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Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions

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World Journal of Gastroenterology 2009年第32期15卷 4055-4061页

作者： Chun-li Da yan Xin jing Zhao Xiang-Dong Luo The Fourth Laboratory of Cancer Institute Department of Tumor Pathology of General Surgery Institute the First Hospital of China Medical University Shenyang 11000 1 Liaoning Province China

AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous ***: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric ***: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P<0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P<0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk=0.279, P<0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P<0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was signifi cantly higher than that in the group without lymph node metastasis (41.2%), P<0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk=0.246, P<***: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.

关键词： Apoptosis Cell proliferation Gastric cancer Immunohistochemistry Neoplastic processes Survivinprotein Yes-associated protein

Structural engineering of Sb-based electrode materials to enhance advanced sodium-ion batteries

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Rare Metals 2024年第10期43卷 4777-4806页

作者： Zheng yang Qiao-ling Kang Rui-Wang li-jing yan Xian-He Meng Ting-li Ma College of Materials and Chemistry Jiliang UniversityHangzhou 310018China

Antimony(Sb)is recognized as a potential electrode material for sodium-ion batteries(SIBs)due to its huge reserves,affordability,and high theoretical capacity(660 mAh·g^(-1)).However,Sb-based materials experience significant volume expansion during cycling,leading to comminution of the active substance and limiting their practical use in ***,the volume expansion issue of Sb-based materials during charging/discharging must be solved to create high-performance *** paper presents a detailed review of structural engineering of Sb-based electrode materials,focusing on the performance effects of different kinds of structures on advanced performance ***,the future development and the challenges of Sb-based materials are *** paper can provide specific perspectives on the structure construction and optimization of Sb-based anode materials so as to promote the rapid development and practical applications of SIBs.

关键词： Sb-based electrode Sodium-ion batteries Structural engineering

The fragmentation of ^(20)Ne at 400 A MeV

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Chinese Physics C 2012年第1期36卷 37-42页

作者： CHENG Jin-Xia ZHANG Dong-Hai yan Shi-Wei li Jun-Sheng WANG li-Chun li yan-jing N.Yasuda College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China Institute of Modern Physics Shanxi Normal UniversityLinfen 041004China Beijing Radiation Center Beijing 100875China Fundamental Technology Center National Institute of Radiological

The total charge-changing cross sections and partial cross sections for the production of projectile fragments are measured in the interactions of 400 A MeV 20 Ne with aluminum,carbon and polyethylene targets sandwiched with CR-39 plastic nuclear track *** measured total charge-changing cross sections are compared with the predictions using the Bradt-Peters semi-empirical formula,and the NUCFRAG2 and PHITS *** is shown that the measured experimental results are in good agreement with the theoretical model prediction and other experimental results,and it can be clearly seen that the partial cross sections for fragment production show obvious odd-even effects.

关键词： heavy ion fragmentation charge-changing cross sections CR-39

Performance of a novel vertical-flow settler: a comparative study

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Journal of Environmental Sciences 2006年第5期18卷 858-863页

作者： ZHANG Zhong-guo CHEN Zhao-yang li yan-zhong FAN jing-hua FAN Bin LUANZhao-kun LU Dao-qiang State Key Laboratory of Environmenial Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing100085 China

By increasing particle concentration and G value （root-mean-square velocity gradient） to enhance flocculation, a novel vertical-flow settler was designed to increase sedimentation effectiveness, and to simultaneously improve operational stabilization. Due to the gradual decrease in upward flow-rate of raw water, a floes blanket would form and suspend in the middle section of the settler, not at the bottom as in a conventional clarifier. Enough large floes, resulted from flocculation or fltration, would continuously settle out of the floes blanket, and simultaneously, the floes in raw water or those forming above the blanket would ceaselessly enter the floes blanket. As a result, the floes concentration in the blanket could keep a dynamic balance. The hydrodynamic shear in the blanket was improved by flow separation, which was induced by the abrupt change in flow channel. Due to the floes blanket and improved hydrodynamic shear, flocculation would be enhanced, which was helpful for removing fine particles in raw water. A comparative study showed that the novel vertical-flow settler had a much better performance in the removal of the particles in raw water than a conventional one, when they treated kaolin suspensions of different concentrations （500, 100 and 50 mg/L, respectively） coagulated by polyaluminum chloride（PAC1） at the up-flow rates of 1 and 2 mm/s, respectively.

关键词： vertical-flow settler settling tank floes blanket coagulation flocculation PAC1

Effect of Cl^-ion on Anodic Iron Dissolution in H_2S-Containing Sulfuric Acid Solutions

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Chinese Chemical Letters 1998年第10期9卷 945-948页

作者： li jing yan lin NIU Hat Chao liN Wei Tao WU Shang Zhang liU(Institute of Corrosion and Protection of Metals, State Key Laboratory for Corrosion and Protection, Chinese Academy of Sciences, Shenyang 110015Department of Chemistry, liaoning University, S Chinese Acad Sci Inst Corros & Protect Met State Key Lab Corros & Protect Shenyang 110015 Peoples R China liaoning Univ Dept Chem Shenyang 110036 Peoples R China

The effect of Cl- ion on the anodic iron dissolution in H2SO4 solutions containing H2S has been studied by using electrochemical polarization curve measurements. The competitive adsorption for Cl- and HS- ions at an anodic potential has been calculated using the CNDO/2method. The results show that a ceftain concentration of the Cl- ion can be adsorbed steadily and inhibit the anodic reaction of iron catalyzed by HS-. However, when the Cl- ion reaches the saturation adsorption, it begins to promote the anodic reaction of iron due tO the increased negative charge of iron atoms.

关键词： iron anodic dissolution Cl H_2S, CNDO/2

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

A suspended sediment satellite sensing algorithm based on gradient transiting from water-leaving to satellite-detected reflectance spectrum

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Chinese Science Bulletin 2000年第10期45卷 925-931页

作者： li yan & li jing1. Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China 2. Institute of Remote Sensing Technology and Application, Peking University, Beijing 100871, China Second Institute of Oceanography State Oceanic Administration Hangzhou China Institute of Remote Sensing Technology and Application Peking University Beijing China

In order to remove the fluctuating atmospheric effects from the Case 2 water, an algorithm for retrieval of suspended sediment concentration from NOAA weather satellite imagery was developed under a new approach. This model is based on the linear response from water-leaving to satellite-detected reflectance spectra, simply reflected by the gradient for correlation curve between reflectance of the advanced very high resolution radiometer (AVHRR) channels 1 (R1, 580-680 nm) and 2 (R2, 720-1 100 nm). Proportional factor for this gradient transiting, mathematically represented as (td2/td1) (toz2/toz1), depends on a ratio of atmospheric transmittance for such two channels, including ozone and diffuse transmittance. As a simple but efficient algorithm of gradient, the algorithm of αR1-R2 is selected to retrieve gradient a and then sea surface suspendend sediment concentration.

关键词： marine remote sensing suspended sediment atmospheric effect removal gradient transit AVHRR.

Study on fluctuations of plume front and turbidity maximum in the Hangzhou Bay by remote sensing data

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Acta Oceanologica Sinica 1993年第1期12卷 51-62页

作者： li yan li jing Su Jilan and Ren Fuhu Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012. China Institute of Remote Sensing, Peking University, Beijing 100871, China China

On the basis of the time series of AVHRR data from NOAA satellites and the geographical information system PURSIS, fluctuations of the plume front and the turbidity maximum in the Hangzhou Bay, reflected by the distributions of temperature and suspended sediment concentration respectively, are studied in view of long-term behaviors or seasonal and tidal cycles. The data suggest that the effect of front plays an important role in the development of the turbidity maximum close to the Changjiang Estuary > while the effect of tide dominates over the development of another very turbid water situated in the shoal areas in the southern Hangzhou Bay.

关键词： esturary front suspended sediment remote sensing geographical information system Hangzhou Bay

Expression of Annexin-1 in patients with endometriosis

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Chinese Medical Journal 2008年第10期121卷 927-931页

作者： li Chun-yan LANG jing-he liU Hai-yuan ZHOU Hui-mei Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Background Annexin-1 was identified as an endometriosis-related protein by comparative proteomics in previous study. As an endogeneous anti-inflammatory mediator, Annexin-1 has been shown to regulate the immune response, cell proliferation and apoptosis. To investigate whether Annexin-1 is involved in the pathogenesis of endometriosis, we examined the expression of Annexin-1 in eutopic endometrium of women with or without endometriosis, and detected its expression in peritoneal fluids of those with endometriosis. Methods Eutopic endometrium samples from twenty-five women with endometriosis and those from sixteen age-matched women without endometriosis were collected. Peritoneal fluids were obtained from ten patients with endometriosis. The expression of Annexin-1 protein in eutopic endometrium was detected by immunohistochemistry and Western blotting, and mRNA detected by real-time PCR. Annexin-1 protein in the peritoneal fluids was detected by Western blotting.Results Annexin-1 mRNA and protein were overexpressed in eutopic endometrium of endometriosis without significant differences between the proliferative and secretory phase. Immunohistochemistry showed that Annexin-1 protein was expressed mainly in endometrial glandular celts throughout the menstrual cycle. Annexin-1 protein was detected in the peritoneal fluids of all the ten patients with endometriosis. Conclusions Annexin-1 is overexpressed in eutopic endometrium and presents in the peritoneal fluids of patients with endometriosis, and may play a role in the pathogenesis of endometriosis.

关键词： Annexin-1 endometriosis endometrium ascitic fluid