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GMAT:A Graph Modeling Method for Group Preference Prediction

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 475-493页

作者： Xiangyu li xunhua Guo Guoqing Chen International Business School Jinan UniversityZhuhai519070China School of Economics and Management Tsinghua UniversityBeijing100084China

Preference prediction is the building block of personalized services,and its implementation at the group level helps enterprises identify their target customers *** methods for preference prediction mainly focus on behavioral interactions to extract the associations between groups and products,ignoring the importance of other auxiliary records(e.g.,online reviews and social tags)in association *** paper proposes a novel method named GMAT for group preference prediction,aiming to collectively detect the sophisticated association patterns from user generated content(UGC)and behavioral *** doing so,we construct a tripartite graph to collaborate these two types of data,and design a deep-learning algorithm with mutual attention module for generating the contextualized representations of groups and *** experiments on two real-world datasets show that GMAT is superior to other baselines in terms of group preference ***,GMAT is able to improve prediction accuracy compared with its different variants,further verifying the proposed method’s effectiveness on association pattern detection.

关键词： Group preference UGC tripartite graph deep learning

富马酸丙酚替诺福韦联合双环醇治疗慢性乙型肝炎合并脂肪肝的疗效

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药品评价 2024年第4期21卷 514-517页

作者：李薰华陈宝龙刘起赟赣州市南康区第一人民医院江西赣州341400 赣南医科大学第一附属医院江西赣州341000

目的探究富马酸丙酚替诺福韦(TAF)联合双环醇治疗慢性乙型肝炎合并脂肪肝的效果。方法选择赣州市南康区第一人民医院2020年4月至2022年8月期间收治的88例慢性乙型肝炎合并脂肪肝患者为研究对象,按照随机数字表法分为对照组和观察组,每... 详细信息

目的探究富马酸丙酚替诺福韦(TAF)联合双环醇治疗慢性乙型肝炎合并脂肪肝的效果。方法选择赣州市南康区第一人民医院2020年4月至2022年8月期间收治的88例慢性乙型肝炎合并脂肪肝患者为研究对象,按照随机数字表法分为对照组和观察组,每组44例。对照组给予TAF治疗,观察组给予TAF联合双环醇片治疗。治疗48周后比较两组治疗效果和相关指标的变化。结果治疗后,两组的血清丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)活性均较治疗前下降;观察组的肝脏脂肪控制衰减指数(CAP)水平较治疗前下降,且观察组的ALT、AST活性和CAP水平均较对照组低,差异有统计学意义(P<0.05);观察组血清乙型肝炎病毒DNA(HBV-DNA)、乙肝e抗原(HBeAg)水平和肝脏硬度值(LSM)均低于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率为4.5%,低于对照组的27.3%(P<0.05)。结论采用富马酸丙酚替诺福韦联合双环醇对慢性乙型肝炎合并脂肪肝患者实施治疗,能改善患者肝功能和肝脏脂肪变程度,抑制病毒水平,安全性高。

关键词：富马酸丙酚替诺福韦双环醇慢性乙型肝炎脂肪肝疗效

伴上尿路扩张的尿崩症患者的诊断和治疗:一项单中心临床研究

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现代泌尿外科杂志 2024年第1期29卷 12-17,64页

作者：王学胜周忠涵李兴李勋华廖利民首都医科大学康复医学院北京100068 中国康复研究中心泌尿外科北京100068 山东大学齐鲁医学院山东济南250000 中国康复研究中心神经泌尿科北京100068

目的通过影像尿动力学检查(VUDS)和全尿路功能障碍(AUTD)分级系统描述伴上尿路扩张(UUTD)的尿崩症(DI)患者的全尿路特征,归纳总结伴UUTD的DI患者的诊断和治疗经验。方法回顾性分析中国康复研究中心于2010年1月—2020年1月收治的28例伴U... 详细信息

目的通过影像尿动力学检查(VUDS)和全尿路功能障碍(AUTD)分级系统描述伴上尿路扩张(UUTD)的尿崩症(DI)患者的全尿路特征,归纳总结伴UUTD的DI患者的诊断和治疗经验。方法回顾性分析中国康复研究中心于2010年1月—2020年1月收治的28例伴UUTD的DI患者的临床资料,采用UUTD和AUTD分级系统评估患者的上尿路特征。总结分析所有患者的实验室检查、VUDS、UUTD、神经电生理检查、治疗方案和随访结果等临床资料。结果28例伴UUTD患者中DI患者21例(75.0%),DI合并神经源性膀胱(NB)患者7例(25.0%)。除2例DI合并NB患者因膀胱容量小、顺应性差以及肾功能不全行肠道膀胱扩大成形术外,其余26例(92.9%)患者通过药物治疗联合膀胱颈切开等个体化治疗以及相应的膀胱管理(包括间歇性导尿、留置尿管和规律排尿)取得了满意的治疗效果。13例(46.4%)肾功能异常患者的血肌酐水平从(269.8±105.7)μmol/L下降到(164.4±90.2)μmol/L。28例患者的48条扩张输尿管的上尿路积水扩张分级明显改善,患者的上尿路积水扩张分级中位数由3级降至2级。结论膀胱容量增加、膀胱小梁形成和感觉减退或消失是伴有UUTD的DI患者的共同特征,个体化药物治疗结合合理的膀胱管理可改善DI患者的上尿路扩张程度和肾功能。

关键词：尿崩症膀胱扩张上尿路扩张神经源性膀胱个体化治疗诊断流程

腹膜外途径腹腔镜保留女性内生殖器官膀胱全切原位回肠新膀胱术疗效分析

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中国医学前沿杂志（电子版） 2024年第7期16卷 87-90页

作者：蒋在庆王科朱冠群赵凯尹心宝李勋华杨瀚王世成张宗亮青岛大学附属医院泌尿外科山东青岛266000

目的探讨腹膜外途径保留女性生殖器官的膀胱全切原位回肠膀胱术手术技术并评估其治疗效果和肿瘤学结果。方法收集2019年2月至2022年12月期间就诊于青岛大学附属医院泌尿外科12例患者的基本资料、手术时间、出血量、性生活质量、排尿控... 详细信息

目的探讨腹膜外途径保留女性生殖器官的膀胱全切原位回肠膀胱术手术技术并评估其治疗效果和肿瘤学结果。方法收集2019年2月至2022年12月期间就诊于青岛大学附属医院泌尿外科12例患者的基本资料、手术时间、出血量、性生活质量、排尿控制情况以及术后并发症的数据。定期随访患者的肿瘤和功能结局,术后使用女性性功能指数(Female Sexual Function Index,FSFI)评估性功能状况。结果回顾性分析12例平均年龄为51岁的接受保留生殖器官膀胱全切原位尿流改道术的女性患者。12例手术均顺利完成。平均手术时间(223.58±28.45)min,平均术中出血量(165.00±80.51)ml,术后病理切缘均显示阴性,无淋巴结转移。日间排尿可控制12例(100%),夜间排尿可控制10例(83.3%),患者术后平均FSFI评分为(21.9±1.2)分。结论对于经过筛选的女性膀胱癌患者,生殖器官保留技术是一种安全可行的手术策略。保存生殖器和血管神经束在肿瘤学上可能是安全的,临床疗效满意。

关键词：腹膜外途径腹腔镜生殖器官保留膀胱全切原位尿流改道

Refining the Factors Affecting N_(2)O Emissions from Upland Soils with and without Nitrogen Fertilizer Application at a Global Scale

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Advances in Atmospheric Sciences 2024年第9期41卷 1804-1820页

作者： Wenqian JIANG Siqi li Yong li Meihui WANG Bo WANG Ji liU Jianlin SHEN xunhua ZHENG State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory for Agro-ecological Processes in Subtropical Regions Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Changsha Research Station for Agricultural&Environmental Monitoring Chinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100049China State Environmental Protection Key Laboratory of Formation and Prevention of the Urban Air Pollution Complex Shanghai Academy of Environment SciencesShanghai 200233China Institute of Carbon Neutrality Qilu ZhongkeJinan 251699China Hubei Province Key Laboratory for Geographical Process Analysis and Simulation Central China Normal UniversityWuhan 430079China Department of Ecohydrology Leibniz Institute of Freshwater Ecology and Inland FisheriesBerlin 12587Germany Key laboratory of Environment Change and Resources Use in Beibu Gulf Ministry of EducationNanning Normal UniversityNanning 530001China Golden Mantis school of Architecture Soochow UniversitySuzhou 215123China

Nitrous oxide(N_(2)O)is a long-lived greenhouse gas that mainly originates from agricultural *** and more studies have explored the sources,influencing factors and effective mitigation measures of N_(2)O in recent ***,the hierarchy of factors influencing N_(2)O emissions from agricultural soils at the global scale remains *** this study,we carry out correlation and structural equation modeling analysis on a global N_(2)O emission dataset to explore the hierarchy of influencing factors affecting N_(2)O emissions from the nitrogen(N)and non-N fertilized upland farming systems,in terms of climatic factors,soil properties,and agricultural *** results show that the average N_(2)O emission intensity in the N fertilized soils(17.83 g N ha^(-1)d^(-1))was significantly greater than that in the non-N fertilized soils(5.34 g N ha^(−1) d^(−1))(plimate factors and agricultural practices are the most important influencing factors on N_(2)O emission in non-N and N fertilized upland soils,*** different climatic zones,without fertilizer,the primary influence factors on soil N_(2)O emissions are soil physical properties in subtropical monsoon zone,whereas climatic factors are key in the temperate *** fertilizer,the primary influence factors for subtropical monsoon and temperate continental zones are soil physical properties,while agricultural measures are the main factors in the temperate monsoon *** enhanced agricultural practices,such as reduced N fertilizer rate combined with the addition of nitrification and urease inhibitors can potentially mitigate N_(2)O emissions by more than 60%in upland farming systems.

关键词： N_(2)O emissions influencing factors nitrogen cycling upland farming systems

Genetic and structural analyses suggest that a novel SPG3A mutation causes severe phenotypes of hereditary spastic paraplegia

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Chinese Science Bulletin 2006年第16期51卷 2038-2040页

作者： CHEN Suqin ZHOU Yan li xunhua Labu HUANG Shuang HUANG Weijun ZHOU Chunlong MAXWELL Patrick H WANG Yiming Department of Medical Genetics Sun Yat-Sen University Guangzhou 510089 China Chinese National Human Genome Center at Shanghai Shanghai 201203 China Department of Neurology 1st Affiliated Hospital Sun Yat-Sen Univerisity Guangzhou 510089 China The Second Hospital of the Tibetan Autonomous Region Lhasa 850001 China Hangzhou Genomics Center Hangzhou 310007 China Department of Medicine Hammersmith Hospital Imperial College London UK

Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases. The genotypes and phenotypes of HSP are extremely heterogenous. SPG3A is one of the identified genes underlying HSP, and codes for a GTPase, atlastin. Mutations in SPG3A are currently believed to be associated with early onset and mild phenotypes. And most structura predictions could not detect gross changes in the mutant protein. However, in a severely affected HSP family we have identified a novel SPG3A mutation, c.1228G>A (p.G410R), in a Tibetan kindred. The mutation occurred at the highly conserved nucleotide and co-segregated with the disease, and was absent in the control subjects. Structural predictions showed that the Tibetan mutation occurred at the linking part between the guanylate-binding protein domain (GB, the ball region) and the transmembrane helices (TM, the rod region) at the start point of an α-helix, which may disrupt the helix, and cause changes in the overall structure of the transmembrane region of the molecule. Our results indicate that severe pheno- types can also arise from SPG3A mutations and the linking part of the guanylate-binding protein domainand the transmembrane helices might be crucial in determining the severity of the disease. This paper not only presents the first SPG3A mutational report from the Chinese population, but also provides po- tential evidence for a possible correlation between the severity of the phenotypes of HSP with the ex- tension of the changes in the protein structures of atlastin.

关键词：遗传性痉孪性截瘫 HSP SPG3A 西藏

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《诗经》重章复沓的的文化研究

中国文学研究 2007年第4期 15-19页

作者：李荀华嘉应学院学中文系广东梅州514071

《诗经》305篇原来都是入乐的歌词,所以,现传的诗篇保留了许多歌词的性质,最为典型的是重章复沓。在重章构成的诗歌中,各章相对应的诗句不仅字数相若,句法相同,而且用字也极少变化,所以,便于记忆、利于传唱,促使了《诗经》在周代社会的... 详细信息

《诗经》305篇原来都是入乐的歌词,所以,现传的诗篇保留了许多歌词的性质,最为典型的是重章复沓。在重章构成的诗歌中,各章相对应的诗句不仅字数相若,句法相同,而且用字也极少变化,所以,便于记忆、利于传唱,促使了《诗经》在周代社会的流行普及,这和今天许多先秦古籍中《诗经》保存最为完整不无关系。重章复沓一咏三叹,抒情效果强烈,律场回环跌宕,增强了诗歌的艺术感染力。

关键词：诗经章法研究美学意义

Leprosy without typical skin involvement but with concurrent tuberculosis: a case report

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Journal of Medical Colleges of PLA(China) 2010年第2期25卷 114-118页

作者： liang Yingyin li xunhua Tian Wei Chen Songlin Luo Diqing ling Jian Department of Neurology The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 China Department of Pathology Guangdong Pharmaceutical University Guangzhou 510006 China Department of Dermatology The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510700 China Department of Radiology The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510700 China

Leprosy is characterized by skin lesions and peripheral nerve damage. It may take a long time before the diagnosis can be confirmed if the patients have no typical skin involvements. Here we report an unusual case. A 40-year-old male with lepromatous leprosy showed a gradual onset of bilateral symmetrical neuropathies without characteristic skin manifestations seven years after onset and with pulmonary tuberculosis simultaneously. He was misdiagnosed as having Guillani-Barr6 syndrome and systemic necrotizing vasculitis for 10 years until the skin biopsy was performed. This case indicates that the risk of leprosy exists, though new cases being detected have significantly declined over the last 50 years; neurologists need to pay more attention to leprosy with various manifestations .

关键词： Leprosy Peripheral nerve lesions Type-2 lepra reaction Concurrent tuberculosis

乡村振兴背景下人才吸引力影响因素的实证研究——基于渝西地区的调查数据

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中国农机化学报 2019年第8期40卷 214-220页

作者：曾升科李勋华重庆财经职业学院

当前乡村老龄化、空心化现象严重,为破解乡村人才瓶颈,实现乡村人才振兴,开展乡村人才吸引力影响因素研究。通过在渝西地区开展人才问卷调查,运用Logistic回归分析方法对乡村人才吸引力影响因素进行研究。发现人才对基础设施、生态环境... 详细信息

当前乡村老龄化、空心化现象严重,为破解乡村人才瓶颈,实现乡村人才振兴,开展乡村人才吸引力影响因素研究。通过在渝西地区开展人才问卷调查,运用Logistic回归分析方法对乡村人才吸引力影响因素进行研究。发现人才对基础设施、生态环境、职业发展、配偶就业、交通状况因素的评价(满意度)每降低1个等级,人才愿意到乡村发展的发生比将分别减少27.3%、39.8%、28.2%、17.6%、28.5%,说明基础设施、生态环境、职业发展、配偶就业、交通状况与乡村人才吸引力存在显著正相关关系;人才对治安环境、休闲娱乐因素的评价(满意度)每降低1个等级,人才愿意到乡村就业发展的发生比将分别增加32.4%、15.3%,证明治安环境、休闲娱乐因素与乡村人才吸引力存在显著负相关关系;优惠政策与乡村人才吸引力变量相关性,在0.1的显著水平下没有通过假设检验,表明各级政府的优惠政策没有成为吸引人才的重要因素。乡村要采取让硬件硬起来、环境美起来、空间广起来、政策活起来等措施,实现人才振兴。

关键词：乡村振兴人才吸引力影响因素 Logistic模型