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Journal of Systems Science & Complexity 2009年第1期22卷 49-62页

作者： Pingke li Edward P.Fitts department of Industrial and Systems Engineering,North Carolina State university,Raleigh,NC 27695-7906,US Shu-Cherng FANG Edward P.Fitts department of Industrial and Systems Engineering,North Carolina State university,Raleigh,NC 27695-7906,USA department of Mathematical Sciences,tsinghua university,beijing 100084,china College of Management,Dalian university of Technology,Dalian 116024,china. Edward P. Fitts department of Industrial and Systems Engineering North Carolina State University Raleigh USA department of Mathematical Sciences Tsinghua University Beijing China College of Management Dalian University of Technology Dalian China

This paper shows that the problem of minimizing a linear fractional function subject to asystem of sup-T equations with a continuous Archimedean triangular norm T can be reduced to a 0-1linear fractional optimization problem in polynomial ***,parametrization techniques,e.g.,Dinkelbach's algorithm,can be applied by solving a classical set covering problem in each *** reduction can also be performed on the sup-T equation constrained optimization problems withan objective function being monotone in each variable *** method could be extended aswell to the case in which the triangular norm is non-Archimedean.

关键词： Fractional optimization fuzzy relational equations triangular norms.

Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2194-2209页

作者： Zhilin li Qianfeng Zhang Zhiqian li long Ren Dayi Pan Qiyong Gong Zhongwei Gu Hao Cai Kui Luo department of Radiology Huaxi MR Research Center(HMRRC)Clinical Research Center for BreastDepartment of Breast SurgeryDepartment of Thoracic Surgery and Institute of Thoracic OncologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China Hospital Sichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Key Laboratory of Research and Development for Natural ProductsSchool of PharmacyYunnan UniversityKunming 650500China

Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their *** address this issue,we constructed a cell membrane-coated nanosystem(mB4S)to reverse an immunosuppressive microenvironment to an immuno-supportive one for strengthening the anti-tumor *** this system,Epirubicin(EPI)as an immunogenic cell death(ICD)inducer was coupled to a branched glycopolymer via hydrazone bonds and diABZI as a stimulator of interferon genes(STING)agonist was encapsulated into *** internalization of mB4S,EPI was acidic-responsively released to induce ICD,which was characterized by an increased level of calreticulin(CRT)exposure and enhanced ATP ***,diABZI effectively activated the STING *** with mB4S in combination with an anti-PD-L1 antibody elicited potent immune responses by increasing the ratio of matured dendritic cells(DCs)and CD8+T cells,promoting cytokines secretion,up-regulating M1-like tumor-associated macrophages(TAMs)and down-regulating immunosuppressive myeloid-derived suppressor cells(MDSCs).Therefore,this nanosystem for co-delivery of an ICD inducer and a STING agonist achieved promotion of DCs maturation and CD8+T cells infiltration,creating an immuno-supportive microenvironment,thus potentiating the therapy effect of the anti-PD-L1 antibody in both 4T1 breast and CT26 colon tumor mice.

关键词： Glycopolymer Polymer prodrug Immunogenic cell death Nanoassembly Epirubicin STING pathway Immuno-supportive microenvironment Immunotherapy

The correlation timescale of the X-ray flux during the outbursts of soft X-ray transients

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 161-167页

作者： WU YuXiang1,2,YU WenFei1 & li TiPei2.1 Shanghai Astronomical Observatory,Shanghai 100012,china 2 department of Engineering physics & Center for Astrophysics,tsinghua university,beijing 100084,china Shanghai Astronomical Observatory Shanghai China department of Engineering physics & Center for Astrophysics Tsinghua University Beijing China

Recent studies of black hole and neutron star low mass X-ray binaries(LMXBs) show a positive correlation between the X-ray flux at which the low/hard(LH)-to-high/soft(HS) state transition occurs and the peak flux of the following HS *** analyzing the data from the All Sky Monitor(ASM) onboard the Rossi X-ray Timing Explorer(RXTE),we show that the HS state flux after the source reaches its HS flux peak still correlates with the transition flux during soft X-ray transient(SXT) *** studying large outbursts or flares of GX 339-4,Aql X-1 and 4U 1705-44,we have found that the correlation holds up to 250,40,and 50 d after the LH-to-HS state transition,*** time scales correspond to the viscous time scale in a standard accretion disk around a stellar mass black hole or a neutron star at a radius of-104-5 Rg,indicating that the mass accretion rates in the accretion flow either correlate over a large range of radii at a given time or correlate over a long period of time at a given *** the accretion geometry is a two-flow geometry composed of a sub-Keplerian inflow or outflow and a disk flow in the LH state,the disk flow with a radius up to-105 Rg would have contributed to the nearly instantaneous non-thermal radiation directly or indirectly,and therefore affects the time when the state transition occurs.

关键词： accretion disks black hole physics star:individual(Aquila X-1 GX 339-4 4U 1705-44)

Coexistence of normal, super-, and hyper-deformation in nuclei: A study with angular momentum projection method

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Chinese Science Bulletin 2009年第3期54卷 358-363页

作者： SUN Yang1,2, ZHANG JingYe3, long guilu4,5 & WU Chengli6,7 1 department of physics, Shanghai Jiao Tong university, Shanghai 200240, china 2 Joint Institute for Nuclear Astrophysics, university of Notre Dame, Notre Dame, Indiana 46556, USA 3 department of physics and Astronomy, university of Tennessee, Knoxville, Tennessee 37996, USA 4 department of physics, tsinghua university, beijing 100084, china 5 Center of Nuclear Theory, Lanzhou National Laboratory of Heavy Ion Accelerator, Lanzhou 730000, china 6 department of physics, Xiamen university, Xiamen 361005, china 7 department of physics, Chung Yuan Christian university, Chung-li, Taiwan 32023, china department of physics Shanghai Jiao Tong University Shanghai China Joint Institute for Nuclear Astrophysics University of Notre Dame Notre Dame Indiana USA department of physics and Astronomy University of Tennessee Knoxville Tennessee USA department of physics Tsinghua University Beijing China Center of Nuclear Theory Lanzhou National Laboratory of Heavy Ion Accelerator Lanzhou China department of physics Xiamen University Xiamen China department of physics Chung Yuan Christian University Chung-Li Taiwan China

Angular-momentum-projected energy surface calculations for A ≈ 110 nuclei indicate three distinct energy minima occurring at different angular-momenta. These correspond to normal, super-, and hy- per-deformed shapes coexisting in one nucleus. 110Pd is studied in detail, with a quantitative prediction on super- and hyper-deformed spectra by the Projected Shell Model calculation. It is found that several other neighboring nuclei in the A-110 mass region, with the neutron number around 64, also exhibit clear super- and hyper-deformation minima in the projected calculation.

关键词：原子核光谱角动量能量

Localization of calmodulin and calmodulin-like protein and their functions in biomineralization in P. fucata

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Progress in Natural Science:Materials International 2008年第4期18卷 405-412页

作者： Zi Fang a, Zhenguang Yan a, Shuo li a, Qin Wang a, Weizhong Cao a, Guangrui Xu a, Xunhao Xiong a, liping Xie a,b, Rongqing Zhang a,b, a Institute of Marine Biotechnology, department of Biological Science and Biotechnology, tsinghua university, beijing 100084, china b Protein Science Laboratory of the Ministry of Education, tsinghua university, beijing 100084, china Institute of Marine Biotechnology Department of Biological Science and Biotechnology Tsinghua University Beijing 100084 China Protein Science Laboratory of the Ministry of Education Tsinghua University Beijing 100084 China

Calmodulin (CaM) and calmodulin-like protein (CaLP) are two proteins involved in biomineralization. Their localizations in Pinct- ada fucata mantle epithelia were studied by Western blot (WB) analysis of the nuclear/cytosol fraction of primary cultured P. fucata mantle cells and immunogold electron microscopy. The results showed a completely different distribution of these two proteins at the subcellular level. CaM was distributed throughout both the nucleus and cytoplasm of the mantle epithelium but CaLP was distributed only in the cytoplasm. The functions of these two proteins in biomineralization were investigated by shell regeneration. During this pro- cess, the expressions of CaM and CaLP were greatly enhanced in different organelles of the mantle epithelium. Overexpression of these two proteins and a mutant of calmodulin-like protein (M-CaLP) that lacks an extra C-terminal tail in MC3T3-E1 promoted the mRNA expression of osteopontin, a biomineralization marker for osteoblasts. All of the results indicated that CaM and CaLP have completely different distributions in the mantle epithelium and affect the biomineralization process at different levels. The extra C-terminal tail of CaLP is important for its functions in biomineralization in P. fucata.

关键词： Pinctada fucata Calmodulin Calmodulin-like protein Immunogold electron microscopy

Ultrahigh strength and uniform corrosion in Zn-li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications

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Rare Metals 2024年第10期43卷 5284-5304页

作者： Wan-Ying li Yi-long Dai Wen-Hao Cai Si-Han lin lin Guo De-Chuang Zhang Yuncang li Cuie Wen School of Materials Science and Engineering Xiangtan University department of Prosthodontics Shanghai Ninth People′s HospitalShanghai Jiao Tong University Key Laboratory of Low Dimensional Materials&Application Technology Ministry of EducationXiangtan University School of Engineering RMIT UniversityMelbourne

Zn-li alloys are considered promising candidate materials for biodegradable orthopedic implant applications due to their high mechanical performance and good ***,the presence of a large number of second-phase particles in this class of Zn alloys can lead to severe localized degradation due to micro-galvanic corrosion,which is detrimental to the mechanical integrity of the alloys during tissue healing in the human *** this study we report ultrahigh strength,uniform corrosion,good cytocompatibility,and effective antibacterial ability in Zn-x li（x=0.3,0.5,0.7;wt%） alloys achieved through supersaturated solid solution treatment （SSST） at 375℃ under ultrahigh pressure of 3 GPa.A high concentration of β-liZn4phases coexisted with the-Zn matrix in the as-cast Zn-x li alloys,whereas almost all the li dissolved into the-Zn matrix of SSST *** yield strength was 437 MPa for SSST Zn-0.3li,592 MPa for SSST Zn-0.5 li and 686 MPa for SSST *** SSST Zn-li alloys showed uniform degradation with remarkably reduced degradation rates compared to their as-cast *** 25% concentration extracts of the Zn-x li alloys demonstrated no cytotoxicity toward MC3T3-E1 cells,and the alloys exhibited effective antibacterial ability agains methicillin-resistant staphylococcus aureus.

关键词： Corrosion behavior Mechanical property Supersaturated solid solution treatment (SSST) Ultrahigh pressure Zn-li alloy

Rapid and real-time detection of municipal sludge moisture content based on microwave reflection principle

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Waste Disposal and Sustainable Energy 2024年第2期6卷 259-269页

作者： Yan Zhang Yanhong Jiao Jun li long Deng Binqi Rao Hao Xu Peng Xu lijiang Hu Chunping li College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou 310018China New Energy Engineering and Automotive College Huzhou Vocational and Technical CollegeHuzhou 313099China College of Electronics and Information Engineering Wuxi UniversityWuxi214105China National Institute of Metrology Beijing 100029China College of Science China Jiliang UniversityHangzhou 310018China Anji Guoqian Environment Co. LtdHuzhou 313300China Zhejiang Hongshi Environmental Protection Co. LtdJinhua 321100China

The moisture content(MC)of municipal sludge is the key factor affecting sludge treatment and disposal technologies,while the vast majority of existing measurement methods are off-line and *** realize rapid online detection for the MC of sludge,a detection method based on the microwave reflection principle is proposed:experiments are carried out and the MC computation model of the sludge is derived using the resonant frequency and the permittivity(e').The results reveal that the detection accuracy of granular sludge with a thickness of 10 mm is *** theoretical model between the MC and the real part of e'is developed,and the relationship between the resonant frequency and e'is expressed by a cubic *** average error and the root mean square error(RMSE)of sludge are 2.06%and 2.49%,*** prediction model for the MC of sludge is also given,and the determination coefficient and RMSE are 0.981 and 2.06%,respectively.

关键词： Municipal sludge Moisture content Resonator Real-time detection Resonant frequency

RECOVERY OF CADMIUM AND NICKEL FROM SCRAP Ni-Cd BATTERIES

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Acta Metallurgica Sinica(English Letters) 2001年第4期14卷 303-312页

作者： J.X. Zhu1), B. Yu2), J.H. li1) and Y.F. Nie1) 1) department of Environmental Engineering, tsinghua university, beijing 100084, china 2) Institute of Nuclear Energy Technology, tsinghua university, beijing 100084, china Dept. of Environ. Eng. Tsinghua Univ. Beijing 100084 China

Several typical methods for the recovery of Ni-Cd batteries are described in detail. Based on the comparison between the hydrometallurgical process and the pyrometallurgical process, the latter is selected as the suit... 详细信息

关键词： Cadmium Nickel Recovery Scrap metal

The size effect on transport properties of colossal magnetoresistance materials La_(0.67)Ca_(0.33)MnO_3

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Science china(physics,Mechanics & Astronomy) 2008年第3期51卷 251-257页

作者： li PeiGang1,2,LEI Ming1,2,GUO YanFeng2,GUO Xi2,CHEN LeiMing2, TANG WeiHua1,2,SONG PengYun3 & CHEN JinPing3 1 department of physics,Center for Optoelectronics Materials and Devices,Zhejiang Sci-Tech university,Hangzhou 310018,china 2 National Laboratory for Condensed Matter physics,Institute of physics,Chinese Academy of Sciences,beijing 100080,china 3 department of physics,Peking university,beijing 100875,china department of physics Center for Optoelectronics Materials and Devices Zhejiang Sci-Tech University Hangzhou China National Laboratory for Condensed Matter physics Institute of Physics Chinese Academy of Sciences Beijing China department of physics Peking University Beijing China

High quality La0.67Ca0.33MnO3 (LCMO) film was deposited via a novel pulsed electron deposition technique on SrTiO3(100) single crystal substrate. The micro-bridge with different widths was fabricated by using electron beam lithography (EBL) technique and their transport properties were studied. For the micro-bridges with width of 2 and 1.5 μm,the insulator-to-metal transition temperature (TP) keeps un-changed compared with the film. For the micro-bridges with width of 1 μm,the TP shifts towards the lower temperature by 50 K. When the width decreases down to 500 nm,the insulator-to-metal transition disappears. The magnetoresistance be-havior of these micro-bridges was studied,and the results show that the low field magnetoresistance (LFMR) decreases and the high field magnetoresistances (HFMR) keep almost unchanged as the width of micro-bridge is reduced.

关键词： colossal magnetoresistance pulsed electron deposition electron beam lithography electrical transport properties

PREPARATION OF B-N FILMS BY ION BEAM ASSISTED DEPOSITION

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Acta Metallurgica Sinica(English Letters) 1993年第11期6卷 379-382页

作者： JIANG Hai TAO Kun li Hengde tsinghua university,beijing,china lecturer,department of Materials Science and Engineering,tsinghua university,beijing 100084,china

BN films,synthesized by ion beam assisted deposition,were analysed by RBS,AES, IR spectra and *** of c-BN phase was shown not only by IR spectra at absorption peak of 1100 cm^(-1),but also by electron diffraction *** results of AES demonstrate an effect of N^+ implantation near the film *** deposited films consist of three layers,i.e.,ion implantation layer,film layer and mixed intermediatelayer, according to the difference of *** micro-Knoop hardness of the film is 25—35 GPa.

关键词： ion beam assisted deposition BN film