤单抗联合阿替普酶治疗大动脉粥样硬化性、Fazekas量表评分为重度的急性脑梗死具有较好的临床疗效,可加快缓解患者的临床症状,并可有效调节患者血脂水平,降低机体炎症反应,值得借鉴应用。

关键词：依洛尤单抗注射液注射用阿替普酶大动脉粥样硬化性急性脑梗死 Fazekas量表总胆固醇三酯甘油低密度脂蛋白细胞间黏附因子神经元特异性烯醇化酶

Effect of orifice geometry on bubble formation in melt gas injection to prepare aluminum foams

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Science China(Technological Sciences) 2015年第1期58卷 64-74页

作者： YUAN JianYu li yanxiang School of Materials Science and Engineering Tsinghua University Key Laboratory for Advanced Materials Processing Technology Ministry of Education

The bubble formation process at submerged orifices with different geometry is investigated in the preparation of aluminum foams by gas injection *** bubble profile on a horizontal plate is calculated by quasi-static analysis through Laplace *** bubble formation process is then distinguished into three stages:nucleation stage,growth stage and detachment stage in wetting and less wetting conditions based on the force balance *** addition,the bubble size at high Reynolds number is obtained by considering the contribution of buoyancy,pressure force,inertial force,drag force and surface tension based on the three stages of bubble *** bubble size is confirmed to be sensitive to the equivalent contact angle,which consists of two terms including the contact angle and the wedge ***,the wedge angle is introduced in the design of gas outlet orifices for the purpose of decreasing bubble size *** experimental study is conducted at three different types of stainless steel orifices under constant gas flow rates(0.05–2 L/min).It is clarified that the orifice geometry and the orifice size are both responsible for the cell size of aluminum *** experimental results for three different types of orifices show a consistent trend with the theoretical predictions at various gas flow *** the design of orifices to generate small bubbles in the melt,the wedge angle that coordinates with the contact angle is thus suggested.

关键词： wedge angle contact angle bubble formation aluminum foams

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三聚氰胺基疏水海绵的制备及其吸油性能

石油学报（石油加工） 2024年第2期40卷 534-545页

作者：张静静李艳香李望良王文辰闻明科沈阳化工大学化学工程学院辽宁沈阳110142 中国科学院过程工程研究所北京100190 中国科学院大学北京100049 中海石油中捷石化有限公司河北沧州061101

采用单宁酸(TA)/Fe^(3+)复合物(TA/Fe^(3+))对三聚氰胺海绵(MS)进行预处理,然后通过生物蜡乳液浸渍法对三聚氰胺海绵进行疏水改性,制备了高吸油倍率的疏水三聚氰胺海绵(MS-TA/Fe^(3+)-Wax)。采用扫描电子显微镜、傅里叶变换红外光谱和... 详细信息

采用单宁酸(TA)/Fe^(3+)复合物(TA/Fe^(3+))对三聚氰胺海绵(MS)进行预处理,然后通过生物蜡乳液浸渍法对三聚氰胺海绵进行疏水改性,制备了高吸油倍率的疏水三聚氰胺海绵(MS-TA/Fe^(3+)-Wax)。采用扫描电子显微镜、傅里叶变换红外光谱和接触角测试等手段对三聚氰胺海绵改性前后样品进行微观形貌、结构组成和表面润湿性表征,并考察其对不同油品的吸油性能。结果表明:MS-TA/Fe^(3+)-Wax具有高度疏水性,水接触角可达141.5°;在常温常压条件下,MS-TA/Fe^(3+)-Wax对正辛烷、二氯甲烷、甲苯、柴油、泵油和菜籽油的吸油量为54.91~97.46 g/g,吸油过程符合拟二级动力学。疏水改性的三聚氰胺海绵材料通过挤压解吸附可实现循环使用,在处理油-水污染物方面具有潜在的应用前景。

关键词：三聚氰胺海绵疏水改性生物蜡油-水混合物吸附吸油性能水接触角

Microstructure and mechanical properties of a new type of austempered boron alloyed high silicon cast steel

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China Foundry 2013年第3期10卷 155-161页

作者： Chen Xiang li yanxiang School of Materials Science and Engineering Tsinghua University Key Laboratory for Advanced Materials Processing Technology Ministry of Education

In the present paper, a new type of austempered boron alloyed high silicon cast steel has been developed, and its microstructures and mechanical properties at different temperatures were investigated. The experimental results indicate that the boron alloyed high silicon cast steel comprises a dendritic matrix and interdendritic eutectic borides in as-cast condition. The dendritic matrix is made up of pearlite, ferrite, and the interdendritic eutectic boride is with a chemical formula of M2B （M represents Fe, Cr, Mn or Mo） which is much like that of carbide in high chromium white cast iron. Pure ausferrite structure that consists of bainitic ferrite and retained austenite can be obtained in the matrix by austempering treatment to the cast steel. No carbides precipitate in the ausferrite structure and the morphology of borides remains almost unchanged after austempering treatments. Secondary boride particles precipitate during the course of austenitizing. The hardness and tensile strength of the austempered cast steel decrease with the increase of the austempering temperature, from 250℃ to 400 ℃. The impact toughness is 4-11 ***^-2 at room temperature and the impact fracture fractogragh indicates that the fracture is caused by the brittle fracture of the borides.

关键词： boron alloyed high silicon cast steel austempering treatment ausferrite structure boride

Pattern Recognition of Thermal Analysis Cooling Curves and Quality Evaluation of Melt Cast Alloys

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Journal of Materials Science & Technology 2001年第1期17卷 73-74页

作者： yanxiang li Xiao HU Xuerong XU Dept.of Mechanical Eng. Tsinghua UniversityBeijing 100084China

The development of thermal analysis techniques for evaluation of cast alloy melt quality and its current applications in the foundry were reviewed. The characteristics of the current thermal analysis techniques were analyzed. A new comprehensive method for cooling curve recognition has been proposed. The evaluation of cast alloy melt quality was realized.

关键词： Quality Evaluation Cooling Curves thermal analysis cooling curve recognition comprehensive method alloy melt

Effects of strontium and boron interactions in Al-7Si alloys

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China Foundry 2010年第4期7卷 325-330页

作者： Chen Xiang li yanxiang Key Laboratory for Advanced Materials Processing Technology Ministry of Education Department of Mechanical EngineeringTsinghua University Beijing 100084 China

Effects of boron and strontium combined treatment on the microstructure of hypoeutectic Al-7Si alloy have been studied. Experimental results show that strontium has no significant effect on the grain refinement efficiency of boron and the eutectic silicon modification efficiency is not only related to the strontium content but also related to the boron content in the Al-7Si alloy melt. There is a negative interaction between boron and strontium that results in the formation of a strontium-boron-aluminum containing compound, which reduces the effective strontium level and decreases the eutectic silicon modifciation efficiency substantially. The refinement and modification mechanisms remain unchanged after the combined addition of strontium and boron. Based on the experimental results, a model for assessing the modifciation level in the Al-Si alloy melts after combined addition of boron and strontium was presented.

关键词： Al-Si alloy strontium boron modification interaction

Coalescence separation of oil water emulsion on amphiphobic fluorocarbon polymer and silica nanoparticles coated fiber-bed coalescer

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Chinese Journal of Chemical Engineering 2021年第8期34卷 29-37页

作者： Qian Zhang Lei li lixia Cao yanxiang li Wangliang li CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Discharging untreated oily wastewater into the environment disrupts the ecological balance,which is a global problem that requires urgent *** and superoleophilic fibrous medium(FM)effectively separated oil–water emulsion as it was hydrophobic *** its separation efficiencies(SEs)first increased to 98.9%,then dropped to 97.6%in 10 min because of *** tackle this problem,FM deposited with 0%–10%silica nanoparticle(NPsFMs),then coated by fluorocarbon polymer(X-[CH_(2)CH_(2)O]nCH_(2)CH_(2)O-Y-NH-COOCH_(2)C4F9)(FCNPs FMs),was used to enhance its roughness and regulate its initial wettability to improve the anti-fouling *** and FCNPs FMs were hydrophobic and oleophobic in air and oleophobic *** water contact angles,oil contact angles and oil contact angles were 115.3°–121.1°,128.8°–136.5°,and 131.6°–136.7°,respectively,meeting the requirement of 90°–140°for coalescence *** FM-5 had the best separation performance with a constant value of 99.8%in 10 min,while that of FCNPs FM-10 slightly decreased to 99.5%.Theoretical released droplet(TRD)diameter,calculated by the square root of the product of pore radius and fiber diameter,was used for the evaluation of coalescence *** by two ideal models,TRD diameter and fiber diameter showed a parabola type relationship,proving that the separation efficiency was a collaborative work of wettability,pore size and fiber ***,it explained the SEs reduction from FCNPs FM-5 to FCNPs FM-10 was revelent to the three ***,FCNPsFMs effectively separated emulsions stabilized by cationic surfactant CTAB(SEs:97.3%–98.4%)and anionic surfactant SDBS(SEs:91.3%–93.4%).But they had an adverse effect on nonionic surfactant Tween-80 emulsion separation(SEs:94.0%–71.76%).Emulsions made by diverse oils can be effectively separated:octane(SEs:99.4%–100%),rapeseed oil(SEs:97.3%–98.8%),and diesel(SEs:95.2%–97.0%).These findings provide new in

关键词： Oil–water separation Fluorocarbon polymer Amphiphobic Coalescence

急性缺血性脑卒中病人静脉溶栓后出血转化与脑白质高信号的相关性

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中国微侵袭神经外科杂志 2024年第3期28卷 144-147页

作者：常虹李雁翔王琳天津市北辰医院脑系科天津300400

目的探究急性缺血性脑卒中(acute ischemic stroke,AIS)病人静脉溶栓治疗后出血转化与脑白质高信号(white matter hyperintensity,WMH)的相关性。方法回顾性分析137例AIS病例资料,均进行静脉溶栓治疗,根据是否发生出血转化分为出血组(53... 详细信息

目的探究急性缺血性脑卒中(acute ischemic stroke,AIS)病人静脉溶栓治疗后出血转化与脑白质高信号(white matter hyperintensity,WMH)的相关性。方法回顾性分析137例AIS病例资料,均进行静脉溶栓治疗,根据是否发生出血转化分为出血组(53例)和未出血组(84例)。采用单因素与Logistic回归分析AIS病人治疗后出血转化的危险因素。结果两组病人年龄、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、高血压、发病到治疗时间、WMH程度比较,差异有统计学意义(P<0.05)。Logistic回归分析显示中重度WMH(OR=2.796,95%CI:1.450-5.391)是AIS病人治疗后出血转化的危险因素(P<0.05)。结论WMH是影响AIS病人溶栓治疗后出血转化的危险因素,中重度WMH病人发生出血转化的风险更高。

关键词：脑卒中,缺血性,急性静脉溶栓治疗出血转化脑白质高信号

基于Arcgis可视化的我国医药制造业科技成果转化绩效研究

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广东药科大学学报 2024年第1期40卷 67-72页

作者：孟光兴李艳香广东药科大学医药商学院/国家药品监督管理局药物警戒技术研究与评价重点实验室广东中山528400

目的分析评价我国医药制造业科技成果转化绩效,为促进科技成果产业化提供参考。方法构建数据包络分析(data envelopment analysis,DEA)模型对我国医药制造业科技成果转化绩效进行测度,结合Arcgis作可视化处理分析。结果中部地区综合技... 详细信息

目的分析评价我国医药制造业科技成果转化绩效,为促进科技成果产业化提供参考。方法构建数据包络分析(data envelopment analysis,DEA)模型对我国医药制造业科技成果转化绩效进行测度,结合Arcgis作可视化处理分析。结果中部地区综合技术效率高于东、西部地区;中、西部地区规模效率明显高于东部地区,规模效率偏低是医药制造业科技成果转化绩效低的一个主要原因;西部地区部分投入产出要素的冗余值远高于东、中部地区;R&D经费内部支出、技术改造经费支出等要素的冗余主要集中于云贵川渝及湖南湖北一带,其余要素冗余表现为零星分散。结论建议加强地区交流合作,缩小地区差异;提高资源配置的合理性和有效性;结合地区优势,利用现有资源推动医药制造业科技成果转化;充分利用政策优势,健全医药科技成果转化机制。

关键词：科技成果转化可视化分析医药制造业数据包络分析

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